Research Topics
Genomes and GenesSpecies | E PeskindSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Safety and acceptability of the research lumbar punctureElaine R Peskind
VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center MIRECC, University of Washington School of Medicine, Seattle, WA 98108, USA
Alzheimer Dis Assoc Disord 19:220-5. 2005....- Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognitionElaine R Peskind
VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
Arch Neurol 63:936-9. 2006..Normal aging and the presence of the apolipoprotein E (APOE*4) allele are the most important known risk factors for Alzheimer disease... - Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled studyElaine R Peskind
Department of Veterans Affairs Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, WA, USA
Alzheimer Dis Assoc Disord 19:23-8. 2005..We evaluated the efficacy of the beta-adrenergic antagonist propranolol for treatment-resistant disruptive behaviors and overall behavioral status in nursing home residents with probable or possible AD... - Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trialElaine R Peskind
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
Am J Geriatr Psychiatry 14:704-15. 2006..The objective of this study was to compare the efficacy and safety of the moderate-affinity, uncompetitive N-methyl-d-aspartate receptor antagonist, memantine, versus placebo in patients with mild to moderate Alzheimer disease (AD)... - Management of depression in long-term care of patients with Alzheimer's diseaseElaine R Peskind
VA Puget Sound Health Care System, Seattle, Washington 98108, USA
J Am Med Dir Assoc 4:S141-5. 2003 - Safety of lumbar puncture procedures in patients with Alzheimer's diseaseE Peskind
VA Northwest Network Mental Illness Research, Education, and Clinical Center, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
Curr Alzheimer Res 6:290-2. 2009..In conclusion, LP performed with a 24g Sprotte atraumatic needle (blunt, "bullet" tip) was a well tolerated procedure, with good acceptability... - Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's diseaseE R Peskind
Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
Neurochem Int 39:409-13. 2001..These results suggest increased CNS expression of S100B in the earlier stages of AD, and are consistent with a role for S100B in the initiation and/or facilitation of neuritic plaque formation in AD brain... - Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and genderS Craft
Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Wash
Neuroendocrinology 70:146-52. 1999.... - Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotypeS Craft
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Ann N Y Acad Sci 903:222-8. 2000.... - Testosterone supplementation improves spatial and verbal memory in healthy older menM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
Neurology 57:80-8. 2001..To determine the relationship between exogenous testosterone administration and cognitive abilities in a population of healthy older men... 
CSF multianalyte profile distinguishes Alzheimer and Parkinson diseasesJing Zhang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Clin Pathol 129:526-9. 2008..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD...- Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluidSimona Vuletic
Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington School of Medicine, Seattle, WA 98109, USA
J Alzheimers Dis 15:409-17. 2008..Our data suggest that there is a significant physiological link between apoE and AbetaPP, as well as between apoE and tau in neurologically healthy, cognitively intact individuals... - Treatment of agitation in AD: a randomized, placebo-controlled clinical trialL Teri
University of Washington, Department of Psychosocial and Community Health, Seattle 98195 7263, USA
Neurology 55:1271-8. 2000.... - Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older menM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 1959 NE Pacific, Box 356560, Seattle, WA 98195, USA
Psychoneuroendocrinology 29:65-82. 2004..This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning... - Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotypeJames B Leverenz
Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
Arch Neurol 63:370-6. 2006..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood... - Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjectsGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 4:e5424. 2009..01). CONCLUSIONS/SIGNIFICANCE: Reduced CSF BDNF was associated with age-related cognitive decline, suggesting a potential mechanism that may contribute in part to cognitive decline in older individuals... - Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodiesPatricia Szot
Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
J Neurosci 26:467-78. 2006.... - Altered medial temporal lobe responses during visuospatial encoding in healthy APOE*4 carriersPaul R Borghesani
Mental Illness Research, Education, and Clinical Center MIRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Neurobiol Aging 29:981-91. 2008..Reduced task-associated MTL activation that does not correlate with either visuospatial perspective or task performance suggests that MTL dysregulation occurs prior to clinical symptoms of dementia in APOE*4 carriers... - Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker associationChang En Yu
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Genomics 89:655-65. 2007..These observations diminish the possibility that loci in the TOMM40 gene may have a major effect on the risk for LOAD in Caucasians... - Biomarkers for Alzheimer's diseaseJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
Expert Rev Neurother 7:1021-8. 2007..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD... - Increased cerebrospinal fluid F2-isoprostanes are associated with aging and latent Alzheimer's disease as identified by biomarkersThomas J Montine
Department of Pathology, University of Washington, Seattle, WA, USA
Neuromolecular Med 13:37-43. 2011..01). These results show that CSF F(2)-IsoPs increased across the human lifespan and that this age-related increase in free radical injury to brain persisted after culling those with laboratory evidence of latent AD... 
Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platformSheng Pan
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Proteome Res 7:720-30. 2008....- Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levelsLynn M Bekris
Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 13:255-66. 2008..Further investigation of the genetic influence of these loci on apoE expression levels in the central nervous system is likely to provide new insight into apoE regulation as well as AD pathogenesis... - Age-varying association between statin use and incident Alzheimer's diseaseGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
J Am Geriatr Soc 58:1311-7. 2010..To determine whether risk reduction of statins for Alzheimer's disease (AD) varies by age or presence of apolipoprotein E (APOE) epsilon4 allele... - Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggressionLucy Y Wang
VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
Am J Geriatr Psychiatry 17:744-51. 2009..This pilot study examined the efficacy and tolerability of prazosin for behavioral symptoms in patients with agitation/aggression in AD... - Insulin effects on CSF norepinephrine and cognition in Alzheimer's diseaseG Stennis Watson
Geriatric Research, Education, and Clinical Center (GRECC, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108-1532, USA
Neurobiol Aging 27:38-41. 2006..These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions... - Quantitative proteomic analysis of age-related changes in human cerebrospinal fluidJing Zhang
Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
Neurobiol Aging 26:207-27. 2005..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases... - Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampusPamela J McMillan
Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington, USA
J Neurochem 91:843-51. 2004.... - The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trialMurray A Raskind
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA
Arch Neurol 61:252-6. 2004..Alzheimer disease (AD) causes progressive cognitive and functional decline over years. Although cholinesterase inhibitors have demonstrated efficacy in studies lasting 3 to 6 months, little is known about long-term therapy... - Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaqueJ Jacob Kulstad
Geriatric Research, Education, and Clinical Center, Veteran's Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Neuropathol Exp Neurol 64:139-46. 2005..These findings support the notion that glucocorticoids regulate IDE and provide a mechanism whereby increased glucocorticoid levels may contribute to AD pathology... - Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expressionPatricia Szot
Northwest Network Mental Illness Research, Education and Clinical Center S 116, VA Puget Sound Health Care System, S 116 MIRECC, 1660 S Columbian Way, Seattle, WA 98108, USA
Brain Res Mol Brain Res 139:367-71. 2005..These results confirm a difference in hippocampal alpha1-AR localization between rat and humans and further describe a difference in the localization of the alpha1A- and alpha1D-AR mRNA subtype between rats and humans... - Salivary cortisol and memory function in human agingGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Neurobiol Aging 27:1705-14. 2006..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition... - Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based studyJames B Leverenz
Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
Arch Neurol 59:1099-106. 2002..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community... - Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitroSimona Vuletic
Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington 98109 4517, USA
J Neurosci Res 80:406-13. 2005..The findings of reduced PLTP activity in AD CSF, and the observation that PLTP can influence apoE secretion in astrocytes suggest a potential link between alterations in the brain lipid metabolism and AD pathogenesis... - Identifying undiagnosed dementia in residential care veterans: comparing telemedicine to in-person clinical examinationMolly M Shores
VA Puget Sound Health Care System, Seattle, WA 98108, USA
Int J Geriatr Psychiatry 19:101-8. 2004..We conducted a pilot study to see if telemedicine could provide reliable, accurate geriatric consultative services to evaluate patients for dementia who were residing at remote sites... - Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorderElaine R Peskind
Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
J Geriatr Psychiatry Neurol 16:165-71. 2003..Prazosin was well tolerated. These open-label results are consistent with demonstrated therapeutic efficacy of prazosin for PTSD nightmares and sleep disturbance in a recent placebo-controlled trial in Vietnam veterans... - Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluidRobert G Riekse
Department of Medicine, Division of Geriatric Medicine, University of Washington School of Medicine, and VA Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 10:399-406. 2006..CONCLUSIONS: Statins may modulate the phosphorylation of tau in humans and this effect may depend on the CNS availability of the statin. These results suggest another mechanism by which statins may act to reduce the risk of AD... - Characterization of proteome of human cerebrospinal fluidJing Xu
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Int Rev Neurobiol 73:29-98. 2006 - A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorderMurray A Raskind
Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
Biol Psychiatry 61:928-34. 2007..The current parallel group trial in a larger sample of veterans evaluated prazosin effects on trauma nightmares, sleep quality, global clinical status, dream characteristics, and comorbid depression... - Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findingsEric C Petrie
Mail Code S 182 GRECC, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 66:632-7. 2009.... - DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's diseaseZhen Hong
Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
Brain 133:713-26. 2010..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration... - Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adultsMark A Fishel
Department of Neurology, University of Washington, Seattle, WA 98108, USA
Arch Neurol 62:1539-44. 2005..05). CONCLUSION: Moderate hyperinsulinemia can elevate inflammatory markers and Abeta42 in the periphery and the brain, thereby potentially increasing the risk of Alzheimer disease... - Statins of different brain penetrability differentially affect CSF PLTP activitySimona Vuletic
Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
Dement Geriatr Cogn Disord 22:392-8. 2006..CONCLUSION: Our data indicate that statins differentially affect two key lipid transfer proteins in the brain, and that effect on PLTP activity depends on statin BBB penetrability... - Statin therapy and risk of dementia in the elderly: a community-based prospective cohort studyG Li
Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
Neurology 63:1624-8. 2004..To assess the association between statin therapy and risk of Alzheimer disease (AD) in a prospective cohort study with documented statin exposure and incident dementia... - Identification of potential CSF biomarkers in ALSG M Pasinetti
Geriatric Research, Education, and Clinical Center, Bronx Veterans Affairs Medical Center, Bronx, NY, USA
Neurology 66:1218-22. 2006..The clinical diagnosis of ALS is based entirely on clinical features. Identification of biomarkers for ALS would be important for diagnosis and might also provide clues to pathogenesis... - A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometrySheng Pan
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Proteomics 7:469-73. 2007..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date... - Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approachSheng Pan
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Proteome Res 5:2769-79. 2006..This investigation, for the first time, not only categorized many glycoproteins in human CSF but also expanded the existing overall CSF protein database... - Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled studyFletcher B Taylor
Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Biol Psychiatry 63:629-32. 2008..We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD... - Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's diseaseMin Shi
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Neurosci Lett 480:78-82. 2010..In conclusion, unlike in cerebrospinal fluid, total DJ-1 or alpha-synuclein in plasma alone is not useful as biomarkers for Parkinson's disease diagnosis or progression/severity... - Prazosin reduces nightmares in combat veterans with posttraumatic stress disorderMurray A Raskind
Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
J Clin Psychiatry 63:565-8. 2002..Preclinical and clinical observations suggest that the centrally active alpha1-adrenergic antagonist prazosin might alleviate trauma content nightmares and other symptoms in combat veterans with chronic posttraumatic stress disorder (PTSD)... - Glycoproteomics in neurodegenerative diseasesHyejin Hwang
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Mass Spectrom Rev 29:79-125. 2010.... - Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled studyMurray A Raskind
Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
Am J Psychiatry 160:371-3. 2003..Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans... - Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's diseaseSimona Vuletic
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Lipid Res 44:1113-23. 2003..Comparison between brain tissues from patients with Alzheimer's disease (AD) and nonAD subjects revealed a significant increase (P = 0.02) in PLTP levels in brain tissue homogenates and increased PLTP immunostaining in AD... - Pharmacologic treatments of dementiaLauren T Bonner
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
Med Clin North Am 86:657-74. 2002..The indications for the use of cholinesterase inhibitor drugs are eventually likely to broaden to include DLB, mixed AD/VaD, and AD in its more advanced stages... - UniPep--a database for human N-linked glycosites: a resource for biomarker discoveryHui Zhang
Institute for Systems Biology, Seattle, WA 98103, USA
Genome Biol 7:R73. 2006..Here, we describe UniPep http://www.unipep.org--a database of human N-linked glycosites--as a resource for biomarker discovery... - Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsyWan Yang
Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
Am J Pathol 171:993-1002. 2007..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy... - Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer diseaseAdam S Fleisher
University of California, San Diego, La Jolla, CA 92037, USA
Arch Neurol 65:1031-8. 2008..To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in Alzheimer disease... - Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorderFletcher B Taylor
Rainier Associates, Tacoma, Washington 98467, USA
Biol Psychiatry 59:577-81. 2006..This study addressed whether daytime prazosin compared to placebo would alleviate psychological distress provoked experimentally by a trauma-related word list included in the emotional Stroop (E-Stroop) paradigm... - The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease CentersJohn C Morris
Washington University, St Louis, MO 63108, USA
Alzheimer Dis Assoc Disord 20:210-6. 2006..Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research... - Beneficial effects of prazosin for visual hallucinations associated with chronic cocaine abuseAndre M Tapp
J Clin Psychiatry 67:1819-20. 2006
Research Grants
- ALZHEIMER'S IN LONG TERM PROPRANOLOL FOR AGITATIONElaine Peskind; Fiscal Year: 2003..We will determine if high plasma NE and/or high lymphocyte beta-adrenergic receptor density, affinity, and/or sensitivity define AD patients with disruptive agitation most responsive to propranolol. ..
- Prazosin Treatment for Disruptive Agitation in Alzheimer's DiseaseElaine Peskind; Fiscal Year: 2009..Prazosin blocks the excessive brain adrenaline arousal that contributes to agitation in AD and both therapeutic and tolerability results of our prazosin feasibility study are very promising. ..
- Prazosin Treatment for Disruptive Agitation in Alzheimer's DiseaseElaine R Peskind; Fiscal Year: 2010..Prazosin blocks the excessive brain adrenaline arousal that contributes to agitation in AD and both therapeutic and tolerability results of our prazosin feasibility study are very promising. ..