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Genomes and GenesSpecies | Kenneth PerkinsSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Smoking in response to negative mood in men versus women as a function of distress toleranceKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Nicotine Tob Res 14:1418-25. 2012..Negative mood situations often increase smoking behavior and reward, effects that may be greater among women and smokers low in tolerance for distress...- Negative mood effects on craving to smoke in women versus menKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 152123, USA
Addict Behav 38:1527-31. 2013..These results suggest that very acute negative mood situations (e.g. just a few minutes in Study 2), and perhaps overnight abstinence, may increase craving to smoke to a greater extent in women relative to men... 
Expectancy for negative affect relief due to smoking may not be predictive under acute mood situationsKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Exp Clin Psychopharmacol 20:161-6. 2012..In sum, assessment of expectancy for NA relief may be of limited use in predicting actual NA relief from smoking during a current mood situation, aside from NA due to overnight abstinence...- Subjective reactivity to smoking cues as a predictor of quitting successKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Nicotine Tob Res 14:383-7. 2012..e., "cue reactivity") is often believed to identify those less able to later quit smoking. Although absolute craving level can predict smoking behavior, smoking cue reactivity per se may not predict cessation outcome... - The reliability of puff topography and subjective responses during ad lib smoking of a single cigaretteKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Nicotine Tob Res 14:490-4. 2012..However, the reliability of such measures is not clear, leaving uncertain the utility of a single assessment of smoking behavior as an individual difference measure... - Is self-efficacy for smoking abstinence a cause of, or a reflection on, smoking behavior change?Kenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Exp Clin Psychopharmacol 20:56-62. 2012.... - Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokersKenneth A Perkins
Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Behav Pharmacol 19:630-40. 2008.... - Association of retrospective early smoking experiences with prospective sensitivity to nicotine via nasal spray in nonsmokersKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Nicotine Tob Res 10:1335-45. 2008.... - Sex differences in long-term smoking cessation rates due to nicotine patchKenneth A Perkins
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Nicotine Tob Res 10:1245-50. 2008..Poorer outcomes in women vs. men treated with nicotine patch suggests that increasing the quit rates of women smokers may require supplementing patch treatment or use of other medications... - Lack of reinforcement enhancing effects of nicotine in non-dependent smokersKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 205:635-45. 2009..Little human research has directly examined this potentially important influence of nicotine... - Initial nicotine sensitivity in humans as a function of impulsivityKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 200:529-44. 2008..Impulsivity is related to greater risk of nicotine dependence, perhaps by enhancing sensitivity to nicotine's reinforcing and rewarding effects during initial smoking experiences... - Development of procedures for early screening of smoking cessation medications in humansK A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Pharmacol Ther 84:216-21. 2008..Intrinsic, but not extrinsic, quit motivation of participants may enhance the validity of brief tests of medication efficacy for smoking cessation... - Mood influences on acute smoking responses are independent of nicotine intake and dose expectancyKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Abnorm Psychol 117:79-93. 2008..Thus, sensory effects of smoke inhalation had a greater influence on relieving negative affect than actual or expected nicotine intake... 
The influence of caffeine on nicotine's discriminative stimulus, subjective, and reinforcing effectsKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Exp Clin Psychopharmacol 13:275-81. 2005..These results do not support the notion that caffeine acutely alters nicotine's discriminative stimulus, subjective, or reinforcing effects...- Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative moodKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Behav Pharmacol 19:641-9. 2008..These results warrant replication but provide the first evidence for genetic associations with the acute increase in smoking reward and reinforcement owing to negative mood... - Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smokingKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 99:47-57. 2009..They also suggest that parental smoking may not increase risk of nicotine dependence in offspring by altering initial nicotine sensitivity, and that cross-tolerance between other drugs and nicotine may not be robust in humans... - Acute responses to nicotine and smoking: implications for prevention and treatment of smoking in lower SES womenKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 104:S79-86. 2009.... - Severity of tobacco abstinence symptoms varies by time of dayKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Nicotine Tob Res 11:84-91. 2009..The time of day in which craving, withdrawal, and other tobacco abstinence symptoms are assessed may moderate the influences of abstinence or medication on those symptoms... - Mood, nicotine, and dose expectancy effects on acute responses to nicotine sprayKenneth A Perkins
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Nicotine Tob Res 11:540-6. 2009..The present study extended this line of research to Nicotrol nasal spray, to determine whether formulation (spray vs. smoking) alters responses... - Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patchKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Cancer Epidemiol Biomarkers Prev 18:2608-12. 2009.... - Acute negative affect relief from smoking depends on the affect situation and measure but not on nicotineKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 67:707-14. 2010..Smoking acutely relieves negative affect (NA) due to smoking abstinence but may not relieve NA from other sources, such as stressors... - Differences in negative mood-induced smoking reinforcement due to distress tolerance, anxiety sensitivity, and depression historyKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 210:25-34. 2010..Negative mood increases smoking reinforcement and may do so to a greater degree in smokers vulnerable to negative mood dysregulation... - Varenicline's effects on acute smoking behavior and reward and their association with subsequent abstinenceKenneth A Perkins
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 210:45-51. 2010..We compared the effects of varenicline versus placebo on smoking behavior and reward, assessed both prospectively and retrospectively, and related these effects to subsequent success in a brief simulated quit attempt with medication... - The discriminative stimulus, subjective, cardiovascular, and reinforcing effects of nicotine as a function of light physical activityKenneth A Perkins
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Nicotine Tob Res 7:791-800. 2005.... - The influence of alcohol pre-treatment on the discriminative stimulus, subjective, and relative reinforcing effects of nicotineK A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Behav Pharmacol 16:521-9. 2005..Acute effects of alcohol on smoking behavior may be due to alterations in other effects of nicotine intake or in non-nicotine effects of tobacco smoking... - Cross-validation of a new procedure for early screening of smoking cessation medications in humansK A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin Pharmacol Ther 88:109-14. 2010..These data confirm the feasibility of a brief, sensitive test of the efficacy of cessation medications in smokers with high quit interest... - Medication screening for smoking cessation: a proposal for new methodologiesKenneth A Perkins
WPIC, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 184:628-36. 2006..The alternative approach of short-term, laboratory-based studies of purported mechanisms of efficacy may overcome some of the practical problems of clinical trials but appear to have limited clinical validity... - Obstacles to determining individual differences in the efficacy of smoking cessation medicationsKenneth A Perkins
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Nicotine Tob Res 6:765-7; discussion 865-7. 2004 - Sex differences in the influence of nicotine dose instructions on the reinforcing and self-reported rewarding effects of smokingKenneth A Perkins
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 184:600-7. 2006..Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions)... - Placebo effects of tobacco smoking and other nicotine intakeKenneth Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Nicotine Tob Res 5:695-709. 2003..Future research also should explore the moderating influences of the environmental context and of individual difference factors on placebo effects of smoking and other nicotine intake... - Varenicline improves mood and cognition during smoking abstinenceFreda Patterson
Department of Psychiatry, University of Pennsylvania, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
Biol Psychiatry 65:144-9. 2009..Varenicline, a partial agonist at the alpha4beta2 nAChRs, is a new, efficacious medication for nicotine dependence. Its effects on the affective and cognitive dimensions of nicotine withdrawal have yet to be well characterized... - Individualizing nicotine replacement therapy for the treatment of tobacco dependence: a randomized trialCaryn Lerman
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 140:426-33. 2004..CONCLUSIONS: Ethnicity, weight, and level of nicotine dependence may help identify smokers who have greater or lesser abstinence rates with either transdermal or nasal spray nicotine... - The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening studyMindi A Styn
Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 150:254-61. 2009..The association between DRD2 TaqIA and smoking cessation supports the hypothesis that genetic variation in the dopamine pathway influences smoking cessation... - Effects of different nicotine replacement therapies on postcessation psychological responsesAndrew A Strasser
Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19140 3309, USA
Addict Behav 30:9-17. 2005..These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome... - Instructions about nicotine dose influence acute responses to nasal sprayKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Nicotine Tob Res 6:1051-60. 2004.... - A placebo-controlled trial of modafinil for nicotine dependenceRobert A Schnoll
Department of Psychiatry, Abramson Cancer Center, and Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA, United States
Drug Alcohol Depend 98:86-93. 2008..Modafinil (Provigil), a wakefulness medication shown to have efficacy for the treatment of cocaine addiction, was tested as a novel therapy for nicotine dependence in a double-blind placebo-controlled trial... - Importance of nonpharmacological factors in nicotine self-administrationAnthony R Caggiula
Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA
Physiol Behav 77:683-7. 2002.... - The return to smoking: 1-year relapse trajectories among female smokersCynthia A Conklin
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Nicotine Tob Res 7:533-40. 2005..Overall, the findings illustrate that, after relapsing, smokers do not follow a unitary course of smoking resumption; rather, they exhibit more variable resumption patterns than previously assumed... - Common factors across acute subjective effects of nicotineKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Nicotine Tob Res 5:869-75. 2003..Similar research may provide directions for exploring potential mechanisms responsible for these broad subjective effects of nicotine... - Smoking behavior 1 year after computed tomography screening for lung cancer: Effect of physician referral for abnormal CT findingsMindi A Styn
Department of Health and Community Systems, University of Pittsburgh School of Nursing, PA, USA
Cancer Epidemiol Biomarkers Prev 18:3484-9. 2009..Focusing on outcomes related to the reporting of CT abnormality, we examined the natural history of smoking in the Pittsburgh Lung Screening Study... - The subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinkingKenneth A Perkins
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Exp Clin Psychopharmacol 11:269-75. 2003..There were no interactions of blockade condition with sex and no effect of blockade on mood. These findings show that nonpharmacological stimuli associated with alcohol consumption influence alcohol's subjective and reinforcing effects... - Bringing the real world into the laboratory: personal smoking and nonsmoking environmentsCynthia A Conklin
University of Pittsburgh, Pittsburgh, PA, USA
Drug Alcohol Depend 111:58-63. 2010..Implications of these findings for exposure-based research and treatment for addiction, as well as other psychological disorders, are discussed... - A history of depression and smoking cessation outcomes among women concerned about post-cessation weight gainMichele D Levine
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, PA 15213, USA
Nicotine Tob Res 5:69-76. 2003..Moreover, because of the prevalence of depression history among this subgroup of women smokers and its impact on early attrition, additional engagement and retention strategies may be useful... - Bupropion and cognitive behavioral therapy for weight-concerned women smokersMichele D Levine
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Arch Intern Med 170:543-50. 2010..However, the efficacy of combining CONCERNS with cessation medication is unknown. We sought to determine if the combination of CONCERNS and bupropion therapy would enhance abstinence for weight-concerned women smokers... - The influence of instructions and nicotine dose on the subjective and reinforcing effects of smokingKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Exp Clin Psychopharmacol 12:91-101. 2004..e., placebo effect). Thus, verbal information (instructions) can influence some responses to smoking consistent with the presence of placebo and antiplacebo effects... - Rate of nicotine onset from nicotine replacement therapy and acute responses in smokersKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Nicotine Tob Res 6:501-7. 2004..patch differentially affected cardiovascular responses and perhaps craving but did not influence withdrawal, subjective ratings, and smoking reinforcement... - Proximal versus distal cues to smoke: the effects of environments on smokers' cue-reactivityCynthia A Conklin
University of Pittsburgh, Pittsburg, PA, USA
Exp Clin Psychopharmacol 16:207-14. 2008..PsycINFO Database Record (c) 2008 APA, all rights reserved)... - Sex differences in the subjective and reinforcing effects of cigarette nicotine doseKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 163:194-201. 2002..However, sex differences in the reinforcing effects of nicotine dose via cigarette smoking have received little attention... - Environmental stimuli promote the acquisition of nicotine self-administration in ratsAnthony R Caggiula
Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 163:230-7. 2002.... - Subjective and reinforcing effects of smoking during negative mood inductionCynthia A Conklin
Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Abnorm Psychol 114:153-64. 2005..Contrary to expectation, smoking did not attenuate negative affect. However, negative mood induction subsequently quickened latency to smoke and increased number of puffs consumed ad lib... - Chronic tolerance to nicotine in humans and its relationship to tobacco dependenceKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Nicotine Tob Res 4:405-22. 2002.... - Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in ratsNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 180:258-66. 2005.... - Acute nicotine reinforcement, but not chronic tolerance, predicts withdrawal and relapse after quitting smokingKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Health Psychol 21:332-9. 2002..Results challenge the common assumption that nicotine tolerance is closely related to dependence but suggest that nicotine reinforcement may have theoretical and clinical significance for dependence... - Effects of smoking status and smoking cessation on leptin levelsKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Nicotine Tob Res 4:459-66. 2002..In conclusion, the influence of cigarette smoking on body weight does not appear to be due directly to changes in leptin levels, as there is no difference in leptin due to smoking status and leptin does not decline after cessation... - The consistency of acute responses to nicotine in humansKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Nicotine Tob Res 5:877-84. 2003..consistency of nonspecific responses to the drug administration procedure... - Translating basic science to improve pharmacotherapy for nicotine dependenceJennifer M Phillips
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nicotine Tob Res 9:S583-98. 2007.... - Comment on Shiffman and colleagues, "Nicotine patch and lozenge are effective for women"Kenneth A Perkins
Nicotine Tob Res 7:915-6. 2005 - Reduced nicotine reward in obesity: cross-comparison in human and mouseJulie A Blendy
Department of Pharmacology, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Psychopharmacology (Berl) 180:306-15. 2005..Tobacco use and obesity lead to significant morbidity and mortality... - Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependenceTimothy B Baker
Nicotine Tob Res 9:S555-70. 2007..Thus the time-to-first-cigarette item appears to tap a pattern of heavy, uninterrupted, and automatic smoking and may be a good single-item measure of nicotine dependence... - Guidelines on nicotine dose selection for in vivo researchShannon G Matta
Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
Psychopharmacology (Berl) 190:269-319. 2007..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure... - Translational research in medication development for nicotine dependenceCaryn Lerman
Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
Nat Rev Drug Discov 6:746-62. 2007.... - Effects of topiramate on smoking in patients with schizoaffective disorder, bipolar typeAndrea H Weinberger
J Clin Psychopharmacol 28:247-8. 2008
Research Grants
- DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINEKenneth Perkins; Fiscal Year: 2001....
- INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANSKenneth Perkins; Fiscal Year: 2003..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
- SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMALKenneth Perkins; Fiscal Year: 2003....
- Affect, Context, and Placebo Responses to NicotineKenneth Perkins; Fiscal Year: 2005..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
- Tobacco Smoking, Nicotine and Negative Affect ReliefKenneth Perkins; Fiscal Year: 2007..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
- CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANSKenneth Perkins; Fiscal Year: 1999....
- CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANSKenneth Perkins; Fiscal Year: 1993..Results may proivde directions for the study of mechanisms responsible for tolerance, as well as for investigations of physiological and behavioral aspects of nicotine depenence and smoking relapse...
- Tobacco Smoking, Nicotine and Negative Affect ReliefKenneth Perkins; Fiscal Year: 2009..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..