Ruth G Perez

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
    Ruth G Perez
    Department of Neurology, University of Pittsburgh, BST South S 510, Pittsburgh, PA 15213, USA
    J Neurochem 89:1318-24. 2004
  2. pmc Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice
    Tshianda N M Alerte
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States
    Neurosci Lett 435:24-9. 2008
  3. ncbi request reprint Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells
    Eva Lin
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosci Res 86:108-17. 2008
  4. ncbi request reprint A role for alpha-synuclein in the regulation of dopamine biosynthesis
    Ruth G Perez
    Department of Neurology and Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 22:3090-9. 2002
  5. pmc Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo
    Haiyan Lou
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:17648-61. 2010
  6. ncbi request reprint Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
    Xiangmin Peng
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cell Sci 118:3523-30. 2005
  7. ncbi request reprint Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
    Roya Tehranian
    Department of Neurology, University of Pittsburgh, School of Medicine, Pitttsburgh, Pennsylvania 15213, USA
    J Neurochem 99:1188-96. 2006
  8. ncbi request reprint Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK
    Susana D Ugarte
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci Res 73:105-12. 2003
  9. ncbi request reprint 6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression
    Qinghua Liang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci Res 77:747-61. 2004
  10. ncbi request reprint Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity?
    Michael J Zigmond
    Department of Neurology, University of Pittsburgh, 5517 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Parkinsonism Relat Disord 8:389-93. 2002

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
    Ruth G Perez
    Department of Neurology, University of Pittsburgh, BST South S 510, Pittsburgh, PA 15213, USA
    J Neurochem 89:1318-24. 2004
    ..This review focuses on how a loss of normal alpha-synuclein function may contribute to the dopamine-related loss of substantia nigra neurons during Parkinson's disease pathogenesis...
  2. pmc Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice
    Tshianda N M Alerte
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States
    Neurosci Lett 435:24-9. 2008
    ..These findings have implications not only for normal alpha-Syn function in TH regulation, but also for measuring cell loss that is associated with synucleinopathy...
  3. ncbi request reprint Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells
    Eva Lin
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosci Res 86:108-17. 2008
    ....
  4. ncbi request reprint A role for alpha-synuclein in the regulation of dopamine biosynthesis
    Ruth G Perez
    Department of Neurology and Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 22:3090-9. 2002
    ..If so, a loss of soluble alpha-synuclein, by reduced expression or aggregation, could increase dopamine synthesis with an accompanying increase in reactive dopamine metabolites...
  5. pmc Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo
    Haiyan Lou
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:17648-61. 2010
    ..These findings extend our understanding of normal a-Syn biology and have implications for the dopamine dysfunction of Parkinson disease...
  6. ncbi request reprint Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
    Xiangmin Peng
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cell Sci 118:3523-30. 2005
    ..Together the data reveal a functional interaction between alpha-synuclein and PP2A that leads to PP2A activation and underscores a key role for alpha-synuclein in protein phosphorylation...
  7. ncbi request reprint Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
    Roya Tehranian
    Department of Neurology, University of Pittsburgh, School of Medicine, Pitttsburgh, Pennsylvania 15213, USA
    J Neurochem 99:1188-96. 2006
    ..These novel findings further support a role for alpha-synuclein in dopamine homeostasis and may explain, at least in part, the selective vulnerability of dopamine neurons that occurs in PD...
  8. ncbi request reprint Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK
    Susana D Ugarte
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci Res 73:105-12. 2003
    ..These studies suggest that GDNF can protect dopaminergic cells against some but not all aspects of 6-OHDA-induced toxicity by acting through both PI3K and MAPK signaling pathways...
  9. ncbi request reprint 6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression
    Qinghua Liang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci Res 77:747-61. 2004
    ....
  10. ncbi request reprint Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity?
    Michael J Zigmond
    Department of Neurology, University of Pittsburgh, 5517 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Parkinsonism Relat Disord 8:389-93. 2002
    ..We suggest that PD is associated with an increase in dopamine turnover, which may not only reduce the immediate symptoms of the disease but also contribute to its progression...
  11. doi request reprint α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion
    Xuehui Geng
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 300:E276-86. 2011
    ..Synuclein might play similar roles in diabetes as it does in other degenerative diseases, including Alzheimer's and Parkinson's diseases...
  12. ncbi request reprint The endocytotic pathway is required for increased A beta 42 secretion during apoptosis
    Chhinder P Sodhi
    Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Brain Res Mol Brain Res 128:201-11. 2004
    ..We demonstrate additionally that more A beta 40 apparently is generated in secretory compartments during apoptosis when APP processing by the endocytotic pathway is impaired...
  13. doi request reprint Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis
    Chhinder P Sodhi
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Brain Res 1198:204-12. 2008
    ..These results are consistent with APP cytoplasmic-tail phosphorylation at T668 during apoptosis as contributory to increased Abeta42 secretion originating from the endocytotic pathway, likely with cell-line restriction...