K A Perkins

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Nicotine discrimination and self-administration in humans as a function of smoking status
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychopharmacology (Berl) 131:361-70. 1997
  2. ncbi request reprint Effects of training dose and two- versus three-choice testing procedure on nicotine discrimination responding in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 145:418-25. 1999
  3. ncbi request reprint Effects of central and peripheral nicotinic blockade on human nicotine discrimination
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 142:158-64. 1999
  4. ncbi request reprint Nicotine self-administration
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Nicotine Tob Res 1:S133-7; discussion S139-40. 1999
  5. ncbi request reprint Influence of acute smoking exposure on the subsequent reinforcing value of smoking
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 5:277-85. 1997
  6. ncbi request reprint Quitting cigarette smoking produces minimal loss of chronic tolerance to nicotine
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 158:7-17. 2001
  7. ncbi request reprint Subjective responses to nicotine in smokers may be associated with responses to caffeine and to alcohol
    K A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 9:91-100. 2001
  8. ncbi request reprint Dissociation of nicotine tolerance from tobacco dependence in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Pharmacol Exp Ther 296:849-56. 2001
  9. ncbi request reprint Reinforcing effects of nicotine as a function of smoking status
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburg School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 9:243-50. 2001
  10. doi request reprint Cross-validation of a new procedure for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 88:109-14. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Nicotine discrimination and self-administration in humans as a function of smoking status
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychopharmacology (Berl) 131:361-70. 1997
    ..These results indicate that smokers may become tolerant to the discriminative stimulus effects of nicotine, perhaps promoting increased use...
  2. ncbi request reprint Effects of training dose and two- versus three-choice testing procedure on nicotine discrimination responding in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 145:418-25. 1999
    ..Discrimination of a drug's interoceptive stimulus effects often depends substantially on training and testing conditions...
  3. ncbi request reprint Effects of central and peripheral nicotinic blockade on human nicotine discrimination
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 142:158-64. 1999
    ..Consistent with previous animal studies, these results suggest that discriminative stimulus effects of nicotine in humans are mediated at least in part by its central effects...
  4. ncbi request reprint Nicotine self-administration
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Nicotine Tob Res 1:S133-7; discussion S139-40. 1999
    ....
  5. ncbi request reprint Influence of acute smoking exposure on the subsequent reinforcing value of smoking
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 5:277-85. 1997
    ..These measures were correlated only weakly with smoke-reinforced responding on the behavioral task, suggesting that subjective versus behavioral measures assess different dimensions of smoking's reward value...
  6. ncbi request reprint Quitting cigarette smoking produces minimal loss of chronic tolerance to nicotine
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 158:7-17. 2001
    ..The time course for loss of this tolerance after cessation of exposure is not known in humans but could relate to risk of smoking relapse...
  7. ncbi request reprint Subjective responses to nicotine in smokers may be associated with responses to caffeine and to alcohol
    K A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 9:91-100. 2001
    ..These results suggest that smokers who are more responsive to some of nicotine's subjective and blood pressure effects are also more sensitive to the same effects of caffeine and, to a lesser extent, of alcohol...
  8. ncbi request reprint Dissociation of nicotine tolerance from tobacco dependence in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Pharmacol Exp Ther 296:849-56. 2001
    ..These results suggest there is no close link between nicotine tolerance and dependence and question the utility of tolerance as one of the criteria for defining dependence...
  9. ncbi request reprint Reinforcing effects of nicotine as a function of smoking status
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburg School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 9:243-50. 2001
    ..In nonsmokers, self-administration was related directly to pleasurable effects but inversely to aversive effects. Few effects were related to self-administration in the other groups...
  10. doi request reprint Cross-validation of a new procedure for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 88:109-14. 2010
    ..These data confirm the feasibility of a brief, sensitive test of the efficacy of cessation medications in smokers with high quit interest...
  11. ncbi request reprint The discriminative stimulus and reinforcing effects of nicotine in humans following nicotine pretreatment
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Behav Pharmacol 12:35-44. 2001
    ..These results only modestly support the notion of acute tolerance to the discriminative stimulus effects of nicotine, and even then only in women and not in men...
  12. ncbi request reprint Threshold doses for nicotine discrimination in smokers and non-smokers
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychopharmacology (Berl) 155:163-70. 2001
    ..Threshold doses for nicotine discrimination therefore may differ between naive and experienced tobacco users...
  13. ncbi request reprint Tobacco withdrawal in women and menstrual cycle phase
    K A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Consult Clin Psychol 68:176-80. 2000
    ..These results indicate that selecting a quit-smoking day early in the follicular phase may attenuate withdrawal and negative affect in premenopausal female smokers...
  14. ncbi request reprint Greater sensitivity to subjective effects of nicotine in nonsmokers high in sensation seeking
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 8:462-71. 2000
    ....
  15. ncbi request reprint Cue dependency of nicotine self-administration and smoking
    A R Caggiula
    Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 70:515-30. 2001
    ....
  16. ncbi request reprint Cognitive-behavioral therapy to reduce weight concerns improves smoking cessation outcome in weight-concerned women
    K A Perkins
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Consult Clin Psychol 69:604-13. 2001
    ..In sum, CBT to reduce weight concerns, but not behavioral weight control counseling to prevent weight gain, improves smoking cessation outcome in weight-concerned women...
  17. ncbi request reprint Interaction of stress, smoking, and dietary restraint in women
    S L Mitchell
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Physiol Behav 64:103-9. 1998
    ..These data suggest that restrainers may use smoking to reduce distress and may increase smoking, but not eating, during stress...
  18. ncbi request reprint Sex differences in nicotine effects and self-administration: review of human and animal evidence
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    Nicotine Tob Res 1:301-15. 1999
    ..Identification of specific factors responsible for these sex differences may lead to improved interventions for smoking cessation and other substance abuse in women...
  19. doi request reprint Development of procedures for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 84:216-21. 2008
    ..Intrinsic, but not extrinsic, quit motivation of participants may enhance the validity of brief tests of medication efficacy for smoking cessation...
  20. ncbi request reprint The role of corticosteroids in nicotine's physiological and behavioral effects
    A R Caggiula
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    Psychoneuroendocrinology 23:143-59. 1998
    ..These findings highlight the feasibility of using self-administration models in future explorations of the relationship between adrenal steroids and nicotine function...
  21. ncbi request reprint The influence of alcohol pre-treatment on the discriminative stimulus, subjective, and relative reinforcing effects of nicotine
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Behav Pharmacol 16:521-9. 2005
    ..Acute effects of alcohol on smoking behavior may be due to alterations in other effects of nicotine intake or in non-nicotine effects of tobacco smoking...
  22. ncbi request reprint Importance of environmental distractors in the effects of nicotine on short-term memory
    J E Grobe
    Department of Psychology, University of Pittsburgh, USA
    Exp Clin Psychopharmacol 6:209-16. 1998
    ..These results suggest that environmental conditions, such as the presence of a distracting stimulus, may play an important role in mediating the effects of nicotine...
  23. ncbi request reprint Sex differences in the subjective and reinforcing effects of visual and olfactory cigarette smoke stimuli
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. perkinskamsx.upmc.edu
    Nicotine Tob Res 3:141-50. 2001
    ..However, this sex difference may not generalize beyond smoking or other drug reinforcement...
  24. ncbi request reprint The characteristics of women smokers concerned about postcessation weight gain
    M D Levine
    School of Medicine, University of Pittsburgh, PA, USA
    Addict Behav 26:749-56. 2001
    ..The discrepancy between expected and tolerable weight gain may undermine efforts to quit smoking in this group of women...
  25. ncbi request reprint Baseline-dependency of nicotine effects: a review
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Behav Pharmacol 10:597-615. 1999
    ..Consideration of the conditions under which baseline-dependent effects of nicotine are observed may clarify both individual difference and situational influences on responses to nicotine...
  26. ncbi request reprint Sex differences in the acute effects of cigarette smoking on the reinforcing value of alcohol
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Pharmacol 11:63-70. 2000
    ..Additional research is needed to determine the extent to which these effects in men are pharmacological in nature or are conditioned responses to smoking or to consuming a preferred alcoholic beverage...
  27. ncbi request reprint Smoking cessation in women. Special considerations
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Drugs 15:391-411. 2001
    ..Greater attention to gender differences in clinical trial outcomes and to addressing concerns of women smokers may aid in the development of substantially improved smoking cessation interventions for women...