Research Topics
| WILLIAM contact PERRYSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigmWilliam Perry
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8218, USA
Psychiatry Res 178:84-91. 2010..The current study extends our methodology for quantifying exploration and over-activity in a controlled laboratory setting and aids in assessing the overlap and distinguishing characteristics of BD and SCZ...- Beyond the numbers: expanding the boundaries of neuropsychologyWilliam Perry
Department of Psychiatry, University of California, San Diego, CA 92093 8620, USA
Arch Clin Neuropsychol 24:21-9. 2009.... 
Sensorimotor gating deficits in adults with autismWilliam Perry
Department of Psychiatry, University of California, San Diego, California, USA
Biol Psychiatry 61:482-6. 2007..Adults with autistic disorder (AD) exhibit clinical features of inhibitory deficits, such as restrictive and repetitive behaviors, that may be explained by deficits in sensorimotor gating...- Neuropsychological test performance in patients co-infected with hepatitis C virus and HIVWilliam Perry
Hepatology Neurobehavioral Research Program, University of California, San Diego, CA 92103 8218, USA
AIDS 19:S79-84. 2005..To determine the effect of co-infection on neuropsychological performance in relatively healthy hepatitis C virus (HCV)-alone patients when compared with HCV/HIV-co-infected patients... - A retrospective review of the neuropsychological test performance of physicians referred for medical infractionsWilliam Perry
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 8218, USA
Arch Clin Neuropsychol 20:161-70. 2005..Applying a neuropsychological framework to the assessment of physicians may uncover potential cognitive factors that contribute to medical practice errors... - Prepulse inhibition in patients with non-psychotic major depressive disorderWilliam Perry
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8218, San Diego, CA 92103 8218, USA
J Affect Disord 81:179-84. 2004..Therefore, we assessed PPI in non-psychotic MDD patients and compared their results to schizophrenia patients and non-patients... - Let's call the whole thing off: a response to Dawes (2001)William Perry
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 8218, USA
Psychol Assess 15:582-5. 2003..Thus, the conclusion presented in this Comment is that it is time for us to "call the whole thing off" and end the Rorschach controversy that has occupied so much recent attention and generated so few new ideas... - The use of the Ego Impairment Index across the schizophrenia spectrumWilliam Perry
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8620, USA
J Pers Assess 80:50-7. 2003.... - Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admissionWilliam Perry
Neuropsychiatry and Behavioral Medicine Service, Department of Psychiatry, University of California San Diego, La Jolla 92093 8620, USA
Am J Psychiatry 159:1375-81. 2002..The present study investigated the effects of antipsychotics on prepulse inhibition and startle habituation in acutely hospitalized patients with schizophrenia... - Schizophrenia patients demonstrate a dissociation on declarative and non-declarative memory testsW Perry
University of California, Department of Psychiatry, 9500 Gilman Drive, La Yolla, San Diego, CA 92093 8620, USA
Schizophr Res 46:167-74. 2000..The schizophrenia patients' dissociation on declarative vs. non-declarative memory tests is discussed in terms of possible underlying structural impairment... - A multimethod approach to assessing perseverations in schizophrenia patientsW Perry
University of California, San Diego, Department of Psychiatry, La Jolla 92093 8620, USA
Schizophr Res 33:69-77. 1998..These data provide evidence that perseverative behavior is widely observed in schizophrenia patients using a variety of instruments. The authors discuss the benefit of using multiple measures of perseveration in schizophrenia research... - Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patientsW Perry
Department of Psychiatry, University of California, San Diego, USA
Arch Gen Psychiatry 56:277-81. 1999..To address this issue, sensorimotor gating and thought disturbance were measured in close temporal proximity, thus strengthening the evidence for the association of these 2 abnormalities in schizophrenic patients... - Working memory in schizophrenia: transient "online" storage versus executive functioningW Perry
Department of Psychiatry, University of California, San Diego, La Jolla 92093 8620, USA
Schizophr Bull 27:157-76. 2001..The importance of clearly identifying which distinct aspects of working memory are assessed is discussed... - Self-monitoring enhances Wisconsin Card Sorting Test performance in patients with schizophrenia: performance is improved by simply asking patients to verbalize their sorting strategyW Perry
University of California, San Diego, Department of Psychiatry, USA
J Int Neuropsychol Soc 7:344-52. 2001..Cumulatively, these data suggest that a simple instruction may enhance executive function and impact WCST performance in patients with schizophrenia... - Incremental validity of the Ego Impairment Index: a re-examination of Dawes (1999)W Perry
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 8218, USA
Psychol Assess 13:403-7. 2001..005) even after the 2 EII variables selected by Dawes and the measure of social competence were 1st entered into the equation. The results suggest that the EII adds meaningful information in the assessment of thought disturbance... - Cognitive dysfunction in chronic hepatitis C: a reviewWilliam Perry
Department of Psychiatry, Hepatology Neurobehavioral Research Program, UCSD Liver Center, University of California, 200 West Arbor Drive, San Diego, CA 92108 8707, USA
Dig Dis Sci 53:307-21. 2008..Implications of these findings and directions for future work are discussed... - Utility of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) in patients with end-stage liver disease awaiting liver transplantScott Mooney
Department of Psychiatry, University of California, San Diego, CA 92103 8212, USA
Arch Clin Neuropsychol 22:175-86. 2007..In summary, the RBANS appears to adequately characterize known patterns of cognitive dysfunction in ESLD patients... - Neuropsychological impairment in patients with chronic hepatitis CRobin C Hilsabeck
University of California, San Diego Medical Center, San Diego, CA, USA
Hepatology 35:440-6. 2002..Future studies need to determine the effect of this decrease in cognitive function on quality of life... - Relationship of tinnitus questionnaires to depressive symptoms, quality of well-being, and internal focusShannon K Robinson
University of California San Diego, USA
Int Tinnitus J 9:97-103. 2003..37-.52; all p values < .01) but not with the PSCS. When controlling for the shared variance between tinnitus measures, the THQ independently predicted the HRSD, whereas the TRQ independently predicted the BDI... - Prepulse inhibition of startle in adults with ADHDDavid Feifel
University of California San Diego, School of Medicine, Department of Psychiatry, San Diego, CA 92103 8218, USA
J Psychiatr Res 43:484-9. 2009..This distinction may be related to a relative sparing of pre-conscious attentional functions in ADHD compared to other disorders with PPI impairment... 
Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathyTarek Hassanein
Department of Medicine, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103 8423, USA
Am J Gastroenterol 104:1392-400. 2009..The grading of hepatic encephalopathy (HE) is based on a combination of indicators that reflect the state of consciousness, intellectual function, changes in behavior, and neuromuscular alterations seen in patients with liver failure...- Introduction to the Hepatic Encephalopathy Scoring Algorithm (HESA)Tarek I Hassanein
Department of Medicine, Hepatology Neurobehavioral Research Program, UCSD Liver Center, University of California, 200 West Arbor Drive, San Diego, CA 92108 8707, USA
Dig Dis Sci 53:529-38. 2008..The results also suggest HESA may be more sensitive to mental status impairment in the middle grades of HE than WHC. These findings suggest HESA holds promise as a multi-method approach to grading all levels of HE... - Heart rate variability in bipolar mania and schizophreniaBrook L Henry
University of California San Diego, Department of Psychiatry, La Jolla, CA 92103 0851, United States
J Psychiatr Res 44:168-76. 2010..We recorded cardiac activity and assessed HRV in acutely hospitalized manic bipolar (BD) and schizophrenia (SCZ) patients compared to age- and gender-matched healthy comparison (HC) subjects... - The category test perseveration, loss of set, and memory scales: three new scales and their relationship to executive functioning measuresArpi Minassian
Department of Psychiatry, University of California, San Diego 92103 8620, USA
Assessment 10:213-21. 2003..Although future studies designed to test discriminant and convergent validity are warranted, these scales may be useful in determining specific aspects of impaired CT performance... - A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to menWilliam Perry
Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, MC 0804, La Jolla, CA 92093 0804, USA
Arch Gen Psychiatry 66:1072-80. 2009..Exploration is fundamental to survival and is dysregulated in these 2 disorders. Although exploratory behavior in rodents has been widely studied, surprisingly little work has examined this critical function in humans... - Adults with autism show increased sensitivity to outcomes at low error rates during decision-makingArpi Minassian
Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
J Autism Dev Disord 37:1279-88. 2007..Thus, behavioral paradigms that provide frequent reinforcement may be helpful in modifying decision-making abilities in AD... - The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patientsArpi Minassian
Department of Psychiatry, University of California, San Diego School of Medicine, USA
Schizophr Res 89:225-31. 2007..Our results suggest that PPI can be improved by short-term treatment, and that improvement in sensorimotor gating is associated with treatment-related improvement of symptoms of schizophrenia... - Assessing disturbed thinking and cognition using the Ego Impairment Index in older schizophrenia patients: paranoid vs. nonparanoid distinctionLisa A Auslander
Department of Psychiatry, University of California, San Diego, CA, USA
Schizophr Res 53:199-207. 2002..We compared thought-disturbance via the Rorschach-derived Ego Impairment Index (EII) between DSM-IV paranoid vs. nonparanoid (undifferentiated and disorganized) subtypes of older schizophrenia patients... - Pupillary dilation to simple vs. complex tasks and its relationship to thought disturbance in schizophrenia patientsArpi Minassian
Department of Psychiatry, University of California, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
Int J Psychophysiol 52:53-62. 2004..These findings support the 'resource limitations hypothesis' of schizophrenia and underscore the utility of a simultaneous paradigm when studying the relationship between attentional deficits and thought disturbance... - Effect of methamphetamine dependence on everyday functional abilityBrook L Henry
University of California San Diego, Department of Psychiatry, La Jolla, CA, United States
Addict Behav 35:593-8. 2010..We assessed the effect of METH dependence on everyday functioning using the UCSD Performance-Based Skills Assessment (UPSA-2), a performance-based measure designed to evaluate real-life skills... - Cross-species assessments of motor and exploratory behavior related to bipolar disorderBrook L Henry
University of California San Diego, Department of Psychiatry, La Jolla, CA, USA
Neurosci Biobehav Rev 34:1296-306. 2010.... - Visual scanning deficits in schizophrenia and their relationship to executive functioning impairmentArpi Minassian
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
Schizophr Res 74:69-79. 2005.... - Increased sensitivity to error during decision-making in bipolar disorder patients with acute maniaArpi Minassian
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
J Affect Disord 82:203-8. 2004..In this study we examined whether BD patients with psychotic mania show altered patterns of decision-making as a function of the frequency of incorrect predictions or error rate... - Inhibitory deficits in ocular motor behavior in adults with attention-deficit/hyperactivity disorderDavid Feifel
Adult ADHD Program, Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Biol Psychiatry 56:333-9. 2004..The ability to suppress unwanted saccadic eye movements is mediated by prefrontal cortex-basal ganglia circuitry and thus constitutes a useful measure of inhibitory ability... - The quantitative assessment of motor activity in mania and schizophreniaArpi Minassian
University of California, Department of Psychiatry, San Diego, CA, USA
J Affect Disord 120:200-6. 2010..We used an ambulatory monitoring device to quantify motor activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM)... - GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behaviorJared W Young
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, USA
Psychopharmacology (Berl) 208:443-54. 2010.... - Modifying the Rorschach Human Experience Variable to create the Human Representational VariableDonald J Viglione
California School of Professional Psychology, San Diego Alliant International University, San Diego, CA 92131 1799, USA
J Pers Assess 81:64-73. 2003..Data presented here suggest that the HRV has improved psychometric properties compared to the HEV and that it is simpler to understand. Research recommendations and interpretive suggestions are also presented... - A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern MonitorJared W Young
University of California San Diego, Department of Psychiatry, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
Neurosci Biobehav Rev 31:882-96. 2007..This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents... - Rapid oral loading of extended release divalproex in patients with acute maniaBrian P Miller
Neuropsychiatry and Behavioral Medicine Unit, University of California, San Diego Medical Center, San Diego, California 92103-8218, USA
Gen Hosp Psychiatry 27:218-21. 2005.... - Implications of hepatitis C virus infection for behavioral symptoms and activities of daily livingCarolina Posada
San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
J Clin Exp Neuropsychol 32:637-44. 2010..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed... - Refinements in the Rorschach Ego Impairment Index incorporating the human representational variableDonald J Viglione
California School of Professional Psychology, Alliant International University, San Diego 92131 1799, USA
J Pers Assess 81:149-56. 2003..This was accomplished by recalculating the factor coefficients with a sample of 363 Rorschach protocols. We present additional validity data for the new EII-2. Research recommendations and interpretive guidelines are also presented... - A method to optimize the response range while maintaining Rorschach Comprehensive System validityKristin L Dean
Department of Clinical Psychology, California School of Professional Psychology at Alliant International University, USA
J Pers Assess 89:149-61. 2007..The findings have clinical implications for protocol administration with thought-disordered populations that typically produce brief records... - Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis CRobin C Hilsabeck
Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
J Int Neuropsychol Soc 9:847-54. 2003.... - Biopsychosocial predictors of fatigue in chronic hepatitis CRobin C Hilsabeck
Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 8321, Lubbock, TX 79430, USA
J Psychosom Res 58:173-8. 2005..The objective of this study was to investigate the relationship of biopsychosocial variables to fatigue in patients with chronic hepatitis C (CHC) with the goal of identifying areas of possible intervention... - Effect of interferon-alpha on cognitive functioning in patients with chronic hepatitis CRobin C Hilsabeck
Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
J Int Neuropsychol Soc 11:16-22. 2005..Additional research is needed to replicate these findings and to explore risk factors for susceptibility to IFN-alpha-induced effects... - A process approach to verbal fluency in patients with schizophreniaLeeza M Maron
Schizophr Res 68:105-6. 2004
Research Grants
- Inhibitory Deficits in Mania and Hyperdopaminiergic MiceWilliam Perry; Fiscal Year: 2007..Such preclinical models, and the human measures essential to their validation, are critical to the future discovery of novel treatments of this condition. ..
- INHIBITORY DEFICITS IN HUMAN AND ANIMAL MODELS OF BIPOLAR DISORDERWILLIAM contact PERRY; Fiscal Year: 2010..Completion of this work will assist in understanding the underlying brain dysfunction of BD as well as assist in discovering and developing novel treatments. ..