M L Perlis

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Meteorologic factors and subjective sleep continuity: a preliminary evaluation
    Juhi Pandey
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester, 300 Crittenden Blvd, Rochester, NY 14642, USA
    Int J Biometeorol 49:152-5. 2005
  2. ncbi request reprint Major Depressive Disorder (MDD) is associated with a primary defect within the serotonergic system
    Michael Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester, NY 14642, USA
    Sleep Med Rev 6:353-7; discussion 359. 2002
  3. ncbi request reprint On the comparability of pharmacotherapy and behavior therapy for chronic insomnia. Commentary and implications
    Michael L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
    J Psychosom Res 54:51-9. 2003
  4. ncbi request reprint Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia
    Michael L Perlis
    Sleep and Neurophysiology Laboratory, Department of Psychiatry, University of Rochester, and the University of Rochester Medical Center, Neurosciences Program, Rochester, NY 14642, USA
    J Clin Psychiatry 65:1128-37. 2004
  5. ncbi request reprint Placebo effects in primary insomnia
    Michael L Perlis
    Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester, 300 Crittenden Blvd Rochester, NY 14642, USA
    Sleep Med Rev 9:381-9. 2005
  6. ncbi request reprint The mesograde amnesia of sleep may be attenuated in subjects with primary insomnia
    M L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
    Physiol Behav 74:71-6. 2001
  7. ncbi request reprint Behavioral treatment of insomnia: treatment outcome and the relevance of medical and psychiatric morbidity
    M L Perlis
    Sleep Disorders Center, Behavioral Sleep Medicine Clinic, Rochester, New York, USA
    J Behav Med 24:281-96. 2001
  8. ncbi request reprint Beta/Gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls
    M L Perlis
    Department of Psychiatry, University of Rochester, NY 14642, USA
    Sleep 24:110-7. 2001
  9. ncbi request reprint Insomnia as a risk factor for onset of depression in the elderly
    Michael L Perlis
    Department of Psychiatry and UR Neurosciences Program, University of Rochester, NY 14642, USA
    Behav Sleep Med 4:104-13. 2006
  10. ncbi request reprint The effects of modafinil and cognitive behavior therapy on sleep continuity in patients with primary insomnia
    Michael L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, NY, USA
    Sleep 27:715-25. 2004

Detail Information

Publications34

  1. ncbi request reprint Meteorologic factors and subjective sleep continuity: a preliminary evaluation
    Juhi Pandey
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester, 300 Crittenden Blvd, Rochester, NY 14642, USA
    Int J Biometeorol 49:152-5. 2005
    ..Interestingly, ambient light and lunar phase were not found to be strongly associated sleep diary measures...
  2. ncbi request reprint Major Depressive Disorder (MDD) is associated with a primary defect within the serotonergic system
    Michael Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester, NY 14642, USA
    Sleep Med Rev 6:353-7; discussion 359. 2002
  3. ncbi request reprint On the comparability of pharmacotherapy and behavior therapy for chronic insomnia. Commentary and implications
    Michael L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
    J Psychosom Res 54:51-9. 2003
    ....
  4. ncbi request reprint Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia
    Michael L Perlis
    Sleep and Neurophysiology Laboratory, Department of Psychiatry, University of Rochester, and the University of Rochester Medical Center, Neurosciences Program, Rochester, NY 14642, USA
    J Clin Psychiatry 65:1128-37. 2004
    ..The present study was designed to further evaluate this issue within a large scale, double-blind, placebo-controlled, long-term trial...
  5. ncbi request reprint Placebo effects in primary insomnia
    Michael L Perlis
    Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester, 300 Crittenden Blvd Rochester, NY 14642, USA
    Sleep Med Rev 9:381-9. 2005
    ..An appreciation of the latter phenomenon may provide increased power to detect therapeutic outcomes and may be used to potentiate clinical gains...
  6. ncbi request reprint The mesograde amnesia of sleep may be attenuated in subjects with primary insomnia
    M L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
    Physiol Behav 74:71-6. 2001
    ..This finding suggests that the natural mesograde amnesia of sleep may be attenuated in subjects with insomnia...
  7. ncbi request reprint Behavioral treatment of insomnia: treatment outcome and the relevance of medical and psychiatric morbidity
    M L Perlis
    Sleep Disorders Center, Behavioral Sleep Medicine Clinic, Rochester, New York, USA
    J Behav Med 24:281-96. 2001
    ..These findings are not significantly different from those reported in literature for both CBT and pharmacotherapy interventions. Medical and psychiatric comorbidity did not influence treatment outcome...
  8. ncbi request reprint Beta/Gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls
    M L Perlis
    Department of Psychiatry, University of Rochester, NY 14642, USA
    Sleep 24:110-7. 2001
    ....
  9. ncbi request reprint Insomnia as a risk factor for onset of depression in the elderly
    Michael L Perlis
    Department of Psychiatry and UR Neurosciences Program, University of Rochester, NY 14642, USA
    Behav Sleep Med 4:104-13. 2006
    ..These data suggest that elderly participants with persistent insomnia are at greater risk for the development of new onset depression...
  10. ncbi request reprint The effects of modafinil and cognitive behavior therapy on sleep continuity in patients with primary insomnia
    Michael L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, NY, USA
    Sleep 27:715-25. 2004
    ....
  11. ncbi request reprint Psychophysiological insomnia: the behavioural model and a neurocognitive perspective
    M L Perlis
    Department of Psychiatry, University of Rochester, NY 14642, USA
    J Sleep Res 6:179-88. 1997
    ....
  12. ncbi request reprint Temporal and stagewise distribution of high frequency EEG activity in patients with primary and secondary insomnia and in good sleeper controls
    M L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Centre, Rochester, NY 14642, USA
    J Sleep Res 10:93-104. 2001
    ..Our data are consistent with the perspective that HFA is related to CNS arousal to the extent that Beta/Gamma activity occurs maximally during shallow stages of sleep and maximally in subjects with PI...
  13. ncbi request reprint Presleep cognitions in patients with insomnia secondary to chronic pain
    M T Smith
    Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, New York 14642, USA
    J Behav Med 24:93-114. 2001
    ..These results are consistent with cognitive-behavioral models of primary insomnia and suggest the content of presleep cognitive arousal may contribute to sleep disturbance secondary to pain...
  14. ncbi request reprint Alpha sleep and information processing, perception of sleep, pain, and arousability in fibromyalgia
    M L Perlis
    Department of Psychiatry, University of Rochester, NY, USA
    Int J Neurosci 89:265-80. 1997
    ..Alpha sleep appears to be, electrophysiologically, a shallow form of sleep. Our results suggest that it is perceived as such phenomenologically and that it is also associated with increased arousability...
  15. ncbi request reprint EEG sleep in African-American patients with major depression: a historical case control study
    D E Giles
    Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
    Depress Anxiety 8:58-64. 1998
    ..The pathological implications of these differences remained to be explored in careful prospective studies of African-American depressed patients and in well-characterized, racially matched normal control comparisons...
  16. doi request reprint The hypocretin neurotransmission system in myotonic dystrophy type 1
    E Ciafaloni
    University of Rochester, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, NY 14642, USA
    Neurology 70:226-30. 2008
    ..Some patients with DM1 show sleep-onset REM, similar to that observed in narcolepsy. Narcolepsy is characterized by impaired hypocretin (Hcrt) neurotransmission...
  17. ncbi request reprint Cancer-related fatigue and sleep disorders
    Joseph A Roscoe
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, James P Wilmot Cancer Center, Rochester, NY 14642, USA
    Oncologist 12:35-42. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  18. pmc A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer
    Oxana Gronskaya Palesh
    University of Rochester, Rochester, NY 14642, United States
    Biol Psychol 75:37-44. 2007
    ..The present study examined depression, pain, life stress, and participation in group therapy in relation to sleep disturbances in a sample of women with metastatic breast cancer...
  19. pmc Is insomnia a perpetuating factor for late-life depression in the IMPACT cohort?
    Wilfred R Pigeon
    Department of Psychiatry, University of Rochester Medical Center, Rochester NY, USA
    Sleep 31:481-8. 2008
    ..The present longitudinal study examines the relationship of insomnia to the continuation of depression in the context of an intervention study in elderly subjects...
  20. ncbi request reprint Sleep homeostasis in primary insomnia
    Wilfred R Pigeon
    Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
    Sleep Med Rev 10:247-54. 2006
    ..In addition, we provide a discussion regarding how hyperarousal and circadian factors may interact with altered sleep homeostasis, and suggestions for further inquiry...
  21. pmc The effect of interpersonal psychotherapy for depression on insomnia symptoms in a cohort of women with sexual abuse histories
    Wilfred R Pigeon
    Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642 8409, USA Wilfred
    J Trauma Stress 22:634-8. 2009
    ..Despite improvements in depression, insomnia persists for most women with CSA...
  22. doi request reprint The incidence and temporal patterning of insomnia: a pilot study
    Michael L Perlis
    Behavioral Sleep Medicine Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    J Sleep Res 19:31-5. 2010
    ..These data suggest that insomnia severity may be mediated/moderated by sleep homeostasis and that the homeostat, or input to the homeostat, may be abnormal in patients with PI...
  23. pmc The efficacy of cognitive-behavioral therapy for insomnia in patients with chronic pain
    Carla R Jungquist
    University of Rochester, School of Nursing, NY, USA
    Sleep Med 11:302-9. 2010
    ..To assess the efficacy of cognitive-behavioral therapy for insomnia (CBT-I) in patients with non-malignant chronic pain...
  24. pmc Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study
    Wilfred R Pigeon
    Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Med Food 13:579-83. 2010
    ..These effects, however, were considerably less than those for evidence-based treatments of insomnia: hypnotic agents and cognitive-behavioral therapies for insomnia...
  25. ncbi request reprint Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia
    Michael T Smith
    Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287 7218, USA
    Am J Psychiatry 159:5-11. 2002
    ..The authors conducted a quantitative review of the literature on the outcome of the two treatments to compare the short-term efficacy of pharmacotherapy and behavioral therapy in primary insomnia...
  26. ncbi request reprint The effects of an orally administered cholinergic agonist on REM sleep in major depression
    Michael L Perlis
    Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Biol Psychiatry 51:457-62. 2002
    ..We tested an orally administered cholinergic agonist (donepezil HCL 10 mg [Aricept]) to determine whether this agent also alters REM timing in depressed patients (n = 8) compared with age- and gender-matched control subjects (n = 8)...
  27. ncbi request reprint Functional imaging of the sleeping brain: review of findings and implications for the study of insomnia
    Sean P A Drummond
    Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, San Diego, CA, USA
    Sleep Med Rev 8:227-42. 2004
    ....
  28. ncbi request reprint No association of sleep with total daily physical activity in normal sleepers
    Shawn D Youngstedt
    Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0667, USA
    Physiol Behav 78:395-401. 2003
    ..These results fail to support epidemiologic data on the value of exercise for sleep, but are consistent with experimental evidence showing only modest effects of exercise on sleep...
  29. ncbi request reprint Suicidal ideation in outpatients with chronic musculoskeletal pain: an exploratory study of the role of sleep onset insomnia and pain intensity
    Michael T Smith
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin J Pain 20:111-8. 2004
    ..This exploratory study evaluates the importance of insomnia in discriminating suicidal ideation in chronic pain relative to depression severity and other pain-related factors...
  30. ncbi request reprint Neuroimaging of NREM sleep in primary insomnia: a Tc-99-HMPAO single photon emission computed tomography study
    Michael T Smith
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21287 7218, USA
    Sleep 25:325-35. 2002
    ..The objectives of this study were to: 1) demonstrate the feasibility of combining polysomnography and SPECT neuroimaging to study NREM sleep in primary insomnia and 2) evaluate possible functional CNS abnormalities associated with insomnia...
  31. pmc Chronic insomnia and MRI-measured hippocampal volumes: a pilot study
    Dieter Riemann
    Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstr 5, D 79104 Germany
    Sleep 30:955-8. 2007
    ..Morphometric analysis of magnetic resonance imaging brain scans was used to investigate possible neuroanatomic differences between patients with primary insomnia compared to good sleepers...
  32. ncbi request reprint Who is a candidate for cognitive-behavioral therapy for insomnia?
    Michael T Smith
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Behavioral Medicine Research Laboratory and Clinic, Baltimore, MD 21287 7101, USA
    Health Psychol 25:15-9. 2006
    ..This report briefly summarizes these issues, including a discussion of potential contraindications, and provides a schematic decision-to-treat algorithm...
  33. ncbi request reprint NREM sleep cerebral blood flow before and after behavior therapy for chronic primary insomnia: preliminary single photon emission computed tomography (SPECT) data
    Michael T Smith
    Sleep Med 6:93-4. 2005
  34. ncbi request reprint Do patients with sleep maintenance insomnia have a problem with sleep maintenance?
    Pamela V Thacher
    Department of Psychology, St Lawrence University, Canton, NY 13617, USA
    Behav Sleep Med 4:203-18. 2006
    ..The data from this study represent the first attempt to characterize the stages from which awakenings occur in sleep maintenance insomnia...

Research Grants3

  1. Is Insomnia a Modifiable Risk Factor for MDD?
    Michael Perlis; Fiscal Year: 2006
    ..abstract_text> ..
  2. Information processing at sleep onset and during sleep in patients with insomnia
    Michael Perlis; Fiscal Year: 2007
    ..This may allow for not only the development of better treatments but also for a better understanding of and "how and why" insomnia confers risk for other illnesses. ..