K A Perkins

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Rate of nicotine onset from nicotine replacement therapy and acute responses in smokers
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:501-7. 2004
  2. ncbi Reinforcing effects of nicotine as a function of smoking status
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburg School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 9:243-50. 2001
  3. ncbi Cognitive-behavioral therapy to reduce weight concerns improves smoking cessation outcome in weight-concerned women
    K A Perkins
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Consult Clin Psychol 69:604-13. 2001
  4. ncbi Quitting cigarette smoking produces minimal loss of chronic tolerance to nicotine
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 158:7-17. 2001
  5. ncbi Acute nicotine reinforcement, but not chronic tolerance, predicts withdrawal and relapse after quitting smoking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Health Psychol 21:332-9. 2002
  6. ncbi Sex differences in the subjective and reinforcing effects of cigarette nicotine dose
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 163:194-201. 2002
  7. ncbi Chronic tolerance to nicotine in humans and its relationship to tobacco dependence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nicotine Tob Res 4:405-22. 2002
  8. ncbi Effects of smoking status and smoking cessation on leptin levels
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nicotine Tob Res 4:459-66. 2002
  9. ncbi Placebo effects of tobacco smoking and other nicotine intake
    Kenneth Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 5:695-709. 2003
  10. ncbi The subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 11:269-75. 2003

Detail Information

Publications58

  1. ncbi Rate of nicotine onset from nicotine replacement therapy and acute responses in smokers
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:501-7. 2004
    ..patch differentially affected cardiovascular responses and perhaps craving but did not influence withdrawal, subjective ratings, and smoking reinforcement...
  2. ncbi Reinforcing effects of nicotine as a function of smoking status
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburg School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 9:243-50. 2001
    ..In nonsmokers, self-administration was related directly to pleasurable effects but inversely to aversive effects. Few effects were related to self-administration in the other groups...
  3. ncbi Cognitive-behavioral therapy to reduce weight concerns improves smoking cessation outcome in weight-concerned women
    K A Perkins
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Consult Clin Psychol 69:604-13. 2001
    ..In sum, CBT to reduce weight concerns, but not behavioral weight control counseling to prevent weight gain, improves smoking cessation outcome in weight-concerned women...
  4. ncbi Quitting cigarette smoking produces minimal loss of chronic tolerance to nicotine
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 158:7-17. 2001
    ..The time course for loss of this tolerance after cessation of exposure is not known in humans but could relate to risk of smoking relapse...
  5. ncbi Acute nicotine reinforcement, but not chronic tolerance, predicts withdrawal and relapse after quitting smoking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Health Psychol 21:332-9. 2002
    ..Results challenge the common assumption that nicotine tolerance is closely related to dependence but suggest that nicotine reinforcement may have theoretical and clinical significance for dependence...
  6. ncbi Sex differences in the subjective and reinforcing effects of cigarette nicotine dose
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 163:194-201. 2002
    ..However, sex differences in the reinforcing effects of nicotine dose via cigarette smoking have received little attention...
  7. ncbi Chronic tolerance to nicotine in humans and its relationship to tobacco dependence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nicotine Tob Res 4:405-22. 2002
    ....
  8. ncbi Effects of smoking status and smoking cessation on leptin levels
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nicotine Tob Res 4:459-66. 2002
    ..In conclusion, the influence of cigarette smoking on body weight does not appear to be due directly to changes in leptin levels, as there is no difference in leptin due to smoking status and leptin does not decline after cessation...
  9. ncbi Placebo effects of tobacco smoking and other nicotine intake
    Kenneth Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 5:695-709. 2003
    ..Future research also should explore the moderating influences of the environmental context and of individual difference factors on placebo effects of smoking and other nicotine intake...
  10. ncbi The subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 11:269-75. 2003
    ..There were no interactions of blockade condition with sex and no effect of blockade on mood. These findings show that nonpharmacological stimuli associated with alcohol consumption influence alcohol's subjective and reinforcing effects...
  11. ncbi Common factors across acute subjective effects of nicotine
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 5:869-75. 2003
    ..Similar research may provide directions for exploring potential mechanisms responsible for these broad subjective effects of nicotine...
  12. ncbi The consistency of acute responses to nicotine in humans
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 5:877-84. 2003
    ..consistency of nonspecific responses to the drug administration procedure...
  13. ncbi The influence of instructions and nicotine dose on the subjective and reinforcing effects of smoking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 12:91-101. 2004
    ..e., placebo effect). Thus, verbal information (instructions) can influence some responses to smoking consistent with the presence of placebo and antiplacebo effects...
  14. ncbi Subjective responses to nicotine in smokers may be associated with responses to caffeine and to alcohol
    K A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 9:91-100. 2001
    ..These results suggest that smokers who are more responsive to some of nicotine's subjective and blood pressure effects are also more sensitive to the same effects of caffeine and, to a lesser extent, of alcohol...
  15. ncbi Dissociation of nicotine tolerance from tobacco dependence in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Pharmacol Exp Ther 296:849-56. 2001
    ..These results suggest there is no close link between nicotine tolerance and dependence and question the utility of tolerance as one of the criteria for defining dependence...
  16. ncbi Greater sensitivity to subjective effects of nicotine in nonsmokers high in sensation seeking
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 8:462-71. 2000
    ....
  17. ncbi Sex differences in the acute effects of cigarette smoking on the reinforcing value of alcohol
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Pharmacol 11:63-70. 2000
    ..Additional research is needed to determine the extent to which these effects in men are pharmacological in nature or are conditioned responses to smoking or to consuming a preferred alcoholic beverage...
  18. ncbi Baseline-dependency of nicotine effects: a review
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Behav Pharmacol 10:597-615. 1999
    ..Consideration of the conditions under which baseline-dependent effects of nicotine are observed may clarify both individual difference and situational influences on responses to nicotine...
  19. ncbi Sex differences in nicotine effects and self-administration: review of human and animal evidence
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    Nicotine Tob Res 1:301-15. 1999
    ..Identification of specific factors responsible for these sex differences may lead to improved interventions for smoking cessation and other substance abuse in women...
  20. ncbi Tobacco withdrawal in women and menstrual cycle phase
    K A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Consult Clin Psychol 68:176-80. 2000
    ..These results indicate that selecting a quit-smoking day early in the follicular phase may attenuate withdrawal and negative affect in premenopausal female smokers...
  21. ncbi The discriminative stimulus and reinforcing effects of nicotine in humans following nicotine pretreatment
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Behav Pharmacol 12:35-44. 2001
    ..These results only modestly support the notion of acute tolerance to the discriminative stimulus effects of nicotine, and even then only in women and not in men...
  22. ncbi Threshold doses for nicotine discrimination in smokers and non-smokers
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychopharmacology (Berl) 155:163-70. 2001
    ..Threshold doses for nicotine discrimination therefore may differ between naive and experienced tobacco users...
  23. ncbi Smoking cessation in women. Special considerations
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Drugs 15:391-411. 2001
    ..Greater attention to gender differences in clinical trial outcomes and to addressing concerns of women smokers may aid in the development of substantially improved smoking cessation interventions for women...
  24. ncbi Cross-validation of a new procedure for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 88:109-14. 2010
    ..These data confirm the feasibility of a brief, sensitive test of the efficacy of cessation medications in smokers with high quit interest...
  25. ncbi Influence of acute smoking exposure on the subsequent reinforcing value of smoking
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Exp Clin Psychopharmacol 5:277-85. 1997
    ..These measures were correlated only weakly with smoke-reinforced responding on the behavioral task, suggesting that subjective versus behavioral measures assess different dimensions of smoking's reward value...
  26. ncbi Nicotine discrimination and self-administration in humans as a function of smoking status
    K A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychopharmacology (Berl) 131:361-70. 1997
    ..These results indicate that smokers may become tolerant to the discriminative stimulus effects of nicotine, perhaps promoting increased use...
  27. ncbi Effects of training dose and two- versus three-choice testing procedure on nicotine discrimination responding in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 145:418-25. 1999
    ..Discrimination of a drug's interoceptive stimulus effects often depends substantially on training and testing conditions...
  28. ncbi Development of procedures for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 84:216-21. 2008
    ..Intrinsic, but not extrinsic, quit motivation of participants may enhance the validity of brief tests of medication efficacy for smoking cessation...
  29. ncbi Sex differences in the subjective and reinforcing effects of visual and olfactory cigarette smoke stimuli
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. perkinskamsx.upmc.edu
    Nicotine Tob Res 3:141-50. 2001
    ..However, this sex difference may not generalize beyond smoking or other drug reinforcement...
  30. ncbi Effects of central and peripheral nicotinic blockade on human nicotine discrimination
    K A Perkins
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 142:158-64. 1999
    ..Consistent with previous animal studies, these results suggest that discriminative stimulus effects of nicotine in humans are mediated at least in part by its central effects...
  31. ncbi The influence of alcohol pre-treatment on the discriminative stimulus, subjective, and relative reinforcing effects of nicotine
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Behav Pharmacol 16:521-9. 2005
    ..Acute effects of alcohol on smoking behavior may be due to alterations in other effects of nicotine intake or in non-nicotine effects of tobacco smoking...
  32. ncbi The characteristics of women smokers concerned about postcessation weight gain
    M D Levine
    School of Medicine, University of Pittsburgh, PA, USA
    Addict Behav 26:749-56. 2001
    ..The discrepancy between expected and tolerable weight gain may undermine efforts to quit smoking in this group of women...
  33. ncbi Nicotine self-administration
    K A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Nicotine Tob Res 1:S133-7; discussion S139-40. 1999
    ....
  34. ncbi Cue dependency of nicotine self-administration and smoking
    A R Caggiula
    Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 70:515-30. 2001
    ....
  35. ncbi Interaction of stress, smoking, and dietary restraint in women
    S L Mitchell
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Physiol Behav 64:103-9. 1998
    ..These data suggest that restrainers may use smoking to reduce distress and may increase smoking, but not eating, during stress...
  36. ncbi The discriminative stimulus, subjective, cardiovascular, and reinforcing effects of nicotine as a function of light physical activity
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 7:791-800. 2005
    ....
  37. ncbi Comment on Shiffman and colleagues, "Nicotine patch and lozenge are effective for women"
    Kenneth A Perkins
    Nicotine Tob Res 7:915-6. 2005
  38. ncbi The influence of caffeine on nicotine's discriminative stimulus, subjective, and reinforcing effects
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Exp Clin Psychopharmacol 13:275-81. 2005
    ..These results do not support the notion that caffeine acutely alters nicotine's discriminative stimulus, subjective, or reinforcing effects...
  39. ncbi Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence
    Timothy B Baker
    Nicotine Tob Res 9:S555-70. 2007
    ..Thus the time-to-first-cigarette item appears to tap a pattern of heavy, uninterrupted, and automatic smoking and may be a good single-item measure of nicotine dependence...
  40. ncbi Mood influences on acute smoking responses are independent of nicotine intake and dose expectancy
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Abnorm Psychol 117:79-93. 2008
    ..Thus, sensory effects of smoke inhalation had a greater influence on relieving negative affect than actual or expected nicotine intake...
  41. ncbi Medication screening for smoking cessation: a proposal for new methodologies
    Kenneth A Perkins
    WPIC, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 184:628-36. 2006
    ..The alternative approach of short-term, laboratory-based studies of purported mechanisms of efficacy may overcome some of the practical problems of clinical trials but appear to have limited clinical validity...
  42. ncbi Sex differences in long-term smoking cessation rates due to nicotine patch
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Nicotine Tob Res 10:1245-50. 2008
    ..Poorer outcomes in women vs. men treated with nicotine patch suggests that increasing the quit rates of women smokers may require supplementing patch treatment or use of other medications...
  43. ncbi Proximal versus distal cues to smoke: the effects of environments on smokers' cue-reactivity
    Cynthia A Conklin
    University of Pittsburgh, Pittsburg, PA, USA
    Exp Clin Psychopharmacol 16:207-14. 2008
    ..PsycINFO Database Record (c) 2008 APA, all rights reserved)...
  44. ncbi The return to smoking: 1-year relapse trajectories among female smokers
    Cynthia A Conklin
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 7:533-40. 2005
    ..Overall, the findings illustrate that, after relapsing, smokers do not follow a unitary course of smoking resumption; rather, they exhibit more variable resumption patterns than previously assumed...
  45. ncbi Importance of nonpharmacological factors in nicotine self-administration
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:683-7. 2002
    ....
  46. ncbi A history of depression and smoking cessation outcomes among women concerned about post-cessation weight gain
    Michele D Levine
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, PA 15213, USA
    Nicotine Tob Res 5:69-76. 2003
    ..Moreover, because of the prevalence of depression history among this subgroup of women smokers and its impact on early attrition, additional engagement and retention strategies may be useful...
  47. ncbi Effects of different nicotine replacement therapies on postcessation psychological responses
    Andrew A Strasser
    Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19140 3309, USA
    Addict Behav 30:9-17. 2005
    ..These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome...
  48. ncbi Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 180:258-66. 2005
    ....
  49. ncbi Obstacles to determining individual differences in the efficacy of smoking cessation medications
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:765-7; discussion 865-7. 2004
  50. ncbi Subjective and reinforcing effects of smoking during negative mood induction
    Cynthia A Conklin
    Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Abnorm Psychol 114:153-64. 2005
    ..Contrary to expectation, smoking did not attenuate negative affect. However, negative mood induction subsequently quickened latency to smoke and increased number of puffs consumed ad lib...
  51. ncbi Reduced nicotine reward in obesity: cross-comparison in human and mouse
    Julie A Blendy
    Department of Pharmacology, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Psychopharmacology (Berl) 180:306-15. 2005
    ..Tobacco use and obesity lead to significant morbidity and mortality...
  52. ncbi Instructions about nicotine dose influence acute responses to nasal spray
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:1051-60. 2004
    ....
  53. ncbi Sex differences in the influence of nicotine dose instructions on the reinforcing and self-reported rewarding effects of smoking
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 184:600-7. 2006
    ..Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions)...
  54. ncbi Environmental stimuli promote the acquisition of nicotine self-administration in rats
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 163:230-7. 2002
    ....
  55. ncbi Translational research in medication development for nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 6:746-62. 2007
    ....
  56. ncbi Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...
  57. ncbi Translating basic science to improve pharmacotherapy for nicotine dependence
    Jennifer M Phillips
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nicotine Tob Res 9:S583-98. 2007
    ....
  58. ncbi Effects of topiramate on smoking in patients with schizoaffective disorder, bipolar type
    Andrea H Weinberger
    J Clin Psychopharmacol 28:247-8. 2008