Kenneth Perkins

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint An efficient early phase 2 procedure to screen medications for efficacy in smoking cessation
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA, 15213, USA
    Psychopharmacology (Berl) 231:1-11. 2014
  2. pmc Influence of reinforcer magnitude and nicotine amount on smoking's acute reinforcement enhancing effects
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA Electronic address
    Drug Alcohol Depend 133:167-71. 2013
  3. pmc Effects of bupropion on cognitive performance during initial tobacco abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA Electronic address
    Drug Alcohol Depend 133:283-6. 2013
  4. pmc Reinforcement enhancing effects of nicotine via smoking
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 228:479-86. 2013
  5. pmc Possible reinforcement enhancing effects of bupropion during initial smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:1141-5. 2013
  6. pmc Optimal carbon monoxide criteria to confirm 24-hr smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:978-82. 2013
  7. pmc Smoking in response to negative mood in men versus women as a function of distress tolerance
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Nicotine Tob Res 14:1418-25. 2012
  8. pmc Negative mood effects on craving to smoke in women versus men
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 152123, USA
    Addict Behav 38:1527-31. 2013
  9. doi request reprint Expectancy for negative affect relief due to smoking may not be predictive under acute mood situations
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 20:161-6. 2012
  10. pmc The reliability of puff topography and subjective responses during ad lib smoking of a single cigarette
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 14:490-4. 2012

Research Grants

  1. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 2001
  2. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2003
  3. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
  4. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
  5. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2007
  6. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1999
  7. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1993
  8. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009

Detail Information

Publications68

  1. doi request reprint An efficient early phase 2 procedure to screen medications for efficacy in smoking cessation
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA, 15213, USA
    Psychopharmacology (Berl) 231:1-11. 2014
    ..e., Food and Drug Administration (FDA) early phase 2), such as in aiding smoking cessation, should be efficient in identifying which drugs do, or do not, warrant more extensive (and expensive) clinical testing...
  2. pmc Influence of reinforcer magnitude and nicotine amount on smoking's acute reinforcement enhancing effects
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA Electronic address
    Drug Alcohol Depend 133:167-71. 2013
    ..Nicotine's acute effects on enhancing reinforcement from sensory rewards, shown in animal models, appear to occur with smoking in humans. These effects may vary due to reinforcer magnitude and amount of acute smoke intake (dose)...
  3. pmc Effects of bupropion on cognitive performance during initial tobacco abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA Electronic address
    Drug Alcohol Depend 133:283-6. 2013
    ..We examined whether bupropion would attenuate abstinence-induced cognitive deficits on the first day of a brief quit attempt, when smokers are most likely to relapse...
  4. pmc Reinforcement enhancing effects of nicotine via smoking
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 228:479-86. 2013
    ..In animals, nicotine enhances reinforcement from stimuli unrelated to nicotine intake. Human research is suggestive but has not clearly shown a similar influence of nicotine...
  5. pmc Possible reinforcement enhancing effects of bupropion during initial smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:1141-5. 2013
    ..Recent rodent research suggests that bupropion may reverse this attenuation, perhaps helping explain its efficacy in aiding cessation...
  6. pmc Optimal carbon monoxide criteria to confirm 24-hr smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:978-82. 2013
    ..Smoking cessation is typically verified biochemically by expired-air carbon monoxide (CO) levels below 9 ppm (i.e., ≤8 ppm), but this CO criterion may lead many who have smoked within 24hr to be misclassified as abstinent...
  7. pmc Smoking in response to negative mood in men versus women as a function of distress tolerance
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Nicotine Tob Res 14:1418-25. 2012
    ..Negative mood situations often increase smoking behavior and reward, effects that may be greater among women and smokers low in tolerance for distress...
  8. pmc Negative mood effects on craving to smoke in women versus men
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 152123, USA
    Addict Behav 38:1527-31. 2013
    ..These results suggest that very acute negative mood situations (e.g. just a few minutes in Study 2), and perhaps overnight abstinence, may increase craving to smoke to a greater extent in women relative to men...
  9. doi request reprint Expectancy for negative affect relief due to smoking may not be predictive under acute mood situations
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 20:161-6. 2012
    ..In sum, assessment of expectancy for NA relief may be of limited use in predicting actual NA relief from smoking during a current mood situation, aside from NA due to overnight abstinence...
  10. pmc The reliability of puff topography and subjective responses during ad lib smoking of a single cigarette
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 14:490-4. 2012
    ..However, the reliability of such measures is not clear, leaving uncertain the utility of a single assessment of smoking behavior as an individual difference measure...
  11. pmc Subjective reactivity to smoking cues as a predictor of quitting success
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 14:383-7. 2012
    ..e., "cue reactivity") is often believed to identify those less able to later quit smoking. Although absolute craving level can predict smoking behavior, smoking cue reactivity per se may not predict cessation outcome...
  12. pmc Is self-efficacy for smoking abstinence a cause of, or a reflection on, smoking behavior change?
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 20:56-62. 2012
    ....
  13. pmc Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Behav Pharmacol 19:641-9. 2008
    ..These results warrant replication but provide the first evidence for genetic associations with the acute increase in smoking reward and reinforcement owing to negative mood...
  14. pmc Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers
    Kenneth A Perkins
    Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Behav Pharmacol 19:630-40. 2008
    ....
  15. doi request reprint Association of retrospective early smoking experiences with prospective sensitivity to nicotine via nasal spray in nonsmokers
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 10:1335-45. 2008
    ....
  16. doi request reprint Sex differences in long-term smoking cessation rates due to nicotine patch
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Nicotine Tob Res 10:1245-50. 2008
    ..Poorer outcomes in women vs. men treated with nicotine patch suggests that increasing the quit rates of women smokers may require supplementing patch treatment or use of other medications...
  17. doi request reprint Initial nicotine sensitivity in humans as a function of impulsivity
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 200:529-44. 2008
    ..Impulsivity is related to greater risk of nicotine dependence, perhaps by enhancing sensitivity to nicotine's reinforcing and rewarding effects during initial smoking experiences...
  18. pmc Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Drug Alcohol Depend 99:47-57. 2009
    ..They also suggest that parental smoking may not increase risk of nicotine dependence in offspring by altering initial nicotine sensitivity, and that cross-tolerance between other drugs and nicotine may not be robust in humans...
  19. doi request reprint Development of procedures for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 84:216-21. 2008
    ..Intrinsic, but not extrinsic, quit motivation of participants may enhance the validity of brief tests of medication efficacy for smoking cessation...
  20. doi request reprint Acute responses to nicotine and smoking: implications for prevention and treatment of smoking in lower SES women
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Drug Alcohol Depend 104:S79-86. 2009
    ....
  21. pmc Severity of tobacco abstinence symptoms varies by time of day
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 11:84-91. 2009
    ..The time of day in which craving, withdrawal, and other tobacco abstinence symptoms are assessed may moderate the influences of abstinence or medication on those symptoms...
  22. pmc Mood, nicotine, and dose expectancy effects on acute responses to nicotine spray
    Kenneth A Perkins
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 11:540-6. 2009
    ..The present study extended this line of research to Nicotrol nasal spray, to determine whether formulation (spray vs. smoking) alters responses...
  23. doi request reprint Lack of reinforcement enhancing effects of nicotine in non-dependent smokers
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 205:635-45. 2009
    ..Little human research has directly examined this potentially important influence of nicotine...
  24. pmc Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cancer Epidemiol Biomarkers Prev 18:2608-12. 2009
    ....
  25. doi request reprint Acute negative affect relief from smoking depends on the affect situation and measure but not on nicotine
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 67:707-14. 2010
    ..Smoking acutely relieves negative affect (NA) due to smoking abstinence but may not relieve NA from other sources, such as stressors...
  26. pmc Differences in negative mood-induced smoking reinforcement due to distress tolerance, anxiety sensitivity, and depression history
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 210:25-34. 2010
    ..Negative mood increases smoking reinforcement and may do so to a greater degree in smokers vulnerable to negative mood dysregulation...
  27. pmc Varenicline's effects on acute smoking behavior and reward and their association with subsequent abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 210:45-51. 2010
    ..We compared the effects of varenicline versus placebo on smoking behavior and reward, assessed both prospectively and retrospectively, and related these effects to subsequent success in a brief simulated quit attempt with medication...
  28. doi request reprint Cross-validation of a new procedure for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 88:109-14. 2010
    ..These data confirm the feasibility of a brief, sensitive test of the efficacy of cessation medications in smokers with high quit interest...
  29. doi request reprint Mood influences on acute smoking responses are independent of nicotine intake and dose expectancy
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Abnorm Psychol 117:79-93. 2008
    ..Thus, sensory effects of smoke inhalation had a greater influence on relieving negative affect than actual or expected nicotine intake...
  30. ncbi request reprint Obstacles to determining individual differences in the efficacy of smoking cessation medications
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:765-7; discussion 865-7. 2004
  31. ncbi request reprint The influence of alcohol pre-treatment on the discriminative stimulus, subjective, and relative reinforcing effects of nicotine
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Behav Pharmacol 16:521-9. 2005
    ..Acute effects of alcohol on smoking behavior may be due to alterations in other effects of nicotine intake or in non-nicotine effects of tobacco smoking...
  32. ncbi request reprint Medication screening for smoking cessation: a proposal for new methodologies
    Kenneth A Perkins
    WPIC, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 184:628-36. 2006
    ..The alternative approach of short-term, laboratory-based studies of purported mechanisms of efficacy may overcome some of the practical problems of clinical trials but appear to have limited clinical validity...
  33. ncbi request reprint The influence of caffeine on nicotine's discriminative stimulus, subjective, and reinforcing effects
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Exp Clin Psychopharmacol 13:275-81. 2005
    ..These results do not support the notion that caffeine acutely alters nicotine's discriminative stimulus, subjective, or reinforcing effects...
  34. ncbi request reprint Sex differences in the influence of nicotine dose instructions on the reinforcing and self-reported rewarding effects of smoking
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 184:600-7. 2006
    ..Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions)...
  35. ncbi request reprint The discriminative stimulus, subjective, cardiovascular, and reinforcing effects of nicotine as a function of light physical activity
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 7:791-800. 2005
    ....
  36. ncbi request reprint Placebo effects of tobacco smoking and other nicotine intake
    Kenneth Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 5:695-709. 2003
    ..Future research also should explore the moderating influences of the environmental context and of individual difference factors on placebo effects of smoking and other nicotine intake...
  37. pmc Varenicline improves mood and cognition during smoking abstinence
    Freda Patterson
    Department of Psychiatry, University of Pennsylvania, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychiatry 65:144-9. 2009
    ..Varenicline, a partial agonist at the alpha4beta2 nAChRs, is a new, efficacious medication for nicotine dependence. Its effects on the affective and cognitive dimensions of nicotine withdrawal have yet to be well characterized...
  38. ncbi request reprint Individualizing nicotine replacement therapy for the treatment of tobacco dependence: a randomized trial
    Caryn Lerman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 140:426-33. 2004
    ....
  39. pmc The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study
    Mindi A Styn
    Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 150:254-61. 2009
    ..The association between DRD2 TaqIA and smoking cessation supports the hypothesis that genetic variation in the dopamine pathway influences smoking cessation...
  40. ncbi request reprint Instructions about nicotine dose influence acute responses to nasal spray
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:1051-60. 2004
    ....
  41. ncbi request reprint Effects of different nicotine replacement therapies on postcessation psychological responses
    Andrew A Strasser
    Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19140 3309, USA
    Addict Behav 30:9-17. 2005
    ..These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome...
  42. pmc A placebo-controlled trial of modafinil for nicotine dependence
    Robert A Schnoll
    Department of Psychiatry, Abramson Cancer Center, and Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA, United States
    Drug Alcohol Depend 98:86-93. 2008
    ..Modafinil (Provigil), a wakefulness medication shown to have efficacy for the treatment of cocaine addiction, was tested as a novel therapy for nicotine dependence in a double-blind placebo-controlled trial...
  43. ncbi request reprint Importance of nonpharmacological factors in nicotine self-administration
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:683-7. 2002
    ....
  44. ncbi request reprint Common factors across acute subjective effects of nicotine
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 5:869-75. 2003
    ..Similar research may provide directions for exploring potential mechanisms responsible for these broad subjective effects of nicotine...
  45. ncbi request reprint The consistency of acute responses to nicotine in humans
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 5:877-84. 2003
    ..consistency of nonspecific responses to the drug administration procedure...
  46. pmc Bringing the real world into the laboratory: personal smoking and nonsmoking environments
    Cynthia A Conklin
    University of Pittsburgh, Pittsburgh, PA, USA
    Drug Alcohol Depend 111:58-63. 2010
    ..Implications of these findings for exposure-based research and treatment for addiction, as well as other psychological disorders, are discussed...
  47. ncbi request reprint The subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 11:269-75. 2003
    ..There were no interactions of blockade condition with sex and no effect of blockade on mood. These findings show that nonpharmacological stimuli associated with alcohol consumption influence alcohol's subjective and reinforcing effects...
  48. ncbi request reprint A history of depression and smoking cessation outcomes among women concerned about post-cessation weight gain
    Michele D Levine
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, PA 15213, USA
    Nicotine Tob Res 5:69-76. 2003
    ..Moreover, because of the prevalence of depression history among this subgroup of women smokers and its impact on early attrition, additional engagement and retention strategies may be useful...
  49. ncbi request reprint Effects of smoking status and smoking cessation on leptin levels
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nicotine Tob Res 4:459-66. 2002
    ..In conclusion, the influence of cigarette smoking on body weight does not appear to be due directly to changes in leptin levels, as there is no difference in leptin due to smoking status and leptin does not decline after cessation...
  50. ncbi request reprint Chronic tolerance to nicotine in humans and its relationship to tobacco dependence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nicotine Tob Res 4:405-22. 2002
    ....
  51. ncbi request reprint Environmental stimuli promote the acquisition of nicotine self-administration in rats
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 163:230-7. 2002
    ....
  52. ncbi request reprint Sex differences in the subjective and reinforcing effects of cigarette nicotine dose
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 163:194-201. 2002
    ..However, sex differences in the reinforcing effects of nicotine dose via cigarette smoking have received little attention...
  53. ncbi request reprint The influence of instructions and nicotine dose on the subjective and reinforcing effects of smoking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 12:91-101. 2004
    ..e., placebo effect). Thus, verbal information (instructions) can influence some responses to smoking consistent with the presence of placebo and antiplacebo effects...
  54. pmc Bupropion and cognitive behavioral therapy for weight-concerned women smokers
    Michele D Levine
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Arch Intern Med 170:543-50. 2010
    ..However, the efficacy of combining CONCERNS with cessation medication is unknown. We sought to determine if the combination of CONCERNS and bupropion therapy would enhance abstinence for weight-concerned women smokers...
  55. ncbi request reprint Rate of nicotine onset from nicotine replacement therapy and acute responses in smokers
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:501-7. 2004
    ..patch differentially affected cardiovascular responses and perhaps craving but did not influence withdrawal, subjective ratings, and smoking reinforcement...
  56. ncbi request reprint The return to smoking: 1-year relapse trajectories among female smokers
    Cynthia A Conklin
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 7:533-40. 2005
    ..Overall, the findings illustrate that, after relapsing, smokers do not follow a unitary course of smoking resumption; rather, they exhibit more variable resumption patterns than previously assumed...
  57. pmc Proximal versus distal cues to smoke: the effects of environments on smokers' cue-reactivity
    Cynthia A Conklin
    University of Pittsburgh, Pittsburg, PA, USA
    Exp Clin Psychopharmacol 16:207-14. 2008
    ..PsycINFO Database Record (c) 2008 APA, all rights reserved)...
  58. ncbi request reprint Subjective and reinforcing effects of smoking during negative mood induction
    Cynthia A Conklin
    Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Abnorm Psychol 114:153-64. 2005
    ..Contrary to expectation, smoking did not attenuate negative affect. However, negative mood induction subsequently quickened latency to smoke and increased number of puffs consumed ad lib...
  59. ncbi request reprint Acute nicotine reinforcement, but not chronic tolerance, predicts withdrawal and relapse after quitting smoking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Health Psychol 21:332-9. 2002
    ..Results challenge the common assumption that nicotine tolerance is closely related to dependence but suggest that nicotine reinforcement may have theoretical and clinical significance for dependence...
  60. pmc Smoking behavior 1 year after computed tomography screening for lung cancer: Effect of physician referral for abnormal CT findings
    Mindi A Styn
    Department of Health and Community Systems, University of Pittsburgh School of Nursing, PA, USA
    Cancer Epidemiol Biomarkers Prev 18:3484-9. 2009
    ..Focusing on outcomes related to the reporting of CT abnormality, we examined the natural history of smoking in the Pittsburgh Lung Screening Study...
  61. ncbi request reprint Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 180:258-66. 2005
    ....
  62. doi request reprint Translating basic science to improve pharmacotherapy for nicotine dependence
    Jennifer M Phillips
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nicotine Tob Res 9:S583-98. 2007
    ....
  63. pmc Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence
    Timothy B Baker
    Nicotine Tob Res 9:S555-70. 2007
    ..Thus the time-to-first-cigarette item appears to tap a pattern of heavy, uninterrupted, and automatic smoking and may be a good single-item measure of nicotine dependence...
  64. ncbi request reprint Comment on Shiffman and colleagues, "Nicotine patch and lozenge are effective for women"
    Kenneth A Perkins
    Nicotine Tob Res 7:915-6. 2005
  65. ncbi request reprint Reduced nicotine reward in obesity: cross-comparison in human and mouse
    Julie A Blendy
    Department of Pharmacology, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Psychopharmacology (Berl) 180:306-15. 2005
    ..Tobacco use and obesity lead to significant morbidity and mortality...
  66. pmc Effects of topiramate on smoking in patients with schizoaffective disorder, bipolar type
    Andrea H Weinberger
    J Clin Psychopharmacol 28:247-8. 2008
  67. ncbi request reprint Translational research in medication development for nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 6:746-62. 2007
    ....
  68. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...

Research Grants34

  1. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 2001
    ....
  2. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2003
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  3. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
    ....
  4. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  5. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2007
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  6. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1999
    ....
  7. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1993
    ..Results may proivde directions for the study of mechanisms responsible for tolerance, as well as for investigations of physiological and behavioral aspects of nicotine depenence and smoking relapse...
  8. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..