Genomes and Genes
Seth W Perry
Affiliation: University of Rochester
- Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cellsSeth W Perry
Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
BMC Cancer 13:411. 2013..Therefore we investigated how MMP13 modulates collagen I, a principal collagen subtype in breast tissue, and affects tumor pathology and metastasis in a mouse model of breast cancer...
- Two-photon and second harmonic microscopy in clinical and translational cancer researchSeth W Perry
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA
Ann Biomed Eng 40:277-91. 2012....
- Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?Seth W Perry
Center for Aging and Developmental Biology, Aab Biomedical Institute, and the Departments of Neurology, University of Rochester Medical Center, Rochester, New York, USA
J Neurovirol 8:611-24. 2002....
- Mitochondrial membrane potential probes and the proton gradient: a practical usage guideSeth W Perry
Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, NY 14627, USA
Biotechniques 50:98-115. 2011..In total, this review will help illustrate both the strengths and potential pitfalls of common mitochondrial membrane potential dyes, and highlight best-usage approaches for their efficacious application in life sciences research...
- Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and VmaxSeth W Perry
Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, Graduate Program in Pathology, and Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 30:14153-64. 2010..Finally, we provide key translational relevance for these findings by highlighting published human data of increased DAT levels in striata of HAND patients and by demonstrating similar findings in Tat-expressing transgenic mice...
- HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosisSeth W Perry
Center for Aging and Developmental Biology, Interdepartmental Program in Neuroscience, Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 174:4333-44. 2005..Finally, Tat and platelet-activating factor also increased neuronal vesicular release, which may be related to increased mitochondrial bioenergetics and serve as a biomarker for early damage to neurons...
- Antioxidants are required during the early critical period, but not later, for neuronal survivalSeth W Perry
Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci Res 78:485-92. 2004..Together, these findings suggest a brief window of high vulnerability to reactive oxygen species, and have important implications for studies of oxidative stress and developmental neuroscience...
- HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarizationJohn P Norman
Center for Neural Development and Disease, The University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
PLoS ONE 3:e3731. 2008..Collectively, these data suggest that abnormal RyR signaling mediates the neuronal UPR with failure of mitochondrial energy metabolism, and is a critical locus for the neuropathogenesis of HIV-1 in the CNS...
- HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neuronsJohn P Norman
Department of Neurology Child Neurology Division, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Immunol 178:869-76. 2007..Based on these findings, we suggest that decreased NADPH and calcium concentration contribute to subsequent respiratory decline after exposure to Tat, with detrimental effects on neuronal signaling...
- Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha productionMichelle Kiebala
Department of Microbiology and Immunology, The University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
PLoS ONE 5:e11875. 2010..These findings identify a novel regulatory pathway for controlling HIV-induced microglial activation and cytokine production that may have important therapeutic implications for the management of HAND...
- Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neuronsQian Huang
Department of Biological Sciences, Hunter College and Graduate Center, City University of New York, New York, New York 10065, USA
J Biol Chem 288:12161-74. 2013..However, if chronic, it could lead to neurodegeneration as regulated protein degradation by the ubiquitin/proteasome pathway is essential for neuronal survival...
- Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generationRyan M Burke
University of Rochester, Aab Cardiovascular Research Institute, 601 Elmwood Avenue Box CVRI, Rochester, New York 14642, USA
J Biomed Opt 18:86003. 2013..Furthermore, these results indicate that quantification of SHG represents a useful strategy for evaluating the cells and molecular pathways responsible for manipulating fibrillar collagen in breast tumor models...
- Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lungRobert Matthew Kottmann
Department of Medicine, University of Rochester, Rochester, NY, USA
Respir Res 16:61. 2015..The objectives herein are to provide new insights into the underlying collagen- and matrix-related biological mechanisms driving COP versus UIP...
- Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomesEchoe M Bouta
Center for Musculoskeletal Research, Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Ann N Y Acad Sci 1240:47-52. 2011..These results demonstrate the potential of lymph node pressure and lymph viscosity measurements, and future studies to test these outcomes as biomarkers of arthritic flare are warranted...