Research Topics
Species | A K PercySummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Detail Information
Publications
Profiling scoliosis in Rett syndromeAlan K Percy
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Pediatr Res 67:435-9. 2010..Clinical trial design should account for scoliosis and related factors judiciously...
Rett syndrome: recent research progressAlan K Percy
Department of Pediatrics, University of Alabama at Birmingham, AL 35294 0021, USA
J Child Neurol 23:543-9. 2008..As such, it is timely to update recent research progress. This update summarizes research advances during the past 18 to 24 months in terms of clinical and translational research, as well as basic research...
Rett syndrome: North American databaseAlan K Percy
Civitan International Research Center, University of Alabama at Birmingham, 35294 0021, USA
J Child Neurol 22:1338-41. 2007....- Rett syndrome: clinical and molecular updateAlan K Percy
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Curr Opin Pediatr 16:670-7. 2004..Recent reports not only present new insights into the clinical and molecular understanding of this unique disorder but also have important implications for the neurobiology beyond Rett syndrome... - Child neurology training via the research pathway: outcome studyAlan K Percy
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1711, USA
J Child Neurol 19:142-4. 2004..Thus far, these trainees have published more than 125 articles in peer-reviewed journals. Although small in scope, this training track has met its objective of producing clinician-scientists... - Rett syndrome diagnostic criteria: lessons from the Natural History StudyAlan K Percy
Department of Pediatric Neurology and Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
Ann Neurol 68:951-5. 2010..This analysis underscores the critical role of main criteria for classic RTT; variant RTT requires both main and supportive criteria... - Rett syndrome: model of neurodevelopmental disordersAlan K Percy
Civitan International Research Center, University of Alabama, Birmingham, AL 35294, USA
J Child Neurol 20:718-21. 2005.... - Rett syndrome: exploring the autism linkAlan K Percy
Civitan International Research Center, University of Alabama at Birmingham, 35294, USA
Arch Neurol 68:985-9. 2011..Fundamental understanding of autism based on unique genetic mechanism(s) must await similar advances... - Paul Dyken Lecture of the Southern Pediatric Neurology Society. Inherited neurodegenerative disease: the evolution of our thinkingA K Percy
Department of Pediatrics, University of Alabama at Birmingham, USA
J Child Neurol 14:256-62. 1999..These issues include a high index of suspicion for an inherited neurometabolic disease and an open mind to possible interrelations with other known and seemingly dissimilar conditions... - Genetics of Rett syndrome: properties of the newly discovered gene and pathobiology of the disorderA K Percy
Department of Pediatrics, University of Alabama at Birmingham, School of Medicine, 35233 1711, USA
Curr Opin Pediatr 12:589-95. 2000..As such, this discovery opens up completely new vistas as to fundamental neurobiologic processes, to disease mechanisms in the neurodevelopmental disabilities, and to potential new therapeutic strategies for RS and related disorders... - Neuropathology of occipital horn syndromeC A Palmer
Department of Neurology, University of Alabama at Birmingham, 35294, USA
J Child Neurol 16:764-6. 2001..These findings are similar to those seen in the brains of patients with Menkes' syndrome, which is not surprising, given the known phenotypic overlap and the proven allelism of occipital horn syndrome with classic Menkes' syndrome... - Cocaine inhibition of neuronal differentiation in NGF-induced PC12 cells is independent of ras signalingD A Zachor
Department of Pediatrics, University of Alabama at Birmingham, UAB, Civitan International Research Center, 35294 0017, USA
Int J Dev Neurosci 18:765-72. 2000..These results suggest that cocaine, dopamine and activation of D1 receptors affect the NGF signaling downstream, independent of ras expression, leading to altered neuronal differentiation... - Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptorsD A Zachor
Department of Pediatrics, University of Alabama at Birmingham, 331C, Sparks Building, 1720 Seventh Avenue South, Birmingham, AL 35294 0017, USA
Brain Res 869:85-97. 2000..Subsequently, up regulation of D(1) receptors alters NGF signaling pathways... - Deep sedation with propofol in patients with Rett syndromeNancy M Tofil
Department of Pediatrics, Division of Critical Care, University of Alabama, Birmingham, AL 35233, USA
J Child Neurol 21:857-60. 2006..Sedation of patients with Rett syndrome is associated with a relatively high rate of complications and should not be done without appropriate personnel available who recognize the risks of sedating this unique population... - Deep sedation with propofol in patients with Rett syndromeNancy M Tofil
Department of Pediatrics, Division of Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA
J Child Neurol 21:210-3. 2006..Sedation of patients with Rett syndrome is associated with a relatively high rate of complications and should not be done without appropriate personnel available who recognize the risks of sedating this unique population... - Rett syndrome. Current status and new vistasAlan K Percy
Departments of Pediatrics, Neurology, and Neurobiology, University of Alabama, Birmingham School of Medicine, 1600 7th Avenue South, Suite 516, Birmingham, AL 35233, USA
Neurol Clin 20:1125-41. 2002..These rapid advances in our understanding of RS over the past three decades have opened new avenues of study in developmental neurobiology... - Clinical trials and treatment prospectsAlan K Percy
University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35233, USA
Ment Retard Dev Disabil Res Rev 8:106-11. 2002..The availability of animal models expressing mutations in MECP2 should enhance the evaluation of innovative therapies for RS... - Clinical severity and quality of life in children and adolescents with Rett syndromeJ B Lane
University of Alabama, Birmingham, AL, USA
Neurology 77:1812-8. 2011..This study describes the impact of clinical severity on QOL among female children and adolescents with classic RTT... - Early progressive encephalopathy in boys and MECP2 mutationsP Kankirawatana
Department of Pediatrics, University of Alabama at Birmingham, USA
Neurology 67:164-6. 2006..MECP2 mutations should be assessed in boys with progressive encephalopathy and one or more of respiratory insufficiency, abnormal movements or tone, and intractable seizures... - Rett syndrome: clinical correlates of the newly discovered geneA K Percy
Department of Pediatrics, Neurology, and Neurobiology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35233, USA
Brain Dev 23:S202-5. 2001.... - C-fos mediates cocaine inhibition of NGF-induced PC12 cell differentiationD A Zachor
Department of Pediatrics, University of Alabama at Birmingham 35294, USA
Mol Genet Metab 64:62-9. 1998..Further studies will be required to examine the role of D1 receptor activation in mediating c-fos expression and to explore the effects of cocaine on other IEGs... - Longevity in Rett syndrome: analysis of the North American DatabaseRussell S Kirby
School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
J Pediatr 156:135-138.e1. 2010..To determine longevity in Rett syndrome (RTT) from a large cohort... - Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutationsChristopher A Chapleau
Department of Neurobiology, Evelyn McKnight Brain Institute, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
Neurobiol Dis 35:219-33. 2009.... - Linking process to outcome: are we training pediatricians to meet evolving health care needs?M Douglas Jones
Department of Pediatrics, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
Pediatrics 123:S1-7. 2009.... - Certification in child neurology: new directions for the twenty-first centuryAlan K Percy
University of Alabama, Birmingham, AL, USA
J Child Neurol 20:644-7. 2005..Training pathways in child neurology are also reviewed as they have evolved in response to evident staff shortages and to promote entry into academic careers... - Board certification in child neurology and neurology: cohort studyDorthea Juul
American Board of Psychiatry and Neurology, Inc, Deerfield, IL 60015, USA
J Child Neurol 20:25-7. 2005..Overall, it was estimated that 82% of the 1994 child neurology and neurology graduates sought ABPN certification, and of these, 82% were successful... - Certification in neurodevelopmental disabilities: the development of a new subspecialty and results of the initial examinationsFrederick B Palmer
University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
Ment Retard Dev Disabil Res Rev 9:128-31. 2003..After the "grandfathering period," candidates for the examination must complete ACGME-approved training programs in the subspecialty... - Eating difficulties in girls with Rett syndrome compared with other developmental disabilitiesJanet Sugarman Isaacs
Children s National Medical Center, Department of Genetics and Metabolism, Washington, DC, USA
J Am Diet Assoc 103:224-30. 2003.... - Rett syndrome: pathogenesis, diagnosis, strategies, therapies, and future research directionsKathleen M Deidrick
Department of Health Psychology, University of Missouri-Columbia, MO, USA
J Child Neurol 20:708-17. 2005