Jesus Perez-Losada

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Stem-cell hierarchy in skin cancer
    Jesus Perez-Losada
    UCSF Comprehensive Cancer Center, 2340 Sutter Street, San Francisco, California 94143, USA
    Nat Rev Cancer 3:434-43. 2003
  2. ncbi request reprint Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
    Jian Hua Mao
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, California 94143, USA
    Nature 432:775-9. 2004
  3. ncbi request reprint Genetic interactions between Pten and p53 in radiation-induced lymphoma development
    Jian Hua Mao
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
    Oncogene 22:8379-85. 2003
  4. pmc Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice
    Jian Hua Mao
    Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 11:161-73. 2007
  5. ncbi request reprint p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo
    Jesus Perez-Losada
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
    Oncogene 24:5521-4. 2005
  6. pmc Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility
    David A Quigley
    Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
    Genome Biol 12:R5. 2011
  7. ncbi request reprint Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway
    Jesus Perez-Losada
    Cancer Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer Res 65:6488-92. 2005
  8. pmc Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer
    Joan Climent
    Helen Diller Family Comprehensive Cancer Center, Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    J Clin Oncol 28:3770-8. 2010
  9. ncbi request reprint Crosstalk between Pten and Ras signaling pathways in tumor development
    Minh D To
    UCSF Comprehensive Cancer Center, San Francisco, California 94115, USA
    Cell Cycle 4:1185-8. 2005
  10. ncbi request reprint A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice
    Minh D To
    University of California San Francisco UCSF Comprehensive Cancer Center, San Francisco, California 94115, USA
    Nat Genet 38:926-30. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Stem-cell hierarchy in skin cancer
    Jesus Perez-Losada
    UCSF Comprehensive Cancer Center, 2340 Sutter Street, San Francisco, California 94143, USA
    Nat Rev Cancer 3:434-43. 2003
    ..Identification of the primary cell of origin of cancers and the mechanisms that influence cell-fate decisions will be crucial for the development of novel non-toxic therapies that influence tumour-cell behaviour...
  2. ncbi request reprint Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
    Jian Hua Mao
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, California 94143, USA
    Nature 432:775-9. 2004
    ..We propose that p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers...
  3. ncbi request reprint Genetic interactions between Pten and p53 in radiation-induced lymphoma development
    Jian Hua Mao
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
    Oncogene 22:8379-85. 2003
    ..This sensitized screen therefore identified complementary roles for Pten and p53 pathways in suppression of tumor development induced by radiation exposure...
  4. pmc Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice
    Jian Hua Mao
    Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 11:161-73. 2007
    ..These data have implications for the design of approaches to targeted cancer therapy involving the crosstalk between Aurora-A kinase and p53 pathways...
  5. ncbi request reprint p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo
    Jesus Perez-Losada
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
    Oncogene 24:5521-4. 2005
    ..No deletions or LOH involving the p73 gene were detected, and expression of both genes was maintained in the tumors. We conclude that p53 homologues do not contribute to p53 tumor suppressor activity in lymphoma development...
  6. pmc Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility
    David A Quigley
    Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
    Genome Biol 12:R5. 2011
    ..Whether germline variants affect gene expression in tumors that have undergone somatic alterations, and the extent to which these variants influence tumor progression, is unknown...
  7. ncbi request reprint Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway
    Jesus Perez-Losada
    Cancer Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer Res 65:6488-92. 2005
    ....
  8. pmc Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer
    Joan Climent
    Helen Diller Family Comprehensive Cancer Center, Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    J Clin Oncol 28:3770-8. 2010
    ..To investigate the role of the PER3 circadian rhythm gene, located within the commonly deleted region of chromosome 1p36, in human breast cancer development...
  9. ncbi request reprint Crosstalk between Pten and Ras signaling pathways in tumor development
    Minh D To
    UCSF Comprehensive Cancer Center, San Francisco, California 94115, USA
    Cell Cycle 4:1185-8. 2005
    ..These findings in this mouse model have important implications for the rational design of new targeted therapies for human tumors...
  10. ncbi request reprint A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice
    Minh D To
    University of California San Francisco UCSF Comprehensive Cancer Center, San Francisco, California 94115, USA
    Nat Genet 38:926-30. 2006
    ..These data demonstrate that cancer predisposition should also be considered in the context of somatic events and could have major implications for the design of human association studies to identify cancer susceptibility genes...
  11. doi request reprint Genetic architecture of mouse skin inflammation and tumour susceptibility
    David A Quigley
    Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94115, USA
    Nature 458:505-8. 2009
    ....
  12. ncbi request reprint Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice
    Jiang Hua Mao
    Cancer Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Oncogene 24:7924-34. 2005
    ..The nature of these early events may determine the overall genomic signature observed in the resulting tumor...
  13. pmc Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients
    Kelly A Harradine
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA
    Clin Cancer Res 15:5101-7. 2009
    ..This study investigates whether TGF-beta signaling is elevated in transplant patients...
  14. pmc Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression
    Jian Hua Mao
    University of California at San Francisco Comprehensive Cancer Center, San Francisco, California 94143, USA
    Genes Dev 18:1800-5. 2004
    ..These data have important implications in designing individual therapeutic strategies for the treatment of cancer...