Affiliation: University of Michigan
Peters Golden M, Henderson W. Leukotrienes. N Engl J Med. 2007;357:1841-54 pubmed
Draijer C, Penke L, Peters Golden M. Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations. J Immunol. 2019;202:2700-2709 pubmed publisher
..These first (to our knowledge) data comparing effects on the two pulmonary macrophage populations demonstrate that the activating actions of GM-CSF and M-CSF on primary AMs are not conserved in primary IMs. ..
Peters Golden M, Henderson W. The role of leukotrienes in allergic rhinitis. Ann Allergy Asthma Immunol. 2005;94:609-18; quiz 618-20, 669 pubmed
..By blocking the cysLT1 receptor responsible for most of these effects, LTRAs represent a useful approach to treatment of this important and prevalent disorder. ..
Peters Golden M. Expanding roles for leukotrienes in airway inflammation. Curr Allergy Asthma Rep. 2008;8:367-73 pubmed
..These recent data highlight a growing appreciation for LTs as pleiotropic effectors, which are integral components in the network of molecules that mediate the expression of asthma. ..
Zaslona Z, Peters Golden M. Prostanoids in Asthma and COPD: Actions, Dysregulation, and Therapeutic Opportunities. Chest. 2015;148:1300-1306 pubmed publisher
..By virtue of their pleiotropic capacity to modulate numerous pathophysiologic processes relevant to the expression and natural history of airway diseases, prostanoids emerge as attractive targets for therapeutic manipulation. ..
ZasÅ‚ona Z, Przybranowski S, Wilke C, Van Rooijen N, Teitz Tennenbaum S, Osterholzer J, et al
. Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma. J Immunol. 2014;193:4245-53 pubmed publisher
..Moreover, maintenance of the AM pool in the early stages of asthmatic inflammation depends on local proliferation, but not recruitment. ..
Speth J, Bourdonnay E, Penke L, Mancuso P, Moore B, Weinberg J, et al
. Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. J Immunol. 2016;196:5112-20 pubmed publisher
..These results demonstrate a novel tunable form of cross-talk in which AECs use PGE2 as a signal to request SOCS3 from AMs to dampen their endogenous inflammatory responses during infection. ..
Draijer C, Peters Golden M. Alveolar Macrophages in Allergic Asthma: the Forgotten Cell Awakes. Curr Allergy Asthma Rep. 2017;17:12 pubmed publisher
..Future research should focus on the diverse roles of monocytes/macrophages during various types and phases of allergic inflammation. These properties could lead us to new therapeutic opportunities. ..
ZasÅ‚ona Z, Okunishi K, Bourdonnay E, Domingo Gonzalez R, Moore B, Lukacs N, et al
. Prostaglandin Eâ‚‚ suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. J Allergy Clin Immunol. 2014;133:379-87 pubmed publisher
..We conclude that the PGE2-EP2 axis is an important endogenous brake on allergic airway inflammation and primarily targets T cells and that its agonism represents a potential novel therapeutic approach to asthma. ..