Genomes and Genes
Brian G Petrich
Affiliation: University of California
- Talin-dependent integrin signalling in vivoBrian G Petrich
Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA 92122, USA
Thromb Haemost 101:1020-4. 2009....
- Antithrombotic effects of targeting alphaIIbbeta3 signaling in plateletsArarat J Ablooglu
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
Blood 113:3585-92. 2009..Thus, deletion of beta3 RGT disrupts c-Src-mediated alphaIIbbeta3 signaling and confers protection from arterial thrombosis. Consequently, targeting alphaIIbbeta3 signaling may represent a feasible antithrombotic strategy...
- Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulationCraig T Lefort
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Blood 119:4275-82. 2012..We conclude that talin-1 and kindlin-3 serve distinct functions in LFA-1 activation...
- Talin-dependent integrin activation is required for fibrin clot retraction by plateletsJacob R Haling
Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Blood 117:1719-22. 2011....
- Talin is required for integrin-mediated platelet function in hemostasis and thrombosisBrian G Petrich
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 204:3103-11. 2007..These data establish that platelet talin plays a crucial role in hemostasis and provide the first proof that talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo...
- Kindlin: helper, co-activator, or booster of talin in integrin activation?Feng Ye
Department of Medicine, University of California San Diego, La Jolla, California, USA
Curr Opin Hematol 18:356-60. 2011..Here we highlight some of the key studies that have described roles for talin and kindlin in integrin function and discuss several models that explain how talin and kindlins might work together to regulate integrin activation...
- Microfluidic devices for studies of shear-dependent platelet adhesionEdgar Gutierrez
Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
Lab Chip 8:1486-95. 2008..Because of small sample volumes required, the devices could be employed in research with genetically-modified model organisms and for adhesion tests in clinical settings with blood from neonates...
- Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytesYanfeng Wang
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 118:812-9. 2008..These observations further demonstrate that individual PIP5KI isoforms fulfill distinct functions within cells...
- Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprintingPrithu Sundd
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
Microcirculation 18:361-72. 2011..However, elucidating the role of specific proteins in addition to topography requires simultaneous visualization of two fluorochromes...
- The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activationBrian G Petrich
Department of Medicine, UCSD School of Medicine, La Jolla, California 92093 0726, USA
J Clin Invest 117:2250-9. 2007..Furthermore, they suggest that modulation of beta(3) integrin-talin interactions may provide an attractive target for antithrombotics and result in a reduced risk of pathological bleeding...
- A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammationChristiane Kummer
Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
J Biol Chem 285:9462-9. 2010....