NORA IRMA PERRONE BIZZOZERO

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. pmc KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons
    Clark W Bird
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United Sates of America
    PLoS ONE 8:e79255. 2013
  2. pmc HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA
    Megan Allen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 8:e55718. 2013
  3. pmc Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets
    Federico Bolognani
    Cell Biology and Physiology, University of New Mexico HSC, Albuquerque, NM 87131, USA
    Nucleic Acids Res 38:117-30. 2010
  4. ncbi Role of HuD in nervous system function and pathology
    Nora Perrone-Bizzozero
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Front Biosci (Schol Ed) 5:554-63. 2013
  5. pmc Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice
    Nora I Perrone-Bizzozero
    Departmemt of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    ASN Neuro 3:259-70. 2011
  6. ncbi Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels
    Juan Bustillo
    Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Neuropsychopharmacology 31:751-6. 2006
  7. ncbi Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD
    Federico Bolognani
    Department of Cell Biology and Physiology, University of New Mexico HSC, Albuquerque, NM 87131, USA
    Neurobiol Learn Mem 87:635-43. 2007
  8. ncbi Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity
    Federico Bolognani
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Neurochem Res 32:2142-51. 2007
  9. pmc Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD
    Daniel C Tanner
    Department of Neurosciences, University of New Mexico HSC, Albuquerque, New Mexico 87106, USA
    Hippocampus 18:814-23. 2008
  10. ncbi Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD
    Andrea C Beckel-Mitchener
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 5223, USA
    J Biol Chem 277:27996-8002. 2002

Research Grants

  1. Mechanisms of Post-Transcriptional Control of Neuronal mRNAs
    Nora Perrone Bizzozero; Fiscal Year: 2009
  2. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2004
  3. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2004
  4. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2003
  5. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 2002
  6. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2001
  7. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 2001
  8. Mechanisms of Post-Transcriptional Control of Neuronal mRNAs
    NORA IRMA PERRONE BIZZOZERO; Fiscal Year: 2010
  9. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 1999
  10. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 1999

Collaborators

  • John Lauriello
  • J Bustillo
  • Gregory J Moore
  • ELIZABETH ANN YOUNG
  • DANIEL SAVAGE
  • Shenfeng Qiu
  • Federico Bolognani
  • Nora I Perrone-Bizzozero
  • Daniel C Tanner
  • Nora Perrone-Bizzozero
  • Clark W Bird
  • Jessie S Chambers
  • Megan Allen
  • Julie Deschenes-Furry
  • Rodrigo D Paz
  • Rachael L Neve
  • Rafael Galindo
  • Catherine L Smith
  • Andrea C Beckel-Mitchener
  • AMY S GARDINER
  • Guanglu Liu
  • Wei Feng
  • Jeffery L Twiss
  • Soonmoon Yoo
  • Ching Yi Chen
  • Wenqi Li
  • Clark Bird
  • Wei Jye Lin
  • Yue Feng
  • Joanna Mounce
  • Edwin J Weeber
  • L Donald Partridge
  • Robin J Parks
  • Kambiz Mousavi
  • Bernard J Jasmin
  • Sami Z Daoud
  • Robert Conley
  • Rosalinda Roberts
  • Nancy C Andreasen
  • Deirdre Thomas
  • Linda Saland
  • Rownak Afroz
  • Shanti Frausto
  • Christina Wolff
  • Henry M Furneaux
  • Ann W Githinji
  • Karina Meiri
  • Richard W Burry
  • Gary J Bassell
  • Kevin K Caldwell
  • Rebecca Keller
  • Angel Miera

Detail Information

Publications21

  1. pmc KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons
    Clark W Bird
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United Sates of America
    PLoS ONE 8:e79255. 2013
    ..Together, our results suggest that KSRP is an important regulator of mRNA stability and axonal length that works in direct opposition to HuD to regulate the levels of GAP-43 and other ARE-containing neuronal mRNAs...
  2. pmc HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA
    Megan Allen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 8:e55718. 2013
    ..Our results identify HuD as the first trans-acting factor that enhances BDNF expression specifically through the long 3'UTR and a novel mechanism that regulates BDNF protein production in selected neuronal populations by HuD abundance...
  3. pmc Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets
    Federico Bolognani
    Cell Biology and Physiology, University of New Mexico HSC, Albuquerque, NM 87131, USA
    Nucleic Acids Res 38:117-30. 2010
    ..These findings provide further insights into the post-transcriptional mechanisms by which HuD promotes neural development and synaptic plasticity...
  4. ncbi Role of HuD in nervous system function and pathology
    Nora Perrone-Bizzozero
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Front Biosci (Schol Ed) 5:554-63. 2013
    ..This review will focus on the involvement of HuD in nervous system function and pathology...
  5. pmc Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice
    Nora I Perrone-Bizzozero
    Departmemt of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    ASN Neuro 3:259-70. 2011
    ..These results support the notion that HuD stabilizes a number of developmentally regulated mRNAs in DGCs, resulting in increased axonal elongation...
  6. ncbi Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels
    Juan Bustillo
    Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Neuropsychopharmacology 31:751-6. 2006
    ..The documented lower NAA in chronically treated schizophrenia patients is most likely not a simple effect of antipsychotic medications...
  7. ncbi Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD
    Federico Bolognani
    Department of Cell Biology and Physiology, University of New Mexico HSC, Albuquerque, NM 87131, USA
    Neurobiol Learn Mem 87:635-43. 2007
    ..We conclude that posttranscriptional regulation of gene expression by stabilization of specific mRNAs may have to be restricted temporally and spatially for proper acquisition and storage of memories...
  8. ncbi Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity
    Federico Bolognani
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Neurochem Res 32:2142-51. 2007
    ..Altogether, these results demonstrate that HuD plays a role in the post-transcriptional control of GAP-43 mRNA in dentate granule cells during developmental and adult plasticity...
  9. pmc Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD
    Daniel C Tanner
    Department of Neurosciences, University of New Mexico HSC, Albuquerque, New Mexico 87106, USA
    Hippocampus 18:814-23. 2008
    ....
  10. ncbi Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD
    Andrea C Beckel-Mitchener
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 5223, USA
    J Biol Chem 277:27996-8002. 2002
    ..We conclude that HuD stabilizes the GAP-43 mRNA through a mechanism that is dependent on the length of the poly(A) tail and involves changes in its affinity for the mRNA...
  11. ncbi In vivo post-transcriptional regulation of GAP-43 mRNA by overexpression of the RNA-binding protein HuD
    Federico Bolognani
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Neurochem 96:790-801. 2006
    ..In conclusion, our results demonstrate that HuD overexpression is sufficient to increase GAP-43 mRNA stability in vivo...
  12. ncbi Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia
    Jessie S Chambers
    Department of Neurosciences, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:283-90. 2005
    ....
  13. ncbi Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm
    Elizabeth Young
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque 87131 5223, USA
    Hippocampus 12:457-64. 2002
    ....
  14. ncbi Fetal alcohol exposure alters GAP-43 phosphorylation and protein kinase C responses to contextual fear conditioning in the hippocampus of adult rat offspring
    Daniel C Tanner
    Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA
    Alcohol Clin Exp Res 28:113-22. 2004
    ..Drawing on these observations, we hypothesized that FAE manifests its cognitive impairment by disrupting PKC activation and membrane translocation, thereby decreasing GAP-43 phosphorylation and function...
  15. ncbi GAP-43 mRNA in growth cones is associated with HuD and ribosomes
    Catherine L Smith
    Department of Neuroscience, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210 1239, USA
    J Neurobiol 61:222-35. 2004
    ..Together, these results demonstrate that many of the components necessary for GAP-43 mRNA translation/stabilization are present within growth cones...
  16. ncbi Dendritic localization of the RNA-binding protein HuD in hippocampal neurons: association with polysomes and upregulation during contextual learning
    Federico Bolognani
    Department of Neurosciences, School of Medicine, University of New Mexico, Albuquerque, NM 87131 5223, USA
    Neurosci Lett 371:152-7. 2004
    ..Our findings suggest that HuD plays a role in synaptic plasticity mechanisms stabilizing mRNAs associated with ribosomes both in the soma and dendrites of hippocampal neurons...
  17. ncbi Prenatal ethanol exposure reduces mGluR5 receptor number and function in the dentate gyrus of adult offspring
    Rafael Galindo
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    Alcohol Clin Exp Res 28:1587-97. 2004
    ....
  18. ncbi RNA-protein interactions and control of mRNA stability in neurons
    Federico Bolognani
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    J Neurosci Res 86:481-9. 2008
    ..In this Mini-Review, we briefly discuss the general mechanisms of control of mRNA turnover and present evidence supporting the importance of these mechanisms in the expression of an increasing number of neuronal genes...
  19. ncbi Altered myelination of the hippocampal formation in subjects with schizophrenia and bipolar disorder
    Jessie S Chambers
    915 Camino de Salud NE, Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Neurochem Res 29:2293-302. 2004
    ..Our results demonstrate an interaction between gender, mental illness, and myelination, and may be related to cognitive deficits seen in schizophrenia and bipolar disorder...
  20. ncbi The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy
    Julie Deschenes-Furry
    Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 27:665-75. 2007
    ..Together, the results of this study demonstrate that AChE expression in neurons of the rat SCG is regulated via post-transcriptional mechanisms that involve the AU-rich element and HuD...
  21. ncbi Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia
    Rodrigo D Paz
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, 87131, USA
    Am J Psychiatry 163:1829-31. 2006
    ..The purpose of this study was to evaluate the functional state of glutamatergic neurons in the cerebellar cortex of patients with schizophrenia...

Research Grants21

  1. Mechanisms of Post-Transcriptional Control of Neuronal mRNAs
    Nora Perrone Bizzozero; Fiscal Year: 2009
    ..abstract_text> ..
  2. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2004
    ..abstract_text> ..
  3. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2004
    ..abstract_text> ..
  4. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2003
    ..abstract_text> ..
  5. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 2002
    ..Ultimately, this information will help design better therapeutic strategies to overcome behavioral and cognitive deficits in children affected with Alcohol Related Neurodevelopmental Disorders (ARND). ..
  6. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2001
    ..abstract_text> ..
  7. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 2001
    ..Ultimately, this information will help design better therapeutic strategies to overcome behavioral and cognitive deficits in children affected with Alcohol Related Neurodevelopmental Disorders (ARND). ..
  8. Mechanisms of Post-Transcriptional Control of Neuronal mRNAs
    NORA IRMA PERRONE BIZZOZERO; Fiscal Year: 2010
    ..abstract_text> ..
  9. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 1999
    ..Ultimately, this information will help design better therapeutic strategies to overcome behavioral and cognitive deficits in children affected with Alcohol Related Neurodevelopmental Disorders (ARND). ..
  10. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 1999
    ....
  11. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 1999
    ....
  12. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 2000
    ..Ultimately, this information will help design better therapeutic strategies to overcome behavioral and cognitive deficits in children affected with Alcohol Related Neurodevelopmental Disorders (ARND). ..
  13. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2002
    ..abstract_text> ..
  14. Mechanisms of Post-Transcriptional Control of Neuronal mRNAs
    Nora Perrone Bizzozero; Fiscal Year: 2007
    ....
  15. ARND--IMPACT ON SYNAPTIC PLASTICITY MECHANISMS
    Nora Perrone Bizzozero; Fiscal Year: 2000
    ..Ultimately, this information will help design better therapeutic strategies to overcome behavioral and cognitive deficits in children affected with Alcohol Related Neurodevelopmental Disorders (ARND). ..
  16. MECHANISMS OF CONTROL OF THE GAP-43 GENE
    Nora Perrone Bizzozero; Fiscal Year: 2000
    ..abstract_text> ..