P K Peterson

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome
    P K Peterson
    Department of Medicine, Hennepin County Medical Center, Minneapolis, Minn 55415, USA
    Arch Intern Med 158:908-14. 1998
  2. ncbi request reprint The opioid-cytokine connection
    P K Peterson
    Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, MN 55404, USA
    J Neuroimmunol 83:63-9. 1998
  3. ncbi request reprint Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor
    P K Peterson
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, MN 55404, USA
    Neuropharmacology 38:273-8. 1999
  4. ncbi request reprint Human cytomegalovirus replication and modulation of apoptosis in astrocytes
    J R Lokensgard
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minnesota 55404, USA
    J Hum Virol 2:91-101. 1999
  5. ncbi request reprint Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus
    J R Lokensgard
    Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
    J Neurovirol 7:208-19. 2001
  6. ncbi request reprint Orphan opioid receptor oligonucleotides inhibit HIV-1 expression in human brain cells
    C C Chao
    Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation MN 55404, USA
    Adv Exp Med Biol 437:83-90. 1998
  7. ncbi request reprint Diazepam inhibits HIV-1 Tat-induced migration of human microglia
    J R Lokensgard
    Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
    J Neurovirol 7:481-6. 2001
  8. ncbi request reprint Inhibition of microglial cell RANTES production by IL-10 and TGF-beta
    S Hu
    Neuroimmunobiology and Host Defense Laboratory, Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, MN 55404, USA
    J Leukoc Biol 65:815-21. 1999
  9. pmc WIN55,212-2 inhibits production of CX3CL1 by human astrocytes: involvement of p38 MAP kinase
    W S Sheng
    Department of Medicine, The Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 4:244-8. 2009
  10. pmc Cytokine expression in the mouse brain in response to immune activation by Corynebacterium parvum
    W S Sheng
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, and the University of Minnesota Medical School, NeuroImmunology Lab D 305, 914 South 8th St, Minneapolis, MN 55404, USA
    Clin Diagn Lab Immunol 8:446-8. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome
    P K Peterson
    Department of Medicine, Hennepin County Medical Center, Minneapolis, Minn 55415, USA
    Arch Intern Med 158:908-14. 1998
    ..To provide a preliminary assessment of the efficacy and safety of fludrocortisone acetate treatment of chronic fatigue syndrome...
  2. ncbi request reprint The opioid-cytokine connection
    P K Peterson
    Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, MN 55404, USA
    J Neuroimmunol 83:63-9. 1998
    ..The importance of opiate addiction in the AIDS epidemic means that gaining a better understanding of the mechanisms of opioid-induced immunomodulation is of more than academic interest...
  3. ncbi request reprint Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor
    P K Peterson
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, MN 55404, USA
    Neuropharmacology 38:273-8. 1999
    ..They also provide evidence, for the first time, that an endogenous mu-opioid peptide has neuroimmunomodulatory activity...
  4. ncbi request reprint Human cytomegalovirus replication and modulation of apoptosis in astrocytes
    J R Lokensgard
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minnesota 55404, USA
    J Hum Virol 2:91-101. 1999
    ..To characterize replication patterns and cytopathic effects during human cytomegalovirus (HCMV) infection of brain cells...
  5. ncbi request reprint Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus
    J R Lokensgard
    Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
    J Neurovirol 7:208-19. 2001
    ..These results suggest that IP-10 possesses direct antiviral activity in neurons and support a role for microglia in both antiviral defense of the brain as well as amplification of immune responses during neuroinflammation...
  6. ncbi request reprint Orphan opioid receptor oligonucleotides inhibit HIV-1 expression in human brain cells
    C C Chao
    Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation MN 55404, USA
    Adv Exp Med Biol 437:83-90. 1998
    ..These findings indicate that while human brain cells constitutively express mRNA for OR, antisense oligonucleotides to OR non-specifically inhibit acute HIV-1 infection...
  7. ncbi request reprint Diazepam inhibits HIV-1 Tat-induced migration of human microglia
    J R Lokensgard
    Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
    J Neurovirol 7:481-6. 2001
    ..These data support the notion that through their effects on microglia, peripheral BDZ receptor ligands could alter the neuropathogenesis of HIV-1...
  8. ncbi request reprint Inhibition of microglial cell RANTES production by IL-10 and TGF-beta
    S Hu
    Neuroimmunobiology and Host Defense Laboratory, Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, MN 55404, USA
    J Leukoc Biol 65:815-21. 1999
    ..These results may have important therapeutic implications for inflammatory diseases of the brain...
  9. pmc WIN55,212-2 inhibits production of CX3CL1 by human astrocytes: involvement of p38 MAP kinase
    W S Sheng
    Department of Medicine, The Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 4:244-8. 2009
    ..Our results support the concept that synthetic cannabinoids have anti-inflammatory properties and that these agents may have therapeutic potential for certain neuroinflammatory disorders...
  10. pmc Cytokine expression in the mouse brain in response to immune activation by Corynebacterium parvum
    W S Sheng
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, and the University of Minnesota Medical School, NeuroImmunology Lab D 305, 914 South 8th St, Minneapolis, MN 55404, USA
    Clin Diagn Lab Immunol 8:446-8. 2001
    ....
  11. ncbi request reprint Effect of thalidomide on chemokine production by human microglia
    J R Lokensgard
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    J Infect Dis 182:983-7. 2000
    ..These results suggest thalidomide could have a therapeutic role in acute bacterial meningitis through inhibition of IL-8-mediated neutrophil chemotaxis...
  12. ncbi request reprint Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: antiviral implications
    M C Cheeran
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
    J Neurovirol 7:135-47. 2001
    ..The host defense function of microglial cells may be directed in part by chemokines, such as MCP-1, produced by infected astrocytes...
  13. ncbi request reprint U50488 inhibits HIV-1 expression in acutely infected monocyte-derived macrophages
    C C Chao
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Hennepin County Medical Center and the University of Minnesota Medical School, Minneapolis, MN 55404, USA
    Drug Alcohol Depend 62:149-54. 2001
    ..Taken together, these in vitro findings support the anti-HIV-1 property of U50488, and suggest that KOR ligands may have therapeutic potential for treating patients with acquired immunodeficiency syndrome...
  14. ncbi request reprint Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes
    P K Peterson
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA
    Biochem Pharmacol 61:1145-51. 2001
    ..The results of this study broaden understanding of the antiviral properties of KOR ligands to include cells outside of the nervous system and suggest a potential role for these agents in the treatment of HIV-1 infection...
  15. ncbi request reprint Naltrexone potentiates anti-HIV-1 activity of antiretroviral drugs in CD4+ lymphocyte cultures
    G Gekker
    Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Hennepin County Medical Center and the University of Minnesota Medical School, Minneapolis, MN 55404, USA
    Drug Alcohol Depend 64:257-63. 2001
    ..Also, based upon naltrexone's safety profile and its synergistic activity in vitro, these findings suggest clinical trials should be considered of naltrexone as an adjunctive therapy of HIV-1 infection...
  16. ncbi request reprint Transcriptional response of human microglial cells to interferon-gamma
    R B Rock
    Department of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Genes Immun 6:712-9. 2005
    ..In sum, our results provide a foundation for the molecular mechanisms of the microglial response to IFN-gamma-a key to understanding cell-mediated immunity of the CNS...
  17. ncbi request reprint CCL5 evokes calcium signals in microglia through a kinase-, phosphoinositide-, and nucleotide-dependent mechanism
    C R Shideman
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurosci Res 83:1471-84. 2006
    ..Because changes in [Ca(2+)](i) affect chemotaxis, secretion, and gene expression, pharmacologic modulation of this pathway may alter inflammatory and degenerative processes in the CNS...
  18. ncbi request reprint Severe sepsis in the emergency department and its association with a complicated clinical course
    S W Smith
    Department of Emergency Medicine, Hennepin County Medical Center, and the University of Minnesota Medical School, Minneapolis 55415, USA
    Acad Emerg Med 5:1169-76. 1998
    ..The objective of the study was to use modified criteria to determine the clinical course associated with three levels of infection severity in infected patients admitted from the ED...
  19. ncbi request reprint Cannabinoids and morphine differentially affect HIV-1 expression in CD4(+) lymphocyte and microglial cell cultures
    P K Peterson
    Minneapolis Medical Research Foundation, 914 S Eighth Street, Minneapolis, MN 55404, USA
    J Neuroimmunol 147:123-6. 2004
    ..These in vitro findings support the notion that pharmacologic factors need to be considered in epidemiological studies and animal models that pertain to HIV-1 infection...
  20. pmc kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression
    C C Chao
    Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation and University of Minnesota Medical School, 55404, USA
    Proc Natl Acad Sci U S A 93:8051-6. 1996
    ..These findings suggest that kappa opioid agonists have immunomodulatory activity in the brain, and that these compounds could have potential in the treatment of HIV-1-associated encephalopathy...
  21. ncbi request reprint Activation of human microglial cells by HIV-1 gp41 and Tat proteins
    W S Sheng
    Department of Pharmacology, Institute for Brain and Immune Disorders, Minneapolis, Minnesota, 55404, USA
    Clin Immunol 96:243-51. 2000
    ..The results of this study suggest that HIV-1 Tat and gp41 proteins impact several key functions of microglial cells which could contribute to the neuropathogenesis of HIV-1...
  22. ncbi request reprint Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell cultures
    C C Chao
    Minneapolis Medical Research Foundation, Department of Medicine, Hennepin County Medical Center, Minnesota, USA
    Clin Immunol Immunopathol 77:358-65. 1995
    ..Exogenous TGF-beta, on the other hand, suppressed LPS-stimulated TNF-alpha release. These findings suggest an autoregulation of microglial cell TNF-alpha production by TGF-beta which may limit inflammation-associated brain injury...