PHILIP PERLMAN

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Molecular biology. Ring around the retroelement
    Philip S Perlman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 303:182-4. 2004
  2. ncbi request reprint Reverse transcriptase and reverse splicing activities encoded by the mobile group II intron cobI1 of fission yeast mitochondrial DNA
    Bernd Schafer
    Department of Biology IV Microbiology, Aachen Technical University, Germany
    J Mol Biol 329:191-206. 2003
  3. pmc A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae
    Brett A Kaufman
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    J Cell Biol 163:457-61. 2003
  4. pmc The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing
    Hon Ren Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Mol Cell Biol 23:8809-19. 2003
  5. pmc A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone
    Sabine Mohr
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:3569-74. 2006
  6. ncbi request reprint Mitochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease
    Joseph M Bateman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 277:47946-53. 2002
  7. pmc Bacterial group II introns in a deep-sea hydrothermal vent environment
    Mircea Podar
    Biology Department, Woods Hole Oceanographic Institution, Massachusetts 02543, USA
    Appl Environ Microbiol 68:6392-8. 2002
  8. pmc Abortive transposition by a group II intron in yeast mitochondria
    Lorna Dickson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390 9148, USA
    Genetics 168:77-87. 2004
  9. pmc The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function
    Hon Ren Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 102:163-8. 2005

Research Grants

  1. GENETIC AND MOLECULAR STUDIES OF RNA SPLICING
    PHILIP PERLMAN; Fiscal Year: 1993
  2. GENETIC AND MOLECULAR STUDIES OF RNA SPLICING
    PHILIP PERLMAN; Fiscal Year: 1991
  3. GENETIC AND MOLECULAR STUDIES OF GROUP II INTRONS
    PHILIP PERLMAN; Fiscal Year: 1999
  4. GENETIC AND MOLECULAR STUDIES OF GROUP II INTRONS
    PHILIP PERLMAN; Fiscal Year: 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Molecular biology. Ring around the retroelement
    Philip S Perlman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 303:182-4. 2004
  2. ncbi request reprint Reverse transcriptase and reverse splicing activities encoded by the mobile group II intron cobI1 of fission yeast mitochondrial DNA
    Bernd Schafer
    Department of Biology IV Microbiology, Aachen Technical University, Germany
    J Mol Biol 329:191-206. 2003
    ..Interestingly, it appears to lack an endonuclease activity, suggesting that the active homing exhibited by this intron in crosses may differ somewhat from that of the better-characterized introns...
  3. pmc A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae
    Brett A Kaufman
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    J Cell Biol 163:457-61. 2003
    ..Our data suggest that the nucleoid dynamics underlying mtDNA transmission are regulated by the interaction between Hsp60 and mtDNA ori sequences...
  4. pmc The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing
    Hon Ren Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Mol Cell Biol 23:8809-19. 2003
    ..Replacing the DIVa of aI2 with that of the closely related intron aI1 improves in vivo splicing but not homing, indicating that DIVa contributes to the specificity of the maturase-RNA interaction needed for homing...
  5. pmc A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone
    Sabine Mohr
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:3569-74. 2006
    ..More generally, our results provide additional evidence for the widespread role of RNA chaperones in folding cellular RNAs...
  6. ncbi request reprint Mitochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease
    Joseph M Bateman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 277:47946-53. 2002
    ....
  7. pmc Bacterial group II introns in a deep-sea hydrothermal vent environment
    Mircea Podar
    Biology Department, Woods Hole Oceanographic Institution, Massachusetts 02543, USA
    Appl Environ Microbiol 68:6392-8. 2002
    ..These types of mobile genetic elements may prove useful in improving our understanding of bacterial genome evolution and may serve as valuable markers in comparative studies of bacterial communities...
  8. pmc Abortive transposition by a group II intron in yeast mitochondria
    Lorna Dickson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390 9148, USA
    Genetics 168:77-87. 2004
    ..We also infer that some intermediates abort by ejecting the intron RNA from the DNA target by forward splicing. These experiments provide new insights to group II intron transposition and homing mechanisms in yeast mitochondria...
  9. pmc The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function
    Hon Ren Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 102:163-8. 2005
    ..Our results suggest that both group I and II introns are prone to kinetic traps in RNA folding in vivo and that the splicing of both types of introns may require DEAD-box proteins that function as RNA chaperones...

Research Grants13

  1. GENETIC AND MOLECULAR STUDIES OF RNA SPLICING
    PHILIP PERLMAN; Fiscal Year: 1993
    ....
  2. GENETIC AND MOLECULAR STUDIES OF RNA SPLICING
    PHILIP PERLMAN; Fiscal Year: 1991
    ..Extracts from both mitochondrial and nuclear mutants will be used to identify specific proteins involved in splicing...
  3. GENETIC AND MOLECULAR STUDIES OF GROUP II INTRONS
    PHILIP PERLMAN; Fiscal Year: 1999
    ..Finally, the applicant will investigate unusual mobility events which may involve an RT-independent pathway and a reverse-splicing-dependent pathway. ..
  4. GENETIC AND MOLECULAR STUDIES OF GROUP II INTRONS
    PHILIP PERLMAN; Fiscal Year: 2002
    ..Finally, the RNA binding and splicing functions of the naturase domain of the intron-encoded protein will be studied. ..