Valentina Perissi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Controlling nuclear receptors: the circular logic of cofactor cycles
    Valentina Perissi
    Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Mol Cell Biol 6:542-54. 2005
  2. pmc TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints
    Valentina Perissi
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 29:755-66. 2008
  3. pmc A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 437:759-63. 2005
  4. pmc Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint
    Wendy Huang
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Mol Cell 35:48-57. 2009
  5. ncbi request reprint Anti-inflammatory and antidiabetic roles of PPARgamma
    Gabriel Pascual
    Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Novartis Found Symp 286:183-96; discussion 196-203. 2007
  6. ncbi request reprint A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
    Valentina Perissi
    Howard Hughes Medical Institute, Department of Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Cell 116:511-26. 2004
  7. pmc A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
    Sumito Ogawa
    Department of Cellular and Molecular Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:14461-6. 2004
  8. doi request reprint Deconstructing repression: evolving models of co-repressor action
    Valentina Perissi
    Department of Medicine, Howard Hughes Medical Institute, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Genet 11:109-23. 2010
  9. pmc The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation
    Claudio Scafoglio
    Howard Hughes Medical Institute and School of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e59986. 2013
  10. pmc A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2
    M Dafne Cardamone
    Howard Hughes Medical Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Cell 46:91-104. 2012

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Controlling nuclear receptors: the circular logic of cofactor cycles
    Valentina Perissi
    Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Mol Cell Biol 6:542-54. 2005
    ....
  2. pmc TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints
    Valentina Perissi
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 29:755-66. 2008
    ..Thus, our data reveal a strategy of dual-factor repression checkpoints, in which dedicated exchange factors serve as sensors for signal-specific dismissal of distinct corepressors, with specificity imposed by upstream signaling pathways...
  3. pmc A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 437:759-63. 2005
    ..This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-kappaB target genes that regulate immunity and homeostasis...
  4. pmc Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint
    Wendy Huang
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Mol Cell 35:48-57. 2009
    ..These findings reveal mechanisms for integration of TLR, calcium, and nuclear receptor signaling pathways that underlie pathogen-specific responses and disease-specific programs of inflammation...
  5. ncbi request reprint Anti-inflammatory and antidiabetic roles of PPARgamma
    Gabriel Pascual
    Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Novartis Found Symp 286:183-96; discussion 196-203. 2007
    ....
  6. ncbi request reprint A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
    Valentina Perissi
    Howard Hughes Medical Institute, Department of Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Cell 116:511-26. 2004
    ..The role of TBLR1 and TBL1 in cofactor exchange appears to also operate for c-Jun and NFkappaB and is therefore likely to be prototypic of similar mechanisms for other signal-dependent transcription factors...
  7. pmc A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
    Sumito Ogawa
    Department of Cellular and Molecular Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:14461-6. 2004
    ....
  8. doi request reprint Deconstructing repression: evolving models of co-repressor action
    Valentina Perissi
    Department of Medicine, Howard Hughes Medical Institute, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Genet 11:109-23. 2010
    ....
  9. pmc The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation
    Claudio Scafoglio
    Howard Hughes Medical Institute and School of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e59986. 2013
    ....
  10. pmc A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2
    M Dafne Cardamone
    Howard Hughes Medical Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Cell 46:91-104. 2012
    ..Together, these studies define GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis...
  11. ncbi request reprint A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription
    Bong Gun Ju
    Howard Hughes Medical Institute, Department of Medicine, School of Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0648, USA
    Science 312:1798-802. 2006
    ..Our data mechanistically link DNA topoisomerase IIbeta-dependent dsDNA breaks and the components of the DNA damage and repair machinery in regulated gene transcription...
  12. ncbi request reprint Tissue-specific regulation of retinal and pituitary precursor cell proliferation
    Xue Li
    Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
    Science 297:1180-3. 2002
    ..These data reveal a molecular mechanism by which a tissue-specific transcriptional repressor-corepressor complex can provide an organ-specific strategy for physiological expansion of precursor populations...

Research Grants2

  1. Role of the NCoR corepressor complex in the development of insulin resistance
    Valentina Perissi; Fiscal Year: 2007
    ..A better characterization of the molecular basis of how the inflammatory pathways are physiologically regulated is critical to develop novel therapeutic approaches. ..