Research Topics
Genomes and GenesSpecies | Diana O PerkinsSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophreniaD O Perkins
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Mol Psychiatry 10:69-78. 2005....- microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorderDiana O Perkins
Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
Genome Biol 8:R27. 2007..They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer... - Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysisDiana O Perkins
Department of Psychiatry, University of North Carolina School of Medicine, CB 7160, Chapel Hill, NC 27599, USA
Am J Psychiatry 162:1785-804. 2005..The authors reviewed the literature on the association of duration of untreated psychosis with symptom severity at first treatment contact and with treatment outcomes and conducted a meta-analysis examining these relationships... - Evaluating and treating the prodromal stage of schizophreniaDiana O Perkins
Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7106, Chapel Hill, NC 27599, USA
Curr Psychiatry Rep 6:289-95. 2004..Pharmacologic intervention targeting the prodromal symptoms is not recommended, given the uncertain risk-benefit ratio... - Predictors of treatment discontinuation and medication nonadherence in patients recovering from a first episode of schizophrenia, schizophreniform disorder, or schizoaffective disorder: a randomized, double-blind, flexible-dose, multicenter studyDiana O Perkins
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, USA
J Clin Psychiatry 69:106-13. 2008..To evaluate predictors of treatment discontinuation against medical advice and poor medication adherence among first-episode patients treated with olanzapine, quetiapine, or risperidone... - Predictors of noncompliance in patients with schizophreniaDiana O Perkins
University of North Carolina Chapel Hill, Department of Psychiatry, Chapel Hill 27599 7160, USA
J Clin Psychiatry 63:1121-8. 2002..The health belief model views noncompliance as a decision made by the patient, arrived at after weighing the perceived risks and benefits of treatment... - Clinical trials in schizophrenia with results for the real worldDiana O Perkins
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
CNS Spectr 11:9-13. 2006..In assessing the practical utility of results from the CATIE study, much can be learned on how to shape future studies of effectiveness so as to better generate data that are applicable to the "real world.".. - Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychoticT Scott Stroup
Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
Am J Psychiatry 163:611-22. 2006..This randomized, double-blind study compared olanzapine, quetiapine, risperidone, and ziprasidone in patients who had just discontinued a different atypical antipsychotic... - Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE studyMarvin S Swartz
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Am J Psychiatry 164:428-36. 2007..This study examined the relative effects of the second-generation antipsychotic drugs and an older representative agent on psychosocial functioning in patients with chronic schizophrenia... - Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episodeDiana O Perkins
Department of Psychiatry, C.B.# 7160, University of North Carolina School of Medicine, Chapel Hill, 27599-7160, USA
Schizophr Res 83:53-63. 2006.... - Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment StudyKeith A Hawkins
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Schizophr Res 105:1-9. 2008..We investigated whether conversion to psychosis and/or olanzapine altered the neuropsychological course of subjects within the first-ever double blind medication study of the putative schizophrenia first episode prodrome... - The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trialDavid L Penn
University of North Carolina Chapel Hill, Department of Psychology, Davie Hall, Chapel Hill, NC 27599 3270, USA
Schizophr Res 115:17-23. 2009..Greater improvement in emotion perception at 2 months was significantly predicted by lower baseline emotion perception and higher baseline neurocognitive functioning, and marginally predicted by less time on an antipsychotic... - Efficacy and tolerability of olanzapine, quetiapine, and risperidone in the treatment of early psychosis: a randomized, double-blind 52-week comparisonJoseph P McEvoy
Duke University Medical Center, Durham, NC, USA
Am J Psychiatry 164:1050-60. 2007.... - Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE TrialRichard S E Keefe
Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
Arch Gen Psychiatry 64:633-47. 2007..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined... - Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosisLarry J Seidman
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Arch Gen Psychiatry 67:578-88. 2010..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions... - Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophreniaRobert A Rosenheck
University of North Carolina, Chapel Hill, USA
Am J Psychiatry 163:2080-9. 2006..Second-generation antipsychotics have largely replaced first-generation antipsychotics for the treatment of schizophrenia, but a large-scale cost/effectiveness analysis has not been attempted... - Assessment of social judgments and complex mental states in the early phases of psychosisShannon M Couture
University of North Carolina at Chapel Hill, Department of Psychology, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
Schizophr Res 100:237-41. 2008..Social cognition plays an important role in the functioning of individuals with psychosis. In this study, we explored two areas of social cognition not previously investigated early in the course of psychosis... - Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal StudyScott W Woods
PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
Schizophr Bull 35:894-908. 2009..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)... - Emotion perception and social skill over the course of psychosis: a comparison of individuals "at-risk" for psychosis and individuals with early and chronic schizophrenia spectrum illnessAmy E Pinkham
Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
Cogn Neuropsychiatry 12:198-212. 2007.... - Effectiveness of antipsychotic drugs in patients with chronic schizophreniaJeffrey A Lieberman
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
N Engl J Med 353:1209-23. 2005..We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study... - Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophreniaS Kristian Hill
Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Int Neuropsychol Soc 14:209-21. 2008.... - Double-blind, placebo-controlled investigation of amantadine for weight loss in subjects who gained weight with olanzapineKaren A Graham
Department of Psychiatry, CB 7160, UNC Neurosciences Hospital, Chapel Hill, NC 27599 7160, USA
Am J Psychiatry 162:1744-6. 2005..This study sought to determine if amantadine affects weight gain in psychiatric patients taking olanzapine... - Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of SchizophreniaHenry A Nasrallah
Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
J Clin Psychiatry 70:4-46. 2009..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research... - Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictorsJ Leserman
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599-7160, USA
Psychol Med 32:1059-73. 2002.... - The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognitionJames J Crowley
Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition... - Metabolic profiles of second-generation antipsychotics in early psychosis: findings from the CAFE studyJayendra K Patel
Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA
Schizophr Res 111:9-16. 2009..To further define the metabolic profiles of second-generation antipsychotics during the treatment of young patients with early psychosis, with a view to better inform prescribing clinicians... - No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognitionThomas I Konneker
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 153:1115-7. 2010..67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons... - Social skill and social cognition in adolescents at genetic risk for psychosisClare M Gibson
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
Schizophr Res 122:179-84. 2010..Furthermore, the findings add to the current body of literature that indicates that social skill impairments are related to schizophrenia vulnerability... - Psychological well-being among individuals with first-episode psychosisSarah R Uzenoff
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
Early Interv Psychiatry 4:174-81. 2010..This study examined predictors of psychological well-being among individuals with first-episode psychosis (FEP) and compared it to a non-clinical college-aged comparison group... - The graduated recovery intervention program for first episode psychosis: treatment development and preliminary dataEvan J Waldheter
Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
Community Ment Health J 44:443-55. 2008..The retention rate of 67%, however, suggests the need for protocol modifications to improve engagement. Initial data on the efficacy of GRIP are encouraging, although the study design precludes more robust conclusions at this time... - A preliminary trial of adherence-coping-education (ACE) therapy for early psychosisSarah R Uzenoff
Departments of Psychology, University of North Carolina, Chapel Hill, North Carolina, USA
J Nerv Ment Dis 196:572-5. 2008..These results lend initial support for the feasibility of ACE Therapy, and suggest that it may have promise in facilitating recovery for individuals recovering from an initial psychotic episode... - Systematic discovery of the grammar of translational inhibition by RNA hairpinsClark Jeffries
Renaissance Computing Institute and School of Pharmacy, Campus Box 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
J Theor Biol 241:205-15. 2006..The result is hypothesis generation. Examples of and predictions from this approach are given in the context of apoptosis. Also discussed is application of the algorithm to rational drug design from a new development platform... - Recognizing and responding to early psychosis: a qualitative analysis of individual narrativesAbigail M Judge
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
Psychiatr Serv 59:96-9. 2008..The ways in which individuals recognize and respond to emerging psychotic illness remain poorly understood. This retrospective study explored when and how individuals recognized changes in themselves and responded to these changes... - Psychosocial treatment for first-episode psychosis: a research updateDavid L Penn
Department of Psychology, CB 3270, Davie Hall, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 3270, USA
Am J Psychiatry 162:2220-32. 2005..This article reviews research on psychosocial treatment for first-episode psychosis... - Brief evaluation of medication influences and beliefs: development and testing of a brief scale for medication adherenceChristian R Dolder
Department of Psychiatry, University of California, San Diego, CA, USA
J Clin Psychopharmacol 24:404-9. 2004..CONCLUSION: The BEMIB represents a promising scale for identifying patients more likely to be nonadherent to their medications... - Effect of olanzapine on body composition and energy expenditure in adults with first-episode psychosisKaren A Graham
Department of Psychiatry, University of North Carolina at Chapel Hill, 27599, USA
Am J Psychiatry 162:118-23. 2005.... - Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processingRajendra A Morey
Duke-UNC Brain Imaging and Analysis Center, Durham, NC, USA
Arch Gen Psychiatry 62:254-62. 2005.... - Nuclear and cytoplasmic localization of neural stem cell microRNAsClark D Jeffries
Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
RNA 17:675-86. 2011..That is, in addition to the seed sequence, 3' sequence similarity criteria identify families of mature miRNAs with consistently high nuclear or cytoplasmic expression... - Pharmacological management of first-episode schizophrenia and related nonaffective psychosesDaniel W Bradford
University of North Carolina School of Medicine, Neurosciences Hospital, Chapel Hill, North Carolina 27599-7160, USA
Drugs 63:2265-83. 2003..Future research will further define their roles in treatment and hopefully identify targets for prevention of first-episode schizophrenia... - Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodromeScott W Woods
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 54:453-64. 2003..Extrapyramidal symptoms with olanzapine were minimal and similar to those with placebo. Future research over the longer term with more patients will be needed before recommendations can be made regarding routine treatment... - Additional layers of gene regulatory complexity from recently discovered microRNA mechanismsClark D Jeffries
Renaissance Computing Institute and Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB 360, Chapel Hill, NC 27599, USA
Int J Biochem Cell Biol 42:1236-42. 2010.... - Fetal brain development of twins assessed in utero by ultrasound: implications for schizophreniaJ H Gilmore
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Schizophr Res 19:141-9. 1996..These results indicate that in monozygotic twins, brain development is not identical. This difference in brain development may contribute to the observed concordance rates in monozygotic twins with schizophrenia... - Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDSJ Leserman
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Am J Psychiatry 157:1221-8. 2000..This study examined prospectively the effects of stressful events, depressive symptoms, social support, coping methods, and cortisol levels on progression of HIV-1 infection... - Progression to AIDS: the effects of stress, depressive symptoms, and social supportJ Leserman
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Psychosom Med 61:397-406. 1999..We examined the effects of stress, depressive symptoms, and social support on the progression of HIV infection... - High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune statusJ M Petitto
Department of Psychiatry, University of Florida College of Medicine, Gainesville, USA
Behav Med 25:143-51. 2000..These data suggest that severe stress in combination with high glucocorticoid activity may modify select parameters of immune status in HIV-infected men... - Characterizing and dating the onset of symptoms in psychotic illness: the Symptom Onset in Schizophrenia (SOS) inventoryD O Perkins
Department of Psychiatry, University of North Carolina, CB 7160, Chapel Hill, NC 27599, USA
Schizophr Res 44:1-10. 2000..Further study is underway to evaluate other psychometric properties of the SOS, including test-retest reliability and predictive validity... - Evaluation of a multi-element treatment center for early psychosis in the United StatesSarah R Uzenoff
Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
Soc Psychiatry Psychiatr Epidemiol 47:1607-15. 2012..This study is a naturalistic, prospective 1-year follow-up of an early psychosis cohort treated in one of the first US-based multi-element treatment centers... - Gene processing control loops suggested by sequencing, splicing, and RNA foldingClark D Jeffries
Eshelman School of Pharmacy and Renaissance Computing Institute, University of North Carolina at Chapel Hill, NC, USA
BMC Bioinformatics 11:602. 2010..We propose that analogous hairpins from RNA molecules that function as part of the spliceosome might also be the source of small, regulatory RNAs (somewhat smaller than miRNAs)... - Discovering collectively informative descriptors from high-throughput experimentsClark D Jeffries
Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA
BMC Bioinformatics 10:431. 2009..Combining information from these studies can increase the reliability and generalizability of results and also yield new insights that guide future research... - Implications for the neural basis of social cognition for the study of schizophreniaAmy E Pinkham
Department of Psychology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-3270, USA
Am J Psychiatry 160:815-24. 2003..CONCLUSIONS: These parallels might help to better elucidate the underlying mechanisms for social cognitive and social behavioral impairments in schizophrenia as well as provide potential targets for treatment and drug development... - Folded RNA from an intron of one gene might inhibit expression of a counteracting geneClark Jeffries
Department of Psychiatry, University of North Carolina at Chapel Hill, USA
In Silico Biol 5:407-13. 2005.... - Impaired neural synchrony in the theta frequency range in adolescents at familial risk for schizophreniaFranc C L Donkers
Department of Psychiatry, University of North Carolina at Chapel Hill Chapel Hill, NC, USA
Front Psychiatry 2:51. 2011..Longitudinal assessments will have to determine their predictive value for illness onset in populations at FR for psychotic illness... - Olanzapine and haloperidol in first episode psychosis: two-year dataA I Green
Department of Psychiatry, Dartmouth Medical School, DHMC, Lebanon, NH 03756, USA
Schizophr Res 86:234-43. 2006..The data from this study suggest some clinical benefits for olanzapine as compared to haloperidol in first episode patients, which must be weighed against those adverse effects that are more likely with olanzapine... - Assessing clinical and functional outcomes in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trialMarvin S Swartz
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3173, Durham, NC 27710, USA
Schizophr Bull 29:33-43. 2003.... - Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliabilityTandy J Miller
Yale University, New Haven, CT, USA
Schizophr Bull 29:703-15. 2003..It also presents data suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop... - Practice guideline for the treatment of patients with schizophrenia, second editionAnthony F Lehman
Am J Psychiatry 161:1-56. 2004 - North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia researchJean Addington
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
Schizophr Bull 33:665-72. 2007.... - A longitudinal study of neurocognitive function in individuals at-risk for psychosisRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Schizophr Res 88:26-35. 2006..The time course and predictive value of cognitive deficits in the development of psychosis has not been established... - Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparisonRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Psychiatry 164:1061-71. 2007..The authors sought to compare the effects of olanzapine, quetiapine, and risperidone on neurocognitive function in patients with early psychosis... - Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal populationRalph E Hoffman
Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
Br J Psychiatry 191:355-6. 2007..no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment... - Social functioning in individuals at clinical high risk for psychosisJean Addington
Department of Psychiatry, University of Toronto, Toronto, Canada
Schizophr Res 99:119-24. 2008.... - Facial affect recognition in individuals at clinical high risk for psychosisJean Addington
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
Br J Psychiatry 192:67-8. 2008..Deficits in facial affect recognition appear to be present before the onset of psychosis and may be a vulnerability marker... - Baseline neurocognitive deficits in the CATIE schizophrenia trialRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 31:2033-46. 2006..Multiple analyses suggested that a broad cognitive deficit characterizes this sample. These deficits are modestly related to negative symptoms and essentially independent of positive symptom severity... - Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatmentJoseph P McEvoy
Clinical Research Service, John Umstead Hospital, 1003 12th St, Bldg 32, Butner, NC 27705, USA
Am J Psychiatry 163:600-10. 2006.... - Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidolRobert B Zipursky
Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Br J Psychiatry 187:537-43. 2005..Substantial weight gain is common with many atypical antipsychotics... - Neuroprotection: a therapeutic strategy to prevent deterioration associated with schizophreniaJeffrey A Lieberman
Columbia University College of Physicians and Surgeons, New York, NY, USA
CNS Spectr 12:1-13; quiz 14. 2007..Finally, L. Fredrik Jarskog, MD, focuses on the neurobiology of functional progression in schizophrenia as well as pharmacology and the potential for neuroprotection... - Single-voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampusTalaignair N Venkatraman
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
NMR Biomed 19:484-91. 2006..Simple calculations suggest that more than 200 subjects would be needed to detect a 5% difference in NAA between patients and controls... - Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigationTeri T Baldewicz
Department of Clinical Operations, Inveresk, Cary, North Carolina, USA
AIDS Behav 8:345-55. 2004..Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments...
Research Grants
- INTERVENING AT PRODROMAL STAGES OF PSYCHOSISDiana Perkins; Fiscal Year: 2004..The results of this study will guide the design of future intervention studies and are anticipated to provide pilot data for an R01 testing novel treatment strategies with patients in the prodromal stage of psychotic illness. ..
- Enhancing the Prospective Prediction of PsychosisDiana Perkins; Fiscal Year: 2007..Each site has proven its ability to recruit prodromal patients in a previous collaboration. ..