Craig Peterson

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Nucleosome dynamics regulates DNA processing
    Nicholas L Adkins
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Struct Mol Biol 20:836-42. 2013
  2. pmc DNA repair choice defines a common pathway for recruitment of chromatin regulators
    Gwendolyn Bennett
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
    Nat Commun 4:2084. 2013
  3. doi request reprint Transcriptional memory: mothers SET the table for daughters
    Craig L Peterson
    Program in Molecular Medicine, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 20:R240-2. 2010
  4. ncbi request reprint Cellular machineries for chromosomal DNA repair
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Genes Dev 18:602-16. 2004
  5. ncbi request reprint Promoter targeting and chromatin remodeling by the SWI/SNF complex
    C L Peterson
    Department of Biochemistry and Molecular Biology, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Curr Opin Genet Dev 10:187-92. 2000
  6. ncbi request reprint Transcriptional activation: getting a grip on condensed chromatin
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 210, Worcester, MA 01605, USA
    Curr Biol 13:R195-7. 2003
  7. ncbi request reprint Genome integrity: a HAT needs a chaperone
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 17:R324-6. 2007
  8. ncbi request reprint Histones and histone modifications
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 14:R546-51. 2004
  9. pmc Chromatin dynamics during repair of chromosomal DNA double-strand breaks
    Manisha Sinha
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Epigenomics 1:371-85. 2009
  10. pmc Chromatin remodeling enzymes: taming the machines. Third in review series on chromatin dynamics
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    EMBO Rep 3:319-22. 2002

Research Grants

  1. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2003
  2. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2004
  3. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2004
  4. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2005
  5. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2005
  6. Analysis of yeast chromatin structure and function
    Craig Peterson; Fiscal Year: 2006
  7. Analysis of yeast chromatin structure and function
    Craig Peterson; Fiscal Year: 2007
  8. Analysis of the yeast SWI1, SWI2, and SWI3 proteins
    Craig Peterson; Fiscal Year: 2007
  9. Analysis of yeast chromatin structure and function
    Craig Peterson; Fiscal Year: 2009
  10. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2003

Collaborators

Detail Information

Publications62

  1. pmc Nucleosome dynamics regulates DNA processing
    Nicholas L Adkins
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Struct Mol Biol 20:836-42. 2013
    ..Z histone variant in Exo1 processing, and it further suggests that the two resection pathways require distinct chromatin remodeling events to navigate chromatin structure. ..
  2. pmc DNA repair choice defines a common pathway for recruitment of chromatin regulators
    Gwendolyn Bennett
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
    Nat Commun 4:2084. 2013
    ..X phosphorylation. Our work indicates that cell cycle position has a key role in DNA repair pathway choice and that recruitment of chromatin regulators is tightly coupled to homologous recombination. ..
  3. doi request reprint Transcriptional memory: mothers SET the table for daughters
    Craig L Peterson
    Program in Molecular Medicine, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 20:R240-2. 2010
    ..A recent study, however, shows that mothers and their daughters share similar transcriptional frequencies, and inheritance of mother's transcriptional tendencies requires methylation of histone H3 by a Set1 methyltransferase...
  4. ncbi request reprint Cellular machineries for chromosomal DNA repair
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Genes Dev 18:602-16. 2004
  5. ncbi request reprint Promoter targeting and chromatin remodeling by the SWI/SNF complex
    C L Peterson
    Department of Biochemistry and Molecular Biology, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Curr Opin Genet Dev 10:187-92. 2000
    ....
  6. ncbi request reprint Transcriptional activation: getting a grip on condensed chromatin
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 210, Worcester, MA 01605, USA
    Curr Biol 13:R195-7. 2003
    ..A recent study, however, suggests a different and surprising viewpoint in which these protein assemblies are quite dynamic and individual subunits play key roles in chromatin remodeling...
  7. ncbi request reprint Genome integrity: a HAT needs a chaperone
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 17:R324-6. 2007
    ..Four groups have now identified protein Rtt109p as the catalytic subunit of a novel histone H3 acetylase complex that harbors a histone chaperone subunit essential for significant activity...
  8. ncbi request reprint Histones and histone modifications
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 14:R546-51. 2004
  9. pmc Chromatin dynamics during repair of chromosomal DNA double-strand breaks
    Manisha Sinha
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Epigenomics 1:371-85. 2009
    ..In particular, we discuss recent studies implicating specialized roles for several, distinct ATP-dependent chromatin remodeling enzymes in facilitating multiple steps within the homologous recombination process...
  10. pmc Chromatin remodeling enzymes: taming the machines. Third in review series on chromatin dynamics
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    EMBO Rep 3:319-22. 2002
    ....
  11. ncbi request reprint Recruitment of chromatin remodeling machines
    C L Peterson
    Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biochem 78:179-85. 2000
    ..Here we review these recent observations and discuss the implications for gene-specific regulation by chromatin remodeling machines...
  12. ncbi request reprint ATP-dependent chromatin remodeling: going mobile
    C L Peterson
    Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, Biotech 2, Suite 301, 373 Plantation St, 01605, Worcester, MA, USA
    FEBS Lett 476:68-72. 2000
    ..Here the biochemical properties of these enzymes are reviewed and the manner in which ATP-driven nucleosome movements might account for many of these diverse activities is discussed...
  13. ncbi request reprint Chromatin: mysteries solved?
    C L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Biochem Cell Biol 79:219-25. 2001
    ..This view could not be further from the truth! Here I briefly outline four areas of chromatin research where new paradigms and mysteries are still waiting to be discovered...
  14. ncbi request reprint Transcription. Unlocking the gates to gene expression
    Christopher J Fry
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 295:1847-8. 2002
  15. ncbi request reprint Chromatin remodeling: nucleosomes bulging at the seams
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 12:R245-7. 2002
    ..Recent mechanistic studies suggest that these enzymes generate localized changes in DNA topology that drive formation of multiple, remodeled nucleosomal states...
  16. ncbi request reprint Histone H4-K16 acetylation controls chromatin structure and protein interactions
    Michael Shogren-Knaak
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 311:844-7. 2006
    ....
  17. ncbi request reprint ATP-dependent and ATP-independent roles for the Rad54 chromatin remodeling enzyme during recombinational repair of a DNA double strand break
    Branden Wolner
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:10855-60. 2005
    ..We also identify a novel Rad54-dependent chromatin remodeling event that occurs in vivo during the DNA strand invasion step of HR. This ATP-dependent remodeling activity of Rad54 appears to control subsequent steps in the HR process...
  18. ncbi request reprint Molecular biology. Chromatin higher order folding--wrapping up transcription
    Peter J Horn
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Science 297:1824-7. 2002
    ..We also discuss evidence suggesting that adenosine-5'-triphosphate-dependent chromatin-remodeling enzymes and histone-modifying enzymes may regulate transcription by controlling the extent and dynamics of chromatin higher order folding...
  19. ncbi request reprint Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin
    Mariela Jaskelioff
    Interdisciplinary Graduate Program and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:9212-8. 2003
    ..Taken together, our results indicate that Rad54p is a chromatin-remodeling enzyme that promotes homologous DNA pairing events within the context of chromatin...
  20. ncbi request reprint Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes
    Laurie A Boyer
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 10:935-42. 2002
    ..Our results are consistent with a general role for SANT domains in functional interactions with histone N-terminal tails...
  21. pmc Dominant role for signal transduction in the transcriptional memory of yeast GAL genes
    Sharmistha Kundu
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 30:2330-40. 2010
    ....
  22. pmc SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster
    Sharmistha Kundu
    Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 21:997-1004. 2007
    ..Genetic studies indicate that SWI/SNF controls transcriptional memory by antagonizing ISWI-like chromatin remodeling enzymes...
  23. ncbi request reprint A Rad51 presynaptic filament is sufficient to capture nucleosomal homology during recombinational repair of a DNA double-strand break
    Manisha Sinha
    Program in Molecular Medicine, Interdisciplinary Graduate Program, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell 30:803-10. 2008
    ..Thus, contrary to popular belief, nucleosomes do not pose a potent barrier for successful recognition and capture of homology by an invading presynaptic filament...
  24. ncbi request reprint Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement
    Xiaofang Yang
    Interdisciplinary Graduate Program, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Struct Mol Biol 14:540-7. 2007
    ..Our data indicate that H2A-H2B dimer loss is not an obligatory consequence of ATP-dependent DNA translocation, and furthermore they suggest that SWI/SNF is composed of at least four interdependent modules...
  25. ncbi request reprint The SIN domain of the histone octamer is essential for intramolecular folding of nucleosomal arrays
    Peter J Horn
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Struct Biol 9:167-71. 2002
    ..Our results suggest that Sin- versions of histones may alleviate the need for SWI/SNF in vivo by disrupting higher-order chromatin folding...
  26. ncbi request reprint A native peptide ligation strategy for deciphering nucleosomal histone modifications
    Michael A Shogren-Knaak
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Biol Chem 278:15744-8. 2003
    ..This difference between peptide and array substrates suggests that the ability to generate specifically modified nucleosomal arrays should provide a powerful tool for understanding the effects of post-translational histone modifications...
  27. ncbi request reprint Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes
    Peter J Horn
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Struct Biol 9:263-7. 2002
    ..These results suggest that linker histones exert a global, genome-wide control over remodeling activities, implicating a new, obligatory coupling between linker histone kinases and ATP-dependent remodeling enzymes...
  28. ncbi request reprint Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases
    Michael R Langer
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    J Biol Chem 277:27337-44. 2002
    ..In each case, the A190T derivative behaved similarly to wild type GCN5, suggesting that the efficacy of HAT activity by GCN5 is not limited by the availability of nuclear acetyl-CoA pools...
  29. pmc Structural characterization of H3K56Q nucleosomes and nucleosomal arrays
    Shinya Watanabe
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
    Biochim Biophys Acta 1799:480-6. 2010
    ..Our data suggests that H3K56 acetylation is one of the molecular mechanisms employed to keep chromatin with nucleosome-free regions accessible to the DNA replication and repair machinery...
  30. pmc Architecture of the SWI/SNF-nucleosome complex
    Mekonnen Lemma Dechassa
    Department of Biochemistry and Molecular Biology, Southern Illinois University, 1245 Lincoln Drive, Carbondale, IL 62901 4413, USA
    Mol Cell Biol 28:6010-21. 2008
    ..The highly conserved Snf5 subunit associates with the histone octamer and not with nucleosomal DNA. The model of the binding trough of SWI/SNF illustrates how nucleosomal DNA can be mobilized while SWI/SNF remains bound...
  31. pmc Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage
    Manolis Papamichos-Chronakis
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:2437-49. 2006
    ..We propose that Ino80 and Swr1 function antagonistically at chromatin surrounding a DSB, and that they regulate the incorporation of different histone H2A variants that can either promote or block cell cycle checkpoint adaptation...
  32. pmc The LRS and SIN domains: two structurally equivalent but functionally distinct nucleosomal surfaces required for transcriptional silencing
    Christopher J Fry
    Program in Molecular Medicine, University of Massachusetts Medical School, Biotech 2, Suite 210, Worcester, MA 01605, USA
    Mol Cell Biol 26:9045-59. 2006
    ..Our study shows that structurally similar nucleosomal surfaces provide distinct functionalities in vivo and in vitro...
  33. pmc The ins and outs of heterochromatic DNA repair
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Dev Cell 20:285-7. 2011
    ..A recent study by Chiolo et al. (2011) published in Cell finds that DNA double-strand breaks formed within heterochromatin are shuttled to adjacent sites that are "safe" to complete repair by recombination...
  34. ncbi request reprint ATP-dependent chromatin remodeling
    Corey L Smith
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Top Dev Biol 65:115-48. 2005
    ..This chapter provides an introduction to the structure of chromatin and then describes how special classes of enzymes modulate chromatin structure to allow access to DNA...
  35. pmc Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling
    Manisha Sinha
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 138:1109-21. 2009
    ..These results suggest that recombinational repair in the context of heterochromatin presents additional constraints that can be overcome by ATP-dependent chromatin-remodeling enzymes...
  36. pmc Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery
    Pranav Oza
    Program in Molecular Medicine, Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 23:912-27. 2009
    ..Based on these findings, we propose that sequestration of unrepaired or slowly repaired DSBs to the nuclear periphery reflects a competition between alternative repair pathways...
  37. pmc Role of chromatin states in transcriptional memory
    Sharmistha Kundu
    Interdisciplinary Graduate Program and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Biochim Biophys Acta 1790:445-55. 2009
    ..We also discuss illuminating cases of cellular memory in budding yeast and evaluate whether transcriptional memory in yeast is nuclear or cytoplasmically inherited...
  38. ncbi request reprint Structural analysis of the yeast SWI/SNF chromatin remodeling complex
    Corey L Smith
    University of Massachusetts Medical School, Program in Molecular Medicine, Worcester 01605, USA
    Nat Struct Biol 10:141-5. 2003
    ..We also report a three-dimensional reconstruction of yeast SWI/SNF derived from electron micrographs...
  39. pmc A conserved Swi2/Snf2 ATPase motif couples ATP hydrolysis to chromatin remodeling
    Corey L Smith
    Program in Molecular Medicine, University of Massachusetts Medical School, Biotech 2, Suite 210, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 25:5880-92. 2005
    ..Interestingly, motif V of the human Swi2p/Snf2p homolog, Brg1p, has been shown to be a possible hot spot for mutational alterations associated with cancers...
  40. ncbi request reprint Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling
    David A Hill
    Department of Cell Biology at the University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 280:41777-83. 2005
    ..We further demonstrate that HMGN1 does not affect SWI/SNF-dependent chromatin remodeling on either mononucleosomes or nucleosomal arrays, indicating that SWI/SNF functions independently of HMGN1...
  41. ncbi request reprint Switching on chromatin: mechanistic role of histone H4-K16 acetylation
    Michael Shogren-Knaak
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Cell Cycle 5:1361-5. 2006
    ..The potential significance of this finding for in vivo chromatin structure, establishment of euchromatic domains, and promotion of gene transcription is examined...
  42. ncbi request reprint HDAC's at work: everyone doing their part
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 9:921-2. 2002
    ..A recent report of genome-wide, microarray maps of histone acetylation has uncovered the intragenic targets for six different yeast HDACs and has led to the discovery of new heterochromatin-like domains...
  43. ncbi request reprint Heterochromatin assembly: a new twist on an old model
    Peter J Horn
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Biotech 2, Suite 210, Worcester, 01605, USA
    Chromosome Res 14:83-94. 2006
    ..Recent studies have also identified a novel E3 ubiquitin ligase universally required for H3 K9 methylation. Here we outline these studies and propose several models for the role of this E3 ligase in heterochromatin assembly...
  44. ncbi request reprint Opening the DNA repair toolbox: localization of DNA double strand breaks to the nuclear periphery
    Pranav Oza
    Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, MA, USA
    Cell Cycle 9:43-9. 2010
    ..In this Extra View, we discuss these recent reports, and we show that the Est1 component of the telomerase machinery plays an essential role in anchoring DSB chromatin to the nuclear envelope protein, Mps3...
  45. ncbi request reprint Recruitment of the recombinational repair machinery to a DNA double-strand break in yeast
    Branden Wolner
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 12:221-32. 2003
    ..These studies provide a near comprehensive view of the molecular events required for the in vivo assembly of a functional Rad51p presynaptic filament...
  46. ncbi request reprint Chromatin and transcription: histones continue to make their marks
    Mariela Jaskelioff
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
    Nat Cell Biol 5:395-9. 2003
  47. ncbi request reprint Creating designer histones by native chemical ligation
    Michael A Shogren-Knaak
    University of Massachusetts Medical School, Worchester, Massachusetss 01605, USA
    Methods Enzymol 375:62-76. 2004
  48. ncbi request reprint Coupling tandem affinity purification and quantitative tyrosine iodination to determine subunit stoichiometry of protein complexes
    Corey L Smith
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech II Suite 210, Worcester, MA 01605, USA
    Methods 31:104-9. 2003
    ....
  49. pmc Polyamine analogues: potent inducers of nucleosomal array oligomerization and inhibitors of yeast cell growth
    Lenny M Carruthers
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Drive, Biotech 2, Suite 210, Worcester, MA 01605, USA
    Biochem J 405:541-5. 2007
    ..We find that a class of long-chain polyamines called oligoamines are potent inducers of nucleosomal array oligomerization in vitro and that these same polyamine analogues rapidly block yeast cell growth...
  50. doi request reprint The Ino80 chromatin-remodeling enzyme regulates replisome function and stability
    Manolis Papamichos-Chronakis
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotechnology 2, Suite 210, Worcester, Massachusetts 01605, USA
    Nat Struct Mol Biol 15:338-45. 2008
    ..Our data indicate that the chromatin-remodeling activity of Ino80 regulates efficient progression of replication forks and that Ino80 has a crucial role in stabilizing a stalled replisome to ensure proper restart of DNA replication...
  51. pmc A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation
    Peter J Horn
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 19:1705-14. 2005
    ..These studies provide evidence for a novel Rik1-associated E3 ubiquitin ligase that is required for heterochromatin formation...
  52. pmc Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA
    Brent D Brower-Toland
    Department of Physics, Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 99:1960-5. 2002
    ..When arrays were relaxed before the dissociated state was reached, nucleosomes were able to reassemble and to repeat the disassembly process. The kinetic parameters for nucleosome disassembly also have been determined...
  53. pmc The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome
    Yutao Fu
    Bioinformatics Program, Boston University, Boston, Massachusetts, USA
    PLoS Genet 4:e1000138. 2008
    ..We suggest that binding of CTCF provides an anchor point for positioning nucleosomes, and chromatin remodeling is an important component of CTCF function...
  54. ncbi request reprint Chromatin remodeling activities act on UV-damaged nucleosomes and modulate DNA damage accessibility to photolyase
    Hélène Gaillard
    Institut für Zellbiologie and Institut für Molekularbiologie, Departement Biologie, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 278:17655-63. 2003
    ..Similar activities might relieve the inhibitory effect of nucleosomes on DNA repair processes in living cells...
  55. ncbi request reprint DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC
    Yongli Zhang
    Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Mol Cell 24:559-68. 2006
    ..Such loop formation may provide a molecular basis for the biological functions of remodelers...
  56. ncbi request reprint Probing SWI/SNF remodeling of the nucleosome by unzipping single DNA molecules
    Alla Shundrovsky
    Cornell University, Department of Physics, Laboratory of Atomic and Solid State Physics, Ithaca, New York 14853, USA
    Nat Struct Mol Biol 13:549-54. 2006
    ..These results impose substantial constraints on the mechanism of SWI/SNF remodeling...
  57. ncbi request reprint gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
    Dipanjan Chowdhury
    CBR Institute for Biomedical Research and The Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 20:801-9. 2005
    ..The effect of PP2A on gamma-H2AX levels is independent of ATM, ATR, or DNA-PK activity...
  58. ncbi request reprint Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae
    Wang L Cheung
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21210, USA
    Curr Biol 15:656-60. 2005
    ..CK2 has been implicated in regulating a DNA-damage response; our data suggest that histone H4 S1 is one of its physiological substrates. These data suggest that this modification is a part of the DNA-repair histone code...
  59. ncbi request reprint DNA instructed displacement of histones H2A and H2B at an inducible promoter
    Guillermo P Vicent
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, Passeig Maritim 37 49, E 08003 Barcelona, Spain
    Mol Cell 16:439-52. 2004
    ..In MMTV nucleosome arrays, SWI/SNF displaces H2A and H2B from nucleosome B and not from the adjacent nucleosome. Thus, the outcome of nucleosome remodeling by SWI/SNF depends on DNA sequence...
  60. ncbi request reprint The SANT domain: a unique histone-tail-binding module?
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Rev Mol Cell Biol 5:158-63. 2004
  61. ncbi request reprint Profound challenges do remain in our understanding of the mechanisms of gene regulation
    Steven J Triezenberg
    Biochim Biophys Acta 1779:1-2. 2008

Research Grants27

  1. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2003
    ..This aim also describes a conditional degron strategy to define the role(s) of individual SWI/SNF subunits for both in vivo and in vitro functions ..
  2. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2004
    ..These studies will test the hypothesis that these histone variants create specialized chromatin structures. ..
  3. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2004
    ..This aim also describes a conditional degron strategy to define the role(s) of individual SWI/SNF subunits for both in vivo and in vitro functions ..
  4. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2005
    ..These studies will test the hypothesis that these histone variants create specialized chromatin structures. ..
  5. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2005
    ..This aim also describes a conditional degron strategy to define the role(s) of individual SWI/SNF subunits for both in vivo and in vitro functions ..
  6. Analysis of yeast chromatin structure and function
    Craig Peterson; Fiscal Year: 2006
    ..The fourth aim will investigate the role of a novel casein kinase 2-dependent phosphorylation of histone H4 Serine 1 in DSB repair. ..
  7. Analysis of yeast chromatin structure and function
    Craig Peterson; Fiscal Year: 2007
    ..The fourth aim will investigate the role of a novel casein kinase 2-dependent phosphorylation of histone H4 Serine 1 in DSB repair. ..
  8. Analysis of the yeast SWI1, SWI2, and SWI3 proteins
    Craig Peterson; Fiscal Year: 2007
    ..This machine is essential for mammalian development and inactivation of human SWI/SNF leads to a variety of cancers. ..
  9. Analysis of yeast chromatin structure and function
    Craig Peterson; Fiscal Year: 2009
    ..The fourth aim will investigate the role of a novel casein kinase 2-dependent phosphorylation of histone H4 Serine 1 in DSB repair. ..
  10. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2003
    ..These studies will test the hypothesis that these histone variants create specialized chromatin structures. ..
  11. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2002
    ..This aim also describes a conditional degron strategy to define the role(s) of individual SWI/SNF subunits for both in vivo and in vitro functions ..
  12. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2002
    ..These studies will test the hypothesis that these histone variants create specialized chromatin structures. ..
  13. YEAST CHROMATIN STRUCTURE/FUNCTION
    Craig Peterson; Fiscal Year: 1999
    ....
  14. YEAST SWI1, SWI2, AND SWI3 PROTEINS
    Craig Peterson; Fiscal Year: 1993
    ..The results from the proposed studies will enrich our knowledge of the global role that SWI products play in transcription and provide valuable insights into the mechanisms for regulating transcription by RNA polymerase II...
  15. YEAST SWI1, SWI2, AND SWI3 PROTEINS
    Craig Peterson; Fiscal Year: 1999
    ..The fifth aim will use in vivo labeling and in vitro association assays to investigate the subunit organization of SWI/SNF. ..
  16. YEAST CHROMATIN STRUCTURE/FUNCTION
    Craig Peterson; Fiscal Year: 2000
    ....
  17. YEAST SWI1, SWI2, AND SWI3 PROTEINS
    Craig Peterson; Fiscal Year: 2000
    ..The fifth aim will use in vivo labeling and in vitro association assays to investigate the subunit organization of SWI/SNF. ..
  18. YEAST SWI1, SWI2, AND SWI3 PROTEINS
    Craig Peterson; Fiscal Year: 2001
    ..The fifth aim will use in vivo labeling and in vitro association assays to investigate the subunit organization of SWI/SNF. ..
  19. Yeast Chromatin Structure and Function
    Craig L Peterson; Fiscal Year: 2010
    ..Consequently, defects in these pathways can impact cell survival and maintenance of genome integrity. The studies described here will investigate the role of key enzymes and structural proteins that regulate these events. ..