M E Peter

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc The flip side of FLIP
    Marcus E Peter
    The Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Biochem J 382:e1-3. 2004
  2. doi request reprint ROS eliminate danger
    Marcus E Peter
    The Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:1-2. 2008
  3. doi request reprint Targeting of mRNAs by multiple miRNAs: the next step
    M E Peter
    The Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Oncogene 29:2161-4. 2010
  4. ncbi request reprint The CD95(APO-1/Fas) DISC and beyond
    M E Peter
    The Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Cell Death Differ 10:26-35. 2003
  5. ncbi request reprint Does CD95 have tumor promoting activities?
    Marcus E Peter
    The Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Biochim Biophys Acta 1755:25-36. 2005
  6. ncbi request reprint The CD95 receptor: apoptosis revisited
    Marcus E Peter
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Cell 129:447-50. 2007
  7. pmc Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression
    Marcus E Peter
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Cell Cycle 8:843-52. 2009
  8. ncbi request reprint Regulating cancer stem cells the miR way
    Marcus E Peter
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Cell Stem Cell 6:4-6. 2010
  9. ncbi request reprint CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8
    B C Barnhart
    The Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Cell Death Differ 12:25-37. 2005
  10. pmc microRNAs and death receptors
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, IL 60637, United States
    Cytokine Growth Factor Rev 19:303-11. 2008

Collaborators

Detail Information

Publications49

  1. pmc The flip side of FLIP
    Marcus E Peter
    The Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Biochem J 382:e1-3. 2004
    ..Our understanding of the regulators of the extrinsic apoptosis signalling pathway biochemically may provide the means to design drugs to correct the imbalance between apoptosis and proliferation, as found in many diseases...
  2. doi request reprint ROS eliminate danger
    Marcus E Peter
    The Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:1-2. 2008
    ..Necrotic cells release HMGB1 as a danger signal to activate the immune system. In this issue of Immunity, Kazama et al. (2008) identify a mechanism that determines whether HMGB1 is tolerogenic or immunogenic...
  3. doi request reprint Targeting of mRNAs by multiple miRNAs: the next step
    M E Peter
    The Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Oncogene 29:2161-4. 2010
    ..This study ushers in a new era of miRNA research that focuses on networks more than on individual connections between miRNA and strongly predicted targets...
  4. ncbi request reprint The CD95(APO-1/Fas) DISC and beyond
    M E Peter
    The Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Cell Death Differ 10:26-35. 2003
    ..A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research...
  5. ncbi request reprint Does CD95 have tumor promoting activities?
    Marcus E Peter
    The Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Biochim Biophys Acta 1755:25-36. 2005
    ....
  6. ncbi request reprint The CD95 receptor: apoptosis revisited
    Marcus E Peter
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Cell 129:447-50. 2007
    ..Recent evidence suggests, however, that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions...
  7. pmc Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression
    Marcus E Peter
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Cell Cycle 8:843-52. 2009
    ..I propose that steps of this process are driven by specific changes in the expression of let-7 and miR-200 family members...
  8. ncbi request reprint Regulating cancer stem cells the miR way
    Marcus E Peter
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Cell Stem Cell 6:4-6. 2010
    ..These findings provide new insight into the network of transcription factors and miRNAs that regulate cancer stem cells...
  9. ncbi request reprint CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8
    B C Barnhart
    The Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Cell Death Differ 12:25-37. 2005
    ..Our data suggest that it is possible to overcome the CD95 apoptosis resistance of many tumor cells that do not efficiently form a DISC through noncanonical activation of the caspase-8 proenzyme...
  10. pmc microRNAs and death receptors
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, IL 60637, United States
    Cytokine Growth Factor Rev 19:303-11. 2008
    ..This review will focus on recent insights into the mechanisms of the two different types of CD95 signaling pathways, and will introduce miRNAs as regulators of death receptor signaling...
  11. doi request reprint MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells
    P Ceppi
    Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Oncogene 33:269-78. 2014
    ..This review will highlight and discuss this link and its possible implications for the fight against cancer. ..
  12. ncbi request reprint Fusing DEDD with ubiquitin changes its intracellular localization and apoptotic potential
    J C Lee
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Apoptosis 10:1483-95. 2005
    ..Our data suggest that monoubiquitination of DEDD regulates both its cytoplasmic localization and its proapoptotic potential and that IAP proteins can regulate DEDD's ubiquitination status...
  13. doi request reprint MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
    R Schickel
    The Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Oncogene 27:5959-74. 2008
    ..Here, we summarize the role of miRNAs and their targets in contributing to human cancers and their function as regulators of apoptotic pathways and the immune system...
  14. ncbi request reprint The relevance of NF-kappaB for CD95 signaling in tumor cells
    Patrick Legembre
    The Ben May Institute for Cancer Research, Committees on Immunology and Cancer Biology, The University of Chicago, Chicago, Illinios 60637, USA
    Cell Cycle 3:1235-9. 2004
    ..We propose a model in which NF-kappaB is generally activated in certain cells but may have different functions depending on whether cells are programmed to die or to survive...
  15. pmc CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells
    Bryan C Barnhart
    The Ben May Institute for Cancer Research, Committee on Immunology, The University of Chicago, Chicago, IL 60637 5420, USA
    EMBO J 23:3175-85. 2004
    ..This could become highly relevant during chemotherapy, which can cause upregulation of CD95 ligand by both tumor and nontumor cells...
  16. doi request reprint The role of let-7 in cell differentiation and cancer
    Benjamin Boyerinas
    The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Endocr Relat Cancer 17:F19-36. 2010
    ..The regulation of let-7 expression, cancer-relevant let-7 targets, and the relationship between let-7 and drug sensitivity are highlighted...
  17. ncbi request reprint Apoptosis and caspases
    A H Stegh
    The Ben May Institute for Cancer Research University of Chicago, Illinois 60637, USA
    Cardiol Clin 19:13-29. 2001
    ..It appears that caspases play a much more fundamental role in cells than originally expected...
  18. pmc Two CD95 tumor classes with different sensitivities to antitumor drugs
    Alicia Algeciras-Schimnich
    The Ben May Institute for Cancer Research, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 100:11445-50. 2003
    ..Our analysis reveals fundamental differences in programs of gene expression between type I and type II cells and could impact the way actin- and microtubule-disrupting antitumor agents are used in tumor therapy...
  19. pmc Let-7 expression defines two differentiation stages of cancer
    Scott Shell
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:11400-5. 2007
    ..These data identify loss of let-7 expression as a marker for less differentiated cancer...
  20. pmc The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
    ..Conversely, inhibition of miR-200 reduced E-cadherin expression, increased expression of Vimentin, and induced EMT. Our data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells...
  21. ncbi request reprint Transplanted islets from lpr mice are resistant to autoimmune destruction in a model of streptozotocin-induced type I diabetes
    S Vijayan
    The Ben May Institute for Cancer Research, Committees on Immunology and Cancer Biology, The University of Chicago, Chicago, IL 60637, USA
    Apoptosis 10:725-30. 2005
    ..In contrast wild-type grafts were rapidly eliminated in autoimmune recipients. Our data provide strong support for a major role of CD95 in the destruction of islets in autoimmune mice...
  22. ncbi request reprint Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription
    O Schickling
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, Illinois, IL 60637, USA
    Cell Death Differ 8:1157-68. 2001
    ..The DED in DEDD therefore represents a novel domain that is structurally similar to other DEDs but functionally different from classical DEDs found in FADD or caspase-8...
  23. ncbi request reprint The TNF receptor 1: a split personality complex
    Bryan C Barnhart
    The Ben May Institute for Cancer Research, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Cell 114:148-50. 2003
    ..Since the first complex can activate survival signals and influence the activity of the second complex, this mechanism provides a checkpoint to control the execution of apoptosis...
  24. ncbi request reprint Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2
    Sun Mi Park
    The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Cell Cycle 6:2585-90. 2007
    ..The late repression of HMGA2 by let-7 during embryonic development, and the early reexpression of HMGA2 during cancer development, is in line with the hypothesis that cancer development represents a case of reverse embryogenesis...
  25. pmc miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1
    Robert Schickel
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Mol Cell 38:908-15. 2010
    ....
  26. ncbi request reprint The CD95 type I/type II model
    Bryan C Barnhart
    The Ben May Institutefor Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Semin Immunol 15:185-93. 2003
    ..This review focuses on recent developments in the delineation of the biochemistry and the physiological function of the two CD95 pathways...
  27. ncbi request reprint The death effector domain protein family
    Bryan C Barnhart
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Oncogene 22:8634-44. 2003
    ..Oncogene (2003) 22, 8634-8644. doi:10.1038/sj.onc.1207103..
  28. pmc CD95 promotes tumour growth
    Lina Chen
    The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Nature 465:492-6. 2010
    ..These results demonstrate that CD95 has a growth-promoting role during tumorigenesis and indicate that efforts to inhibit its activity rather than to enhance it should be considered during cancer therapy...
  29. ncbi request reprint Nonapoptotic functions of FADD-binding death receptors and their signaling molecules
    Sun Mi Park
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Curr Opin Cell Biol 17:610-6. 2005
    ..However, recent work has ascribed multiple non-apoptotic activities to these receptors and/or the signaling components of the DISC...
  30. pmc DEDD regulates degradation of intermediate filaments during apoptosis
    Justine C Lee
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    J Cell Biol 158:1051-66. 2002
    ..Our data suggest that DEDD represents a novel scaffold protein that directs the effector caspase-3 to certain substrates facilitating their ordered degradation during apoptosis...
  31. doi request reprint Methods to analyze the palmitoylated CD95 high molecular weight death-inducing signaling complex
    Christine Feig
    The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA
    Methods Enzymol 442:83-100. 2008
    ..Data revealed that CD95 is palmitoylated on cysteine 199. This lipid modification enhances receptor aggregation to the high molecular weight DISC...
  32. ncbi request reprint Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein
    Alexander H Stegh
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:4351-60. 2002
    ....
  33. doi request reprint Identification of let-7-regulated oncofetal genes
    Benjamin Boyerinas
    The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 68:2587-91. 2008
    ..Our data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1. LOGs could be novel therapeutic targets and potential biomarkers for cancer treatment...
  34. pmc Molecular ordering of the initial signaling events of CD95
    Alicia Algeciras-Schimnich
    The Ben May Institute for Cancer Research Department of Medicine Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 22:207-20. 2002
    ..The data indicate that the signal initiation by CD95 is a complex process actively regulated at various levels, providing a number of new drug targets to specifically modulate CD95 signaling...
  35. doi request reprint Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond
    Lina Chen
    Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 16:1071-6. 2010
    ..This review critically discusses the data on the possible function of CD95 as an apoptosis-inducing receptor in IBD and discusses alternative mechanisms for epithelial cell loss in IBD...
  36. ncbi request reprint CD95 signaling deficient mice with a wild-type hematopoietic system are prone to hepatic neoplasia
    Sun Mi Park
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Apoptosis 13:41-51. 2008
    ..Our data represent the first case of CD95 protecting from developing a solid cancer...
  37. ncbi request reprint Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis
    Francesca Zazzeroni
    Gwen Knapp Center for Lupus and Immunoolgy Research, Ben May Institute, and Committee on Immunology, University of Chicago, IL 60637, USA
    Blood 102:3270-9. 2003
    ..These findings identify Gadd45 beta as a critical mediator of the prosurvival response to CD40 stimulation and provide important new insights into the apoptotic mechanism that is triggered by Fas in B cells...
  38. doi request reprint CD95 is cytoprotective for intestinal epithelial cells in colitis
    Sun Mi Park
    Ben May Department for Cancer Research, Johns Hopkins Medical Institute, Baltimore, Maryland, USA
    Inflamm Bowel Dis 16:1063-70. 2010
    ..Although some of these studies have considerably influenced our view on the role of the CD95/CD95L system compelling evidence for an involvement of the CD95/CD95L system in the physiological epithelial cell turnover is lacking...
  39. pmc Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling
    Christine Feig
    The Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    EMBO J 26:221-31. 2007
    ..Our data demonstrate that SDS-stable forms of CD95 are the sites of apoptosis initiation and represent an important early step in apoptosis signaling through CD95 before activation of caspases...
  40. ncbi request reprint Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness
    Patrick Legembre
    Committees on Immunology and Cancer Biology, Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 279:46742-7. 2004
    ..SNARK therefore represents an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells...
  41. ncbi request reprint Actin dependent CD95 internalization is specific for Type I cells
    Alicia Algeciras-Schimnich
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    FEBS Lett 546:185-8. 2003
    ..The data suggest that CD95 is linked to the cytoskeleton in different ways in the two cell types and that they have adapted to different levels of active caspase-8 generated at the activated receptor...
  42. pmc Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds
    Patrick Legembre
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    EMBO Rep 5:1084-9. 2004
    ..Mutations in CD95 may eliminate the tumour-suppressive function of CD95, at the same time allowing induction of survival or proliferative pathways, which could contribute to the increased risk for lymphoma seen in ALPS type Ia patients...
  43. ncbi request reprint A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes
    David Gilot
    INSERM U620, Rennes, France
    Carcinogenesis 26:2086-94. 2005
    ..Our data provide new insights into the mechanisms by which apoptotic proteins participate to mitogenic signals during the G(1) phase...
  44. pmc The role of receptor internalization in CD95 signaling
    Kyeong Hee Lee
    Department of Immunology, Genentech Inc, South San Francisco, CA 94080, USA
    EMBO J 25:1009-23. 2006
    ..Hence, the subcellular localization and internalization pathways of CD95 play important roles in controlling activation of distinct signaling cascades to determine divergent cellular fates...
  45. pmc c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
    David W Chang
    Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    EMBO J 21:3704-14. 2002
    ..c-FLIP(L) acts as an apoptosis inhibitor only at high ectopic expression levels. Thus, c-FLIP(L) defines a novel type of caspase regulator, distinct from the death adaptors, that can either promote or inhibit apoptosis...
  46. ncbi request reprint Apoptosis-independent functions of killer caspases
    Alicia Algeciras-Schimnich
    The Ben May Institute for Cancer Research, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Curr Opin Cell Biol 14:721-6. 2002
    ..In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization...
  47. pmc Intermediate filaments control the intracellular distribution of caspases during apoptosis
    David Dinsdale
    Medical Research Council Toxicology Unit, Leicester, United Kingdom
    Am J Pathol 164:395-407. 2004
    ..Thus, such inclusions do not merely accumulate disrupted cytokeratins but also sequestrate potentially noxious proteins that could injure healthy neighboring cells...
  48. pmc Interdimer processing mechanism of procaspase-8 activation
    David W Chang
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    EMBO J 22:4132-42. 2003
    ..These results reveal the key steps leading to the activation of procaspase-8 by oligomerization...
  49. ncbi request reprint Two faces of caspase-8
    Bryan C Barnhart
    Nat Immunol 3:896-8. 2002