Brian G Petrich

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Talin-dependent integrin signalling in vivo
    Brian G Petrich
    Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA 92122, USA
    Thromb Haemost 101:1020-4. 2009
  2. pmc Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets
    Ararat J Ablooglu
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    Blood 113:3585-92. 2009
  3. pmc Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
    Craig T Lefort
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Blood 119:4275-82. 2012
  4. pmc Talin-dependent integrin activation is required for fibrin clot retraction by platelets
    Jacob R Haling
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Blood 117:1719-22. 2011
  5. doi request reprint The mechanism of kindlin-mediated activation of integrin αIIbβ3
    Feng Ye
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Curr Biol 23:2288-95. 2013
  6. pmc Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
    Brian G Petrich
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 204:3103-11. 2007
  7. doi request reprint Kindlin: helper, co-activator, or booster of talin in integrin activation?
    Feng Ye
    Department of Medicine, University of California San Diego, La Jolla, California, USA
    Curr Opin Hematol 18:356-60. 2011
  8. pmc Microfluidic devices for studies of shear-dependent platelet adhesion
    Edgar Gutierrez
    Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
    Lab Chip 8:1486-95. 2008
  9. pmc Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes
    Yanfeng Wang
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:812-9. 2008
  10. pmc Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting
    Prithu Sundd
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Microcirculation 18:361-72. 2011

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Talin-dependent integrin signalling in vivo
    Brian G Petrich
    Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA 92122, USA
    Thromb Haemost 101:1020-4. 2009
    ....
  2. pmc Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets
    Ararat J Ablooglu
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    Blood 113:3585-92. 2009
    ..Thus, deletion of beta3 RGT disrupts c-Src-mediated alphaIIbbeta3 signaling and confers protection from arterial thrombosis. Consequently, targeting alphaIIbbeta3 signaling may represent a feasible antithrombotic strategy...
  3. pmc Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
    Craig T Lefort
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Blood 119:4275-82. 2012
    ..We conclude that talin-1 and kindlin-3 serve distinct functions in LFA-1 activation...
  4. pmc Talin-dependent integrin activation is required for fibrin clot retraction by platelets
    Jacob R Haling
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Blood 117:1719-22. 2011
    ....
  5. doi request reprint The mechanism of kindlin-mediated activation of integrin αIIbβ3
    Feng Ye
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Curr Biol 23:2288-95. 2013
    ..Thus, in contrast to talins, kindlins have little primary effect on integrin αIIbβ3 affinity for monovalent ligands and increase multivalent ligand binding by promoting the clustering of talin-activated integrins...
  6. pmc Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
    Brian G Petrich
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 204:3103-11. 2007
    ..These data establish that platelet talin plays a crucial role in hemostasis and provide the first proof that talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo...
  7. doi request reprint Kindlin: helper, co-activator, or booster of talin in integrin activation?
    Feng Ye
    Department of Medicine, University of California San Diego, La Jolla, California, USA
    Curr Opin Hematol 18:356-60. 2011
    ..Here we highlight some of the key studies that have described roles for talin and kindlin in integrin function and discuss several models that explain how talin and kindlins might work together to regulate integrin activation...
  8. pmc Microfluidic devices for studies of shear-dependent platelet adhesion
    Edgar Gutierrez
    Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
    Lab Chip 8:1486-95. 2008
    ..Because of small sample volumes required, the devices could be employed in research with genetically-modified model organisms and for adhesion tests in clinical settings with blood from neonates...
  9. pmc Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes
    Yanfeng Wang
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:812-9. 2008
    ..These observations further demonstrate that individual PIP5KI isoforms fulfill distinct functions within cells...
  10. pmc Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting
    Prithu Sundd
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Microcirculation 18:361-72. 2011
    ..However, elucidating the role of specific proteins in addition to topography requires simultaneous visualization of two fluorochromes...
  11. pmc The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation
    Brian G Petrich
    Department of Medicine, UCSD School of Medicine, La Jolla, California 92093 0726, USA
    J Clin Invest 117:2250-9. 2007
    ..Furthermore, they suggest that modulation of beta(3) integrin-talin interactions may provide an attractive target for antithrombotics and result in a reduced risk of pathological bleeding...
  12. pmc A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation
    Christiane Kummer
    Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:9462-9. 2010
    ....