R D Perry

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Integral and peripheral association of proteins and protein complexes with Yersinia pestis inner and outer membranes
    Rembert Pieper
    Craig Venter Institute, 9704 Medical Center Drive, Rockville, Maryland, USA
    Proteome Sci 7:5. 2009
  2. pmc Proteomic analysis of iron acquisition, metabolic and regulatory responses of Yersinia pestis to iron starvation
    Rembert Pieper
    J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    BMC Microbiol 10:30. 2010
  3. pmc Temperature regulation of the hemin storage (Hms+) phenotype of Yersinia pestis is posttranscriptional
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536, USA
    J Bacteriol 186:1638-47. 2004
  4. pmc Yersinia pestis TonB: role in iron, heme, and hemoprotein utilization
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536 8994, USA
    Infect Immun 71:4159-62. 2003
  5. ncbi request reprint Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation
    R D Perry
    Department of Microbiology and Immunology, MS415 Medical Center, University of Kentucky, Lexington 40536 0084, USA
    Microbiology 145:1181-90. 1999
  6. pmc DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of Yersinia pestis KIM5
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Infect Immun 66:4611-23. 1998
  7. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
  8. pmc Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization
    J M Thompson
    Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Infect Immun 67:3879-92. 1999
  9. ncbi request reprint YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis
    J D Fetherston
    Department of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536 0084, USA
    Mol Microbiol 32:289-99. 1999
  10. ncbi request reprint HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis
    H A Jones
    University of Kentucky, Department of Microbiology and Immunology, Lexington 40536 0084, USA
    Microbiology 145:2117-28. 1999

Collaborators

Detail Information

Publications49

  1. pmc Integral and peripheral association of proteins and protein complexes with Yersinia pestis inner and outer membranes
    Rembert Pieper
    Craig Venter Institute, 9704 Medical Center Drive, Rockville, Maryland, USA
    Proteome Sci 7:5. 2009
    ..The total number of proteins associated with Y. pestis membranes increased to 456 and included representatives of all six beta-barrel OM protein families and 25 distinct IM transporter families...
  2. pmc Proteomic analysis of iron acquisition, metabolic and regulatory responses of Yersinia pestis to iron starvation
    Rembert Pieper
    J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    BMC Microbiol 10:30. 2010
    ..pestis strain KIM6+ at two physiologically relevant temperatures (26 degrees C and 37 degrees C)...
  3. pmc Temperature regulation of the hemin storage (Hms+) phenotype of Yersinia pestis is posttranscriptional
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536, USA
    J Bacteriol 186:1638-47. 2004
    ..However, HmsT at 37 degrees C is sensitive to degradation by Lon and/or ClpPX. Thus, the stability of HmsH, HmsR, and HmsT proteins likely plays a role in temperature regulation of the Hms+ phenotype of Y. pestis...
  4. pmc Yersinia pestis TonB: role in iron, heme, and hemoprotein utilization
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536 8994, USA
    Infect Immun 71:4159-62. 2003
    ..Here we demonstrate that hemin uptake and iron utilization from Ybt are TonB dependent. However, the Yfe iron and manganese transport system does not require TonB...
  5. ncbi request reprint Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation
    R D Perry
    Department of Microbiology and Immunology, MS415 Medical Center, University of Kentucky, Lexington 40536 0084, USA
    Microbiology 145:1181-90. 1999
    ..In contrast to Y. pestis, in which a psn mutation does not repress synthesis of Ybt siderophore or expression of the iron-regulated HMWP1 and HMWP2 proteins, the same mutation in Y. pseudotuberculosis partially repressed these products...
  6. pmc DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of Yersinia pestis KIM5
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Infect Immun 66:4611-23. 1998
    ..Eight other ORFs not associated with IS elements were identified and deserve future investigation into their functions...
  7. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
    ..These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague...
  8. pmc Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization
    J M Thompson
    Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Infect Immun 67:3879-92. 1999
    ..Growth studies showed that a DeltahmuP'RSTUV mutant could grow in iron-depleted medium containing high concentrations of hemoglobin, suggesting that an Hmu-independent, lower-affinity hemoglobin uptake system may exist...
  9. ncbi request reprint YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis
    J D Fetherston
    Department of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536 0084, USA
    Mol Microbiol 32:289-99. 1999
    ..In addition, a ybtP mutant showed reduced iron accumulation and was avirulent in mice by a subcutaneous route of infection that mimics flea transmission of bubonic plague...
  10. ncbi request reprint HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis
    H A Jones
    University of Kentucky, Department of Microbiology and Immunology, Lexington 40536 0084, USA
    Microbiology 145:2117-28. 1999
    ..E. coli MG1655 contains homologues of hmsHFRST (ycdSRQPT) but has an Hms- phenotype. Only ycdQ and ycdP complement mutations in their respective homologues, hmsR and hmsS, in Y. pestis...
  11. pmc Genetic organization of the yersiniabactin biosynthetic region and construction of avirulent mutants in Yersinia pestis
    S W Bearden
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084, USA
    Infect Immun 65:1659-68. 1997
    ..Finally, Y. pestis strains with mutations in either the psn or irp2 gene were avirulent in mice when inoculated subcutaneously...
  12. pmc An ABC transporter system of Yersinia pestis allows utilization of chelated iron by Escherichia coli SAB11
    S W Bearden
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084, USA
    J Bacteriol 180:1135-47. 1998
    ..The approximately 21-kDa protein encoded by the separately transcribed yfeE gene may be located in the cell envelope, since a yfeE::TnphoA fusion is PhoA+. Mutations in this gene abrogate growth of SAB11 on iron-chelated media...
  13. ncbi request reprint YbtA, an AraC-type regulator of the Yersinia pestis pesticin/yersiniabactin receptor
    J D Fetherston
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084, USA
    Mol Microbiol 22:315-25. 1996
    ..YbtA also represses its own transcription...
  14. ncbi request reprint Sequence and genetic analysis of the hemin storage (hms) system of Yersinia pestis
    J W Lillard
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084, USA
    Gene 193:13-21. 1997
    ..5 kDa protein with a pI of 6.68. Hms- Y. pestis strain M23-2 transformed with the cloned hmsHFRS locus developed an Hms(c) phenotype (Hms+ at 26-37 degrees C) due to mutations in genes outside the pgm locus...
  15. ncbi request reprint Loss of the pigmentation phenotype in Yersinia pestis is due to the spontaneous deletion of 102 kb of chromosomal DNA which is flanked by a repetitive element
    J D Fetherston
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084
    Mol Microbiol 6:2693-704. 1992
    ..pestis genome. This element may be responsible for generating the deletion...
  16. ncbi request reprint HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms-dependent biofilm formation in Yersinia pestis
    Olga Kirillina
    Department of Microbiology, Immunology, and Molecular Genetics, MS415 Medical Center, University of Kentucky, Lexington, KY 40536 0298, USA
    Mol Microbiol 54:75-88. 2004
    ..We propose that HmsT and HmsP together control the amount of biofilm produced in Y. pestis. Degradation of HmsT at 37 degrees C may be a critical factor in controlling the temperature-dependent expression of the Hms biofilm...
  17. pmc Characterization of the Yersinia pestis Yfu ABC inorganic iron transport system
    S Gong
    Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536-0298, USA
    Infect Immun 69:2829-37. 2001
    ..Fifty percent lethal dose studies in mice did not demonstrate a role for the Yfu system in mammalian virulence...
  18. ncbi request reprint Fur regulation in Yersinia species
    T M Staggs
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084, USA
    Mol Microbiol 17:601. 1995
  19. pmc Analysis of the pesticin receptor from Yersinia pestis: role in iron-deficient growth and possible regulation by its siderophore
    J D Fetherston
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084
    J Bacteriol 177:1824-33. 1995
    ..HMWP2 likely participates in synthesis of a siderophore which may induce expression of the receptor for pesticin and the siderophore...
  20. pmc Polyamines are required for the expression of key Hms proteins important for Yersinia pestis biofilm formation
    Brian W Wortham
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Environ Microbiol 12:2034-47. 2010
    ..Finally, we have shown that polyamines play a role in bubonic plague...
  21. ncbi request reprint The hmu locus of Yersinia pestis is essential for utilization of free haemin and haem--protein complexes as iron sources
    J M Hornung
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536 0084, USA
    Mol Microbiol 20:725-39. 1996
    ....
  22. ncbi request reprint Regulation of the Yersinia pestis Yfe and Ybt iron transport systems
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, USA
    Adv Exp Med Biol 529:275-83. 2003
  23. doi request reprint Yersinia ironomics: comparison of iron transporters among Yersinia pestis biotypes and its nearest neighbor, Yersinia pseudotuberculosis
    Stanislav Forman
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, USA
    Biometals 23:275-94. 2010
    ..pestis CO92 (epidemic orientalis biovar). Experimental studies failed to identify a role for hemin uptake systems in the virulence of pneumonic plague and suggest that Y. pestis CO92 does not make a siderophore other than Ybt...
  24. ncbi request reprint Fur regulation in Yersinia species
    T M Staggs
    Department of Microbiology and Immunology, Chandler Medical Center, University of Kentucky, Lexington 40536 0084
    Mol Microbiol 6:2507-16. 1992
    ..pestis fur gene. These data indicate that Y. pestis and Y. enterocolitica possess homologous Fur systems which regulate expression of proteins in response to iron availability...
  25. ncbi request reprint Unexpected results from the application of signature-tagged mutagenesis to identify Yersinia pestis genes required for adherence and invasion
    S A Leigh
    Department of Microbiology, Immunology, and Molecular Genetics, MS415 Chandler Medical Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0298, USA
    Microb Pathog 38:259-66. 2005
    ..pestis, since gentamicin has been recommended for treatment of plague. Further, to use STM in the context of invasion assays, a selection other than gentamicin should be applied...
  26. ncbi request reprint Identification of critical amino acid residues in the plague biofilm Hms proteins
    Stanislav Forman
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0084, USA
    Microbiology 152:3399-410. 2006
    ..Substitutions within the glycosyltransferase domain of HmsR and the deacetylase domain of HmsF abolished biofilm formation in Y. pestis. Surprisingly, substitution of highly conserved residues within COG1649 did not affect HmsF function...
  27. pmc Phenotypic convergence mediated by GGDEF-domain-containing proteins
    Roger Simm
    Department of Microbiology, Immunology, and Molecular Genetics, MS415 Medical Center, University of Kentucky, Lexington, KY 40536 0298, USA
    J Bacteriol 187:6816-23. 2005
    ..pestis cells carrying adrA under the control of an arabinose-inducible promoter produced substantial biofilms in the presence of arabinose. Finally, we demonstrate that HmsT is involved in the synthesis of cyclic di-GMP...
  28. pmc Yersiniabactin production requires the thioesterase domain of HMWP2 and YbtD, a putative phosphopantetheinylate transferase
    Alexander G Bobrov
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington 40536 0084, USA
    Infect Immun 70:4204-14. 2002
    ..In contrast, cells containing a single amino acid substitution (S2908A) in the terminal thioesterase domain of HMWP2 failed to exhibit any ybt regulatory defects but did not elaborate extracellular Ybt under iron-deficient conditions...
  29. pmc Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA
    Mol Microbiol 79:533-51. 2011
    ..pestis from the ancestral Yersinia pseudotuberculosis was a significant reduction in the complexity of its c-di-GMP signalling network likely resulting from the different disease cycles of these human pathogens...
  30. doi request reprint Insights into Yersinia pestis biofilm development: topology and co-interaction of Hms inner membrane proteins involved in exopolysaccharide production
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA
    Environ Microbiol 10:1419-32. 2008
    ..Biochemical analyses confirmed some of these protein-protein interactions. Our results indicate that synthesis and regulation of the Y. pestis biofilm EPS occurs in the cytoplasm by a proposed Hms enzymatic complex...
  31. pmc Analysis of HmsH and its role in plague biofilm formation
    Arwa Abu Khweek
    Department of Microbiology, University of Kentucky, 800 Rose St, Lexington, KY, USA
    Microbiology 156:1424-38. 2010
    ..Finally, using a polar hmsH : : mini-kan mutant, we demonstrated that biofilm development is not important for the pathogenesis of bubonic or pneumonic plague in mice...
  32. ncbi request reprint Regulation of biofilm formation in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, USA
    Adv Exp Med Biol 603:201-10. 2007
    ..Finally, protein-protein interactions and the cytoplasmic location of the enzymatic domains of HmsT and HmsP are evaluated...
  33. ncbi request reprint Functional quorum sensing systems affect biofilm formation and protein expression in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, USA
    Adv Exp Med Biol 603:178-91. 2007
    ..Two-dimensional gel electrophoresis revealed altered levels of protein expression in a Y. pestis triple QS mutant at 26 degrees C and 37 degrees C...
  34. ncbi request reprint Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis
    Stanislav Forman
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Microbiology 153:2332-41. 2007
    ..Mutations in the fhu operon, but not in iutA, affected the ability of KIM6 to use ferrichrome. This demonstrates that Y. pestis uses both ferrichrome and aerobactin, but has lost the ability to synthesize aerobactin...
  35. ncbi request reprint Roles of the Yfe and Feo transporters of Yersinia pestis in iron uptake and intracellular growth
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, 800 Rose St, MS415 Med Ctr, Lexington, KY 40536 0298, USA
    Biometals 20:699-703. 2007
    ..1 cells. These results suggest that the Yfe and Feo systems are somewhat redundant ferrous iron transporters capable of iron acquisition during intracellular growth of the plague bacterium...
  36. pmc Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis
    Olga Kirillina
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40656 0298, USA
    Infect Immun 74:6171-8. 2006
    ..pestis and indicate that there is a hierarchy of iron transporters, with Ybt being most effective and Yiu being the least effective of those systems which have been characterized...
  37. ncbi request reprint The phosphodiesterase activity of the HmsP EAL domain is required for negative regulation of biofilm formation in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    FEMS Microbiol Lett 247:123-30. 2005
    ..While the proposed function of EAL-domain proteins is to linearize c-di-GMP, this is a direct demonstration of the required phosphodiesterase activity of a purified EAL-domain protein...
  38. ncbi request reprint Yersinia pestis lacZ expresses a beta-galactosidase with low enzymatic activity
    Alexander G Bobrov
    Department of Microbiology, Immunology, and Molecular Genetics, MS415 Medical Center, University of Kentucky, Lexington, 40536 0298, USA
    FEMS Microbiol Lett 255:43-51. 2006
    ..The Y. pestis lacZ promoter was not regulated by isopropylthiogalactoside or glucose. Finally, uptake of lactose by Y. pestis may be impaired...
  39. pmc yadBC of Yersinia pestis, a new virulence determinant for bubonic plague
    Stanislav Forman
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 76:578-87. 2008
    ..pestis adherence, invasion, and virulence. We found that loss of yadBC caused a modest loss of invasiveness for epithelioid cells and a large decrease in virulence for bubonic plague but not for pneumonic plague in mice...
  40. pmc The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague
    Jacqueline D Fetherston
    Department of Microbiology, Immunology, and Molecular Genetics, MS415 Medical Center, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 78:2045-52. 2010
    ..Finally, a Delta pgm mutant had a greater loss of virulence than the Ybt biosynthetic mutant, indicating that the 102-kb pgm locus encodes a virulence factor, in addition to Ybt, that plays a role in the pathogenesis of pneumonic plague...
  41. pmc Reduced synthesis of the Ybt siderophore or production of aberrant Ybt-like molecules activates transcription of yersiniabactin genes in Yersinia pestis
    M Clarke Miller
    Department of Chemistry, University of Kentucky, Lexington, KY 40506 0055, USA
    Microbiology 156:2226-38. 2010
    ..While these compounds are not biologically relevant to normal Ybt regulation, a comparison of the structures of Ybt and other signalling molecules will help in determining the chemical structures recognized as a Ybt signal...
  42. doi request reprint Isolation and confirmation of Yersinia pestis mutants exempt from select agent regulations
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA
    Curr Protoc Microbiol . 2008
    ..Strains lacking either the chromosomal pgm locus or the Lcr plasmid can be safely studied under BSL-2 conditions and are exempt from Select Agent regulations in the U.S...
  43. pmc Polyamines are essential for the formation of plague biofilm
    Chandra N Patel
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Bacteriol 188:2355-63. 2006
    ..Chemical complementation of the double mutant and recovery of the biofilm defect were only observed with the polyamine putrescine...
  44. ncbi request reprint Crystal structure of ferric-yersiniabactin, a virulence factor of Yersinia pestis
    M Clarke Miller
    Department of Chemistry, University of Kentucky Lexington, Chemistry Physics Building, Room 104, Lexington, Kentucky 40506 0055, USA
    J Inorg Biochem 100:1495-500. 2006
    ..To our knowledge this is the first report of the ferric crystal structure of 5-member heterocycle siderophore...
  45. ncbi request reprint The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase
    Karsten R O Hazlett
    Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030 3710, USA
    J Biol Chem 278:20687-94. 2003
    ..Our data also indicate that Gpm expression and, therefore, glycolysis would not be abrogated when T. pallidum encounters high Zn2+ levels...
  46. pmc Replication of Yersinia pestis in interferon gamma-activated macrophages requires ripA, a gene encoded in the pigmentation locus
    Céline Pujol
    Department of Molecular Genetics and Microbiology and Center for Infectious Diseases, State University of New York, Stony Brook, NY 11794 5222, USA
    Proc Natl Acad Sci U S A 102:12909-14. 2005
    ..These data demonstrate that intracellular Y. pestis can evade killing by macrophages that are exposed to IFN-gamma and identify a potential virulence gene encoded in the pgm locus that is required for this activity...
  47. pmc Genome sequence of Yersinia pestis KIM
    Wen Deng
    Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Bacteriol 184:4601-11. 2002
    ..In KIM-specific islands, new genes encode candidate pathogenicity proteins, including iron transport systems, putative adhesins, toxins, and fimbriae...
  48. doi request reprint Characterizing the dynamic nature of the Yersinia pestis periplasmic proteome in response to nutrient exhaustion and temperature change
    Rembert Pieper
    J Craig Venter Institute, Rockville, MD 20850, USA
    Proteomics 8:1442-58. 2008
    ..pestis life cycle were strongly altered in abundance. This included a putative nitrate/sulfonate/bicarbonate-specific SBP (Y1004), encoded by the virulence-associated plasmid pMT1 and increased in abundance at 37 degrees C...
  49. ncbi request reprint Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague
    Christine G Branger
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, USA
    Adv Exp Med Biol 603:387-99. 2007
    ..This finding should facilitate the design and development of a new generation of vaccines against Y. pestis...