Guy Perkins

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Electron tomography of mitochondria after the arrest of protein import associated with Tom19 depletion
    G A Perkins
    National Center for Microscopy and Imaging Research, and Department of Neurosciences, University of California San Diego, La Jolla 92093 0608, USA
    Eur J Cell Biol 80:139-50. 2001
  2. pmc The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites
    M Lutter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    BMC Cell Biol 2:22. 2001
  3. pmc Three-dimensional structure of the gap junction connexon
    G Perkins
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0322, USA
    Biophys J 72:533-44. 1997
  4. pmc Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves
    Guy A Perkins
    National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0608, USA
    J Struct Biol 161:469-80. 2008
  5. pmc PKA, PKC, and AKAP localization in and around the neuromuscular junction
    G A Perkins
    Department of Neurosciences and the National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093 0608, USA
    BMC Neurosci 2:17. 2001
  6. pmc New insights into mitochondrial structure during cell death
    Guy Perkins
    National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, 92093 0608, USA
    Exp Neurol 218:183-92. 2009
  7. pmc Mitochondrial configurations in peripheral nerve suggest differential ATP production
    Guy A Perkins
    National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA 92093 0608, United States
    J Struct Biol 173:117-27. 2011
  8. ncbi request reprint Recent structural insight into mitochondria gained by microscopy
    G A Perkins
    Department of Biology, San Diego State University, CA 92182 4614, USA
    Micron 31:97-111. 2000
  9. ncbi request reprint Electron tomography of neuronal mitochondria: three-dimensional structure and organization of cristae and membrane contacts
    G Perkins
    Biology Department, San Diego State University, California 92115, USA
    J Struct Biol 119:260-72. 1997
  10. doi request reprint Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa
    Pam R Taub
    School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Clin Sci (Lond) 125:383-9. 2013

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Electron tomography of mitochondria after the arrest of protein import associated with Tom19 depletion
    G A Perkins
    National Center for Microscopy and Imaging Research, and Department of Neurosciences, University of California San Diego, La Jolla 92093 0608, USA
    Eur J Cell Biol 80:139-50. 2001
    ....
  2. pmc The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites
    M Lutter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    BMC Cell Biol 2:22. 2001
    ..Once associated with mitochondria, truncated Bid (tBid) causes the potent release of cytochrome c, endonuclease G, and smac...
  3. pmc Three-dimensional structure of the gap junction connexon
    G Perkins
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0322, USA
    Biophys J 72:533-44. 1997
    ..The implication of our hemichannel structure is discussed in relation to the in vivo state of unpaired connexons, which have been shown to exist in the plasma membrane...
  4. pmc Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves
    Guy A Perkins
    National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0608, USA
    J Struct Biol 161:469-80. 2008
    ..Interactions between cytoskeleton, membranes, and extracellular matrix associations in the paranodal region are likely critical not only for scaffolding, but also for intracellular and extracellular communication...
  5. pmc PKA, PKC, and AKAP localization in and around the neuromuscular junction
    G A Perkins
    Department of Neurosciences and the National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093 0608, USA
    BMC Neurosci 2:17. 2001
    ..We found previously that a new class of AKAPs, dual-specific AKAPs, denoted D-AKAP1 and D-AKAP2, bind to RIalpha in addition to the RII subunits...
  6. pmc New insights into mitochondrial structure during cell death
    Guy Perkins
    National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, 92093 0608, USA
    Exp Neurol 218:183-92. 2009
    ....
  7. pmc Mitochondrial configurations in peripheral nerve suggest differential ATP production
    Guy A Perkins
    National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA 92093 0608, United States
    J Struct Biol 173:117-27. 2011
    ..The greater density of condensed mitochondria in the PNS axoplasm and in particular at the PNP suggests a need for these organelles to operate at a high workload of ATP production...
  8. ncbi request reprint Recent structural insight into mitochondria gained by microscopy
    G A Perkins
    Department of Biology, San Diego State University, CA 92182 4614, USA
    Micron 31:97-111. 2000
    ..Sometimes these advances have produced surprising results and more often than not, they have challenged current conceptions of how mitochondria work...
  9. ncbi request reprint Electron tomography of neuronal mitochondria: three-dimensional structure and organization of cristae and membrane contacts
    G Perkins
    Biology Department, San Diego State University, California 92115, USA
    J Struct Biol 119:260-72. 1997
    ..In addition, a close association was observed between endoplasmic reticulum membranes and the outer mitochondrial membrane, consistent with the reported mechanism of transport of certain lipids into the mitochondrion...
  10. doi request reprint Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa
    Pam R Taub
    School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Clin Sci (Lond) 125:383-9. 2013
    ..These initial results warrant further rigorous investigation, since the use of ERC (or pure epicatechin) may represent a safe and novel means of improving muscle function...
  11. pmc Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization
    Ryuji Yamaguchi
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Mol Cell 31:557-69. 2008
    ..Thus, apoptosis requires a subtle form of Opa1-dependent crista remodeling that is induced by BH3-only proteins and Bax/Bak but independent of MOMP...
  12. ncbi request reprint Transform-based backprojection for volume reconstruction of large format electron microscope tilt series
    Albert Lawrence
    National Center for Microscopy and Imaging Research, Center for Research in Biological Structure, University of California at San Diego, La Jolla, CA 92093 0608, USA
    J Struct Biol 154:144-67. 2006
    ..We will also report on new reconstruction codes and describe our results using these codes...
  13. ncbi request reprint Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell 111:331-42. 2002
    ..We conclude that mitochondrial protein release in apoptosis can be mediated by supramolecular openings in the outer mitochondrial membrane, promoted by BH3/Bax/lipid interaction and directly inhibited by Bcl-x(L)...
  14. ncbi request reprint A thermodynamic model describing the nature of the crista junction: a structural motif in the mitochondrion
    Christian Renken
    Department of Biology, San Diego State University, San Diego, CA 92185, USA
    J Struct Biol 138:137-44. 2002
    ..We conclude that the crista junction exists predominantly as a circular junction, with other shapes as exceptions made possible by specific characteristics of the lipid bilayer...
  15. pmc Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1
    Ryuji Yamaguchi
    Burnham Institute for Medical Science, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1787:963-72. 2009
    ..We review the recent literature pertaining to the coordinated release of cytochrome c during cell death...
  16. pmc Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis
    Sandra E Wiley
    Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA
    EMBO Mol Med 5:904-18. 2013
    ..Treatment with the sulphydryl anti-oxidant N-acetylcysteine reversed the abnormalities in the Miner1 deficient cells, suggesting that sulphydryl reducing agents should be explored as a treatment for this rare genetic disease...
  17. pmc Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise
    Israel Ramirez-Sanchez
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cardiovasc Pharmacol 60:429-38. 2012
    ..Thus, the use of Epi may represent a safe and novel means to stimulate myocardial angiogenesis...
  18. pmc Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster
    Guy Perkins
    National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e45344. 2012
    ....
  19. doi request reprint Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa
    Pam R Taub
    School of Medicine, University of California, San Diego, California, USA
    Clin Transl Sci 5:43-7. 2012
    ..Future controlled studies are warranted using Epi-rich cocoa (or pure Epi) to translate improved mitochondrial structure into enhanced cardiac and/or SkM muscle function...
  20. pmc NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum
    L J Huang
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0654, USA
    J Cell Biol 145:951-9. 1999
    ..This represents the first example of a differentially targeted AKAP and adds an additional level of complexity to the PKA signaling network...
  21. pmc Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein
    L Wang
    Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093 0654, USA
    Proc Natl Acad Sci U S A 98:3220-5. 2001
    ..D-AKAP2 from all three species is highly enriched in mitochondria. The mitochondrial localization and the presence of RGS domains in D-AKAP2 may have important implications for its function in PKA and G protein signal transduction...
  22. ncbi request reprint Neuronal expression of a functional receptor for the C5a complement activation fragment
    J Caguioa
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 166:4154-62. 2001
    ..These results have implications for understanding the role of neuronal C5aR receptors in normal neuronal development, neuronal homeostasis, and neuroinflammatory conditions such as Alzheimer's disease...
  23. ncbi request reprint Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications
    Guy A Perkins
    Department of Neurosciences and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, USA
    Mol Vis 9:60-73. 2003
    ..Therefore, we investigated the oxidative metabolism and three-dimensional membrane architecture of mouse rod and cone inner segment mitochondria...
  24. ncbi request reprint Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis
    Mei G Sun
    Department of Biology, San Diego State University, San Diego, CA 92182 4614, USA
    Nat Cell Biol 9:1057-65. 2007
    ..Swelling occurs only late in apoptosis after release of cytochrome c and loss of the mitochondrial membrane potential...
  25. pmc Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses
    Jerry E Johnson
    Department of Natural Sciences, University of Houston Downtown, Houston, TX, USA
    Mol Vis 13:887-919. 2007
    ..The goal of our structural and functional studies was to determine the spatiotemporal regulation of ATP and Ca2+ dynamics in rod spherules and cone pedicles...
  26. ncbi request reprint Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells
    Won Kyu Ju
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 48:2145-51. 2007
    ..The purpose of this study was to determine whether elevated hydrostatic pressure induces mitochondrial fission and dysfunction in cultured retinal ganglion cells...
  27. pmc Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
    Mark J Barsoum
    Apoptosis and Cell Death Program, Burnham Institute for Medical Research, La Jolla, CA, USA
    EMBO J 25:3900-11. 2006
    ..Importantly, NO-induced neuronal cell death was mitigated by Mfn1 and Drp1(K38A). Thus, persistent mitochondrial fission may play a causal role in NO-mediated neurotoxicity...
  28. pmc Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
    Lihua He
    College of Optometry, Department of Biology, University of Houston, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 100:1022-7. 2003
    ..These results have relevance for therapies in a wide variety of progressive retinal and neuronal degenerations where Ca(2+) overload, lead exposure, andor mitochondrial dysfunction occur...
  29. ncbi request reprint Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
    Jean Ehrland Ricci
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell 117:773-86. 2004
    ..Therefore, caspase cleavage of NDUFS1 is required for several mitochondrial changes associated with apoptosis...
  30. ncbi request reprint Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels
    Ella Bossy-Wetzel
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Neuron 41:351-65. 2004
    ..Thus, these data establish a new form of crosstalk between NO and Zn2+ apoptotic signal transduction pathways that may contribute to neurodegeneration...
  31. pmc Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve
    Won Kyu Ju
    Department of Ophthalmology, Hamilton Glaucoma Center, School of Medicine, University of California San Diego, La Jolla, California 92037 0946, USA
    Invest Ophthalmol Vis Sci 49:4903-11. 2008
    ..To determine whether elevation of intraocular pressure (IOP) triggers mitochondrial fission and ultrastructural changes and alters optic atrophy type 1 (OPA1) expression and distribution in the optic nerve (ON) of glaucomatous DBA/2J mice...