Research Topics
| Leigh PerreaultSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetesLeigh Perreault
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Obesity (Silver Spring) 18:2093-100. 2010..4 µg/mg dry weight, P = 0.03) and FSR being lower (0.23 ± 0.04 vs. 0.42 ± 0.06 %/h, P = 0.02) in women. Alterations in IMTG metabolism relate to diminished insulin action in men, but not women, in the progression toward diabetes...- Fenofibrate administration does not affect muscle triglyceride concentration or insulin sensitivity in humansLeigh Perreault
Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Metabolism 60:1107-14. 2011..Intramuscular triglyceride saturation, rather than IMTG concentration or FSR, most closely (but not significantly) related to Si and was unchanged by fenofibrate administration... 
Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucoseLeigh Perreault
University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
Diabetes Res Clin Pract 90:87-94. 2010..To determine whether altered GLP-1 activity contributes to the abnormal endogenous glucose production (EGP) and insulin secretion characteristic of people with impaired fasting glucose (IFG)...- Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humansLeigh Perreault
Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Obesity (Silver Spring) 18:1524-31. 2010..Altogether, higher basal IMTG concentration that is metabolically inflexible distinguishes obese people with PD from those with NGT... - Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletesBryan C Bergman
Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, PO Box 6511, MS 8106, Aurora, CO 80045, USA
J Appl Physiol 108:1134-41. 2010..Increased synthesis rates are not due to recovery from exercise and are likely adaptations to chronic endurance exercise training... - Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes?Leigh Perreault
Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 295:E428-35. 2008..Together, these data indicate that IFG/IGT may be a distinct prediabetic syndrome rather than progression from IFG... - Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetesBryan C Bergman
Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045, USA
J Clin Endocrinol Metab 97:1663-72. 2012..It is unclear whether insulin resistance is due to glucose toxicity in the post-Diabetes Control and Complications Trial era of tighter glucose control... - Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes StudyLeigh Perreault
University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Lancet 379:2243-51. 2012.... - Regression from pre-diabetes to normal glucose regulation in the diabetes prevention programLeigh Perreault
Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver School of Medicine, Aurora, Colorado, USA
Diabetes Care 32:1583-8. 2009..We explored the effect of baseline characteristics, weight change, ILS, and metformin on regression from pre-diabetes to the lowest-risk state of normal glucose regulation (NGR) defined by American Diabetes Association criteria... - Intramuscular lipid metabolism in the insulin resistance of smokingBryan C Bergman
Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Diabetes 58:2220-7. 2009..We hypothesized smokers would have increased intramuscular triglyceride (IMTG) and diacylglycerol (DAG) concentration and decreased fractional synthesis rate (FSR) compared with nonsmokers... 
Gender differences in insulin action after a single bout of exerciseLeigh Perreault
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Appl Physiol 97:1013-21. 2004..Together, these data imply gender differences in insulin action postexercise exist in peripheral tissues and not in liver...- Menopause and risk of diabetes in the Diabetes Prevention ProgramCatherine Kim
Department of Medicine, University of Michigan, Ann Arbor, MI, USA
Menopause 18:857-68. 2011..The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions... - Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention programMarie France Hivert
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Diabetes 60:1340-8. 2011..We tested if a GRS based on an updated list of 34 type 2 diabetes-associated loci predicted progression to diabetes or regression toward normal glucose regulation (NGR) in the Diabetes Prevention Program (DPP)... - Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention ProgramLeigh Perreault
University of Colorado Health Sciences Center, Aurora, Colorado, USA
Diabetes Care 31:1416-21. 2008..Men met significantly more ILS goals than women but had a similar incidence of diabetes. Therefore, we explored sex differences in risk factors for diabetes and the effect of ILS on risk factors... - Novel and reversible mechanisms of smoking-induced insulin resistance in humansBryan C Bergman
Department of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
Diabetes 61:3156-66. 2012..Therapeutic agents designed to oppose skeletal muscle mTOR activation may prevent insulin resistance in humans who are unable to stop smoking or are chronically exposed to secondhand smoke... - Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes studyRichard R Rubin
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Diabetes Care 33:2549-51. 2010..To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS)... - Gender differences in lipoprotein lipase activity after acute exerciseLeigh Perreault
Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Obes Res 12:241-9. 2004..Exercise and insulin are known modulators of LPL activity in men, but this is less clear in women. LPL activity may predict propensity for obesity; therefore, understanding its modulators is of considerable importance...