Camillo Peracchia

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Chemical gating of gap junction channels
    C Peracchia
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642 8711, USA
    Methods 20:188-95. 2000
  2. ncbi request reprint Unusual slow gating of gap junction channels in oocytes expressing connexin32 or its COOH-terminus truncated mutant
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8711, USA
    J Membr Biol 215:161-8. 2007
  3. ncbi request reprint Inversion of both gating polarity and CO2 sensitivity of voltage gating with D3N mutation of Cx50
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642 8711, USA
    Am J Physiol Cell Physiol 288:C1381-9. 2005
  4. ncbi request reprint CO(2) sensitivity of voltage gating and gating polarity of gapjunction channels--connexin40 and its COOH-terminus-truncated mutant
    C Peracchia
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642 8711, USA
    J Membr Biol 200:105-13. 2004
  5. ncbi request reprint Chemical gating of gap junction channels; roles of calcium, pH and calmodulin
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642 8711, USA
    Biochim Biophys Acta 1662:61-80. 2004
  6. ncbi request reprint The voltage gates of connexin channels are sensitive to CO(2)
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    Cell Commun Adhes 10:233-7. 2003
  7. ncbi request reprint Is the voltage gate of connexins CO2-sensitive? Cx45 channels and inhibition of calmodulin expression
    C Peracchia
    University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642 8711, USA
    J Membr Biol 195:53-62. 2003
  8. ncbi request reprint Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes
    Basilio A Kotsias
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8711, USA
    J Membr Biol 214:1-8. 2006
  9. pmc Interactions of connexins with other membrane channels and transporters
    Marc Chanson
    Department of Pediatrics, Geneva University Hospitals, Geneva, Switzerland
    Prog Biophys Mol Biol 94:233-44. 2007
  10. pmc Calmodulin association with connexin32-derived peptides suggests trans-domain interaction in chemical gating of gap junction channels
    Ryan Dodd
    Division of Basic Medical Sciences, St George s, University of London, London, SW17 0RE United Kingdom
    J Biol Chem 283:26911-20. 2008

Research Grants

  1. STRUCTURE/FUNCTION IN LOW RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 2000
  2. STRUCTURE & FUNCTION IN LOW RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 1980
  3. STRUCTURE-FUNCTION IN LOW RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 1992
  4. STRUCTURE-FUNCTION IN LOW-RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 1993
  5. Structure Function in Low Resistance Junctions
    Camillo Peracchia; Fiscal Year: 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Chemical gating of gap junction channels
    C Peracchia
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642 8711, USA
    Methods 20:188-95. 2000
    ..In addition, various channel forms, including homotypic, heterotypic, and heteromeric channel combinations, have been evaluated for chemical gating sensitivity...
  2. ncbi request reprint Unusual slow gating of gap junction channels in oocytes expressing connexin32 or its COOH-terminus truncated mutant
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8711, USA
    J Membr Biol 215:161-8. 2007
    ..Based on previous evidence for direct calmodulin (CaM) involvement in chemical/slow gating, this may also be CaM-mediated...
  3. ncbi request reprint Inversion of both gating polarity and CO2 sensitivity of voltage gating with D3N mutation of Cx50
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642 8711, USA
    Am J Physiol Cell Physiol 288:C1381-9. 2005
    ..This hypothesis is confirmed here by evidence that the D3N mutation inverts the gating polarity as well as the effect of CO(2) on V(j) gating sensitivity and speed...
  4. ncbi request reprint CO(2) sensitivity of voltage gating and gating polarity of gapjunction channels--connexin40 and its COOH-terminus-truncated mutant
    C Peracchia
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642 8711, USA
    J Membr Biol 200:105-13. 2004
    ....
  5. ncbi request reprint Chemical gating of gap junction channels; roles of calcium, pH and calmodulin
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642 8711, USA
    Biochim Biophys Acta 1662:61-80. 2004
    ..At least three molecular models of channel gating have been proposed, but all of them are mostly based on circumstantial evidence...
  6. ncbi request reprint The voltage gates of connexin channels are sensitive to CO(2)
    Camillo Peracchia
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    Cell Commun Adhes 10:233-7. 2003
    ..In contrast, sensitivity and speed of V(j) gating of Cx40 and Cx26 channels decreased, rather than increased, with CO(2) application...
  7. ncbi request reprint Is the voltage gate of connexins CO2-sensitive? Cx45 channels and inhibition of calmodulin expression
    C Peracchia
    University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642 8711, USA
    J Membr Biol 195:53-62. 2003
    ..The data indicate that both the speed and sensitivity of V(j)-dependent inactivation of the junctional current of Cx45 channels are affected by CO2 application, and that CaM plays a key role in channel gating...
  8. ncbi request reprint Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes
    Basilio A Kotsias
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8711, USA
    J Membr Biol 214:1-8. 2006
    ..The data suggest a cross-talk between CFTR and a variety of gap junction channels. Cytoskeletal scaffolding proteins and/or other intermediate cytoplasmic proteins are likely to play a role in CFTR-Cx interaction...
  9. pmc Interactions of connexins with other membrane channels and transporters
    Marc Chanson
    Department of Pediatrics, Geneva University Hospitals, Geneva, Switzerland
    Prog Biophys Mol Biol 94:233-44. 2007
    ..Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis...
  10. pmc Calmodulin association with connexin32-derived peptides suggests trans-domain interaction in chemical gating of gap junction channels
    Ryan Dodd
    Division of Basic Medical Sciences, St George s, University of London, London, SW17 0RE United Kingdom
    J Biol Chem 283:26911-20. 2008
    ..Our data, showing separate functions of the N- and C-lobes of calmodulin in the interactions with connexin32, suggest trans-domain or trans-subunit bridging by calmodulin as a possible mechanism of gap junction gating...

Research Grants27

  1. STRUCTURE/FUNCTION IN LOW RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 2000
    ..Finally, the molecular basis of channel insulation and connexin interaction will be probed through appropriate deletions and mutations of external Cx domains. ..
  2. STRUCTURE & FUNCTION IN LOW RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 1980
    ..Various methodologies including thin sectioning, membrane fractionation, SDS PAGE, intracellular recordings etc. will be applied. ..
  3. STRUCTURE-FUNCTION IN LOW RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 1992
    ..The extent of gap junction phosphorylation in coupled/uncoupled state will be determined in normal and RSV-transformed cells. The nature of interparticle bridges will be determined in split junctions...
  4. STRUCTURE-FUNCTION IN LOW-RESISTANCE JUNCTIONS
    Camillo Peracchia; Fiscal Year: 1993
    ..The hypothesis suggesting a mostly hydrophobic connexin domain as part of the external "channel seal" will be tested by expressing appropriate connexins mutants...
  5. Structure Function in Low Resistance Junctions
    Camillo Peracchia; Fiscal Year: 2005
    ..The relevance of a potential CaM binding site identified in connexins (similar to that of CaM kinase II) will be tested with deletion and mutation of crucial Cx32 residues. ..