Research Topics
| M L PerlisSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Meteorologic factors and subjective sleep continuity: a preliminary evaluationJuhi Pandey
Sleep Research Laboratory, Department of Psychiatry, University of Rochester, 300 Crittenden Blvd, Rochester, NY 14642, USA
Int J Biometeorol 49:152-5. 2005..Interestingly, ambient light and lunar phase were not found to be strongly associated sleep diary measures...- Major Depressive Disorder (MDD) is associated with a primary defect within the serotonergic systemMichael Perlis
Sleep Research Laboratory, Department of Psychiatry, University of Rochester, NY 14642, USA
Sleep Med Rev 6:353-7; discussion 359. 2002 - On the comparability of pharmacotherapy and behavior therapy for chronic insomnia. Commentary and implicationsMichael L Perlis
Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
J Psychosom Res 54:51-9. 2003.... - Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomniaMichael L Perlis
Sleep and Neurophysiology Laboratory, Department of Psychiatry, University of Rochester, and the University of Rochester Medical Center, Neurosciences Program, Rochester, NY 14642, USA
J Clin Psychiatry 65:1128-37. 2004..The present study was designed to further evaluate this issue within a large scale, double-blind, placebo-controlled, long-term trial... - Placebo effects in primary insomniaMichael L Perlis
Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester, 300 Crittenden Blvd Rochester, NY 14642, USA
Sleep Med Rev 9:381-9. 2005..An appreciation of the latter phenomenon may provide increased power to detect therapeutic outcomes and may be used to potentiate clinical gains... - The mesograde amnesia of sleep may be attenuated in subjects with primary insomniaM L Perlis
Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Physiol Behav 74:71-6. 2001..This finding suggests that the natural mesograde amnesia of sleep may be attenuated in subjects with insomnia... - Behavioral treatment of insomnia: treatment outcome and the relevance of medical and psychiatric morbidityM L Perlis
Sleep Disorders Center, Behavioral Sleep Medicine Clinic, Rochester, New York, USA
J Behav Med 24:281-96. 2001..These findings are not significantly different from those reported in literature for both CBT and pharmacotherapy interventions. Medical and psychiatric comorbidity did not influence treatment outcome... - Beta/Gamma EEG activity in patients with primary and secondary insomnia and good sleeper controlsM L Perlis
Department of Psychiatry, University of Rochester, NY 14642, USA
Sleep 24:110-7. 2001.... - Insomnia as a risk factor for onset of depression in the elderlyMichael L Perlis
Department of Psychiatry and UR Neurosciences Program, University of Rochester, NY 14642, USA
Behav Sleep Med 4:104-13. 2006..These data suggest that elderly participants with persistent insomnia are at greater risk for the development of new onset depression... - The effects of modafinil and cognitive behavior therapy on sleep continuity in patients with primary insomniaMichael L Perlis
Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, NY, USA
Sleep 27:715-25. 2004.... - Psychophysiological insomnia: the behavioural model and a neurocognitive perspectiveM L Perlis
Department of Psychiatry, University of Rochester, NY 14642, USA
J Sleep Res 6:179-88. 1997.... - Temporal and stagewise distribution of high frequency EEG activity in patients with primary and secondary insomnia and in good sleeper controlsM L Perlis
Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Centre, Rochester, NY 14642, USA
J Sleep Res 10:93-104. 2001..Our data are consistent with the perspective that HFA is related to CNS arousal to the extent that Beta/Gamma activity occurs maximally during shallow stages of sleep and maximally in subjects with PI... - Presleep cognitions in patients with insomnia secondary to chronic painM T Smith
Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, New York 14642, USA
J Behav Med 24:93-114. 2001..These results are consistent with cognitive-behavioral models of primary insomnia and suggest the content of presleep cognitive arousal may contribute to sleep disturbance secondary to pain... - Alpha sleep and information processing, perception of sleep, pain, and arousability in fibromyalgiaM L Perlis
Department of Psychiatry, University of Rochester, NY, USA
Int J Neurosci 89:265-80. 1997..Alpha sleep appears to be, electrophysiologically, a shallow form of sleep. Our results suggest that it is perceived as such phenomenologically and that it is also associated with increased arousability... - EEG sleep in African-American patients with major depression: a historical case control studyD E Giles
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
Depress Anxiety 8:58-64. 1998..The pathological implications of these differences remained to be explored in careful prospective studies of African-American depressed patients and in well-characterized, racially matched normal control comparisons... 
The hypocretin neurotransmission system in myotonic dystrophy type 1E Ciafaloni
University of Rochester, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, NY 14642, USA
Neurology 70:226-30. 2008..Some patients with DM1 show sleep-onset REM, similar to that observed in narcolepsy. Narcolepsy is characterized by impaired hypocretin (Hcrt) neurotransmission...- Cancer-related fatigue and sleep disordersJoseph A Roscoe
Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, James P Wilmot Cancer Center, Rochester, NY 14642, USA
Oncologist 12:35-42. 2007..Disclosure of potential conflicts of interest is found at the end of this article... 
A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancerOxana Gronskaya Palesh
University of Rochester, Rochester, NY 14642, United States
Biol Psychol 75:37-44. 2007..The present study examined depression, pain, life stress, and participation in group therapy in relation to sleep disturbances in a sample of women with metastatic breast cancer...- Is insomnia a perpetuating factor for late-life depression in the IMPACT cohort?Wilfred R Pigeon
Department of Psychiatry, University of Rochester Medical Center, Rochester NY, USA
Sleep 31:481-8. 2008..The present longitudinal study examines the relationship of insomnia to the continuation of depression in the context of an intervention study in elderly subjects... - Sleep homeostasis in primary insomniaWilfred R Pigeon
Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
Sleep Med Rev 10:247-54. 2006..In addition, we provide a discussion regarding how hyperarousal and circadian factors may interact with altered sleep homeostasis, and suggestions for further inquiry... - The effect of interpersonal psychotherapy for depression on insomnia symptoms in a cohort of women with sexual abuse historiesWilfred R Pigeon
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642 8409, USA Wilfred
J Trauma Stress 22:634-8. 2009..Despite improvements in depression, insomnia persists for most women with CSA... - The incidence and temporal patterning of insomnia: a pilot studyMichael L Perlis
Behavioral Sleep Medicine Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
J Sleep Res 19:31-5. 2010..These data suggest that insomnia severity may be mediated/moderated by sleep homeostasis and that the homeostat, or input to the homeostat, may be abnormal in patients with PI... - The efficacy of cognitive-behavioral therapy for insomnia in patients with chronic painCarla R Jungquist
University of Rochester, School of Nursing, NY, USA
Sleep Med 11:302-9. 2010..To assess the efficacy of cognitive-behavioral therapy for insomnia (CBT-I) in patients with non-malignant chronic pain... - Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot studyWilfred R Pigeon
Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
J Med Food 13:579-83. 2010..These effects, however, were considerably less than those for evidence-based treatments of insomnia: hypnotic agents and cognitive-behavioral therapies for insomnia... - Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomniaMichael T Smith
Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287 7218, USA
Am J Psychiatry 159:5-11. 2002..The authors conducted a quantitative review of the literature on the outcome of the two treatments to compare the short-term efficacy of pharmacotherapy and behavioral therapy in primary insomnia... - The effects of an orally administered cholinergic agonist on REM sleep in major depressionMichael L Perlis
Sleep Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
Biol Psychiatry 51:457-62. 2002..7 vs. 69.3). CONCLUSIONS: These data indicate that donepezil is likely to be useful in testing hypotheses related to cholinergic function in mood disorders... - Functional imaging of the sleeping brain: review of findings and implications for the study of insomniaSean P A Drummond
Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, San Diego, CA, USA
Sleep Med Rev 8:227-42. 2004.... - No association of sleep with total daily physical activity in normal sleepersShawn D Youngstedt
Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0667, USA
Physiol Behav 78:395-401. 2003..These results fail to support epidemiologic data on the value of exercise for sleep, but are consistent with experimental evidence showing only modest effects of exercise on sleep... - Suicidal ideation in outpatients with chronic musculoskeletal pain: an exploratory study of the role of sleep onset insomnia and pain intensityMichael T Smith
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Clin J Pain 20:111-8. 2004..This exploratory study evaluates the importance of insomnia in discriminating suicidal ideation in chronic pain relative to depression severity and other pain-related factors... - Neuroimaging of NREM sleep in primary insomnia: a Tc-99-HMPAO single photon emission computed tomography studyMichael T Smith
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21287 7218, USA
Sleep 25:325-35. 2002..The objectives of this study were to: 1) demonstrate the feasibility of combining polysomnography and SPECT neuroimaging to study NREM sleep in primary insomnia and 2) evaluate possible functional CNS abnormalities associated with insomnia... - Chronic insomnia and MRI-measured hippocampal volumes: a pilot studyDieter Riemann
Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstr 5, D 79104 Germany
Sleep 30:955-8. 2007..Morphometric analysis of magnetic resonance imaging brain scans was used to investigate possible neuroanatomic differences between patients with primary insomnia compared to good sleepers... - Who is a candidate for cognitive-behavioral therapy for insomnia?Michael T Smith
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Behavioral Medicine Research Laboratory and Clinic, Baltimore, MD 21287 7101, USA
Health Psychol 25:15-9. 2006..This report briefly summarizes these issues, including a discussion of potential contraindications, and provides a schematic decision-to-treat algorithm... - NREM sleep cerebral blood flow before and after behavior therapy for chronic primary insomnia: preliminary single photon emission computed tomography (SPECT) dataMichael T Smith
Sleep Med 6:93-4. 2005 - Do patients with sleep maintenance insomnia have a problem with sleep maintenance?Pamela V Thacher
Department of Psychology, St Lawrence University, Canton, NY 13617, USA
Behav Sleep Med 4:203-18. 2006..The data from this study represent the first attempt to characterize the stages from which awakenings occur in sleep maintenance insomnia...
Research Grants
- Is Insomnia a Modifiable Risk Factor for MDD?Michael Perlis; Fiscal Year: 2006..abstract_text> ..
- Information processing at sleep onset and during sleep in patients with insomniaMichael Perlis; Fiscal Year: 2007..This may allow for not only the development of better treatments but also for a better understanding of and "how and why" insomnia confers risk for other illnesses. ..