Research Topics
Species | C PepineSummaryAffiliation: University of Florida Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome EvaluationMichael A Pacanowski
Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL, USA
J Transl Med 6:11. 2008..Adrenergic gene polymorphisms are associated with cardiovascular and metabolic phenotypes. We investigated the influence of adrenergic gene polymorphisms on cardiovascular risk in women with suspected myocardial ischemia...
Endothelial dysfunction and its role in the cycle of cardiovascular diseaseC Pepine
University of Florida, Division of Cardiovascular Medicine, Gainsville 32610 0277, USA
Can J Cardiol 14:5D-7D. 1998..An overview of normal endothelial function and endothelial dysfunction, and a unifying model to illustrate the cascade of events that occur in the coronary artery disease process are presented...- Cardiovascular therapies and risk for development of diabetesCarl J Pepine
Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 44:509-12. 2004..Physicians should consider this possible diabetes consequence when prescribing long-term beta-blockers and diuretics, particularly in patients at high risk of developing diabetes... - Effects of angiotensin-converting enzyme inhibition on transient ischemia: the Quinapril Anti-Ischemia and Symptoms of Angina Reduction (QUASAR) trialCarl J Pepine
University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 42:2049-59. 2003..We sought to determine whether angiotensin-converting enzyme inhibition (ACE-I) (i.e., quinapril) prevents transient ischemia (exertional and spontaneous) in patients with coronary artery disease (CAD)... - Predictors of adverse outcome among patients with hypertension and coronary artery diseaseCarl J Pepine
Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 47:547-51. 2006..We sought to determine predictors for adverse outcomes in hypertensive patients with coronary artery disease (CAD)... - Introduction: new and emerging implications for the field of vascular biologyCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610-0277, USA
Am J Cardiol 91:1H-2H. 2003 - Some thoughts on the vasculopathy of women with ischemic heart diseaseCarl J Pepine
Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
J Am Coll Cardiol 47:S30-5. 2006..A better understanding of these findings should provide direction for new algorithms to improve management of the vasculopathy underlying IHD in women... - Optimizing lipid management in patients with acute coronary syndromesCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville 32610, USA
Am J Cardiol 91:30B-35B. 2003..These programs are the Cardiac Hospitalization Atherosclerosis Management Program (CHAMP) and the Guidelines Applied in Practice (GAP)... - Introduction: there is an important need for increased understanding of the pathophysiology of heart failure postinfarction, new treatment strategies, earlier implementation of effective strategies, and more effective use of existing therapiesCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Am J Cardiol 97:1F-3F. 2006 - Ischemic heart disease in women: facts and wishful thinkingCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610-0277, USA
J Am Coll Cardiol 43:1727-30. 2004 - Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertensionC J Pepine
Division of Cardiovascular Medicine, University of Florida, College of Medicine, Gainesville 32610 0277, USA
J Am Coll Cardiol 32:1228-37. 1998.... - Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) studyCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 55:2825-32. 2010..We investigated whether coronary microvascular dysfunction predicts major adverse outcomes during follow-up among women with signs and symptoms of ischemia... - Why vascular biology mattersC J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 Archer Road, Gainesville, FL 32610, USA
Am J Cardiol 88:5K-9K. 2001..However, if this information is not incorporated into clinical practice in a timely manner, cardiovascular disease will continue to present a major cause of morbidity and mortality worldwide... 
The impact of nitric oxide in cardiovascular medicine: untapped potential utilityCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
Am J Med 122:S10-5. 2009..This background provides the rationale for exploring the potential therapeutic role for NO-donating agents in the prevention of adverse cardiovascular outcomes...- The pathophysiology of chronic ischemic heart diseaseCarl J Pepine
Division of Cardiovascular Medicine, Gainesville, FL 32610 0277, USA
Clin Cardiol 30:I4-9. 2007..Where possible, targets for novel therapeutic approaches are highlighted... - Phytoestrogens and coronary microvascular function in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE) StudyCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
J Womens Health (Larchmt) 16:481-8. 2007..Accordingly, we investigated the relationship between blood phytoestrogen levels and coronary reactivity in women with suspected myocardial ischemia referred for coronary angiography... - Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST])Rhonda Cooper-DeHoff
University of Florida College of Medicine, Gainesville, Florida, USA
Am J Cardiol 98:890-4. 2006.... - Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trialBernard R Chaitman
Department of Medicine, Division of Cardiology, St Louis University School of Medicine, St Louis, MO, USA
JAMA 291:309-16. 2004.... - Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: an INternational VErapamil SR-Trandolapril (INVEST) substudySripal Bangalore
Division of Cardiovascular Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
Am Heart J 156:241-7. 2008..The purpose of the study was to compare a beta-blocker-based strategy with a heart rate-lowering calcium antagonists-based strategy in patients with prior MI... - Dual therapy in hypertensive patients with coronary artery disease: the role of calcium channel blockers and beta-blockersGeorge L Bakris
University of Chicago School of Medicine, Department of Medicine, Hypertensive Diseases Unit, Chicago, Illinois 60637, USA
Am J Cardiovasc Drugs 7:25-9. 2007.... - A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trialCarl J Pepine
Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
JAMA 290:2805-16. 2003..CONCLUSION: The verapamil-trandolapril-based strategy was as clinically effective as the atenolol-hydrochlorothiazide-based strategy in hypertensive CAD patients... - Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)Gregory O von Mering
University of Florida College of Medicine, Gainesville, Fla 32610-0277, USA
Circulation 109:722-5. 2004..006). CONCLUSIONS: In women in this study, impaired coronary vasomotor response to acetylcholine was independently linked to adverse cardiovascular outcomes regardless of CAD severity... - Factors influencing blood pressure response to trandolapril add-on therapy in patients taking verapamil SR (from the International Verapamil SR/Trandolapril [INVEST] Study)Martin Brunner
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, USA
Am J Cardiol 99:1549-54. 2007..Race was associated with diastolic BP response, although the difference is likely not to be clinically significant and AGTR1 genotype was not associated with BP response... - Pharmacologic plaque passivation for the reduction of recurrent cardiac events in acute coronary syndromesV Stephen Monroe
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Am Coll Cardiol 41:23S-30S. 2003..This article reviews atherosclerotic plaque development and vulnerability and discusses some clinical studies highlighting the role of plaque passivation in the management of ACS patients... - Systolic blood pressure and subjective well-being in patients with coronary artery diseaseYan Gong
College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
Clin Cardiol 32:627-32. 2009..Limited information exists regarding the association between subjective well-being (SWB) and systolic blood pressure (SBP) among hypertensive patients with coronary artery disease (CAD)... - The QUinapril Ischemic Event Trial (QUIET): evaluation of chronic ACE inhibitor therapy in patients with ischemic heart disease and preserved left ventricular functionB Pitt
Department of Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan 48109, USA
Am J Cardiol 87:1058-63. 2001..However, the absence of the demonstrable effect of quinapril may be due to several limitations in study design... - CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment responseAmber L Beitelshees
Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL, USA
Circ Cardiovasc Genet 2:362-70. 2009..The gene encoding the target of calcium channel blockers, the alpha1c-subunit of the L-type calcium channel (CACNA1C), has not been well characterized, and only small pharmacogenetic studies testing this gene have been published to date... - Global differences in blood pressure control and clinical outcomes in the INternational VErapamil SR-Trandolapril STudy (INVEST)Issam Zineh
Department of Pharmacy Practice, College of Pharmacy University of Florida, Gainesville, Florida 32610, USA
Clin Cardiol 28:321-8. 2005..These disparities warrant further investigation to define appropriate care for patients with hypertension and stable CAD from an international public health perspective... - Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES)Tobias Gerhard
College of Pharmacy, University of Florida, Gainesville, FL 32610 0486, USA
Am Heart J 156:397-404. 2008..The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists... - Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE)Timothy R Wessel
University of Florida, Division of Cardiovascular Medicine, Gainesville, FL 32610 0277, USA
Clin Cardiol 30:69-74. 2007..Accordingly, the relationship between adenosine-related microvascular coronary reactivity and risk factors in symptomatic women evaluated for suspected ischemia remains uncertain... - Antihypertensive properties of a high-dose combination of trandolapril and verapamil-SRFranz Messerli
Department of Medicine, Division of Cardiology, St Luke s Roosevelt Hospital and Columbia University, New York, NY, USA
Blood Press Suppl 16:6-9. 2007..Despite differences in the risk profiles of previously studied patients and INVEST patients, the antihypertensive effects of Ve+Tr were similar... - Antihypertensive properties of a high-dose combination of trandolapril and verapamil-SRFranz Messerli
Department of Medicine, Division of Cardiology, St Luke s Roosevelt Hospital and Columbia University, New York, NY, USA
Blood Press Suppl 1:6-9. 2007..Despite differences in the risk profiles of previously studied patients and INVEST patients, the antihypertensive effects of Ve+Tr were similar... - KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)Amber L Beitelshees
Department of Pharmacy Practice, University of Florida, College of Pharmacy, Gainesville, USA
Pharmacogenet Genomics 17:719-29. 2007.... - Pulse pressure and risk of cardiovascular outcomes in patients with hypertension and coronary artery disease: an INternational VErapamil SR-trandolapril STudy (INVEST) analysisSripal Bangalore
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 1000 Tenth Avenue, Suite 3B 30, New York, NY 10025, USA
Eur Heart J 30:1395-401. 2009.... - The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint dataV J Dzau
Department of Medicine, Brigham Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Cardiol 88:1L-20L. 2001..More comparative experimental and clinical studies should address the significance of these drug differences and their impact on clinical events... - The value of estimated functional capacity in estimating outcome: results from the NHBLI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) StudyLeslee J Shaw
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Am Coll Cardiol 47:S36-43. 2006..Our objective was to determine the prognostic value of estimated metabolic equivalents (METs) based on self-reported functional capacity by the Duke Activity Status Index (DASI) in symptomatic women... - Comparison of effects of nisoldipine-extended release and amlodipine in patients with systemic hypertension and chronic stable angina pectorisCarl J Pepine
University of Florida College of Medicine, Gainesville, Florida 32610, USA
Am J Cardiol 91:274-9. 2003..Thus, nisoldipine-ER and amlodipine provided comparable antihypertensive and anti-ischemic efficacy, and both were generally well tolerated... - Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE studyC Noel Bairey Merz
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
J Am Coll Cardiol 41:413-9. 2003..We sought to evaluate hypoestrogenemia of hypothalamic origin and its association with angiographic coronary artery disease (CAD) in premenopausal women... - Importance of socioeconomic status as a predictor of cardiovascular outcome and costs of care in women with suspected myocardial ischemia. Results from the National Institutes of Health, National Heart, Lung and Blood Institute-sponsored Women's Ischemia Leslee J Shaw
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30306, USA
J Womens Health (Larchmt) 17:1081-92. 2008..For women, who are more likely to live in poverty, defining the clinical and economic impact of socioeconomic factors may aid in defining redistributive policies to improve healthcare quality... - Commentary on "new and emerging theories of cardiovascular disease"Timothy R Wessel
Division of Cardiovascular Medicine at the University of Florida College of Medicine, Gainesville, FL 32610, USA
Biol Res Nurs 6:17-20; discussion 21-3. 2004 - Metabolic syndrome and cardiovascular disease: challenges and opportunitiesRhonda M Cooper-Dehoff
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
Clin Cardiol 30:593-7. 2007.... - Influence of Hispanic ethnicity on blood pressure control and cardiovascular outcomes in women with CAD and hypertension: findings from INVESTRhonda M Cooper-Dehoff
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Womens Health (Larchmt) 16:632-40. 2007..Prospective data regarding blood pressure (BP) control and cardiovascular (CV) outcomes in Hispanic women are lacking... - Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: Results from the Psychophysiological Investigations of Myocardial Ischemia studyDavid S Sheps
University of Florida College of Medicine, the Malcom Randall Veterans Affairs Medical Center, and the Medical Research Service of the Department of Veterans Affairs, Gainesville, Fla 32610 0277, USA
Circulation 105:1780-4. 2002..Ischemia during laboratory mental stress tests has been linked to significantly higher rates of adverse cardiac events. Previous studies have not been designed to detect differences in mortality rates... - Marrow cell therapies for cardiovascular diseasesChristopher R Cogle
Department of Medicine, Division of Hematology Oncology, Program in Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0278, USA
Exp Hematol 36:687-94. 2008..The next generation of studies will aim to answers these questions and make way for cellular therapies that result in effective cardiac repair... - Revisiting the culprit lesion in non-Q-wave myocardial infarction. Results from the VANQWISH trial angiographic core laboratoryRichard A Kerensky
Malcom Randall Veterans Affairs Medical Center and the University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 39:1456-63. 2002..We sought to determine the underlying coronary anatomy and characterize the culprit lesion after non-Q-wave myocardial infarction (NQWMI)... - Cardiovascular therapies and associated glucose homeostasis: implications across the dysglycemia continuumRhonda M Cooper-Dehoff
Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 53:S28-34. 2009..These considerations have particular importance in younger patients who may also have pre-diabetes or the metabolic syndrome and who are likely to require therapy over the course of decades... - Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudyScott J Denardo
Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Am J Med 123:719-26. 2010..Our understanding of the growing population of very old patients (aged >or=80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes... - Pathophysiologic mechanisms linking impaired cardiovascular health and neurologic dysfunction: the year in reviewKi E Park
Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
Cleve Clin J Med 77:S40-5. 2010.... - Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery diseaseRhonda M Cooper-Dehoff
Department of Pharmacotherapy and Translational Research and Division of Cardiovascular Medicine, College of Pharmacy, University of Florida, 1600 SW Archer Rd, PO Box 100486, Gainesville, FL 32610 0486, USA
JAMA 304:61-8. 2010..Hypertension guidelines advocate treating systolic blood pressure (BP) to less than 130 mm Hg for patients with diabetes mellitus; however, data are lacking for the growing population who also have coronary artery disease (CAD)... - Residual risk for secondary ischemic events in patients with atherothrombotic disease: opportunity for future improvements in patient careCarl J Pepine
University of Florida, Gainesville, Florida 32610 0277, USA
Ann Med 42:19-35. 2010..These considerations suggest that novel therapies with a different mechanism of action may provide additional reductions in morbidity and mortality beyond those observed with current agents... - Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudyScott J Denardo
Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL 32610, USA
Hypertension 53:624-30. 2009..Because, as a group, revascularized patients with hypertension had worse outcomes compared with nonrevascularized patients, management of blood pressure to a specific target in future studies could result in improved outcomes... - Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudyAnthony A Bavry
Division of Cardiovascular Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL 32610 0277, USA
Hypertension 55:48-53. 2010..PAD patients displayed a J-shape relationship with systolic blood pressure and the primary outcome, although individuals without PAD did not. PAD patients may require a different target blood pressure than those without PAD... - INVEST revisited: review of findings from the International Verapamil SR-Trandolapril StudyRhonda M Cooper-Dehoff
University of Florida College of Pharmacy, Department of Pharmacotherapy and Translational Research, 1600 SW Archer Road, Box 100486, Gainesville, FL 32610 0486, USA
Expert Rev Cardiovasc Ther 7:1329-40. 2009..g., risk for diabetes) and not necessarily that any one drug be given to all... - Depressive symptoms in coronary artery disease patients after hypertension treatmentL Douglas Ried
Department of Pharmacy Health Care Administration, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
Ann Pharmacother 40:597-604. 2006..Depression is highly prevalent and frequently recurs in patients with coronary artery disease (CAD) and hypertension. Certain medications used to treat hypertension are alleged to be associated with higher risk of depression... - Multimarker approach predicts adverse cardiovascular events in women evaluated for suspected ischemia: results from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome EvaluationChristopher B Arant
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
Clin Cardiol 32:244-50. 2009..Inflammatory marker and hemoglobin levels (eg biomarkers) considered separately, predict adverse events in selected populations... - Combination rosuvastatin plus fenofibric acid in a cohort of patients 65 years or older with mixed dyslipidemia: subanalysis of two randomized, controlled studiesCarl J Pepine
Division of Cardiovscular Medicine, The University of Florida, Gainesville, Florida, USA
Clin Cardiol 33:609-19. 2010..Combination lipid therapy is an option; however, efficacy and safety data among elderly patients are lacking... - Blood pressure lowering in patients with diabetes--one level might not fit allRhonda M Cooper-Dehoff
Department of Pharmacotherapy and Translational Research, College of Pharmacy, PO Box 100486, University of Florida, Gainesville, FL 32610 0486, USA
Nat Rev Cardiol 8:42-9. 2011..In the future, a personalized approach will maximize the benefits from treatment... - Coronary revascularization strategy and outcomes according to blood pressure (from the International Verapamil SR-Trandolapril Study [INVEST])Scott J Denardo
University of Florida College of Medicine, Gainesville, FL, USA
Am J Cardiol 106:498-503. 2010..The management of BP might, therefore, require modification of targets according to the revascularization strategy to improve outcomes... - Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the Women's Ischemia Syndrome Evaluation (WISE)C Noel Bairey Merz
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
Am J Med 113:723-7. 2002..We also sought to evaluate this association, independent of statin use, particularly among premenopausal women of childbearing age... - Characteristics of contemporary patients with hypertension and coronary artery diseaseRhonda M Cooper-Dehoff
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
Clin Cardiol 27:571-6. 2004..This is particularly true for black and Hispanic patients who have been underrepresented in randomized CAD trials... - An academic-community cardiovascular service line affiliation: design, implementation, and performanceCharles R Lambert
Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, 32610, USA
Am Heart Hosp J 4:86-94. 2006.... - Blood pressure control and cardiovascular outcomes in high-risk Hispanic patients--findings from the International Verapamil SR/Trandolapril Study (INVEST)Rhonda M Cooper-Dehoff
University of Florida College of Medicine, Gainesville, FL, USA
Am Heart J 151:1072-9. 2006..People of Hispanic origin are the fastest growing ethnic minority in the United States and often have hypertension and other comorbidities which increase the risk associated with coronary artery disease (CAD)... - Exercise treadmill testing using a modified exercise protocol in women with suspected myocardial ischemia: findings from the National Heart, Lung and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE)Jannet F Lewis
WISE Clinical Centers, Division of Cardiology, University of Florida, Gainesville, Fla, USA
Am Heart J 149:527-33. 2005..As part of the WISE, a modified protocol was examined with the intention of improving reliability of exercise testing... - Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation StudyChristopher B Arant
University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 43:2009-14. 2004..This study was designed to investigate the relationship between hemoglobin level (Hgb) and adverse cardiovascular outcomes in women with suspected ischemia... - Ischemic heart disease: metabolic approaches to managementDaniel F Pauly
University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610, USA
Clin Cardiol 27:439-41. 2004..Metabolic modulators also include the nutriceuticals L-carnitine and D-ribose. The available evidence regarding the benefits of each of these five agents is reviewed... - Impaired coronary vascular reactivity and functional capacity in women: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE) StudyEileen Handberg
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 47:S44-9. 2006..We investigated the relationship between coronary vascular reactivity and functional capacity as assessed from the Duke Activity Status Index (DASI) in a cohort of women evaluated for suspected ischemia... - A Study of Antihypertensive Drugs and Depressive Symptoms (SADD-Sx) in patients treated with a calcium antagonist versus an atenolol hypertension Treatment Strategy in the International Verapamil SR-Trandolapril Study (INVEST)L Douglas Ried
Rehabilitation Outcomes Research Center, Malcom Randall Veterans Affairs Medical Center, Department of Veterans Affairs, Gainesville, Florida, USA
Psychosom Med 67:398-406. 2005..Effects of these antihypertension strategies on mood-related issues are not well understood... - What is the optimal blood pressure and drug therapy for patients with coronary artery disease?Carl J Pepine
JAMA 292:2271-3. 2004 - Clinical outcomes in the diabetes cohort of the INternational VErapamil SR-Trandolapril studyGeorge L Bakris
Rush Medical University, 1700 W Van Buren St, Suite 470, Chicago, IL
Hypertension 44:637-42. 2004..Thus, a verapamil SR-based antihypertensive treatment strategy is an alternative to a beta-blocker-based strategy in adults with CAD and diabetes... - Efficacy and safety of sildenafil citrate in men with erectile dysfunction and stable coronary artery diseaseRobert F Debusk
Stanford Cardiac Rehabilitation Program, Stanford University School of Medicine, Palo Alto, California 94304, USA
Am J Cardiol 93:147-53. 2004..There were no serious drug-related cardiovascular effects. Thus, sildenafil is an effective and well-tolerated treatment for ED in men with CAD. Sildenafil was not associated with additional safety risks in this patient population... - Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in womenTimothy R Wessel
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
JAMA 292:1179-87. 2004..Individual contributions of obesity and physical fitness (physical activity and functional capacity) to risk of coronary heart disease in women remain unclear... - Managing hypertension in European patients with coronary artery disease: design, results, and clinical implications of INVESTCarl J Pepine
Ital Heart J 5:411-6. 2004 - Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)B Delia Johnson
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Circulation 109:2993-9. 2004..Further evaluation into the underlying pathophysiology and possible treatment options for women with evidence of myocardial ischemia but without CAD is indicated... - Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women's Ischemia Syndrome EvaluationOscar C Marroquin
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
Circulation 109:714-21. 2004..Specifically, the metabolic syndrome was found to be a predictor of 4-year cardiovascular risk only when associated with significant angiographic CAD... - Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: executive summaryNoel Bairey Merz
Circulation 109:805-7. 2004 - Hostility scores are associated with increased risk of cardiovascular events in women undergoing coronary angiography: a report from the NHLBI-Sponsored WISE StudyMarian B Olson
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Psychosom Med 67:546-52. 2005..To evaluate hostility-related personality traits assessed by the Cook Medley Hostility Inventory and to relate these to the occurrence of adverse cardiac events in women with suspected myocardial ischemia... - A drug dose model for predicting clinical outcomes in hypertensive coronary disease patientsWilliam J Elliott
Department of Preventive Medicine, Rush Medical College of Rush University, Chicago, IL 60612, USA
J Clin Hypertens (Greenwich) 7:654-63. 2005.... - Social networks are associated with lower mortality rates among women with suspected coronary disease: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation studyThomas Rutledge
University of California, San Diego, San Diego, California, USA
Psychosom Med 66:882-8. 2004..To examine the association between social relationships measured by the Social Network Scale and coronary artery disease (CAD) risk and mortality among a sample of women with suspected CAD... - Blood pressure control and improved cardiovascular outcomes in the International Verapamil SR-Trandolapril StudyGiuseppe Mancia
Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione, Universita Milano Bicocca, Milan, Italy
Hypertension 50:299-305. 2007..Consistency of BP control during treatment provides additional information on the protective effect of antihypertensive treatment. Physicians need to be concerned at each visit if BP is not controlled... - Anger, hostility, and cardiac symptoms in women with suspected coronary artery disease: the Women's Ischemia Syndrome Evaluation (WISE) StudyDavid S Krantz
Department of Medical and Clinical Psychology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, USA
J Womens Health (Larchmt) 15:1214-23. 2006..To determine the relationship of anger and hostility to angiographic coronary artery disease (CAD), symptoms, and functional status among women with suspected CAD... - Inflammation in atherosclerosis: some thoughts about acute coronary syndromesAlexandra R Lucas
Robarts Research Institute, Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
Circulation 113:e728-32. 2006 - Obesity paradox in patients with hypertension and coronary artery diseaseSeth Uretsky
Division of Cardiology, St Luke s Roosevelt Hospital, New York, NY, USA
Am J Med 120:863-70. 2007..However, whether this phenomenon exists in patients with hypertension and coronary artery disease is not known... - Predicting stroke risk in hypertensive patients with coronary artery disease: a report from the INVESTAntonio Coca
Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
Stroke 39:343-8. 2008..Accordingly, factors predicting stroke risk in hypertensive, clinically stable coronary artery disease patients were determined with data from the INternational VErapamil SR-trandolapril STudy (INVEST)... - Assessment of women with suspected myocardial ischemia: review of findings of the Women's Ischemia Syndrome Evaluation (WISE) StudyJannet F Lewis
Division of Cardiology, George Washington University Medical Center, Suite 4-414, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA
Curr Womens Health Rep 2:110-4. 2002..The following discussion provides an overview of the WISE study and reviews the reported and published data from the study... - The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health--National Heart, Lung, and Blood Institute--sponsored Women's Ischemia Syndrome EvaluationLeslee J Shaw
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, Calif, USA
Circulation 114:894-904. 2006..Few data exist regarding the type and intensity of resource consumption in women with chest pain after coronary angiography... - Depression symptom severity and reported treatment history in the prediction of cardiac risk in women with suspected myocardial ischemia: The NHLBI-sponsored WISE studyThomas Rutledge
Department of Psychiatry, VA San Diego Healthcare System and University of California, San Diego, CA 92161, USA
Arch Gen Psychiatry 63:874-80. 2006..Typically, however, studies in this area focus only on baseline symptom severity and lack any data concerning symptom duration or symptom history... - Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?Franz H Messerli
Division of Cardiology, St Luke s Roosevelt Hospital, New York, New York 10019, USA
Ann Intern Med 144:884-93. 2006..Because coronary perfusion occurs mainly during diastole, patients with coronary artery disease (CAD) could be at increased risk for coronary events if diastolic pressure falls below critical levels... - Effect of ACAT inhibition on the progression of coronary atherosclerosisSteven E Nissen
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
N Engl J Med 354:1253-63. 2006..The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects... - The role of carnitine in myocardial dysfunctionDaniel F Pauly
Division of Cardiovascular Medicine, University of Florida, Gainesville, FL 32610, USA
Am J Kidney Dis 41:S35-43. 2003..Because a dialysis-related carnitine disorder is common among these patients, L-carnitine supplementation would be among these specific therapies... - Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)B Delia Johnson
Graduate School of Public Health, University of Pittsburgh, Parran 127, 130 DeSoto St, Pittsburgh, PA 15261, USA
Circulation 109:726-32. 2004..However, prior studies have yielded inconsistent results, and the independent predictive value of SAA for coronary artery disease (CAD) severity and cardiovascular events remains unclear...
Research Grants
- Renin Angiotensin for Coronary Microvascular DysfunctionCarl Pepine; Fiscal Year: 2005....
- UFCC for Cardiovascular Cell Therapy Research NetworkCarl Pepine; Fiscal Year: 2007..This work will improve our understanding of the role of cell therapy in patients with CAD and heart failure. (End of Abstract) ..
- Ancillary Functional Studies for the CCTRNCarl Pepine; Fiscal Year: 2009..Results from ancillary studies in this proposal are crucially important for the interpretation of current CCTRN trials and will be used to construct future CCTRN cell therapy trials. (End of Abstract) ..
- Ancillary Functional Studies for the CCTRNMark S Segal; Fiscal Year: 2010..Results from ancillary studies in this proposal are crucially important for the interpretation of current CCTRN trials and will be used to construct future CCTRN cell therapy trials. (End of Abstract) ..