John H Petrini
Affiliation: University of Wisconsin
- The Mre11 complex and ATM: collaborating to navigate S phaseJ H Petrini
University of Wisconsin Medical School, Madison, WI 53706, USA
Curr Opin Cell Biol 12:293-6. 2000..In addition, functions of the Mre11 complex have been biochemically linked to ATM, the large protein kinase that is defective in ataxia-telangiectasia cells by the observation that Nbs1 is a bona fide substrate of the ATM kinase...
- hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaksR S Maser
Laboratory of Genetics, University of Wisconsin Medical School, Madison 53706, USA
Mol Cell Biol 17:6087-96. 1997..Further, these data indicate that hMre11-hRad50 foci form in response to DNA DSBs and are dependent upon a DNA damage-induced signaling pathway...
- Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11D A Bressan
Laboratory of Genetics, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
Genetics 150:591-600. 1998..Mutagenesis of the phosphoesterase signatures in Mre11 thus demonstrated the importance of these conserved motifs for recombinational DNA repair...
- Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesisR S Maser
Laboratory of Genetics, University of Wisconsin Medical School, 445 Henry Mall, Madison, WI 53706, USA
Mol Cell Biol 21:6006-16. 2001..These data suggest that the Mre11 complex suppresses genomic instability through its influence on both the regulation and progression of DNA replication...