Diana O Perkins

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Evaluating and treating the prodromal stage of schizophrenia
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7106, Chapel Hill, NC 27599, USA
    Curr Psychiatry Rep 6:289-95. 2004
  2. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
  3. ncbi request reprint Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis
    Diana O Perkins
    Department of Psychiatry, University of North Carolina School of Medicine, CB 7160, Chapel Hill, NC 27599, USA
    Am J Psychiatry 162:1785-804. 2005
  4. ncbi request reprint Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia
    D O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Mol Psychiatry 10:69-78. 2005
  5. ncbi request reprint Clinical trials in schizophrenia with results for the real world
    Diana O Perkins
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
    CNS Spectr 11:9-13. 2006
  6. ncbi request reprint Predictors of treatment discontinuation and medication nonadherence in patients recovering from a first episode of schizophrenia, schizophreniform disorder, or schizoaffective disorder: a randomized, double-blind, flexible-dose, multicenter study
    Diana O Perkins
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, USA
    J Clin Psychiatry 69:106-13. 2008
  7. ncbi request reprint Predictors of noncompliance in patients with schizophrenia
    Diana O Perkins
    University of North Carolina Chapel Hill, Department of Psychiatry, Chapel Hill 27599 7160, USA
    J Clin Psychiatry 63:1121-8. 2002
  8. ncbi request reprint Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic
    T Scott Stroup
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 163:611-22. 2006
  9. ncbi request reprint Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Psychiatry 164:428-36. 2007
  10. ncbi request reprint Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode
    Diana O Perkins
    Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, 27599 7160, USA
    Schizophr Res 83:53-63. 2006

Research Grants

  1. INTERVENING AT PRODROMAL STAGES OF PSYCHOSIS
    Diana Perkins; Fiscal Year: 2004
  2. Enhancing the Prospective Prediction of Psychosis
    Diana Perkins; Fiscal Year: 2007

Detail Information

Publications71

  1. ncbi request reprint Evaluating and treating the prodromal stage of schizophrenia
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7106, Chapel Hill, NC 27599, USA
    Curr Psychiatry Rep 6:289-95. 2004
    ..Pharmacologic intervention targeting the prodromal symptoms is not recommended, given the uncertain risk-benefit ratio...
  2. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
    ..They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer...
  3. ncbi request reprint Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis
    Diana O Perkins
    Department of Psychiatry, University of North Carolina School of Medicine, CB 7160, Chapel Hill, NC 27599, USA
    Am J Psychiatry 162:1785-804. 2005
    ..The authors reviewed the literature on the association of duration of untreated psychosis with symptom severity at first treatment contact and with treatment outcomes and conducted a meta-analysis examining these relationships...
  4. ncbi request reprint Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia
    D O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Mol Psychiatry 10:69-78. 2005
    ....
  5. ncbi request reprint Clinical trials in schizophrenia with results for the real world
    Diana O Perkins
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
    CNS Spectr 11:9-13. 2006
    ..In assessing the practical utility of results from the CATIE study, much can be learned on how to shape future studies of effectiveness so as to better generate data that are applicable to the "real world."..
  6. ncbi request reprint Predictors of treatment discontinuation and medication nonadherence in patients recovering from a first episode of schizophrenia, schizophreniform disorder, or schizoaffective disorder: a randomized, double-blind, flexible-dose, multicenter study
    Diana O Perkins
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, USA
    J Clin Psychiatry 69:106-13. 2008
    ..To evaluate predictors of treatment discontinuation against medical advice and poor medication adherence among first-episode patients treated with olanzapine, quetiapine, or risperidone...
  7. ncbi request reprint Predictors of noncompliance in patients with schizophrenia
    Diana O Perkins
    University of North Carolina Chapel Hill, Department of Psychiatry, Chapel Hill 27599 7160, USA
    J Clin Psychiatry 63:1121-8. 2002
    ..The health belief model views noncompliance as a decision made by the patient, arrived at after weighing the perceived risks and benefits of treatment...
  8. ncbi request reprint Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic
    T Scott Stroup
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 163:611-22. 2006
    ..This randomized, double-blind study compared olanzapine, quetiapine, risperidone, and ziprasidone in patients who had just discontinued a different atypical antipsychotic...
  9. ncbi request reprint Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Psychiatry 164:428-36. 2007
    ..This study examined the relative effects of the second-generation antipsychotic drugs and an older representative agent on psychosocial functioning in patients with chronic schizophrenia...
  10. ncbi request reprint Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode
    Diana O Perkins
    Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, 27599 7160, USA
    Schizophr Res 83:53-63. 2006
    ..Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, treatment with typical versus atypical antipsychotic and medication side effects...
  11. doi request reprint Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment Study
    Keith A Hawkins
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Res 105:1-9. 2008
    ..We investigated whether conversion to psychosis and/or olanzapine altered the neuropsychological course of subjects within the first-ever double blind medication study of the putative schizophrenia first episode prodrome...
  12. ncbi request reprint Efficacy and tolerability of olanzapine, quetiapine, and risperidone in the treatment of early psychosis: a randomized, double-blind 52-week comparison
    Joseph P McEvoy
    Duke University Medical Center, Durham, NC, USA
    Am J Psychiatry 164:1050-60. 2007
    ....
  13. ncbi request reprint Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
    ..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
  14. pmc The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trial
    David L Penn
    University of North Carolina Chapel Hill, Department of Psychology, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Schizophr Res 115:17-23. 2009
    ..Greater improvement in emotion perception at 2 months was significantly predicted by lower baseline emotion perception and higher baseline neurocognitive functioning, and marginally predicted by less time on an antipsychotic...
  15. pmc Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis
    Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Gen Psychiatry 67:578-88. 2010
    ..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions...
  16. ncbi request reprint Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia
    Robert A Rosenheck
    University of North Carolina, Chapel Hill, USA
    Am J Psychiatry 163:2080-9. 2006
    ..Second-generation antipsychotics have largely replaced first-generation antipsychotics for the treatment of schizophrenia, but a large-scale cost/effectiveness analysis has not been attempted...
  17. pmc Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study
    Scott W Woods
    PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Bull 35:894-908. 2009
    ..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...
  18. pmc Assessment of social judgments and complex mental states in the early phases of psychosis
    Shannon M Couture
    University of North Carolina at Chapel Hill, Department of Psychology, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Schizophr Res 100:237-41. 2008
    ..Social cognition plays an important role in the functioning of individuals with psychosis. In this study, we explored two areas of social cognition not previously investigated early in the course of psychosis...
  19. ncbi request reprint Emotion perception and social skill over the course of psychosis: a comparison of individuals "at-risk" for psychosis and individuals with early and chronic schizophrenia spectrum illness
    Amy E Pinkham
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    Cogn Neuropsychiatry 12:198-212. 2007
    ....
  20. ncbi request reprint Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    Jeffrey A Lieberman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    N Engl J Med 353:1209-23. 2005
    ..We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study...
  21. ncbi request reprint Double-blind, placebo-controlled investigation of amantadine for weight loss in subjects who gained weight with olanzapine
    Karen A Graham
    Department of Psychiatry, CB 7160, UNC Neurosciences Hospital, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:1744-6. 2005
    ..This study sought to determine if amantadine affects weight gain in psychiatric patients taking olanzapine...
  22. ncbi request reprint Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of Schizophrenia
    Henry A Nasrallah
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 70:4-46. 2009
    ..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...
  23. pmc Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Int Neuropsychol Soc 14:209-21. 2008
    ....
  24. ncbi request reprint Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Psychol Med 32:1059-73. 2002
    ....
  25. pmc Altered fronto-limbic activity in children and adolescents with familial high risk for schizophrenia
    Sarah J Hart
    Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Psychiatry Res 212:19-27. 2013
    ....
  26. doi request reprint Evaluation of a multi-element treatment center for early psychosis in the United States
    Sarah R Uzenoff
    Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
    Soc Psychiatry Psychiatr Epidemiol 47:1607-15. 2012
    ..This study is a naturalistic, prospective 1-year follow-up of an early psychosis cohort treated in one of the first US-based multi-element treatment centers...
  27. doi request reprint Metabolic profiles of second-generation antipsychotics in early psychosis: findings from the CAFE study
    Jayendra K Patel
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Schizophr Res 111:9-16. 2009
    ..To further define the metabolic profiles of second-generation antipsychotics during the treatment of young patients with early psychosis, with a view to better inform prescribing clinicians...
  28. pmc Social skill and social cognition in adolescents at genetic risk for psychosis
    Clare M Gibson
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Schizophr Res 122:179-84. 2010
    ..Furthermore, the findings add to the current body of literature that indicates that social skill impairments are related to schizophrenia vulnerability...
  29. pmc No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition
    Thomas I Konneker
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1115-7. 2010
    ..67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons...
  30. doi request reprint The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008
    ..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition...
  31. pmc The graduated recovery intervention program for first episode psychosis: treatment development and preliminary data
    Evan J Waldheter
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    Community Ment Health J 44:443-55. 2008
    ..The retention rate of 67%, however, suggests the need for protocol modifications to improve engagement. Initial data on the efficacy of GRIP are encouraging, although the study design precludes more robust conclusions at this time...
  32. doi request reprint Psychological well-being among individuals with first-episode psychosis
    Sarah R Uzenoff
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Early Interv Psychiatry 4:174-81. 2010
    ..This study examined predictors of psychological well-being among individuals with first-episode psychosis (FEP) and compared it to a non-clinical college-aged comparison group...
  33. doi request reprint Between-site reliability of startle prepulse inhibition across two early psychosis consortia
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Neuroreport 24:626-30. 2013
    ..In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites. ..
  34. doi request reprint Recognizing and responding to early psychosis: a qualitative analysis of individual narratives
    Abigail M Judge
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Psychiatr Serv 59:96-9. 2008
    ..The ways in which individuals recognize and respond to emerging psychotic illness remain poorly understood. This retrospective study explored when and how individuals recognized changes in themselves and responded to these changes...
  35. ncbi request reprint Psychosocial treatment for first-episode psychosis: a research update
    David L Penn
    Department of Psychology, CB 3270, Davie Hall, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Am J Psychiatry 162:2220-32. 2005
    ..This article reviews research on psychosocial treatment for first-episode psychosis...
  36. ncbi request reprint Systematic discovery of the grammar of translational inhibition by RNA hairpins
    Clark Jeffries
    Renaissance Computing Institute and School of Pharmacy, Campus Box 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Theor Biol 241:205-15. 2006
    ..The result is hypothesis generation. Examples of and predictions from this approach are given in the context of apoptosis. Also discussed is application of the algorithm to rational drug design from a new development platform...
  37. doi request reprint A preliminary trial of adherence-coping-education (ACE) therapy for early psychosis
    Sarah R Uzenoff
    Departments of Psychology, University of North Carolina, Chapel Hill, North Carolina, USA
    J Nerv Ment Dis 196:572-5. 2008
    ..These results lend initial support for the feasibility of ACE Therapy, and suggest that it may have promise in facilitating recovery for individuals recovering from an initial psychotic episode...
  38. pmc Differences in subcortical structures in young adolescents at familial risk for schizophrenia: a preliminary study
    Michael K Dougherty
    University of North Carolina School of Medicine, Department of Psychiatry, Chapel Hill, NC 27599 7160, USA
    Psychiatry Res 204:68-74. 2012
    ..These results suggest that relatives of individuals with schizophrenia exhibit structural abnormalities in the subcortex as early as pre-adolescence, which may reflect altered neurodevelopment of these regions...
  39. pmc Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing
    Rajendra A Morey
    Duke UNC Brain Imaging and Analysis Center, Durham, NC, USA
    Arch Gen Psychiatry 62:254-62. 2005
    ..The neurobiological underpinnings of such executive deficits in ultra-high-risk individuals remains unclear...
  40. ncbi request reprint Effect of olanzapine on body composition and energy expenditure in adults with first-episode psychosis
    Karen A Graham
    Department of Psychiatry, University of North Carolina at Chapel Hill, 27599, USA
    Am J Psychiatry 162:118-23. 2005
    ....
  41. ncbi request reprint Brief evaluation of medication influences and beliefs: development and testing of a brief scale for medication adherence
    Christian R Dolder
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Psychopharmacol 24:404-9. 2004
    ..The purpose of this study was to develop and test a brief scale (Brief Evaluation of Medication Influences and Beliefs [BEMIB]) designed to identify patients who are more likely to be nonadherent to their antipsychotic medication...
  42. ncbi request reprint Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodrome
    Scott W Woods
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 54:453-64. 2003
    ..The prodromal phase of schizophrenic disorders has been described prospectively. The present study aimed to determine the short-term efficacy and safety of olanzapine treatment of prodromal symptoms compared with placebo...
  43. ncbi request reprint Pharmacological management of first-episode schizophrenia and related nonaffective psychoses
    Daniel W Bradford
    University of North Carolina School of Medicine, Neurosciences Hospital, Chapel Hill, North Carolina 27599 7160, USA
    Drugs 63:2265-83. 2003
    ..Future research will further define their roles in treatment and hopefully identify targets for prevention of first-episode schizophrenia...
  44. pmc Nuclear and cytoplasmic localization of neural stem cell microRNAs
    Clark D Jeffries
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    RNA 17:675-86. 2011
    ..That is, in addition to the seed sequence, 3' sequence similarity criteria identify families of mature miRNAs with consistently high nuclear or cytoplasmic expression...
  45. pmc Additional layers of gene regulatory complexity from recently discovered microRNA mechanisms
    Clark D Jeffries
    Renaissance Computing Institute and Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB 360, Chapel Hill, NC 27599, USA
    Int J Biochem Cell Biol 42:1236-42. 2010
    ....
  46. ncbi request reprint Progression to AIDS: the effects of stress, depressive symptoms, and social support
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Psychosom Med 61:397-406. 1999
    ..We examined the effects of stress, depressive symptoms, and social support on the progression of HIV infection...
  47. ncbi request reprint High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status
    J M Petitto
    Department of Psychiatry, University of Florida College of Medicine, Gainesville, USA
    Behav Med 25:143-51. 2000
    ..These data suggest that severe stress in combination with high glucocorticoid activity may modify select parameters of immune status in HIV-infected men...
  48. ncbi request reprint Characterizing and dating the onset of symptoms in psychotic illness: the Symptom Onset in Schizophrenia (SOS) inventory
    D O Perkins
    Department of Psychiatry, University of North Carolina, CB 7160, Chapel Hill, NC 27599, USA
    Schizophr Res 44:1-10. 2000
    ..Further study is underway to evaluate other psychometric properties of the SOS, including test-retest reliability and predictive validity...
  49. ncbi request reprint Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 157:1221-8. 2000
    ..This study examined prospectively the effects of stressful events, depressive symptoms, social support, coping methods, and cortisol levels on progression of HIV-1 infection...
  50. ncbi request reprint Fetal brain development of twins assessed in utero by ultrasound: implications for schizophrenia
    J H Gilmore
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Schizophr Res 19:141-9. 1996
    ..These results indicate that in monozygotic twins, brain development is not identical. This difference in brain development may contribute to the observed concordance rates in monozygotic twins with schizophrenia...
  51. pmc Gene processing control loops suggested by sequencing, splicing, and RNA folding
    Clark D Jeffries
    Eshelman School of Pharmacy and Renaissance Computing Institute, University of North Carolina at Chapel Hill, NC, USA
    BMC Bioinformatics 11:602. 2010
    ..We propose that analogous hairpins from RNA molecules that function as part of the spliceosome might also be the source of small, regulatory RNAs (somewhat smaller than miRNAs)...
  52. pmc Discovering collectively informative descriptors from high-throughput experiments
    Clark D Jeffries
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA
    BMC Bioinformatics 10:431. 2009
    ..Combining information from these studies can increase the reliability and generalizability of results and also yield new insights that guide future research...
  53. ncbi request reprint Implications for the neural basis of social cognition for the study of schizophrenia
    Amy E Pinkham
    Department of Psychology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Am J Psychiatry 160:815-24. 2003
    ..This article attempts to bridge this gap by discussing how the neural basis of social cognition may inform future clinical research in schizophrenia...
  54. ncbi request reprint Folded RNA from an intron of one gene might inhibit expression of a counteracting gene
    Clark Jeffries
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    In Silico Biol 5:407-13. 2005
    ....
  55. pmc Impaired neural synchrony in the theta frequency range in adolescents at familial risk for schizophrenia
    Franc C L Donkers
    Department of Psychiatry, University of North Carolina at Chapel Hill Chapel Hill, NC, USA
    Front Psychiatry 2:51. 2011
    ..Longitudinal assessments will have to determine their predictive value for illness onset in populations at FR for psychotic illness...
  56. ncbi request reprint Olanzapine and haloperidol in first episode psychosis: two-year data
    A I Green
    Department of Psychiatry, Dartmouth Medical School, DHMC, Lebanon, NH 03756, USA
    Schizophr Res 86:234-43. 2006
    ..The data from this study suggest some clinical benefits for olanzapine as compared to haloperidol in first episode patients, which must be weighed against those adverse effects that are more likely with olanzapine...
  57. ncbi request reprint Assessing clinical and functional outcomes in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3173, Durham, NC 27710, USA
    Schizophr Bull 29:33-43. 2003
    ....
  58. pmc Facial affect recognition in individuals at clinical high risk for psychosis
    Jean Addington
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Br J Psychiatry 192:67-8. 2008
    ..Deficits in facial affect recognition appear to be present before the onset of psychosis and may be a vulnerability marker...
  59. ncbi request reprint Practice guideline for the treatment of patients with schizophrenia, second edition
    Anthony F Lehman
    Am J Psychiatry 161:1-56. 2004
  60. ncbi request reprint Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol
    Robert B Zipursky
    Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Br J Psychiatry 187:537-43. 2005
    ..Substantial weight gain is common with many atypical antipsychotics...
  61. ncbi request reprint Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment
    Joseph P McEvoy
    Clinical Research Service, John Umstead Hospital, 1003 12th St, Bldg 32, Butner, NC 27705, USA
    Am J Psychiatry 163:600-10. 2006
    ....
  62. ncbi request reprint Baseline neurocognitive deficits in the CATIE schizophrenia trial
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:2033-46. 2006
    ..Multiple analyses suggested that a broad cognitive deficit characterizes this sample. These deficits are modestly related to negative symptoms and essentially independent of positive symptom severity...
  63. ncbi request reprint Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability
    Tandy J Miller
    Yale University, New Haven, CT, USA
    Schizophr Bull 29:703-15. 2003
    ..It also presents data suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop...
  64. ncbi request reprint A longitudinal study of neurocognitive function in individuals at-risk for psychosis
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Schizophr Res 88:26-35. 2006
    ..The time course and predictive value of cognitive deficits in the development of psychosis has not been established...
  65. pmc North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research
    Jean Addington
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Schizophr Bull 33:665-72. 2007
    ....
  66. ncbi request reprint Neuroprotection: a therapeutic strategy to prevent deterioration associated with schizophrenia
    Jeffrey A Lieberman
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    CNS Spectr 12:1-13; quiz 14. 2007
    ..Finally, L. Fredrik Jarskog, MD, focuses on the neurobiology of functional progression in schizophrenia as well as pharmacology and the potential for neuroprotection...
  67. ncbi request reprint Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 164:1061-71. 2007
    ..The authors sought to compare the effects of olanzapine, quetiapine, and risperidone on neurocognitive function in patients with early psychosis...
  68. ncbi request reprint Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population
    Ralph E Hoffman
    Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
    Br J Psychiatry 191:355-6. 2007
    ..no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment...
  69. pmc Social functioning in individuals at clinical high risk for psychosis
    Jean Addington
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Schizophr Res 99:119-24. 2008
    ....
  70. ncbi request reprint Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation
    Teri T Baldewicz
    Department of Clinical Operations, Inveresk, Cary, North Carolina, USA
    AIDS Behav 8:345-55. 2004
    ..Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments...
  71. ncbi request reprint Single-voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus
    Talaignair N Venkatraman
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
    NMR Biomed 19:484-91. 2006
    ..Simple calculations suggest that more than 200 subjects would be needed to detect a 5% difference in NAA between patients and controls...

Research Grants2

  1. INTERVENING AT PRODROMAL STAGES OF PSYCHOSIS
    Diana Perkins; Fiscal Year: 2004
    ..The results of this study will guide the design of future intervention studies and are anticipated to provide pilot data for an R01 testing novel treatment strategies with patients in the prodromal stage of psychotic illness. ..
  2. Enhancing the Prospective Prediction of Psychosis
    Diana Perkins; Fiscal Year: 2007
    ..Each site has proven its ability to recruit prodromal patients in a previous collaboration. ..