Paul J Peters

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors
    Paul J Peters
    Center for AIDS Research, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Retrovirology 5:5. 2008
  2. pmc Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis
    Paul J Peters
    Center for AIDS Research, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Biotech II Suite 315, Worcester, MA 01605, USA
    J Virol 80:6324-32. 2006
  3. pmc Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced
    Paul J Peters
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester MA 01605, USA
    J Virol 78:6915-26. 2004
  4. pmc A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection
    Thomas Musich
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Virol 85:2397-405. 2011
  5. ncbi request reprint Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: effects of viral diversity, target cell and receptor density
    Samantha Willey
    Center for AIDS Research, Program in Molecular Medicine, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech II, 373 Plantation St, Worcester, MA 01605, USA
    Antiviral Res 68:96-108. 2005
  6. ncbi request reprint Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues
    Paul J Peters
    Center for AIDS Research, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 373 Plantation Street Biotech II Suite 315, Worcester, MA 01605, USA
    J Neuroimmune Pharmacol 2:32-41. 2007
  7. pmc Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes
    Maria José Duenas-Decamp
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Virol 83:2575-83. 2009
  8. ncbi request reprint CD4-independent infection of HIV and SIV: implications for envelope conformation and cell tropism in vivo
    Jayanta Bhattacharya
    Suite 315, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA
    AIDS 17:S35-43. 2003
  9. pmc Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles
    Jayanta Bhattacharya
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA 01605, USA
    J Virol 78:5500-6. 2004
  10. doi request reprint Human immunodeficiency viruses: propagation, quantification, and storage
    Paul J Peters
    Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Microbiol . 2013

Collaborators

Detail Information

Publications10

  1. pmc Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors
    Paul J Peters
    Center for AIDS Research, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Retrovirology 5:5. 2008
    ..These R5 envelopes conferred a wide range of macrophage tropism and included highly macrophage-tropic variants from brain and non-macrophage-tropic variants from lymph node...
  2. pmc Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis
    Paul J Peters
    Center for AIDS Research, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Biotech II Suite 315, Worcester, MA 01605, USA
    J Virol 80:6324-32. 2006
    ..The extensive variation in R5 tropism reported here is likely to have an important impact on pathogenesis and on the capacity of HIV-1 to transmit...
  3. pmc Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced
    Paul J Peters
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester MA 01605, USA
    J Virol 78:6915-26. 2004
    ..These envelopes are able to infect cells that express low levels of CD4 and/or CCR5 and may have adapted for replication in brain macrophages and microglia, which are known to express limited amounts of CD4...
  4. pmc A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection
    Thomas Musich
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Virol 85:2397-405. 2011
    ..In summary, we show that a conserved determinant in the V1 loop modulates the V3 loop to prime low CD4 use and macrophage infection...
  5. ncbi request reprint Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: effects of viral diversity, target cell and receptor density
    Samantha Willey
    Center for AIDS Research, Program in Molecular Medicine, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech II, 373 Plantation St, Worcester, MA 01605, USA
    Antiviral Res 68:96-108. 2005
    ..The extent of inhibition was dependent on cell type and on cell surface CCR5 concentration. Our results underscore the potential of CCR5 inhibitors for clinical development...
  6. ncbi request reprint Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues
    Paul J Peters
    Center for AIDS Research, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 373 Plantation Street Biotech II Suite 315, Worcester, MA 01605, USA
    J Neuroimmune Pharmacol 2:32-41. 2007
    ..e., do highly macrophage-tropic variants confer a broader tropism among CD4(+) T-cell populations late in disease and contribute to their depletion?)...
  7. pmc Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes
    Maria José Duenas-Decamp
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Virol 83:2575-83. 2009
    ..Our results have relevance for env-based vaccines that will need to expose critical CD4 contact residues to the immune system...
  8. ncbi request reprint CD4-independent infection of HIV and SIV: implications for envelope conformation and cell tropism in vivo
    Jayanta Bhattacharya
    Suite 315, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA
    AIDS 17:S35-43. 2003
  9. pmc Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles
    Jayanta Bhattacharya
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA 01605, USA
    J Virol 78:5500-6. 2004
    ..Our results demonstrate that gp41 cytoplasmic cysteines that are targets for palmitoylation and are required for envelope trafficking to classical lipid rafts are not essential for HIV-1 replication...
  10. doi request reprint Human immunodeficiency viruses: propagation, quantification, and storage
    Paul J Peters
    Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Microbiol . 2013
    ..Provided are methods for propagating and quantifying HIV, as well as recommendations for long-term storage. Background information about these methods is also provided and includes their advantages, disadvantages, and troubleshooting...