Lisa Peterson

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Polyamines are traps for reactive intermediates in furan metabolism
    Lisa A Peterson
    Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 24:1924-36. 2011
  2. pmc Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes
    Leah A Gates
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Drug Metab Dispos 40:596-601. 2012
  3. pmc Decomposition of S-nitrosocysteine via S- to N-transnitrosation
    Lisa A Peterson
    Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:721-3. 2007
  4. ncbi request reprint Electrophilic intermediates produced by bioactivation of furan
    Lisa A Peterson
    Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Rev 38:615-26. 2006
  5. pmc Identification of a cis-2-butene-1,4-dial-derived glutathione conjugate in the urine of furan-treated rats
    Lisa A Peterson
    Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:1138-41. 2006
  6. ncbi request reprint Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis
    L A Peterson
    Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Res 61:5757-63. 2001
  7. ncbi request reprint Glutathione trapping to measure microsomal oxidation of furan to cis-2-butene-1,4-dial
    Lisa A Peterson
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Drug Metab Dispos 33:1453-8. 2005
  8. ncbi request reprint Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan
    Michael C Byrns
    Cancer Center and Division of Environmental and Occupational Health, School of Public Health, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 15:373-9. 2002
  9. pmc Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan
    Ding Lu
    Department of Medicinal Chemistry, Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:997-1007. 2009
  10. pmc Identification of furan metabolites derived from cysteine-cis-2-butene-1,4-dial-lysine cross-links
    Ding Lu
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:142-51. 2010

Collaborators

  • Thomas Kensler
  • Helmut Sies
  • ELIZABETH WATTENBERG
  • S S Hecht
  • Peter Dedon
  • F Guengerich
  • Li Li
  • SHANA STURLA
  • Michael C Byrns
  • Ding Lu
  • Choua C Vu
  • Jiachang Gong
  • Nicole M Thomson
  • Leah A Gates
  • Linda E Sandercock
  • Xiang Yu
  • Bingzi Chen
  • Jeong Yun Choi
  • Renée S Mijal
  • Anita E Wichmann
  • John R Jalas
  • Martin B Phillips
  • Mathilde M Sullivan
  • H Artee Luchman
  • Jennifer N Hahn
  • Frank R Jirik
  • Jennette L Giesbrecht
  • V G Vaidyanathan
  • Jose Luis Abad
  • Roger A Jones
  • Karen C Angel
  • James F Neels
  • Jonathan W Neidigh
  • Hong Zang
  • Goutam Chowdhury
  • Sreenivas Kanugula
  • Qingming Fang
  • Anthony E Pegg
  • Robert C Moschel
  • Nancy L Fleischer
  • Gary T Pauly
  • Edward J McIntee
  • Patrick M Kenney
  • Pramod Upadhyaya
  • Patrick M J Kenney
  • Daniel P Predecki

Detail Information

Publications24

  1. pmc Polyamines are traps for reactive intermediates in furan metabolism
    Lisa A Peterson
    Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 24:1924-36. 2011
    ..Their detection in furan-treated hepatocytes and in urine from furan-treated rats indicates that polyamines may play an important role in the toxicity of furan...
  2. pmc Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes
    Leah A Gates
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Drug Metab Dispos 40:596-601. 2012
    ..These results suggest that humans are capable of oxidizing furan to its toxic metabolite, BDA, at rates comparable to those of species sensitive to furan exposure. Therefore, humans may be susceptible to furan's toxic effects...
  3. pmc Decomposition of S-nitrosocysteine via S- to N-transnitrosation
    Lisa A Peterson
    Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:721-3. 2007
    ..The formation of a reactive intermediate in this process indicates the potential for this reaction to contribute to the toxicological properties of nitric oxide...
  4. ncbi request reprint Electrophilic intermediates produced by bioactivation of furan
    Lisa A Peterson
    Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Rev 38:615-26. 2006
    ..Metabolism studies indicate that this reactive metabolite is formed in vivo. It is also an intermediate leading to other metabolites whose role in furan-derived toxicities has yet to be explored...
  5. pmc Identification of a cis-2-butene-1,4-dial-derived glutathione conjugate in the urine of furan-treated rats
    Lisa A Peterson
    Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:1138-41. 2006
    ..These results indicate that glutathione conjugation of the reactive metabolite of furan occurs in vivo. This metabolite may serve as a useful marker for furan exposure and metabolism in risk assessment studies...
  6. ncbi request reprint Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis
    L A Peterson
    Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Res 61:5757-63. 2001
    ..It is likely that similar interactions are important for the organospecific effects of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone...
  7. ncbi request reprint Glutathione trapping to measure microsomal oxidation of furan to cis-2-butene-1,4-dial
    Lisa A Peterson
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Drug Metab Dispos 33:1453-8. 2005
    ..However, the data are also consistent with the involvement of other P450 enzymes in the oxidation of furan in untreated animals. This assay will be a valuable tool to explore tissue and species differences in rates of furan oxidation...
  8. ncbi request reprint Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan
    Michael C Byrns
    Cancer Center and Division of Environmental and Occupational Health, School of Public Health, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 15:373-9. 2002
    ..The data provide support for the hypothesis that cis-2-butene-1,4-dial is an important genotoxic intermediate in furan-induced carcinogenesis...
  9. pmc Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan
    Ding Lu
    Department of Medicinal Chemistry, Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:997-1007. 2009
    ..Given the abundance of these metabolites in urine of furan-treated rats, these pathways appear to be major pathways of furan biotransformation in vivo...
  10. pmc Identification of furan metabolites derived from cysteine-cis-2-butene-1,4-dial-lysine cross-links
    Ding Lu
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:142-51. 2010
    ..Because they are derived from cellular BDA reaction products, these metabolites are markers of furan exposure and bioactivation and could be explored as potential biomarkers in human studies...
  11. pmc Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial
    Michael C Byrns
    Division of Environmental Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:414-20. 2006
    ..These data support the hypothesis that cis-butene-1,4-dial is a genotoxic metabolite of furan. This method will allow us to explore the role of these adducts in furan-induced carcinogenesis...
  12. ncbi request reprint Synthesis of a 2'-deoxyguanosine adduct of cis-2-butene-1,4-dial, a reactive metabolite of furan
    Choua C Vu
    Division of Environmental Health Sciences and Cancer Center, University of Minnesota, Box 806 Mayo, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Chem Res Toxicol 18:1012-7. 2005
    ..Finally, these studies provide the necessary groundwork for the preparation of oligonucleotides with site specifically incorporated cis-2-butene-1,4-dial-derived adducts...
  13. ncbi request reprint The formation of substituted 1,N6-etheno-2'-deoxyadenosine and 1,N2-etheno-2'-deoxyguanosine adducts by cis-2-butene-1,4-dial, a reactive metabolite of furan
    Michael C Byrns
    Division of Environmental Health Sciences and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:1607-13. 2004
    ..These secondary adducts retain a reactive aldehyde with the potential to form cross-links and are likely to contribute significantly to furan's toxic and carcinogenic effects...
  14. ncbi request reprint Nucleophilic reactions between thiols and a tobacco specific nitrosamine metabolite, 4-hydroxy-1-(3-pyridyl)-1-butanone
    Lisa A Peterson
    Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455
    Chem Res Toxicol 16:661-7. 2003
    ....
  15. ncbi request reprint The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice
    Nicole M Thomson
    Division of Environmental and Occupation Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:1-6. 2003
    ..These data are consistent with previous studies, which indicate that DNA methylation is the critical pathway for NNK-induced lung carcinogenesis in A/J mice...
  16. ncbi request reprint Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cells
    Anita E Wichmann
    Division of Environmental and Occupational Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:87-94. 2003
    ..Altogether, these data indicate that genotoxic methylating agents activate MAPKs through mechanisms that are likely to involve the alkylation of cellular targets other than DNA...
  17. ncbi request reprint Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent
    Jiachang Gong
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Am Chem Soc 129:2101-11. 2007
    ..Moreover, a positive correlation was observed between DNA adduct levels and cell sensitivity to AF. The potential contributing roles of AOR-mediated bioactivation and adduct stability to the cytotoxicity of AF are discussed...
  18. ncbi request reprint Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    John R Jalas
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:794-806. 2003
    ....
  19. ncbi request reprint The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants
    Renée S Mijal
    Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:424-34. 2004
    ..In addition, differences observed in the repair of this adduct by mammalian proteins may translate into differences in sensitivity to the mutagenic and carcinogenic effects of NNK or other pyridyloxobutylating nitrosamines...
  20. ncbi request reprint Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity
    Jiachang Gong
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    J Med Chem 49:2593-9. 2006
    ..These data support the role of AOR-mediated metabolism and indicate the involvement of other stereochemically dictated pathways, such as transport and biomolecule binding, in contributing to the cytotoxicity of acylfulvenes...
  21. doi request reprint Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    Linda E Sandercock
    Department of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Carcinogenesis 29:866-74. 2008
    ..Extrapolating to humans, MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as NNK...
  22. ncbi request reprint Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases
    Jeong Yun Choi
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 23rd and Pierce Avenues, Nashville, TN 37232 0146, USA
    J Biol Chem 281:38244-56. 2006
    ..The results with pol eta may be relevant to some mutations previously reported with O(6)-alkylG adducts in mammalian cells...
  23. pmc Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytidine in oxidized DNA
    Bingzi Chen
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47 277, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 19:982-5. 2006
    ..These results suggest that the oxadiazabicyclo(3.3.0)octaimine adducts of dC and dA could represent endogenous DNA lesions arising from oxidative stresses that also give rise to other DNA adducts...

Research Grants23

  1. Role of O6-alkylguanine in nitrosamine-induced cancers
    Lisa Peterson; Fiscal Year: 2007
    ..These studies will set the stage for a molecular epidemiological study to determine whether individuals who are unable to repair this mutagenic adduct are at increased risk of tobacco-related cancers. ..
  2. Mechanism of Furan-Induced Toxicity and Carcinogencity
    Lisa Peterson; Fiscal Year: 2007
    ..Some concerns are the potential for a null result in specific aims 1 and, particularly in aim 3 which may negate the use of a rodent model for determination of furan toxicity and mutagenicity in humans. ..
  3. Role of O6-alkylguanine in nitrosamine-induced cancers
    Lisa Peterson; Fiscal Year: 2009
    ..These studies will set the stage for a molecular epidemiological study to determine whether individuals who are unable to repair this mutagenic adduct are at increased risk of tobacco-related cancers. ..
  4. Mechanism of Furan-Induced Toxicity and Carcinogencity
    Lisa Peterson; Fiscal Year: 2009
    ..Some concerns are the potential for a null result in specific aims 1 and, particularly in aim 3 which may negate the use of a rodent model for determination of furan toxicity and mutagenicity in humans. ..
  5. Mechanism of Furan-Induced Toxicity and Carcinogencity
    Lisa A Peterson; Fiscal Year: 2010
    ..abstract_text> ..
  6. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    ..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
  7. COCARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2002
    ..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
  8. MECHANISMS OF FURAN-INDUCED TOXICITY AND CARCINOGENICITY
    Lisa Peterson; Fiscal Year: 2003
    ..They will also help understand how "nongenotoxic" compounds exert their effects on DNA function. ..
  9. Mechanism of Furan-Induced Toxicity and Carcinogencity
    Lisa A Peterson; Fiscal Year: 2010
    ..abstract_text> ..