Leigh Perreault

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucose
    Leigh Perreault
    University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
    Diabetes Res Clin Pract 90:87-94. 2010
  2. doi request reprint Approaching pre-diabetes
    Leigh Perreault
    University of Colorado Anschutz Medical Center, Aurora, CO, USA Electronic address
    J Diabetes Complications 28:226-33. 2014
  3. pmc Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 8:e69991. 2013
  4. pmc Fenofibrate administration does not affect muscle triglyceride concentration or insulin sensitivity in humans
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Metabolism 60:1107-14. 2011
  5. pmc Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:2093-100. 2010
  6. pmc Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans
    Leigh Perreault
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:1524-31. 2010
  7. pmc Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    J Appl Physiol (1985) 108:1134-41. 2010
  8. pmc The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045
    J Clin Endocrinol Metab 98:E40-50. 2013
  9. pmc Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes?
    Leigh Perreault
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 295:E428-35. 2008
  10. pmc Depression as a predictor of weight regain among successful weight losers in the diabetes prevention program
    David W Price
    Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA
    Diabetes Care 36:216-21. 2013

Detail Information

Publications21

  1. doi request reprint Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucose
    Leigh Perreault
    University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
    Diabetes Res Clin Pract 90:87-94. 2010
    ..To determine whether altered GLP-1 activity contributes to the abnormal endogenous glucose production (EGP) and insulin secretion characteristic of people with impaired fasting glucose (IFG)...
  2. doi request reprint Approaching pre-diabetes
    Leigh Perreault
    University of Colorado Anschutz Medical Center, Aurora, CO, USA Electronic address
    J Diabetes Complications 28:226-33. 2014
    ..Herein, we provide an update on the global burden of pre-diabetes, its underlying pathophysiology and discuss clinical considerations in these individuals at high risk of developing diabetes. ..
  3. pmc Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 8:e69991. 2013
    ..Estrogen can stimulate glucokinase activity, whereas the pervasive environmental pollutant bisphenol A (BPA) can inhibit estrogen action, hence we aimed to determine the effect of BPA on glucokinase activity directly...
  4. pmc Fenofibrate administration does not affect muscle triglyceride concentration or insulin sensitivity in humans
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Metabolism 60:1107-14. 2011
    ..Intramuscular triglyceride saturation, rather than IMTG concentration or FSR, most closely (but not significantly) related to Si and was unchanged by fenofibrate administration...
  5. pmc Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:2093-100. 2010
    ..4 µg/mg dry weight, P = 0.03) and FSR being lower (0.23 ± 0.04 vs. 0.42 ± 0.06 %/h, P = 0.02) in women. Alterations in IMTG metabolism relate to diminished insulin action in men, but not women, in the progression toward diabetes...
  6. pmc Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans
    Leigh Perreault
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:1524-31. 2010
    ..Altogether, higher basal IMTG concentration that is metabolically inflexible distinguishes obese people with PD from those with NGT...
  7. pmc Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    J Appl Physiol (1985) 108:1134-41. 2010
    ..Increased synthesis rates are not due to recovery from exercise and are likely adaptations to chronic endurance exercise training...
  8. pmc The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045
    J Clin Endocrinol Metab 98:E40-50. 2013
    ..Our previous report implicated skeletal muscle and liver insulin resistance in people with type 1 diabetes, but this occurred independently of generalized, visceral, or ectopic fat...
  9. pmc Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes?
    Leigh Perreault
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 295:E428-35. 2008
    ..Together, these data indicate that IFG/IGT may be a distinct prediabetic syndrome rather than progression from IFG...
  10. pmc Depression as a predictor of weight regain among successful weight losers in the diabetes prevention program
    David W Price
    Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA
    Diabetes Care 36:216-21. 2013
    ..To determine whether depression symptoms or antidepressant medication use predicts weight regain in overweight individuals with impaired glucose tolerance (IGT) who are successful with initial weight loss...
  11. pmc Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:1663-72. 2012
    ..It is unclear whether insulin resistance is due to glucose toxicity in the post-Diabetes Control and Complications Trial era of tighter glucose control...
  12. pmc Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study
    Leigh Perreault
    University of Colorado Anschutz Medical Campus, Aurora, CO, USA
    Lancet 379:2243-51. 2012
    ....
  13. pmc Menopause and risk of diabetes in the Diabetes Prevention Program
    Catherine Kim
    Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Menopause 18:857-68. 2011
    ..The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions...
  14. pmc Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program
    Leigh Perreault
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver School of Medicine, Aurora, Colorado, USA
    Diabetes Care 32:1583-8. 2009
    ..We explored the effect of baseline characteristics, weight change, ILS, and metformin on regression from pre-diabetes to the lowest-risk state of normal glucose regulation (NGR) defined by American Diabetes Association criteria...
  15. ncbi request reprint Gender differences in insulin action after a single bout of exercise
    Leigh Perreault
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Appl Physiol (1985) 97:1013-21. 2004
    ..Together, these data imply gender differences in insulin action postexercise exist in peripheral tissues and not in liver...
  16. pmc Intramuscular lipid metabolism in the insulin resistance of smoking
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Diabetes 58:2220-7. 2009
    ..We hypothesized smokers would have increased intramuscular triglyceride (IMTG) and diacylglycerol (DAG) concentration and decreased fractional synthesis rate (FSR) compared with nonsmokers...
  17. pmc Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program
    Marie France Hivert
    Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 60:1340-8. 2011
    ..We tested if a GRS based on an updated list of 34 type 2 diabetes-associated loci predicted progression to diabetes or regression toward normal glucose regulation (NGR) in the Diabetes Prevention Program (DPP)...
  18. pmc Novel and reversible mechanisms of smoking-induced insulin resistance in humans
    Bryan C Bergman
    Department of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
    Diabetes 61:3156-66. 2012
    ..Therapeutic agents designed to oppose skeletal muscle mTOR activation may prevent insulin resistance in humans who are unable to stop smoking or are chronically exposed to secondhand smoke...
  19. pmc Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention Program
    Leigh Perreault
    University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Diabetes Care 31:1416-21. 2008
    ..Men met significantly more ILS goals than women but had a similar incidence of diabetes. Therefore, we explored sex differences in risk factors for diabetes and the effect of ILS on risk factors...
  20. pmc Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study
    Richard R Rubin
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:2549-51. 2010
    ..To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS)...
  21. ncbi request reprint Gender differences in lipoprotein lipase activity after acute exercise
    Leigh Perreault
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obes Res 12:241-9. 2004
    ..Exercise and insulin are known modulators of LPL activity in men, but this is less clear in women. LPL activity may predict propensity for obesity; therefore, understanding its modulators is of considerable importance...