Marc Peters-Golden

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Influence of body mass index on the response to asthma controller agents
    M Peters-Golden
    Division of Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Eur Respir J 27:495-503. 2006
  2. ncbi Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages
    Claudio Canetti
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0642, USA
    J Leukoc Biol 79:1234-41. 2006
  3. ncbi Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts
    Natalie Walker
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Pathol 178:2461-9. 2011
  4. ncbi Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:5644-9. 2005
  5. ncbi Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523
    Ming Luo
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:41512-20. 2004
  6. ncbi Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 168:4018-24. 2002
  7. ncbi Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function
    Kevin M Vannella
    Immunology Graduate Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:7883-90. 2007
  8. ncbi Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent
    Vibha Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor 48109 0642, USA
    Am J Respir Cell Mol Biol 27:752-8. 2002
  9. ncbi Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation
    Ryan P Charbeneau
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1103-11. 2003
  10. ncbi Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Immunol 178:1628-34. 2007

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi Influence of body mass index on the response to asthma controller agents
    M Peters-Golden
    Division of Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Eur Respir J 27:495-503. 2006
    ....
  2. ncbi Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages
    Claudio Canetti
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0642, USA
    J Leukoc Biol 79:1234-41. 2006
    ..These results identify a fundamental difference in Fc gammaR signaling between DCs and MØ, which may relate to the divergent, functional consequences of target ingestion in the two cell types...
  3. ncbi Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts
    Natalie Walker
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Pathol 178:2461-9. 2011
    ..These data suggest a key role for local tissue-specific, organ-resident, mesenchymal precursors in the fibrogenic processes in human adult lungs...
  4. ncbi Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:5644-9. 2005
    ..Our results for the first time link EP2 receptor loss on fibroblasts following fibrotic lung injury to altered suppression by PGE(2) and thus identify a novel fibrogenic mechanism...
  5. ncbi Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523
    Ming Luo
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:41512-20. 2004
    ....
  6. ncbi Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 168:4018-24. 2002
    ..This study demonstrates for the first time that leptin-deficient mice display impaired host defense in bacterial pneumonia that may be due to a defect in alveolar macrophage phagocytosis and leukotriene synthesis...
  7. ncbi Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function
    Kevin M Vannella
    Immunology Graduate Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:7883-90. 2007
    ..These data provide mechanistic insight into the therapeutic benefit of leukotriene synthesis inhibitors and CysLT1 receptor antagonists in animal models of fibrosis...
  8. ncbi Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent
    Vibha Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor 48109 0642, USA
    Am J Respir Cell Mol Biol 27:752-8. 2002
    ..These alterations in AEC phenotype likely contribute to the propensity for pulmonary fibrosis observed in COX-2-deficient mice...
  9. ncbi Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation
    Ryan P Charbeneau
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1103-11. 2003
    ..In conclusion, these data demonstrate that GM-CSF regulates PGE(2) production in pulmonary fibroblasts and AECs and thus plays an important role in limiting fibroproliferation...
  10. ncbi Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Immunol 178:1628-34. 2007
    ....
  11. ncbi Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression
    Rommel L Sagana
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:32264-71. 2009
    ..This is the first description, to our knowledge, of PI3K/PTEN balance directing GPCR expression, and provides a novel mechanism for cellular effects of PTEN...
  12. ncbi Prostaglandin E2 as an inhibitory modulator of fibrogenesis in human lung allografts
    Natalie M Walker
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 185:77-84. 2012
    ..However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood...
  13. ncbi Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, SPHI A Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Infect Immun 78:2264-71. 2010
    ..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia...
  14. ncbi Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism
    Michael J Coffey
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0642, USA
    Biochim Biophys Acta 1584:81-90. 2002
    ..Zileuton reduced ROI generation in LPS-treated cells. These studies identify an important role for ROI and ONOO(-) in the suppression of 5-LO metabolism by LPS...
  15. ncbi Protection from pulmonary fibrosis in leukotriene-deficient mice
    Marc Peters-Golden
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Crit Care Med 165:229-35. 2002
    ....
  16. ncbi Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity
    Ming Luo
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12165-70. 2003
    ..These results unequivocally demonstrate that the positioning of 5-LO within the nucleus of resting cells is a powerful determinant of the capacity to generate LTB4 upon subsequent activation...
  17. ncbi Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells
    Linda Badri
    Department of Internal Medicine, University of Michigan Health System, 1500 E Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Am J Respir Cell Mol Biol 45:809-16. 2011
    ....
  18. ncbi Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages
    Michael Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Exp Lung Res 30:615-33. 2004
    ..iNOS knock-out mice were protected from the decrease in alveolar macrophage 5-lipoxygenase metabolism. iNOS regulates alveolar macrophage 5-lipoxygenase metabolism following endotoxin exposure...
  19. ncbi Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase
    Carlos H C Serezani
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Blood 106:1067-75. 2005
    ..Our results demonstrate that LTs, especially LTB4, enhanceAM microbicidal activity through the PKC-delta-dependent activation of NADPH oxidase...
  20. ncbi Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling
    Zbigniew Zaslona
    Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Blood 119:2358-67. 2012
    ..Our findings reveal a novel role for PGE(2)/EP2/protein kinase A signaling in the suppression of macrophage maturation...
  21. ncbi Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins
    Thomas G Brock
    Department of Internal Medicine, University of Michigan, 6301 MSRB III, Ann Arbor, MI 48109 0642, USA
    Prostaglandins Other Lipid Mediat 71:131-45. 2003
    ..The shift in mediator profile, to one that minimizes leukotrienes and emphasizes prostacyclin, prostaglandin E2 and NO, provides a signal that reduces leukocyte function, as indicated by impaired killing of Gram-negative bacteria...
  22. ncbi Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP
    Sang Pyo Lee
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 182:530-7. 2009
    ....
  23. ncbi Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils
    Carlos H C Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Medical School, University of Michigan Health System, 6301 MSRB III, Box 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    J Leukoc Biol 78:976-84. 2005
    ..These results identify a heretofore unrecognized role for activation of 5-LO and subsequent production of LTB(4) in stimulation of PMN NADPH oxidase activation by PUFAs...
  24. ncbi Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Cell Mol Biol 32:135-41. 2005
    ..Collectively, these data describe the novel mechanistic finding that PGE(2), via the EP2 receptor, decreases tyrosine phosphorylation on PTEN, resulting in increased PTEN enzyme activity and inhibition of fibroblast migration...
  25. ncbi Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Interferon Cytokine Res 26:827-33. 2006
    ..This finding may be important in the pharmacologic regulation of immune responses through manipulation of cAMP signaling cascades and contributes to our understanding of the differences between these cell types...
  26. ncbi The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice
    Kristy A Bauman
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 120:1950-60. 2010
    ..These studies demonstrate crosstalk between plasminogen activation and PGE2 generation in the lung and provide a mechanism for the well-known antifibrotic actions of the fibrinolytic pathway...
  27. ncbi Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signaling
    Katsuhide Okunishi
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:32231-43. 2011
    ....
  28. ncbi Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 37:562-70. 2007
    ..We conclude that PGE2 suppresses the microbicidal activity of AMs through the G(s)-coupled EP2/EP4 receptors, with increased cAMP inhibiting the assembly and activation of p47phox...
  29. ncbi Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 189:867-75. 2012
    ..These results demonstrate that leptin receptor-mediated ERK activation plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions...
  30. ncbi Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2
    Emilie Bourdonnay
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health Systems, Ann Arbor, MI, USA
    J Leukoc Biol 92:219-31. 2012
    ..Defining the kinases that control AM p40phox activation and that are the targets for inhibition by PGE(2) provides new insights into immunoregulation in the infected lung...
  31. ncbi PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi
    C Henrique Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Sci Signal 5:ra12. 2012
    ..Because enhanced production of PGE(2) accompanies many immunosuppressed states, the PTEN-dependent pathway described here may contribute to impaired antifungal defenses...
  32. ncbi Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation
    Megan N Ballinger
    The Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 295:L114-22. 2008
    ..These results highlight the complex regulation of GM-CSF and innate immunity post-BMT...
  33. ncbi Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein
    Sandra M Jones
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
    J Biol Chem 277:38550-6. 2002
    ..Moreover, we suggest that another sequence that can mediate nuclear import of 5-lipoxygenase remains to be identified...
  34. ncbi Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis
    Claudia F Benjamim
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:1616-20. 2005
    ..They also suggest the possible therapeutic utility of targeting vascular events in sepsis with cysteinyl-LT blockade...
  35. ncbi Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2
    Bethany B Moore
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 284:L342-9. 2003
    ..Diminished PGE(2) production by AECs results in enhanced fibroproliferation. Thus an important profibrotic mechanism of MCP-1/CCR2 interactions is to limit PGE(2) production in AECs after injury, thus promoting fibrogenesis...
  36. ncbi Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling
    Steven Huang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 292:L405-13. 2007
    ..Our data indicate that PGE(2) inhibits fibroblast activation in primary lung fibroblasts via binding of EP2 receptor and production of cAMP; inhibition of collagen I proceeds via activation of PKA...
  37. ncbi Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling
    Alexandra I Medeiros
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Exp Med 206:61-8. 2009
    ..They also identify an opportunity to reduce the incidence and severity of pneumonia in the setting of lung injury by pharmacologically targeting synthesis of PGE(2) or ligation of EP2...
  38. ncbi Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia
    Steven K Huang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Respir Crit Care Med 177:66-74. 2008
    ..Although fibroblasts from patients with idiopathic pulmonary fibrosis are known to exhibit a defect in PGE2 synthesis, there is little information about their responsiveness to this lipid mediator...
  39. ncbi Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions
    Camila M Peres
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 179:5454-61. 2007
    ....
  40. ncbi NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis
    Michael J Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    J Leukoc Biol 82:1585-91. 2007
    ..In view of the antimicrobial actions of LT, a reduction in LT synthetic capacity by AM from NADPH oxidase KO mice may contribute to the susceptibility of these animals to infection...
  41. ncbi Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells
    Claudio Canetti
    Division of Pulmonary and Critical Care Medicine, 6301 MSRB III, University of Michigan Medical Center, Ann Arbor, MI 48109 0642, USA
    Blood 102:1877-83. 2003
    ..As LTB4 is an important proinflammatory product of macrophages, we speculate that this divergence evolved to permit FcgammaR-mediated phagocytosis to proceed in an inflammatory milieu, while apoptotic cell clearance is noninflammatory...
  42. ncbi Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways
    Steven K Huang
    Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5642, USA
    FASEB J 23:4317-26. 2009
    ..They provide another dimension by which PGE(2) may inhibit, and perhaps even reverse, fibrogenesis in patients with interstitial lung disease...
  43. ncbi Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages
    Thomas G Brock
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan Health System, Ann Arbor, MI 48109, USA
    Exp Cell Res 314:255-63. 2008
    ..The absence of Rap1 on late phagosomes suggests that the effect of Epac-1 might not require Rap1...
  44. ncbi Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences SPH II, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Am J Respir Crit Care Med 173:212-8. 2006
    ..Previously, we employed leptin-deficient (ob/ob) mice to identify an important role for leptin in the host defense against Klebsiella pneumonia...
  45. ncbi Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung
    Thomas G Brock
    Dept of Internal Medicine, Univ of Michigan, 6301 MSRB III, Ann Arbor, MI 48109 0642, USA
    Am J Physiol Lung Cell Mol Physiol 289:L224-32. 2005
    ..Furthermore, the aminopeptidase activity of LTA4 hydrolase within the nucleus may play a role in promoting epithelial cell growth...
  46. ncbi Rap1 activation is required for Fc gamma receptor-dependent phagocytosis
    Jooho Chung
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 181:5501-9. 2008
    ..Taken together, our data demonstrate a novel role for Rap1 and its exchange factor C3G in mediating Fc gammaR-dependent phagocytosis...
  47. ncbi Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages
    Claudio Canetti
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor 48109, USA
    J Immunol 179:8350-6. 2007
    ..We suggest that this mechanism contributes to the ability of PGE2 to inhibit PI3K-dependent innate immune signaling in primary macrophages...
  48. ncbi Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
    Peter Mancuso
    Dept of Environmental Health Sciences, Univ of Michigan, 1420 Washington Hts, SPH II, Ann Arbor, MI 48109 2029, USA
    Am J Physiol Lung Cell Mol Physiol 287:L497-502. 2004
    ....
  49. ncbi Prostaglandin E₂ increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression
    Steven K Huang
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    FASEB J 26:3703-14. 2012
    ....
  50. ncbi Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2
    Megan N Ballinger
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan, Ann Arbor, MI, USA
    Respir Res 12:155. 2011
    ..This study examines the relationship between alveolar macrophage (AM) host defense and production of lipid mediators during the neonatal period compared to adult AMs...
  51. ncbi Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export
    Nicolas Flamand
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:306-13. 2009
    ..This action works in concert with nuclear import, which is regulated by phosphorylation on Ser-523, to determine the subcellular distribution of 5-LO, which in turn regulates leukotriene biosynthesis...
  52. ncbi PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling
    Peedikayil E Thomas
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 293:L417-28. 2007
    ..Taken together, our results demonstrate that PGE(2) has the potential to limit TGF-beta1-induced myofibroblast differentiation via adhesion-dependent, but Smad-independent, pathways...
  53. ncbi Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 5642, USA
    J Clin Invest 121:671-82. 2011
    ..These results uncover a pivotal role in macrophages for the GPCR BLT1 in regulating activation of NF-κB through Stat1-dependent expression of MyD88...
  54. ncbi Role of leukotrienes in killing of Mycobacterium bovis by neutrophils
    Michael Joseph Coffey
    Division of Pulmonary Medicine, Department of Internal Medicine, University of Michigan Health System, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0642, USA
    Prostaglandins Leukot Essent Fatty Acids 71:185-90. 2004
    ..Furthermore, exogenous LTB4 augmented dose-dependent killing of M. bovis by PMN. In conclusion, LT play a vital role in promoting mycobactericidal actions of PMN...
  55. ncbi Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1
    Steven K Huang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5642, USA
    Am J Respir Cell Mol Biol 39:482-9. 2008
    ..The selective use of PKA and Epac-1 pathways to inhibit distinct aspects of fibroblast activation illustrate the pleiotropic ability of PGE(2) to inhibit diverse fibroblast functions...
  56. ncbi Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice
    Steven K Huang
    Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Pathol 177:2245-55. 2010
    ....
  57. ncbi Cysteinyl leukotriene interactions with other mediators and with glucocorticosteroids during airway inflammation
    Marc Peters Golden
    Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor 48109 0642, USA
    J Allergy Clin Immunol 111:S37-42; discussion S43-8. 2003
    ..Understanding whether glucocorticosteroids reduce cysteinyl leukotriene levels in the airway is important in determining the clinical value of combining glucocorticosteroid therapy with leukotriene modifier therapy...
  58. ncbi Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis
    C Henrique Serezani
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 189:906-15. 2012
    ..Our results identify LTB(4)-BLT1 signaling as an unrecognized controller of dectin-1 transcription via GM-CSF and PU.1 that is required for fungi-protective host responses...
  59. ncbi FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5642, USA
    Blood 114:3316-24. 2009
    ..These data identify a novel form of regulation in which engagement of a macrophage immunoreceptor recruits a stimulatory G protein-coupled receptor into a LR microdomain with resultant enhanced antimicrobial signaling...
  60. ncbi Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages
    Sang Hoon Kim
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:8875-83. 2011
    ..Our data illustrate the pleiotropic manner in which G protein-coupled receptor-derived cAMP signaling can influence TLR responses in primary macrophages and suggest that AKAP10 may coordinate increases in gene expression...
  61. ncbi Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities
    M B Bailie
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 157:5221-4. 1996
    ..We conclude that endogenous LTs play a critical role in the defense against bacterial pneumonia in this murine model...
  62. ncbi E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection
    David M Aronoff
    Divisions of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 183:2642-9. 2009
    ..Pharmacological targeting of the PGE(2)-EP3 axis represents a novel area warranting greater investigative interest in the prevention and/or treatment of infectious diseases...
  63. ncbi Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts
    Vibha N Lama
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0360, USA
    J Clin Invest 117:989-96. 2007
    ....
  64. ncbi Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator
    Lamis Jarvinen
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 181:4389-96. 2008
    ..This is the first report to demonstrate that human tissue-derived MSCs isolated from an allogeneic environment have the potential to mediate immunological responses in vitro...
  65. ncbi Expanding roles for leukotrienes in airway inflammation
    Marc Peters-Golden
    Division of Pulmonary and Critical Care Medicine, 6301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5642, USA
    Curr Allergy Asthma Rep 8:367-73. 2008
    ..These recent data highlight a growing appreciation for LTs as pleiotropic effectors, which are integral components in the network of molecules that mediate the expression of asthma...
  66. ncbi Leukotrienes: underappreciated mediators of innate immune responses
    Marc Peters-Golden
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor 48109, USA
    J Immunol 174:589-94. 2005
    ..The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity...
  67. ncbi Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:1081-90. 2011
    ..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia...
  68. ncbi Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase
    Ming Luo
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:40609-16. 2005
    ....
  69. ncbi Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence
    T G Brock
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0652, USA
    J Biol Chem 272:8276-80. 1997
    ..Nuclear import of 5-lipoxygenase may be a universal accompaniment of neutrophil recruitment into sites of inflammation, and this may be associated with alterations in enzymatic function...
  70. ncbi Cyclic AMP: master regulator of innate immune cell function
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health, System, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 39:127-32. 2008
    ..This article reviews the anatomy of the cAMP axis, the mechanisms by which it controls phagocyte immune function, microbial strategies to dysregulate it, and its clinical relevance...
  71. ncbi Leukotrienes
    Marc Peters-Golden
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor 48109-5642, USA
    N Engl J Med 357:1841-54. 2007
  72. ncbi Transient increase in cyclic AMP localized to macrophage phagosomes
    Megan N Ballinger
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e13962. 2010
    ..These studies indicate that localized increases in cAMP accompany phagosome formation and provide a framework for a more complete understanding of how cAMP regulates macrophage host defense functions...
  73. ncbi Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation
    Megan N Ballinger
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109-2200, USA
    J Immunol 177:5499-508. 2006
    ..Genetic reduction of cyclooxygenase-2 in BMT mice also had similar effects. These data clearly demonstrate that overproduction of PGE2 post-BMT is a critical factor determining impaired host defense against pathogens...
  74. ncbi Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages
    Michael J Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 1150 N Medical Center Drive, Ann Arbor, MI 48109, USA
    Biochim Biophys Acta 1781:299-305. 2008
    ..The nuclear localization of enzymes sGC, CGK1 and cGKII in the AM, which also demonstrates preferential nuclear 5-LO expression, may confer tighter regulation of LT synthesis...
  75. ncbi Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts
    Camila Leindecker Stumm
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Physiol Lung Cell Mol Physiol 301:L636-44. 2011
    ....
  76. ncbi Extending the understanding of leukotrienes in asthma
    Michael Coffey
    University of Michigan Health System, Ann Arbor, USA
    Curr Opin Allergy Clin Immunol 3:57-63. 2003
    ....
  77. ncbi Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109-0642, USA
    J Immunol 173:559-65. 2004
    ..Our data support a negative regulatory role for PGE(2) on the antimicrobial activity of AMs, which has important implications for future efforts to prevent and treat bacterial pneumonia...
  78. ncbi Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells
    T G Brock
    Department of Internal Medicine, University of Michigan, Ann Arbor
    J Biol Chem 269:22059-66. 1994
    ..The finding that a substantial proportion of enzyme is localized within the nucleus of unstimulated RBL cells suggests potentially novel roles for 5-LO or its products within the nucleus...
  79. ncbi Putting on the brakes: cyclic AMP as a multipronged controller of macrophage function
    Marc Peters-Golden
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5642, USA
    Sci Signal 2:pe37. 2009
    ..A better understanding of crosstalk between cAMP signaling and proinflammatory pathways in macrophages may provide a basis for improved immunomodulatory strategies...
  80. ncbi Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation
    Jill E Kolodsick
    Department of Internal Medicine, University of Michigan School of Medicine, 1150 W. Medical Center Dr, Ann Arbor, MI 48109-0642, USA
    Am J Respir Cell Mol Biol 29:537-44. 2003
    ..Our results demonstrate that PGE2 inhibits transition of fibroblasts to myofibroblasts by an EP2 receptor-activated pathway. Augmenting this pathway may serve as a potent antifibrotic therapeutic strategy...
  81. ncbi Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 180:8222-30. 2008
    ....
  82. ncbi Eicosanoids: mediators and therapeutic targets in fibrotic lung disease
    Ryan P Charbeneau
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0642, USA
    Clin Sci (Lond) 108:479-91. 2005
    ..This review highlights the role of this imbalance in the evolution of fibrotic lung disease, discusses the mechanisms by which it may arise and considers approaches for therapeutic targeting of eicosanoids in these conditions...
  83. ncbi Prognostic value of bronchiolitis obliterans syndrome stage 0-p in single-lung transplant recipients
    Vibha N Lama
    Division of Pulmonary and Critical Care Medicine, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109 0360, USA
    Am J Respir Crit Care Med 172:379-83. 2005
    ..Objective: The aim of this study was to define the predictive ability of BOS 0-p in single-lung transplantation...
  84. ncbi The role of leukotrienes in allergic rhinitis
    Marc Peters-Golden
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
    Ann Allergy Asthma Immunol 94:609-18; quiz 618-20, 669. 2005
    ..To review the role of cysteinyl leukotrienes (cysLTs) in allergic rhinitis and the scientific rationale for therapy with leukotriene receptor antagonists (LTRAs)...
  85. ncbi Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility
    Carlos H Serezani
    Department of Immunology, Institute of Biomedical Science IV, University of Sao Paulo, Sao Paulo, Brazil
    J Immunol 177:3201-8. 2006
    ..amazonensis, identify relevant leishmanicidal mechanisms, and suggest that genetic variation in LTB4 synthesis might influence resistance and susceptibility patterns to infection...
  86. ncbi The alveolar macrophage: the forgotten cell in asthma
    Marc Peters-Golden
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109-0642, USA
    Am J Respir Cell Mol Biol 31:3-7. 2004
  87. ncbi Regulation of 5-lipoxygenase metabolism in mononuclear phagocytes by CD4 T lymphocytes
    M J Coffey
    Division of Pulmonary, University of Michigan Medical Center, Ann Arbor 48109 0642, USA
    Exp Lung Res 25:617-29. 1999
    ..In summary, factors secreted constitutively by lung lymphocytes, in particular CD4 cells, contribute to the increased 5-LO metabolism in AM...
  88. ncbi GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism
    B B Moore
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
    J Immunol 165:4032-9. 2000
    ..These data demonstrate that GM-CSF deficiency results in enhanced fibrogenesis in bleomycin-induced pulmonary fibrosis and indicate that one mechanism for this effect is impaired production of the potent antifibrotic eicosanoid, PGE2...
  89. ncbi Prolonged exposure to lipopolysaccharide inhibits macrophage 5-lipoxygenase metabolism via induction of nitric oxide synthesis
    M J Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 165:3592-8. 2000
    ..Because LT contribute to antimicrobial defense, this down-regulation of 5-LO metabolism may contribute to the increased susceptibility to pneumonia in patients following sepsis...
  90. ncbi Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets
    M Peters-Golden
    Division of Pulmonary and Critical Care Medicine, The University of Michigan Health System, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    FEBS Lett 487:323-6. 2001
    ....
  91. ncbi Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils
    T G Brock
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 162:1669-76. 1999
    ....
  92. ncbi Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2
    T G Brock
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:11660-6. 1999
    ....
  93. ncbi Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor
    M J Coffey
    Divisions of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    Prostaglandins Other Lipid Mediat 56:103-17. 1998
    ..Inactivation by boiling and roteinase K suggest that is a protein. We speculate that this cytosolic factor(s) may serve as an endogenous means for the down-regulation of 5-LO in macrophages...
  94. ncbi Co-localization of leukotriene a4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils
    T G Brock
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
    J Biol Chem 276:35071-7. 2001
    ..The degree to which these two enzymes are co-localized may influence their metabolic coupling in the conversion of arachidonic acid to leukotriene B(4)...
  95. ncbi 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae
    P Mancuso
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Infect Immun 66:5140-6. 1998
    ..The restorative and pharmacologic effects of LTC4, LTB4, and 5-HETE may provide a basis for their exogenous administration as an adjunctive treatment for patients with gram-negative bacterial pneumonia...
  96. ncbi Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotriene synthesis and anticryptococcal activity in neutrophils
    M J Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 102:663-70. 1998
    ..In conclusion, PMN from HIV-infected subjects demonstrate reduced 5-LO metabolism and antifungal activity in vitro, which was reversed by in vivo G-CSF therapy...
  97. ncbi Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton
    M J Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan USA
    J Pharmacol Exp Ther 299:198-203. 2001
    ..We conclude that the suppression of 5-LO activity occurring with LPS treatment can be blocked by zileuton. The mechanism by which zileuton is effective is in part explained by blocking nitrotyrosination of 5-LO...
  98. ncbi Hydrogen peroxide inhibits alveolar macrophage 5-lipoxygenase metabolism in association with depletion of ATP
    P H Sporn
    Department of Internal Medicine, University of Michigan, Ann Arbor
    J Biol Chem 263:14776-83. 1988
    ..Depletion of cellular energy stores by oxidants generated during inflammation in vivo may be a means by which the inflammatory response is self-limited...
  99. ncbi 5-lipoxygenase and FLAP
    M Peters-Golden
    Department of Internal Medicine, University of Michigan Health System, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Prostaglandins Leukot Essent Fatty Acids 69:99-109. 2003
    ..The last decade has witnessed remarkable progress in our understanding of these two proteins. Here we review the molecular and cellular aspects of the expression, function, and regulation of 5-LO and FLAP...
  100. ncbi Granulocyte-macrophage colony-stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome
    M J Coffey
    Divisions of Pulmonary and Critical Care Medicine and Infectious Diseases, University of Michigan Medical Center, Ann Arbor, MI 48109 0642, USA
    Blood 94:3897-905. 1999
    ..GM-CSF therapy reversed this defect in both PBM and PMN. In view of the role of LT in antimicrobial function, cytokine administration in AIDS may play a role as adjunct therapy for infections...
  101. ncbi Arachidonic acid metabolism by rat alveolar epithelial cells
    J B Chauncey
    Department of Internal Medicine, University of Michigan, Ann Arbor
    Lab Invest 58:133-40. 1988
    ..However, after stimulation, little or no lipoxygenase products accumulated in media. Thus, the alveolar epithelium may be a source of bioactive eicosanoids with potentially important roles in pulmonary physiology and pathophysiology...