Research Topics
| I N PessahSummaryAffiliation: University of California Country: USA Publications
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Publications
Homer regulates gain of ryanodine receptor type 1 channel complexWei Feng
Department of Molecular Biosciences, University of California, Davis, California 95616, USA
J Biol Chem 277:44722-30. 2002..This form of regulation may be important in other cell types that express Homer and RyR1...
Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damageBenjamin Yuen
Department of Veterinary Molecular Biosciences, University of California, Davis, California, USA
FASEB J 26:1311-22. 2012..These data demonstrate that an MHS mutation within the S4-S5 cytoplasmic linker of RYR1 confers genotype- and sex-dependent susceptibility to pharmacological and environmental stressors that trigger fulminant MH and promote myopathy...- Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control studyIrva Hertz-Picciotto
Department of Public Health Sciences, School of Medicine, University of California, MS1C, One Shields Ave, Davis, California, USA
Environ Health 10:1. 2011..PBDEs and their metabolites cross the placenta and studies in rodents demonstrate neurodevelopmental toxicity from prenatal exposures. PBDE exposures occur both via breastfeeding and hand-to-mouth activities in small children... - Redox sensing properties of the ryanodine receptor complexIsaac N Pessah
Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
Front Biosci 7:a72-9. 2002..New data is presented that directly measure the pKa of hyperreactive thiols that occur when the closed conformation of the RyR channel complex is assumed, and that appear to be an integral component of the redox sensor... - Immunologic and neurodevelopmental susceptibilities of autismIsaac N Pessah
School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Neurotoxicology 29:532-45. 2008.... - Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1)Isaac N Pessah
Department of VM Molecular Biosciences and Center for Children s Environmental Health, University of California, Davis, California 95616, USA
Chem Res Toxicol 19:92-101. 2006.... - Ryanodine receptor acts as a sensor for redox stressI N Pessah
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Pest Manag Sci 57:941-5. 2001..Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context... - Functional role of hyperreactive sulfhydryl moieties within the ryanodine receptor complexI N Pessah
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA
Antioxid Redox Signal 2:17-25. 2000..g., glutathione, nitric oxide) and pathophysiologic (quinones, reactive oxygen species) channel modulators to the Ca2+ release process. The molecular and functional details of such a redox sensor remains to be elucidated... - A bioactive metabolite of benzo[a]pyrene, benzo[a]pyrene-7,8-dione, selectively alters microsomal Ca2+ transport and ryanodine receptor functionI N Pessah
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA
Mol Pharmacol 59:506-13. 2001.... - Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2Isaac N Pessah
Department of VM, Molecular Biosciences and UC Davis Center for Children s Environmental Health, University of California, One Shields Avenue, Davis, California 95616, USA
Chem Res Toxicol 22:201-7. 2009..Evidence for enantioselective enrichment of PCBs in biological tissues that express RyR1 and RyR2channels may provide new mechanistic leads about their toxicological impacts on human health.. - Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicityIsaac N Pessah
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Pharmacol Ther 125:260-85. 2010.... - Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell lineJ D Fessenden
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
Biophys J 79:2509-25. 2000..These functional differences between RyR1 and RyR3 expressed in a mammalian muscle context may reflect differences in association with accessory proteins, especially FKBP12, as well as structural differences in modulator binding sites... - Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydrylsG Liu
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616
J Biol Chem 269:33028-34. 1994..The present results suggest a possible molecular mechanism by which localized transient changes in the redox state within the RyR1-triadin complex can signal information across the SR membrane... - Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantroleneGennady Cherednichenko
Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
Mol Pharmacol 73:1203-12. 2008..The inhibitory potency of dantrolene on ECCE found in wild-type and MH-susceptible muscle is consistent with the drug's clinical potency for reversing the MH syndrome and is incomplete as predicted by its efficacy as a muscle relaxant... - Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptorsJuliette Gafni
Department of Molecular Biosciences, and Center for Children's Environmental Health and Disease Prevention, University of California, Davis, California 95616, USA
Toxicol Sci 77:72-82. 2004.... - Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95)Tram Anh Ta
UC Davis, Center for Children s Environmental Health, Davis, CA 95616, USA
Neurotoxicology 28:770-9. 2007.... - Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiolsAndrew J Phimister
Department of Veterinary Molecular Biosciences and Center for Children s Environmental Health and Disease Prevention, University of California, Davis, California 95616, USA
J Biol Chem 282:8667-77. 2007..These findings support a model in which JP1 interacts with the RyR1 channel complex in a conformationally sensitive manner and may contribute integral redox-sensing properties through reactive sulfhydryl chemistry... - Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complexMakoto N Masuno
Department of Chemistry and Biochemistry, and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
J Med Chem 49:4497-511. 2006..These data suggest that cyclic analogues of bastadin-5 interact with the channel complex in a complex manner that can either enhance or inhibit channel activity... - ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanismP W Wong
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA
J Neurochem 76:450-63. 2001.... 
A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and functionR A Moore
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Cell Biol 140:843-51. 1998..The 1B5 cell line provides a powerful and easily managed homologous expression system in which to study how Ry1R structure relates to function...- Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanismLili Chen
Department of Molecular Biosciences and Graduate Program in Neurosciences, University of California, Davis, CA 95616, USA
J Biol Chem 278:16095-106. 2003..These results provide evidence that sMCa and pA stabilize distinct RyR1 channel states through distinct mechanisms that allosterically stabilize gating states having proportional conductance... - NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium releaseGennady Cherednichenko
Department of Molecular Biosciences, Northern California Health Care System, University of California, Davis, Calif 95616, USA
Circ Res 94:478-86. 2004.... - Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometryAndrew A Voss
School of Veterinary Medicine, Department of Molecular Biosciences, University of California, Davis, CA 95616, USA
J Biol Chem 279:34514-20. 2004..In addition to Cys-3635, the nitrosylation site, six additional cysteines may contribute toward redox regulation of the RyR1 complex... - Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparationKyung Ho Kim
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Toxicol Appl Pharmacol 237:168-77. 2009..Differential sensitization of ryanodine receptors by Ca(2+) appears to mediate, at least in part, hippocampal excitotoxicity by non-coplanar PCBs... - Allosterically coupled calcium and magnesium binding sites are unmasked by ryanodine receptor chimerasAndrew A Voss
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Biochem Biophys Res Commun 366:988-93. 2008.... - Detection of redox sensor of ryanodine receptor complexesWei Feng
Department of Molecular Biosciences, University of California, Davis, California 95616, USA
Methods Enzymol 353:240-53. 2002 - Gene expression changes in children with autismJeffrey P Gregg
Department of Pathology, University of California at Davis Medical Center, Sacramento, CA 95817, USA University of California at Davis, Davis, CA 95616, USA
Genomics 91:22-9. 2008..05). We conclude that the gene expression data support emerging evidence for abnormalities in peripheral blood leukocytes in autism that could represent a genetic and/or environmental predisposition to the disorder... - Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expressionSamuel R Goth
NIEHS Center for Children s Environmental Health, University of California at Davis, Davis, CA 95616, USA
J Immunol Methods 308:179-91. 2006..The O2 tension (but not 2-Me addition) in vitro significantly influences overall DC subset frequencies and yield, and governs DC maturation by regulating the surface class II MHC expression of GM-CSF expanded BMDC cultures... - Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomesPaul Ashwood
Department of Medical Microbiology and Immunology, University of California at Davis, United States
J Neuroimmunol 204:149-53. 2008..Such immune dysregulation may predispose to the development of possible autoimmune responses and/or adverse neuroimmune interactions during critical windows in development... - Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL miceRobert F Berman
Department of Neurological Surgery and the Center for Children s Environmental Health, University of California Davis, CA 95616, USA
Toxicol Sci 101:294-309. 2008.... - Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1)Wei Feng
Department of Molecular Biosciences, University of California, Davis, 95616, United States of America
Biochem Pharmacol 80:512-21. 2010..The results identify RyR1 as a sensitive target for the major tea catechins EGCG and ECG, and this interaction is likely to contribute to their observed biological activities... - Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosalSamuel R Goth
National Institute of Environmental Health Sciences Center for Children's Environmental Health, and Department of Veterinary Molecular Biosciences, University of California-Davis, Davis, California, USA
Environ Health Perspect 114:1083-91. 2006..DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca2+ signals contributed by RyR1... - The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autismIrva Hertz-Picciotto
Division of Epidemiology, Department of Public Health Sciences, School of Medicine, and Medical Investigations of Neurodevelopmental Disorders MIND Institute, University of California Davis, Davis, California, USA
Environ Health Perspect 114:1119-25. 2006.... - Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1Wei Feng
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Cell Calcium 43:307-14. 2008..These data provide a mechanism by which constitutively and transiently expressed H1 forms can tightly regulate RyR1 channel activity in response to changing levels of expression and degradation of H1 proteins... 
Mitochondrial dysfunction in autismCecilia Giulivi
University of California, School of Veterinary Medicine, Department of Molecular Biosciences, One Shields Avenue, 1120 Haring Hall, Davis, CA 95616, USA
JAMA 304:2389-96. 2010..No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism...- Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in miceCecilia Giulivi
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Biol Chem 286:99-113. 2011..Chronically elevated resting Ca(2+) in R163C skeletal muscle elicited the maintenance of a fast-twitch fiber program and the development of insulin resistance-like phenotype as part of a metabolic adaptation to the R163C RyR1 mutation... - Correlations of gene expression with blood lead levels in children with autism compared to typically developing controlsYingfang Tian
Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
Neurotox Res 19:1-13. 2011..We postulate that this may relate to the underlying genetic differences between the two groups, though other explanations cannot be excluded... - Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermiaMonica Aleman
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Muscle Nerve 30:356-65. 2004..3H]ryanodine-binding analysis suggests that long-lasting changes in RyR1 conformation persists in vitro after the triggering event... - Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degenerationYucui Chen
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Hum Mol Genet 19:196-208. 2010..The reduced viability of preCGG neurons is consistent with the mRNA toxicity and neurodegeneration associated with FXTAS... - Correlations between gene expression and mercury levels in blood of boys with and without autismBoryana Stamova
Department of Neurology, University of California at Davis Medical Center, Sacramento, CA 95817, USA
Neurotox Res 19:31-48. 2011..These findings might suggest different genetic transcriptional programs associated with mercury in AU compared to TD children... - Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptorsChristophe Morisseau
Department of Entomology and Cancer Center, University of California at Davis, Davis, California 95616, USA
Environ Health Perspect 117:1867-72. 2009..Whole-animal toxicologic studies cannot yield the necessary throughput in a cost-effective fashion, leading to a critical need for a faster and more cost-effective toxicologic evaluation of xenobiotics... - Blood mercury concentrations in CHARGE Study children with and without autismIrva Hertz-Picciotto
Department of Public Health Sciences, University of California Davis, Davis, California 95616 8638, USA
Environ Health Perspect 118:161-6. 2010..Some authors have reported higher blood mercury (Hg) levels in persons with autism, relative to unaffected controls... - Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletionAlanna M Hurne
Department of Molecular Biosciences, School of Veterinary Medicine and Center for Children's Environmental Health and Disease Prevention, University of California, Davis, California 95616, USA
J Biol Chem 280:36994-7004. 2005..This study demonstrates the essential role of Cys(4958) and Cys(4961) within an invariant CXXC motif for stabilizing conformations of RyR1 that influence both its function as a release channel and its interaction with ECCE channels... - Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodineJ D Fessenden
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 98:2865-70. 2001..In the case of E4032A, these changes overcome unfavorable energy barriers introduced by the E4032A mutation to restore channel function... - Dyspedic mouse skeletal muscle expresses major elements of the triadic junction but lacks detectable ryanodine receptor protein and functionE D Buck
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Biol Chem 272:7360-7. 1997..Dyspedic mice and cells derived from them serve as excellent homologous expression systems in which to study how Ry1R structure relates to function... - Conformational activation of Ca2+ entry by depolarization of skeletal myotubesGennady Cherednichenko
Department of Molecular Biosciences and Center for Children's Environmental Health and Disease Prevention, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 101:15793-8. 2004..ECCE may provide a fundamental means to rapidly maintain Ca(2+) stores and control important aspects of Ca(2+) signaling in both muscle and nonmuscle cells... - Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptorsTram Anh Ta
Center for Children s Environmental Health, University of California, Davis, 95616, USA
Mol Pharmacol 69:532-8. 2006..Hydroxylated bis-oxaquinolizadine derivatives isolated from Xestospongia species are novel bifunctional reagents that may be useful in ascertaining how IP(3)Rs and RyRs contribute to cell signaling... - Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortexT Kenet
Keck Center of Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:7646-51. 2007..We conclude that the health implications associated with exposure to noncoplanar PCBs in human populations merit a more careful examination... - (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin DSurk-Sik Moon
Department of Chemistry, College of Letters and Science, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, California 95616, USA
J Nat Prod 65:249-54. 2002..Xestospongins A, C, and D, araguspongine C, and demethylxestospongin B exhibited modest antifungal activity (MIC 30-100 g/mL) against various fluconazole-resistant Candida spp., but 7S-hydroxyxestospongin A was inactive... - Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxinsRipon Paul
MIND Institute, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
Neurotoxicology 31:399-402. 2010.... - The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channelsGenaro Barrientos
Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
Mol Pharmacol 76:560-8. 2009..Our results identify that KB-R7943 is a reversible, activity-dependent blocker of the two most broadly expressed RyR channel isoforms and contributes to its pharmacological and therapeutic activities... - Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activityBora Inceoglu
Department of Entomology and Cancer Research Center, University of California at Davis, CA 95616, USA
Toxicon 45:727-33. 2005..Therefore the amino acid sequences presented here can be used to make more specific and effective antivenins. Possible approaches to a systematic nomenclature of toxins are suggested... - Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenaseChristoph F A Vogel
Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616, USA
Biochem Biophys Res Commun 375:331-5. 2008.... - Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible miceWei Feng
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Mol Pharmacol 79:420-31. 2011..Dysregulated R163C channels produce a more overt phenotype in myotubes than in adult fibers in the absence of triggering agents, suggesting tighter negative regulation of R163C-RyR1 within the Ca(2+) release unit of adult fibers... - One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of actionBora Inceoglu
Department of Entomology, Chemistry and Superfund Analytical Laboratory, Molecular Biosciences, School of Veterinary Medicine, and Chemical Engineering and Materials Science, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 100:922-7. 2003.... - Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cellsMark E Hansen
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
Toxicology 220:218-31. 2006..They also provide insight into the similarities and differences between tumorigenic and non-tumorigenic OCs, in terms of the mechanisms and the extent of the [Ca2+]i increased by these agents... - Reduced levels of immunoglobulin in children with autism correlates with behavioral symptomsLuke Heuer
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
Autism Res 1:275-83. 2008..To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms... - In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screensKi Chang Ahn
Department of Entomology and Cancer Research Center, University of California, Davis, Davis, CA 95616, USA
Environ Health Perspect 116:1203-10. 2008..Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects... - Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disordersPaul Ashwood
Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
J Neuroimmunol 208:130-5. 2009..Moreover, PBMC from the ASD subjects were differentially affected when compared with the TD controls suggesting a biological basis for altered sensitivity to BDE-47 in the ASD population... - MECP2 promoter methylation and X chromosome inactivation in autismRaman P Nagarajan
Medical Microbiology and Immunology and Rowe Program in Human Genetics, University of California, Davis, CA 95616, USA
Autism Res 1:169-78. 2008..These results suggest that the aberrant MECP2 methylation in autism brain DNA samples is due to locus-specific rather than global X chromosome methylation changes... - Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype?Paul Ashwood
Department of Medical Microbiology and Immunology, University of California at Davis, Davis, CA 95616, USA
J Autism Dev Disord 38:169-75. 2008..042), TD controls (p<.0015), and DD controls (p<.004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group... - Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cellsOlga Ostrovskaya
Department of Pharmacology, University of Mississippi School of Pharmacy, University of Mississippi, 303 Faser Hall, University, MS 38677, USA
J Pharmacol Exp Ther 323:381-90. 2007..Thus, FLA 365 preferentially blocks RyRs with limited inhibition of L-type Ca2+ channels or InsP3R in canine PASMCs... - Evidence for conformational coupling between two calcium channelsC Paolini
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104-6058, USA
Proc Natl Acad Sci U S A 101:12748-52. 2004..We find a substantial ( approximately 2-nm) shift in the alpha(1S)DHPR positions, indicating that ryanodine induces large conformational changes in the RyR1 cytoplasmic domain and that the alpha(1S)DHPR-RyR complex acts as a unit... - Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction couplingWei Feng
Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
Biophys J 82:2428-35. 2002..In either case, Ca2+ activation of RyR1 does not appear to be necessary for the initiation of Ca2+ release during EC coupling in skeletal muscle... - Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscleChristopher W Ward
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 279:5781-7. 2004.... - Conformational coupling of DHPR and RyR1 in skeletal myotubes is influenced by long-range allosterism: evidence for a negative regulatory moduleEun Hui Lee
Department of Anesthesia Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Cell Physiol 286:C179-89. 2004..Although we were unable to define the negative module using RyR1-RyR2 chimeras, they further demonstrated that the RyR is very sensitive to long-range allosterism... - Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cellsEric Esteve
INSERM EMI 9931, CEA, CIS, 17 rue des Martyrs, 38054 Grenoble Cedex 09, France
J Biol Chem 278:37822-31. 2003..Overall, these data identify some amino acid residues of MCa that support the effect of this toxin on ryanodine binding, RyR1 biophysical properties, and Ca2+ release from SR... - Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SRTianzhong Yang
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Am J Physiol Cell Physiol 292:C1591-8. 2007.... - Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresolJames D Fessenden
Department of Anesthesia Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 278:28727-35. 2003..Taken together, these results suggest that essential determinants required for activation of RyR1 by 4-CmC reside within a 173-amino acid region between residues 4007 and 4180... - Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction couplingTianzhong Yang
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 278:25722-30. 2003..Decreased sensitivity to Ca2+ and Mg2+ inhibition and inability of MHRyR1s to be fully inactivated at [Ca2+]i typical of normal myotubes at rest are key defects that contribute to the initiation of MH episodes... - RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C couplingClaudio F Perez
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Biophys J 84:2655-63. 2003..These results both support and refine the previous hypothesis that multiple domains of RyR1 combine to functionally interact with the DHPR during E-C coupling... - Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1James D Fessenden
Department of Anesthesia Research, Brigham and Women s Hospital, Boston, MA 02115, USA
J Biol Chem 279:53028-35. 2004..However, in [(3)H]ryanodine binding experiments, the Ca(2+)-dependent activation and inactivation of mutated RyRs containing EF3, EF4, or EF5 was unaffected when compared with wtRyR1... - Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channelsDelavar Shahbazzadeh
Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, 13 Place Pasteur, Tunis, BP 74, 1002 Tunisia
Biochem J 404:89-96. 2007..Overall, these data identify a new biologically active toxin that belongs to a family of peptides active on the ryanodine-sensitive channel... - Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteinsEun Hui Lee
Laboratory of Calcium Communication, Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
J Biol Chem 281:10042-8. 2006.... - Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutationsTianzhong Yang
Department of Anesthesiology Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Biol Chem 282:37471-8. 2007.... - Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHgCindy S Roegge
Psychiatry Department, Duke University Medical Center, Durham, NC 27710, USA
Neurotoxicol Teratol 28:74-85. 2006.... - Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouseMihail G Chelu
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
FASEB J 20:329-30. 2006..We conclude that the heterozygous expression of the Y522S mutation confers susceptibility to both heat- and anesthetic-induced MH responses... - Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouseTianzhong Yang
Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Anesthesiology 105:1164-75. 2006..In the majority of human cases and all cases in animals, malignant hyperthermia has been associated with missense mutations in the skeletal ryanodine receptor (RyR1)... - Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fishPaul J Kostyniak
University at Buffalo, New York 14214, USA
Toxicol Sci 88:400-11. 2005..This illustrates that Aroclor mixtures are useful for formulating dosing solutions which closely approximate actual environmental exposures... - Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytesJun Gao
The University of New Mexico College of Pharmacy Toxicology Program, Albuquerque, 87131-0001, USA
Toxicol Sci 87:419-26. 2005..Collectively, these results demonstrate a novel mechanism of Ca(2+) elevation by an environmentally relevant metabolite of BaP in murine and human lymphocytes... - Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]iJose R Lopez
Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Am J Physiol Cell Physiol 288:C606-12. 2005..These results suggest that the differences in the response of MHS skeletal myoballs to caffeine and 4-CmC may be mediated at least in part by the chronic high resting [Ca(2+)](i) levels in these cells... - Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubesMarcin P Gach
Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Biophys J 94:3023-34. 2008..Thus, we conclude that the alpha(2)delta(1) dihydropyridine receptor subunit is physiologically necessary for sustaining Ca(2+) transients in response to prolonged depolarization or repeated trains of action potentials... - Autism: maternally derived antibodies specific for fetal brain proteinsDaniel Braunschweig
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, CA, USA
Neurotoxicology 29:226-31. 2008.... - Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresolJames D Fessenden
Department of Anesthesia Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 281:21022-31. 2006.... - Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention ResearchKim N Dietrich
University of Cincinnati College of Medicine, Division of Epidemiology and Biostatistics, Department of Environmental Health, and the Cincinnati Children's Environmental Health Center, Cincinnati, Ohio, USA
Environ Health Perspect 113:1437-46. 2005..The human neurodevelopmental phenotype will be most clearly represented in models that include environmental chemical exposures, the social milieu, and complex human genetic characteristics that we are just beginning to understand...
Research Grants
- Annual Autism, Genes and the Environment ConferenceIsaac Pessah; Fiscal Year: 2004..Three workshops for parents and caregivers will address the following: Dietary Factors Influencing Autistic Behaviors; Pharmacological Interventions, and Behavioral Interventions. ..
- Neuroprotection and Promotion of Repair Following Neurotoxic InjuryIsaac Pessah; Fiscal Year: 2007....
- UC Davis Center Children's Environmental Health (CCEH)Isaac Pessah; Fiscal Year: 2007..abstract_text> ..