E Peskind

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Safety and acceptability of the research lumbar puncture
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center MIRECC, University of Washington School of Medicine, Seattle, WA 98108, USA
    Alzheimer Dis Assoc Disord 19:220-5. 2005
  2. ncbi request reprint Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Arch Neurol 63:936-9. 2006
  3. ncbi request reprint Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, WA, USA
    Alzheimer Dis Assoc Disord 19:23-8. 2005
  4. ncbi request reprint Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial
    Elaine R Peskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 14:704-15. 2006
  5. ncbi request reprint Management of depression in long-term care of patients with Alzheimer's disease
    Elaine R Peskind
    VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Am Med Dir Assoc 4:S141-5. 2003
  6. ncbi request reprint Safety of lumbar puncture procedures in patients with Alzheimer's disease
    E Peskind
    VA Northwest Network Mental Illness Research, Education, and Clinical Center, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Curr Alzheimer Res 6:290-2. 2009
  7. ncbi request reprint Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease
    E R Peskind
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Neurochem Int 39:409-13. 2001
  8. ncbi request reprint Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender
    S Craft
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Wash
    Neuroendocrinology 70:146-52. 1999
  9. ncbi request reprint Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype
    S Craft
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann N Y Acad Sci 903:222-8. 2000
  10. ncbi request reprint Testosterone supplementation improves spatial and verbal memory in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
    Neurology 57:80-8. 2001

Detail Information

Publications60

  1. ncbi request reprint Safety and acceptability of the research lumbar puncture
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center MIRECC, University of Washington School of Medicine, Seattle, WA 98108, USA
    Alzheimer Dis Assoc Disord 19:220-5. 2005
    ....
  2. ncbi request reprint Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Arch Neurol 63:936-9. 2006
    ..Normal aging and the presence of the apolipoprotein E (APOE*4) allele are the most important known risk factors for Alzheimer disease...
  3. ncbi request reprint Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, WA, USA
    Alzheimer Dis Assoc Disord 19:23-8. 2005
    ..We evaluated the efficacy of the beta-adrenergic antagonist propranolol for treatment-resistant disruptive behaviors and overall behavioral status in nursing home residents with probable or possible AD...
  4. ncbi request reprint Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial
    Elaine R Peskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 14:704-15. 2006
    ..The objective of this study was to compare the efficacy and safety of the moderate-affinity, uncompetitive N-methyl-d-aspartate receptor antagonist, memantine, versus placebo in patients with mild to moderate Alzheimer disease (AD)...
  5. ncbi request reprint Management of depression in long-term care of patients with Alzheimer's disease
    Elaine R Peskind
    VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Am Med Dir Assoc 4:S141-5. 2003
  6. ncbi request reprint Safety of lumbar puncture procedures in patients with Alzheimer's disease
    E Peskind
    VA Northwest Network Mental Illness Research, Education, and Clinical Center, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Curr Alzheimer Res 6:290-2. 2009
    ..In conclusion, LP performed with a 24g Sprotte atraumatic needle (blunt, "bullet" tip) was a well tolerated procedure, with good acceptability...
  7. ncbi request reprint Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease
    E R Peskind
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Neurochem Int 39:409-13. 2001
    ..These results suggest increased CNS expression of S100B in the earlier stages of AD, and are consistent with a role for S100B in the initiation and/or facilitation of neuritic plaque formation in AD brain...
  8. ncbi request reprint Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender
    S Craft
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Wash
    Neuroendocrinology 70:146-52. 1999
    ....
  9. ncbi request reprint Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype
    S Craft
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann N Y Acad Sci 903:222-8. 2000
    ....
  10. ncbi request reprint Testosterone supplementation improves spatial and verbal memory in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
    Neurology 57:80-8. 2001
    ..To determine the relationship between exogenous testosterone administration and cognitive abilities in a population of healthy older men...
  11. pmc CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Clin Pathol 129:526-9. 2008
    ..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD...
  12. pmc Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid
    Simona Vuletic
    Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Alzheimers Dis 15:409-17. 2008
    ..Our data suggest that there is a significant physiological link between apoE and AbetaPP, as well as between apoE and tau in neurologically healthy, cognitively intact individuals...
  13. ncbi request reprint Treatment of agitation in AD: a randomized, placebo-controlled clinical trial
    L Teri
    University of Washington, Department of Psychosocial and Community Health, Seattle 98195 7263, USA
    Neurology 55:1271-8. 2000
    ....
  14. ncbi request reprint Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 1959 NE Pacific, Box 356560, Seattle, WA 98195, USA
    Psychoneuroendocrinology 29:65-82. 2004
    ..This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning...
  15. pmc Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
    James B Leverenz
    Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
    Arch Neurol 63:370-6. 2006
    ..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood...
  16. pmc Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
    ..We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline...
  17. ncbi request reprint Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neurosci 26:467-78. 2006
    ....
  18. pmc Altered medial temporal lobe responses during visuospatial encoding in healthy APOE*4 carriers
    Paul R Borghesani
    Mental Illness Research, Education, and Clinical Center MIRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurobiol Aging 29:981-91. 2008
    ..Reduced task-associated MTL activation that does not correlate with either visuospatial perspective or task performance suggests that MTL dysregulation occurs prior to clinical symptoms of dementia in APOE*4 carriers...
  19. pmc Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 89:655-65. 2007
    ..These observations diminish the possibility that loci in the TOMM40 gene may have a major effect on the risk for LOAD in Caucasians...
  20. ncbi request reprint Biomarkers for Alzheimer's disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Expert Rev Neurother 7:1021-8. 2007
    ..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD...
  21. pmc Increased cerebrospinal fluid F2-isoprostanes are associated with aging and latent Alzheimer's disease as identified by biomarkers
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA, USA
    Neuromolecular Med 13:37-43. 2011
    ..01). These results show that CSF F(2)-IsoPs increased across the human lifespan and that this age-related increase in free radical injury to brain persisted after culling those with laboratory evidence of latent AD...
  22. doi request reprint Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 7:720-30. 2008
    ....
  23. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
    ..Further investigation of the genetic influence of these loci on apoE expression levels in the central nervous system is likely to provide new insight into apoE regulation as well as AD pathogenesis...
  24. pmc Age-varying association between statin use and incident Alzheimer's disease
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    J Am Geriatr Soc 58:1311-7. 2010
    ..To determine whether risk reduction of statins for Alzheimer's disease (AD) varies by age or presence of apolipoprotein E (APOE) epsilon4 allele...
  25. pmc Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    Lucy Y Wang
    VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
    Am J Geriatr Psychiatry 17:744-51. 2009
    ..This pilot study examined the efficacy and tolerability of prazosin for behavioral symptoms in patients with agitation/aggression in AD...
  26. ncbi request reprint Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108 1532, USA
    Neurobiol Aging 27:38-41. 2006
    ..These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions...
  27. ncbi request reprint Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
    Jing Zhang
    Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
    Neurobiol Aging 26:207-27. 2005
    ..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
  28. ncbi request reprint Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus
    Pamela J McMillan
    Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington, USA
    J Neurochem 91:843-51. 2004
    ....
  29. ncbi request reprint The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial
    Murray A Raskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA
    Arch Neurol 61:252-6. 2004
    ..Alzheimer disease (AD) causes progressive cognitive and functional decline over years. Although cholinesterase inhibitors have demonstrated efficacy in studies lasting 3 to 6 months, little is known about long-term therapy...
  30. ncbi request reprint Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque
    J Jacob Kulstad
    Geriatric Research, Education, and Clinical Center, Veteran s Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neuropathol Exp Neurol 64:139-46. 2005
    ..These findings support the notion that glucocorticoids regulate IDE and provide a mechanism whereby increased glucocorticoid levels may contribute to AD pathology...
  31. ncbi request reprint Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression
    Patricia Szot
    Northwest Network Mental Illness Research, Education and Clinical Center S 116, VA Puget Sound Health Care System, S 116 MIRECC, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 139:367-71. 2005
    ..These results confirm a difference in hippocampal alpha1-AR localization between rat and humans and further describe a difference in the localization of the alpha1A- and alpha1D-AR mRNA subtype between rats and humans...
  32. ncbi request reprint Salivary cortisol and memory function in human aging
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neurobiol Aging 27:1705-14. 2006
    ..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition...
  33. ncbi request reprint Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study
    James B Leverenz
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1099-106. 2002
    ..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community...
  34. ncbi request reprint Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro
    Simona Vuletic
    Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington 98109 4517, USA
    J Neurosci Res 80:406-13. 2005
    ..The findings of reduced PLTP activity in AD CSF, and the observation that PLTP can influence apoE secretion in astrocytes suggest a potential link between alterations in the brain lipid metabolism and AD pathogenesis...
  35. ncbi request reprint Identifying undiagnosed dementia in residential care veterans: comparing telemedicine to in-person clinical examination
    Molly M Shores
    VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Int J Geriatr Psychiatry 19:101-8. 2004
    ..We conducted a pilot study to see if telemedicine could provide reliable, accurate geriatric consultative services to evaluate patients for dementia who were residing at remote sites...
  36. ncbi request reprint Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 16:165-71. 2003
    ..Prazosin was well tolerated. These open-label results are consistent with demonstrated therapeutic efficacy of prazosin for PTSD nightmares and sleep disturbance in a recent placebo-controlled trial in Vietnam veterans...
  37. ncbi request reprint Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid
    Robert G Riekse
    Department of Medicine, Division of Geriatric Medicine, University of Washington School of Medicine, and VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 10:399-406. 2006
    ..Putative neuroprotective effects of statins may vary in relation to their ability to penetrate into the central nervous system (CNS)...
  38. ncbi request reprint Characterization of proteome of human cerebrospinal fluid
    Jing Xu
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Int Rev Neurobiol 73:29-98. 2006
  39. ncbi request reprint A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Murray A Raskind
    Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 61:928-34. 2007
    ..The current parallel group trial in a larger sample of veterans evaluated prazosin effects on trauma nightmares, sleep quality, global clinical status, dream characteristics, and comorbid depression...
  40. pmc Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings
    Eric C Petrie
    Mail Code S 182 GRECC, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 66:632-7. 2009
    ....
  41. pmc DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    Zhen Hong
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Brain 133:713-26. 2010
    ..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration...
  42. ncbi request reprint Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
    Mark A Fishel
    Department of Neurology, University of Washington, Seattle, WA 98108, USA
    Arch Neurol 62:1539-44. 2005
    ..Hyperinsulinemia induces inflammation and is a risk factor for Alzheimer disease. Thus, insulin abnormalities may contribute to Alzheimer disease pathophysiology through effects on the inflammatory network...
  43. ncbi request reprint Statins of different brain penetrability differentially affect CSF PLTP activity
    Simona Vuletic
    Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Dement Geriatr Cogn Disord 22:392-8. 2006
    ..However, the effects of statins of differing blood-brain barrier (BBB) penetrability on brain-derived molecules in cognitively normal individuals are largely unknown...
  44. ncbi request reprint Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study
    G Li
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
    Neurology 63:1624-8. 2004
    ..To assess the association between statin therapy and risk of Alzheimer disease (AD) in a prospective cohort study with documented statin exposure and incident dementia...
  45. ncbi request reprint Identification of potential CSF biomarkers in ALS
    G M Pasinetti
    Geriatric Research, Education, and Clinical Center, Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neurology 66:1218-22. 2006
    ..The clinical diagnosis of ALS is based entirely on clinical features. Identification of biomarkers for ALS would be important for diagnosis and might also provide clues to pathogenesis...
  46. ncbi request reprint A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Proteomics 7:469-73. 2007
    ..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date...
  47. ncbi request reprint Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approach
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Proteome Res 5:2769-79. 2006
    ..This investigation, for the first time, not only categorized many glycoproteins in human CSF but also expanded the existing overall CSF protein database...
  48. pmc Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study
    Fletcher B Taylor
    Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Biol Psychiatry 63:629-32. 2008
    ..We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD...
  49. pmc Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Neurosci Lett 480:78-82. 2010
    ..In conclusion, unlike in cerebrospinal fluid, total DJ-1 or alpha-synuclein in plasma alone is not useful as biomarkers for Parkinson's disease diagnosis or progression/severity...
  50. ncbi request reprint Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder
    Murray A Raskind
    Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    J Clin Psychiatry 63:565-8. 2002
    ..Preclinical and clinical observations suggest that the centrally active alpha1-adrenergic antagonist prazosin might alleviate trauma content nightmares and other symptoms in combat veterans with chronic posttraumatic stress disorder (PTSD)...
  51. pmc Glycoproteomics in neurodegenerative diseases
    Hyejin Hwang
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Mass Spectrom Rev 29:79-125. 2010
    ....
  52. ncbi request reprint Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
    Am J Psychiatry 160:371-3. 2003
    ..Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans...
  53. ncbi request reprint Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease
    Simona Vuletic
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 44:1113-23. 2003
    ..Comparison between brain tissues from patients with Alzheimer's disease (AD) and nonAD subjects revealed a significant increase (P = 0.02) in PLTP levels in brain tissue homogenates and increased PLTP immunostaining in AD...
  54. ncbi request reprint Pharmacologic treatments of dementia
    Lauren T Bonner
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Med Clin North Am 86:657-74. 2002
    ..The indications for the use of cholinesterase inhibitor drugs are eventually likely to broaden to include DLB, mixed AD/VaD, and AD in its more advanced stages...
  55. pmc UniPep--a database for human N-linked glycosites: a resource for biomarker discovery
    Hui Zhang
    Institute for Systems Biology, Seattle, WA 98103, USA
    Genome Biol 7:R73. 2006
    ..Here, we describe UniPep http://www.unipep.org--a database of human N-linked glycosites--as a resource for biomarker discovery...
  56. pmc Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy
    Wan Yang
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 171:993-1002. 2007
    ..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy...
  57. pmc Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
    Adam S Fleisher
    University of California, San Diego, La Jolla, CA 92037, USA
    Arch Neurol 65:1031-8. 2008
    ..To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in Alzheimer disease...
  58. ncbi request reprint Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder
    Fletcher B Taylor
    Rainier Associates, Tacoma, Washington 98467, USA
    Biol Psychiatry 59:577-81. 2006
    ..This study addressed whether daytime prazosin compared to placebo would alleviate psychological distress provoked experimentally by a trauma-related word list included in the emotional Stroop (E-Stroop) paradigm...
  59. ncbi request reprint The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers
    John C Morris
    Washington University, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 20:210-6. 2006
    ..Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research...
  60. ncbi request reprint Beneficial effects of prazosin for visual hallucinations associated with chronic cocaine abuse
    Andre M Tapp
    J Clin Psychiatry 67:1819-20. 2006

Research Grants7

  1. ALZHEIMER'S IN LONG TERM PROPRANOLOL FOR AGITATION
    Elaine Peskind; Fiscal Year: 2003
    ..We will determine if high plasma NE and/or high lymphocyte beta-adrenergic receptor density, affinity, and/or sensitivity define AD patients with disruptive agitation most responsive to propranolol. ..
  2. Prazosin Treatment for Disruptive Agitation in Alzheimer's Disease
    Elaine Peskind; Fiscal Year: 2009
    ..Prazosin blocks the excessive brain adrenaline arousal that contributes to agitation in AD and both therapeutic and tolerability results of our prazosin feasibility study are very promising. ..
  3. Prazosin Treatment for Disruptive Agitation in Alzheimer's Disease
    Elaine R Peskind; Fiscal Year: 2010
    ..Prazosin blocks the excessive brain adrenaline arousal that contributes to agitation in AD and both therapeutic and tolerability results of our prazosin feasibility study are very promising. ..