Miklos Peterfy

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism
    Miklos Peterfy
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States
    Biochim Biophys Acta 1821:790-4. 2012
  2. ncbi Characterization and chromosomal mapping of two pseudogenes of the mouse Pafaha/Lis1 gene: retrointegration hotspots in the mouse genome
    M Peterfy
    Department of Biomedical Science, Amgen Inc, Thousand Oaks, CA 91320 1789, USA
    Gene 216:225-31. 1998
  3. ncbi Metabolic syndrome as a modifier of atherosclerosis in murine models
    Miklos Peterfy
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90073, USA
    Curr Drug Targets 8:1215-20. 2007
  4. ncbi Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 39:1483-7. 2007
  5. pmc Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum
    Mark H Doolittle
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:33623-33. 2009
  6. pmc Lipase maturation factor 1 is required for endothelial lipase activity
    Osnat Ben-Zeev
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Lipid Res 52:1162-9. 2011
  7. pmc Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans
    Maryam Hosseini
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 32:1204-10. 2012
  8. pmc Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice
    Richard C Davis
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Diabetes 59:1616-25. 2010
  9. pmc Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes
    Miklos Peterfy
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 285:3857-64. 2010
  10. ncbi Biphasic expression of lipin suggests dual roles in adipocyte development
    Jack Phan
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Drug News Perspect 18:5-11. 2005

Collaborators

Detail Information

Publications20

  1. pmc Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism
    Miklos Peterfy
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States
    Biochim Biophys Acta 1821:790-4. 2012
    ..Further studies will be required to test this hypothesis and elucidate the full spectrum of phenotypes in combined lipase deficiency. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease...
  2. ncbi Characterization and chromosomal mapping of two pseudogenes of the mouse Pafaha/Lis1 gene: retrointegration hotspots in the mouse genome
    M Peterfy
    Department of Biomedical Science, Amgen Inc, Thousand Oaks, CA 91320 1789, USA
    Gene 216:225-31. 1998
    ..Our results indicate that only one of the three LIS1-related mouse loci (Pafaha/Lis1) is functional, in contrast with two closely related functional genes (LIS1 and LIS2) reported in humans. 1998 Elsevier Science B.V...
  3. ncbi Metabolic syndrome as a modifier of atherosclerosis in murine models
    Miklos Peterfy
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90073, USA
    Curr Drug Targets 8:1215-20. 2007
    ..Furthermore, murine models are invaluable for the evaluation of therapeutic approaches and will no doubt facilitate the genetic dissection of atherosclerosis-susceptibility in the Metabolic Syndrome...
  4. ncbi Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 39:1483-7. 2007
    ..Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia...
  5. pmc Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum
    Mark H Doolittle
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:33623-33. 2009
    ..We discuss the implication of our results with regard to lipase maturation and DUF1222 domain structure...
  6. pmc Lipase maturation factor 1 is required for endothelial lipase activity
    Osnat Ben-Zeev
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Lipid Res 52:1162-9. 2011
    ..Thus, our study indicates that EL is critically dependent on Lmf1 for its maturation in the ER and demonstrates that Lmf1 is a required factor for all three vascular lipases, LPL, HL, and EL...
  7. pmc Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans
    Maryam Hosseini
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 32:1204-10. 2012
    ..The objective of this study is to investigate whether, beyond its role as a required factor in lipase maturation, variation in Lmf1 expression is sufficient to modulate LPL activity in vivo...
  8. pmc Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice
    Richard C Davis
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Diabetes 59:1616-25. 2010
    ..To identify metabolic derangements contributing to diabetes susceptibility in the leptin receptor-deficient obese C57BLKS/J-db/db (BKS-db) mouse strain...
  9. pmc Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes
    Miklos Peterfy
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 285:3857-64. 2010
    ..In summary, our studies suggest that insulin may modulate the cellular function of lipin-1 by regulating its subcellular localization through interactions with 14-3-3 proteins...
  10. ncbi Biphasic expression of lipin suggests dual roles in adipocyte development
    Jack Phan
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Drug News Perspect 18:5-11. 2005
    ..Thus, lipin appears to have critical roles in both adipocyte differentiation and in the function of mature adipocytes...
  11. pmc A quantitative assay measuring the function of lipase maturation factor 1
    Fen Yin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:2265-9. 2009
    ..Our results demonstrate the ability of the assay to detect and analyze Lmf1 mutations having a wide range of effects on Lmf1 function and protein expression...
  12. ncbi Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    J Biol Chem 280:32883-9. 2005
    ....
  13. ncbi The cld mutation: narrowing the critical chromosomal region and selecting candidate genes
    Miklos Peterfy
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, 90095, USA
    Mamm Genome 17:1013-24. 2006
    ..We discuss the implications of our mapping results and our selection of candidates with respect to other genes, deletions, and mutations occurring in the cld critical region...
  14. ncbi Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains
    Hui Z Mao
    Department of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Biochim Biophys Acta 1762:440-6. 2006
    ..In summary, our study reveals novel aspects of the genetic fine-structure of BKS and related strains and facilitates the identification of diabetes-susceptibility loci in this mouse model...
  15. doi Lipase maturation factor 1: structure and role in lipase folding and assembly
    Mark H Doolittle
    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Curr Opin Lipidol 21:198-203. 2010
    ..The purpose of this review is to examine recent studies that have begun to elucidate the structure and function of LMF1 and to place it in the context of lipase folding and assembly...
  16. pmc Systems genetics of susceptibility to obesity-induced diabetes in mice
    Richard C Davis
    Department of Medicine, University of California, Los Angeles, California 90095 1679, USA
    Physiol Genomics 44:1-13. 2012
    ..These results add to the understanding of the complex genetic interactions contributing to obesity-induced diabetes...
  17. ncbi Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility
    Richard C Davis
    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Diabetes 54:1191-9. 2005
    ..To further prioritize these candidates, we identified those cis-acting expression quantitative trait loci whose expression significantly correlates with diabetes-related phenotypes...
  18. pmc Hepatic lipase maturation: a partial proteome of interacting factors
    Mark H Doolittle
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:1173-84. 2009
    ..BiP/Grp94 may stabilize misfolded HL during its transition between cycles of CNX binding and may help direct its eventual degradation...
  19. pmc Lamin B1 is required for mouse development and nuclear integrity
    Laurent Vergnes
    Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Proc Natl Acad Sci U S A 101:10428-33. 2004
    ..These mutant mice and cell lines derived from them will be useful models for studying the role of the nuclear lamina in various cellular processes...
  20. ncbi Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro
    Jack Phan
    Departments of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 279:29558-64. 2004
    ..Thus, we conclude that lipin expression is required prior to PPARgamma during adipocyte differentiation...