Research Topics
| Lisa PetersonSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Polyamines are traps for reactive intermediates in furan metabolismLisa A Peterson
Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 24:1924-36. 2011..Their detection in furan-treated hepatocytes and in urine from furan-treated rats indicates that polyamines may play an important role in the toxicity of furan...- Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymesLeah A Gates
Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Drug Metab Dispos 40:596-601. 2012..These results suggest that humans are capable of oxidizing furan to its toxic metabolite, BDA, at rates comparable to those of species sensitive to furan exposure. Therefore, humans may be susceptible to furan's toxic effects... - Decomposition of S-nitrosocysteine via S- to N-transnitrosationLisa A Peterson
Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 20:721-3. 2007..The formation of a reactive intermediate in this process indicates the potential for this reaction to contribute to the toxicological properties of nitric oxide... 
Electrophilic intermediates produced by bioactivation of furanLisa A Peterson
Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Drug Metab Rev 38:615-26. 2006..Metabolism studies indicate that this reactive metabolite is formed in vivo. It is also an intermediate leading to other metabolites whose role in furan-derived toxicities has yet to be explored...- Identification of a cis-2-butene-1,4-dial-derived glutathione conjugate in the urine of furan-treated ratsLisa A Peterson
Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 19:1138-41. 2006..These results indicate that glutathione conjugation of the reactive metabolite of furan occurs in vivo. This metabolite may serve as a useful marker for furan exposure and metabolism in risk assessment studies... - Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesisL A Peterson
Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Res 61:5757-63. 2001..It is likely that similar interactions are important for the organospecific effects of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone... - Glutathione trapping to measure microsomal oxidation of furan to cis-2-butene-1,4-dialLisa A Peterson
The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St S E, Minneapolis, MN 55455, USA
Drug Metab Dispos 33:1453-8. 2005..However, the data are also consistent with the involvement of other P450 enzymes in the oxidation of furan in untreated animals. This assay will be a valuable tool to explore tissue and species differences in rates of furan oxidation... - Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furanMichael C Byrns
Cancer Center and Division of Environmental and Occupational Health, School of Public Health, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 15:373-9. 2002..The data provide support for the hypothesis that cis-2-butene-1,4-dial is an important genotoxic intermediate in furan-induced carcinogenesis... - Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furanDing Lu
Department of Medicinal Chemistry, Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 22:997-1007. 2009..Given the abundance of these metabolites in urine of furan-treated rats, these pathways appear to be major pathways of furan biotransformation in vivo... - Identification of furan metabolites derived from cysteine-cis-2-butene-1,4-dial-lysine cross-linksDing Lu
Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 23:142-51. 2010..Because they are derived from cellular BDA reaction products, these metabolites are markers of furan exposure and bioactivation and could be explored as potential biomarkers in human studies... - Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dialMichael C Byrns
Division of Environmental Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 19:414-20. 2006..These data support the hypothesis that cis-butene-1,4-dial is a genotoxic metabolite of furan. This method will allow us to explore the role of these adducts in furan-induced carcinogenesis... - The formation of substituted 1,N6-etheno-2'-deoxyadenosine and 1,N2-etheno-2'-deoxyguanosine adducts by cis-2-butene-1,4-dial, a reactive metabolite of furanMichael C Byrns
Division of Environmental Health Sciences and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 17:1607-13. 2004..These secondary adducts retain a reactive aldehyde with the potential to form cross-links and are likely to contribute significantly to furan's toxic and carcinogenic effects... - Synthesis of a 2'-deoxyguanosine adduct of cis-2-butene-1,4-dial, a reactive metabolite of furanChoua C Vu
Division of Environmental Health Sciences and Cancer Center, University of Minnesota, Box 806-Mayo, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Chem Res Toxicol 18:1012-7. 2005..Finally, these studies provide the necessary groundwork for the preparation of oligonucleotides with site specifically incorporated cis-2-butene-1,4-dial-derived adducts... - Nucleophilic reactions between thiols and a tobacco specific nitrosamine metabolite, 4-hydroxy-1-(3-pyridyl)-1-butanoneLisa A Peterson
Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455
Chem Res Toxicol 16:661-7. 2003.... - The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J miceNicole M Thomson
Division of Environmental and Occupation Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 16:1-6. 2003..These data are consistent with previous studies, which indicate that DNA methylation is the critical pathway for NNK-induced lung carcinogenesis in A/J mice... - Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agentJiachang Gong
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Am Chem Soc 129:2101-11. 2007..Moreover, a positive correlation was observed between DNA adduct levels and cell sensitivity to AF. The potential contributing roles of AOR-mediated bioactivation and adduct stability to the cytotoxicity of AF are discussed... - Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cellsAnita E Wichmann
Division of Environmental and Occupational Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 16:87-94. 2003..Altogether, these data indicate that genotoxic methylating agents activate MAPKs through mechanisms that are likely to involve the alkylation of cellular targets other than DNA... - Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)John R Jalas
Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 16:794-806. 2003.... - The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variantsRenée S Mijal
Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 17:424-34. 2004..In addition, differences observed in the repair of this adduct by mammalian proteins may translate into differences in sensitivity to the mutagenic and carcinogenic effects of NNK or other pyridyloxobutylating nitrosamines... - Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicityJiachang Gong
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
J Med Chem 49:2593-9. 2006..These data support the role of AOR-mediated metabolism and indicate the involvement of other stereochemically dictated pathways, such as transport and biomolecule binding, in contributing to the cytotoxicity of acylfulvenes... - Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerasesJeong-Yun Choi
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 23rd and Pierce Avenues, Nashville, TN 37232-0146, USA
J Biol Chem 281:38244-56. 2006..The results with pol eta may be relevant to some mutations previously reported with O(6)-alkylG adducts in mammalian cells... 
Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)Linda E Sandercock
Department of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
Carcinogenesis 29:866-74. 2008..Extrapolating to humans, MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as NNK...- Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytidine in oxidized DNABingzi Chen
Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-277, Cambridge, Massachusetts 02139, USA
Chem Res Toxicol 19:982-5. 2006..These results suggest that the oxadiazabicyclo(3.3.0)octaimine adducts of dC and dA could represent endogenous DNA lesions arising from oxidative stresses that also give rise to other DNA adducts...
Research Grants
- Role of O6-alkylguanine in nitrosamine-induced cancersLisa Peterson; Fiscal Year: 2007..These studies will set the stage for a molecular epidemiological study to determine whether individuals who are unable to repair this mutagenic adduct are at increased risk of tobacco-related cancers. ..
- Mechanism of Furan-Induced Toxicity and CarcinogencityLisa Peterson; Fiscal Year: 2007..Some concerns are the potential for a null result in specific aims 1 and, particularly in aim 3 which may negate the use of a rodent model for determination of furan toxicity and mutagenicity in humans. ..
- Role of O6-alkylguanine in nitrosamine-induced cancersLisa Peterson; Fiscal Year: 2009..These studies will set the stage for a molecular epidemiological study to determine whether individuals who are unable to repair this mutagenic adduct are at increased risk of tobacco-related cancers. ..
- Mechanism of Furan-Induced Toxicity and CarcinogencityLisa Peterson; Fiscal Year: 2009..Some concerns are the potential for a null result in specific aims 1 and, particularly in aim 3 which may negate the use of a rodent model for determination of furan toxicity and mutagenicity in humans. ..
- Mechanism of Furan-Induced Toxicity and CarcinogencityLisa A Peterson; Fiscal Year: 2010..abstract_text> ..
- CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITESLisa Peterson; Fiscal Year: 2006..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
- COCARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITESLisa Peterson; Fiscal Year: 2002..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
- MECHANISMS OF FURAN-INDUCED TOXICITY AND CARCINOGENICITYLisa Peterson; Fiscal Year: 2003..They will also help understand how "nongenotoxic" compounds exert their effects on DNA function. ..
- Mechanism of Furan-Induced Toxicity and CarcinogencityLisa A Peterson; Fiscal Year: 2010..abstract_text> ..