C Pepine

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation
    Michael A Pacanowski
    Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL, USA
    J Transl Med 6:11. 2008
  2. ncbi request reprint Endothelial dysfunction and its role in the cycle of cardiovascular disease
    C Pepine
    University of Florida, Division of Cardiovascular Medicine, Gainsville 32610 0277, USA
    Can J Cardiol 14:5D-7D. 1998
  3. ncbi request reprint Cardiovascular therapies and risk for development of diabetes
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 44:509-12. 2004
  4. ncbi request reprint Effects of angiotensin-converting enzyme inhibition on transient ischemia: the Quinapril Anti-Ischemia and Symptoms of Angina Reduction (QUASAR) trial
    Carl J Pepine
    University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 42:2049-59. 2003
  5. ncbi request reprint Predictors of adverse outcome among patients with hypertension and coronary artery disease
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 47:547-51. 2006
  6. ncbi request reprint Introduction: new and emerging implications for the field of vascular biology
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    Am J Cardiol 91:1H-2H. 2003
  7. ncbi request reprint Some thoughts on the vasculopathy of women with ischemic heart disease
    Carl J Pepine
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    J Am Coll Cardiol 47:S30-5. 2006
  8. ncbi request reprint Optimizing lipid management in patients with acute coronary syndromes
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    Am J Cardiol 91:30B-35B. 2003
  9. ncbi request reprint Introduction: there is an important need for increased understanding of the pathophysiology of heart failure postinfarction, new treatment strategies, earlier implementation of effective strategies, and more effective use of existing therapies
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Am J Cardiol 97:1F-3F. 2006
  10. ncbi request reprint Ischemic heart disease in women: facts and wishful thinking
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 43:1727-30. 2004

Research Grants

Collaborators

Detail Information

Publications90

  1. pmc Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation
    Michael A Pacanowski
    Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL, USA
    J Transl Med 6:11. 2008
    ..Adrenergic gene polymorphisms are associated with cardiovascular and metabolic phenotypes. We investigated the influence of adrenergic gene polymorphisms on cardiovascular risk in women with suspected myocardial ischemia...
  2. ncbi request reprint Endothelial dysfunction and its role in the cycle of cardiovascular disease
    C Pepine
    University of Florida, Division of Cardiovascular Medicine, Gainsville 32610 0277, USA
    Can J Cardiol 14:5D-7D. 1998
    ..An overview of normal endothelial function and endothelial dysfunction, and a unifying model to illustrate the cascade of events that occur in the coronary artery disease process are presented...
  3. ncbi request reprint Cardiovascular therapies and risk for development of diabetes
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 44:509-12. 2004
    ..Physicians should consider this possible diabetes consequence when prescribing long-term beta-blockers and diuretics, particularly in patients at high risk of developing diabetes...
  4. ncbi request reprint Effects of angiotensin-converting enzyme inhibition on transient ischemia: the Quinapril Anti-Ischemia and Symptoms of Angina Reduction (QUASAR) trial
    Carl J Pepine
    University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 42:2049-59. 2003
    ..We sought to determine whether angiotensin-converting enzyme inhibition (ACE-I) (i.e., quinapril) prevents transient ischemia (exertional and spontaneous) in patients with coronary artery disease (CAD)...
  5. ncbi request reprint Predictors of adverse outcome among patients with hypertension and coronary artery disease
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 47:547-51. 2006
    ..We sought to determine predictors for adverse outcomes in hypertensive patients with coronary artery disease (CAD)...
  6. ncbi request reprint Introduction: new and emerging implications for the field of vascular biology
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    Am J Cardiol 91:1H-2H. 2003
  7. ncbi request reprint Some thoughts on the vasculopathy of women with ischemic heart disease
    Carl J Pepine
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    J Am Coll Cardiol 47:S30-5. 2006
    ..A better understanding of these findings should provide direction for new algorithms to improve management of the vasculopathy underlying IHD in women...
  8. ncbi request reprint Optimizing lipid management in patients with acute coronary syndromes
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    Am J Cardiol 91:30B-35B. 2003
    ..These programs are the Cardiac Hospitalization Atherosclerosis Management Program (CHAMP) and the Guidelines Applied in Practice (GAP)...
  9. ncbi request reprint Introduction: there is an important need for increased understanding of the pathophysiology of heart failure postinfarction, new treatment strategies, earlier implementation of effective strategies, and more effective use of existing therapies
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Am J Cardiol 97:1F-3F. 2006
  10. ncbi request reprint Ischemic heart disease in women: facts and wishful thinking
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 43:1727-30. 2004
  11. ncbi request reprint Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertension
    C J Pepine
    Division of Cardiovascular Medicine, University of Florida, College of Medicine, Gainesville 32610 0277, USA
    J Am Coll Cardiol 32:1228-37. 1998
    ....
  12. pmc Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 55:2825-32. 2010
    ..We investigated whether coronary microvascular dysfunction predicts major adverse outcomes during follow-up among women with signs and symptoms of ischemia...
  13. ncbi request reprint Why vascular biology matters
    C J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 Archer Road, Gainesville, FL 32610, USA
    Am J Cardiol 88:5K-9K. 2001
    ..However, if this information is not incorporated into clinical practice in a timely manner, cardiovascular disease will continue to present a major cause of morbidity and mortality worldwide...
  14. doi request reprint The impact of nitric oxide in cardiovascular medicine: untapped potential utility
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    Am J Med 122:S10-5. 2009
    ..This background provides the rationale for exploring the potential therapeutic role for NO-donating agents in the prevention of adverse cardiovascular outcomes...
  15. ncbi request reprint The pathophysiology of chronic ischemic heart disease
    Carl J Pepine
    Division of Cardiovascular Medicine, Gainesville, FL 32610 0277, USA
    Clin Cardiol 30:I4-9. 2007
    ..Where possible, targets for novel therapeutic approaches are highlighted...
  16. ncbi request reprint Phytoestrogens and coronary microvascular function in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE) Study
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    J Womens Health (Larchmt) 16:481-8. 2007
    ..Accordingly, we investigated the relationship between blood phytoestrogen levels and coronary reactivity in women with suspected myocardial ischemia referred for coronary angiography...
  17. ncbi request reprint Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST])
    Rhonda Cooper-DeHoff
    University of Florida College of Medicine, Gainesville, Florida, USA
    Am J Cardiol 98:890-4. 2006
    ....
  18. ncbi request reprint Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial
    Bernard R Chaitman
    Department of Medicine, Division of Cardiology, St Louis University School of Medicine, St Louis, MO, USA
    JAMA 291:309-16. 2004
    ....
  19. doi request reprint Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: an INternational VErapamil SR-Trandolapril (INVEST) substudy
    Sripal Bangalore
    Division of Cardiovascular Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Am Heart J 156:241-7. 2008
    ..The purpose of the study was to compare a beta-blocker-based strategy with a heart rate-lowering calcium antagonists-based strategy in patients with prior MI...
  20. ncbi request reprint Dual therapy in hypertensive patients with coronary artery disease: the role of calcium channel blockers and beta-blockers
    George L Bakris
    University of Chicago School of Medicine, Department of Medicine, Hypertensive Diseases Unit, Chicago, Illinois 60637, USA
    Am J Cardiovasc Drugs 7:25-9. 2007
    ....
  21. ncbi request reprint A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial
    Carl J Pepine
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    JAMA 290:2805-16. 2003
    ..Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials...
  22. ncbi request reprint Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)
    Gregory O von Mering
    University of Florida College of Medicine, Gainesville, Fla 32610 0277, USA
    Circulation 109:722-5. 2004
    ..Coronary vascular dysfunction has been linked to atherosclerosis and adverse cardiovascular outcomes in men, but these relationships have not been firmly established in women...
  23. pmc Factors influencing blood pressure response to trandolapril add-on therapy in patients taking verapamil SR (from the International Verapamil SR/Trandolapril [INVEST] Study)
    Martin Brunner
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, USA
    Am J Cardiol 99:1549-54. 2007
    ..Race was associated with diastolic BP response, although the difference is likely not to be clinically significant and AGTR1 genotype was not associated with BP response...
  24. ncbi request reprint Pharmacologic plaque passivation for the reduction of recurrent cardiac events in acute coronary syndromes
    V Stephen Monroe
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Am Coll Cardiol 41:23S-30S. 2003
    ..This article reviews atherosclerotic plaque development and vulnerability and discusses some clinical studies highlighting the role of plaque passivation in the management of ACS patients...
  25. pmc Systolic blood pressure and subjective well-being in patients with coronary artery disease
    Yan Gong
    College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Clin Cardiol 32:627-32. 2009
    ..Limited information exists regarding the association between subjective well-being (SWB) and systolic blood pressure (SBP) among hypertensive patients with coronary artery disease (CAD)...
  26. ncbi request reprint The QUinapril Ischemic Event Trial (QUIET): evaluation of chronic ACE inhibitor therapy in patients with ischemic heart disease and preserved left ventricular function
    B Pitt
    Department of Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Cardiol 87:1058-63. 2001
    ..However, the absence of the demonstrable effect of quinapril may be due to several limitations in study design...
  27. pmc CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response
    Amber L Beitelshees
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL, USA
    Circ Cardiovasc Genet 2:362-70. 2009
    ..The gene encoding the target of calcium channel blockers, the alpha1c-subunit of the L-type calcium channel (CACNA1C), has not been well characterized, and only small pharmacogenetic studies testing this gene have been published to date...
  28. ncbi request reprint Global differences in blood pressure control and clinical outcomes in the INternational VErapamil SR-Trandolapril STudy (INVEST)
    Issam Zineh
    Department of Pharmacy Practice, College of Pharmacy University of Florida, Gainesville, Florida 32610, USA
    Clin Cardiol 28:321-8. 2005
    ....
  29. pmc Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES)
    Tobias Gerhard
    College of Pharmacy, University of Florida, Gainesville, FL 32610 0486, USA
    Am Heart J 156:397-404. 2008
    ..The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists...
  30. ncbi request reprint Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE)
    Timothy R Wessel
    University of Florida, Division of Cardiovascular Medicine, Gainesville, FL 32610 0277, USA
    Clin Cardiol 30:69-74. 2007
    ..Accordingly, the relationship between adenosine-related microvascular coronary reactivity and risk factors in symptomatic women evaluated for suspected ischemia remains uncertain...
  31. ncbi request reprint Antihypertensive properties of a high-dose combination of trandolapril and verapamil-SR
    Franz Messerli
    Department of Medicine, Division of Cardiology, St Luke s Roosevelt Hospital and Columbia University, New York, NY, USA
    Blood Press Suppl 16:6-9. 2007
    ..Despite differences in the risk profiles of previously studied patients and INVEST patients, the antihypertensive effects of Ve+Tr were similar...
  32. ncbi request reprint Antihypertensive properties of a high-dose combination of trandolapril and verapamil-SR
    Franz Messerli
    Department of Medicine, Division of Cardiology, St Luke s Roosevelt Hospital and Columbia University, New York, NY, USA
    Blood Press Suppl 1:6-9. 2007
    ..Despite differences in the risk profiles of previously studied patients and INVEST patients, the antihypertensive effects of Ve+Tr were similar...
  33. pmc KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)
    Amber L Beitelshees
    Department of Pharmacy Practice, University of Florida, College of Pharmacy, Gainesville, USA
    Pharmacogenet Genomics 17:719-29. 2007
    ....
  34. doi request reprint Pulse pressure and risk of cardiovascular outcomes in patients with hypertension and coronary artery disease: an INternational VErapamil SR-trandolapril STudy (INVEST) analysis
    Sripal Bangalore
    Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 1000 Tenth Avenue, Suite 3B 30, New York, NY 10025, USA
    Eur Heart J 30:1395-401. 2009
    ....
  35. ncbi request reprint The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data
    V J Dzau
    Department of Medicine, Brigham Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Cardiol 88:1L-20L. 2001
    ..More comparative experimental and clinical studies should address the significance of these drug differences and their impact on clinical events...
  36. ncbi request reprint The value of estimated functional capacity in estimating outcome: results from the NHBLI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study
    Leslee J Shaw
    Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Am Coll Cardiol 47:S36-43. 2006
    ..Our objective was to determine the prognostic value of estimated metabolic equivalents (METs) based on self-reported functional capacity by the Duke Activity Status Index (DASI) in symptomatic women...
  37. ncbi request reprint Comparison of effects of nisoldipine-extended release and amlodipine in patients with systemic hypertension and chronic stable angina pectoris
    Carl J Pepine
    University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Am J Cardiol 91:274-9. 2003
    ..Thus, nisoldipine-ER and amlodipine provided comparable antihypertensive and anti-ischemic efficacy, and both were generally well tolerated...
  38. ncbi request reprint Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study
    C Noel Bairey Merz
    Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Am Coll Cardiol 41:413-9. 2003
    ..We sought to evaluate hypoestrogenemia of hypothalamic origin and its association with angiographic coronary artery disease (CAD) in premenopausal women...
  39. pmc Importance of socioeconomic status as a predictor of cardiovascular outcome and costs of care in women with suspected myocardial ischemia. Results from the National Institutes of Health, National Heart, Lung and Blood Institute-sponsored Women's Ischemia
    Leslee J Shaw
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    J Womens Health (Larchmt) 17:1081-92. 2008
    ..For women, who are more likely to live in poverty, defining the clinical and economic impact of socioeconomic factors may aid in defining redistributive policies to improve healthcare quality...
  40. ncbi request reprint Commentary on "new and emerging theories of cardiovascular disease"
    Timothy R Wessel
    Division of Cardiovascular Medicine at the University of Florida College of Medicine, Gainesville, FL 32610, USA
    Biol Res Nurs 6:17-20; discussion 21-3. 2004
  41. pmc Metabolic syndrome and cardiovascular disease: challenges and opportunities
    Rhonda M Cooper-Dehoff
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    Clin Cardiol 30:593-7. 2007
    ....
  42. ncbi request reprint Influence of Hispanic ethnicity on blood pressure control and cardiovascular outcomes in women with CAD and hypertension: findings from INVEST
    Rhonda M Cooper-Dehoff
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Womens Health (Larchmt) 16:632-40. 2007
    ..Prospective data regarding blood pressure (BP) control and cardiovascular (CV) outcomes in Hispanic women are lacking...
  43. ncbi request reprint Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: Results from the Psychophysiological Investigations of Myocardial Ischemia study
    David S Sheps
    University of Florida College of Medicine, the Malcom Randall Veterans Affairs Medical Center, and the Medical Research Service of the Department of Veterans Affairs, Gainesville, Fla 32610 0277, USA
    Circulation 105:1780-4. 2002
    ..Ischemia during laboratory mental stress tests has been linked to significantly higher rates of adverse cardiac events. Previous studies have not been designed to detect differences in mortality rates...
  44. doi request reprint Marrow cell therapies for cardiovascular diseases
    Christopher R Cogle
    Department of Medicine, Division of Hematology Oncology, Program in Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0278, USA
    Exp Hematol 36:687-94. 2008
    ..The next generation of studies will aim to answers these questions and make way for cellular therapies that result in effective cardiac repair...
  45. ncbi request reprint Revisiting the culprit lesion in non-Q-wave myocardial infarction. Results from the VANQWISH trial angiographic core laboratory
    Richard A Kerensky
    Malcom Randall Veterans Affairs Medical Center and the University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 39:1456-63. 2002
    ..We sought to determine the underlying coronary anatomy and characterize the culprit lesion after non-Q-wave myocardial infarction (NQWMI)...
  46. pmc Cardiovascular therapies and associated glucose homeostasis: implications across the dysglycemia continuum
    Rhonda M Cooper-Dehoff
    Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 53:S28-34. 2009
    ..These considerations have particular importance in younger patients who may also have pre-diabetes or the metabolic syndrome and who are likely to require therapy over the course of decades...
  47. pmc Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy
    Scott J Denardo
    Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Med 123:719-26. 2010
    ..Our understanding of the growing population of very old patients (aged >or=80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes...
  48. doi request reprint Pathophysiologic mechanisms linking impaired cardiovascular health and neurologic dysfunction: the year in review
    Ki E Park
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
    Cleve Clin J Med 77:S40-5. 2010
    ....
  49. pmc Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease
    Rhonda M Cooper-Dehoff
    Department of Pharmacotherapy and Translational Research and Division of Cardiovascular Medicine, College of Pharmacy, University of Florida, 1600 SW Archer Rd, PO Box 100486, Gainesville, FL 32610 0486, USA
    JAMA 304:61-8. 2010
    ..Hypertension guidelines advocate treating systolic blood pressure (BP) to less than 130 mm Hg for patients with diabetes mellitus; however, data are lacking for the growing population who also have coronary artery disease (CAD)...
  50. doi request reprint Residual risk for secondary ischemic events in patients with atherothrombotic disease: opportunity for future improvements in patient care
    Carl J Pepine
    University of Florida, Gainesville, Florida 32610 0277, USA
    Ann Med 42:19-35. 2010
    ..These considerations suggest that novel therapies with a different mechanism of action may provide additional reductions in morbidity and mortality beyond those observed with current agents...
  51. pmc Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudy
    Scott J Denardo
    Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL 32610, USA
    Hypertension 53:624-30. 2009
    ..Because, as a group, revascularized patients with hypertension had worse outcomes compared with nonrevascularized patients, management of blood pressure to a specific target in future studies could result in improved outcomes...
  52. pmc Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudy
    Anthony A Bavry
    Division of Cardiovascular Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL 32610 0277, USA
    Hypertension 55:48-53. 2010
    ..PAD patients displayed a J-shape relationship with systolic blood pressure and the primary outcome, although individuals without PAD did not. PAD patients may require a different target blood pressure than those without PAD...
  53. pmc INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study
    Rhonda M Cooper-Dehoff
    University of Florida College of Pharmacy, Department of Pharmacotherapy and Translational Research, 1600 SW Archer Road, Box 100486, Gainesville, FL 32610 0486, USA
    Expert Rev Cardiovasc Ther 7:1329-40. 2009
    ..g., risk for diabetes) and not necessarily that any one drug be given to all...
  54. ncbi request reprint Depressive symptoms in coronary artery disease patients after hypertension treatment
    L Douglas Ried
    Department of Pharmacy Health Care Administration, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Ann Pharmacother 40:597-604. 2006
    ..Depression is highly prevalent and frequently recurs in patients with coronary artery disease (CAD) and hypertension. Certain medications used to treat hypertension are alleged to be associated with higher risk of depression...
  55. pmc Multimarker approach predicts adverse cardiovascular events in women evaluated for suspected ischemia: results from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation
    Christopher B Arant
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Clin Cardiol 32:244-50. 2009
    ..Inflammatory marker and hemoglobin levels (eg biomarkers) considered separately, predict adverse events in selected populations...
  56. doi request reprint Combination rosuvastatin plus fenofibric acid in a cohort of patients 65 years or older with mixed dyslipidemia: subanalysis of two randomized, controlled studies
    Carl J Pepine
    Division of Cardiovscular Medicine, The University of Florida, Gainesville, Florida, USA
    Clin Cardiol 33:609-19. 2010
    ..Combination lipid therapy is an option; however, efficacy and safety data among elderly patients are lacking...
  57. pmc Blood pressure lowering in patients with diabetes--one level might not fit all
    Rhonda M Cooper-Dehoff
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, PO Box 100486, University of Florida, Gainesville, FL 32610 0486, USA
    Nat Rev Cardiol 8:42-9. 2011
    ..In the future, a personalized approach will maximize the benefits from treatment...
  58. pmc Coronary revascularization strategy and outcomes according to blood pressure (from the International Verapamil SR-Trandolapril Study [INVEST])
    Scott J Denardo
    University of Florida College of Medicine, Gainesville, FL, USA
    Am J Cardiol 106:498-503. 2010
    ..The management of BP might, therefore, require modification of targets according to the revascularization strategy to improve outcomes...
  59. ncbi request reprint Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the Women's Ischemia Syndrome Evaluation (WISE)
    C Noel Bairey Merz
    Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Med 113:723-7. 2002
    ..We also sought to evaluate this association, independent of statin use, particularly among premenopausal women of childbearing age...
  60. ncbi request reprint Characteristics of contemporary patients with hypertension and coronary artery disease
    Rhonda M Cooper-Dehoff
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    Clin Cardiol 27:571-6. 2004
    ..This is particularly true for black and Hispanic patients who have been underrepresented in randomized CAD trials...
  61. ncbi request reprint An academic-community cardiovascular service line affiliation: design, implementation, and performance
    Charles R Lambert
    Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, 32610, USA
    Am Heart Hosp J 4:86-94. 2006
    ....
  62. ncbi request reprint Blood pressure control and cardiovascular outcomes in high-risk Hispanic patients--findings from the International Verapamil SR/Trandolapril Study (INVEST)
    Rhonda M Cooper-Dehoff
    University of Florida College of Medicine, Gainesville, FL, USA
    Am Heart J 151:1072-9. 2006
    ..People of Hispanic origin are the fastest growing ethnic minority in the United States and often have hypertension and other comorbidities which increase the risk associated with coronary artery disease (CAD)...
  63. ncbi request reprint Exercise treadmill testing using a modified exercise protocol in women with suspected myocardial ischemia: findings from the National Heart, Lung and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE)
    Jannet F Lewis
    WISE Clinical Centers, Division of Cardiology, University of Florida, Gainesville, Fla, USA
    Am Heart J 149:527-33. 2005
    ..As part of the WISE, a modified protocol was examined with the intention of improving reliability of exercise testing...
  64. ncbi request reprint Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation Study
    Christopher B Arant
    University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 43:2009-14. 2004
    ..This study was designed to investigate the relationship between hemoglobin level (Hgb) and adverse cardiovascular outcomes in women with suspected ischemia...
  65. ncbi request reprint Ischemic heart disease: metabolic approaches to management
    Daniel F Pauly
    University of Florida College of Medicine, Division of Cardiovascular Medicine, Gainesville, Florida 32610, USA
    Clin Cardiol 27:439-41. 2004
    ..Metabolic modulators also include the nutriceuticals L-carnitine and D-ribose. The available evidence regarding the benefits of each of these five agents is reviewed...
  66. ncbi request reprint Impaired coronary vascular reactivity and functional capacity in women: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE) Study
    Eileen Handberg
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 47:S44-9. 2006
    ..We investigated the relationship between coronary vascular reactivity and functional capacity as assessed from the Duke Activity Status Index (DASI) in a cohort of women evaluated for suspected ischemia...
  67. ncbi request reprint A Study of Antihypertensive Drugs and Depressive Symptoms (SADD-Sx) in patients treated with a calcium antagonist versus an atenolol hypertension Treatment Strategy in the International Verapamil SR-Trandolapril Study (INVEST)
    L Douglas Ried
    Rehabilitation Outcomes Research Center, Malcom Randall Veterans Affairs Medical Center, Department of Veterans Affairs, Gainesville, Florida, USA
    Psychosom Med 67:398-406. 2005
    ..Effects of these antihypertension strategies on mood-related issues are not well understood...
  68. ncbi request reprint What is the optimal blood pressure and drug therapy for patients with coronary artery disease?
    Carl J Pepine
    JAMA 292:2271-3. 2004
  69. ncbi request reprint Clinical outcomes in the diabetes cohort of the INternational VErapamil SR-Trandolapril study
    George L Bakris
    Rush Medical University, 1700 W Van Buren St, Suite 470, Chicago, IL
    Hypertension 44:637-42. 2004
    ..Thus, a verapamil SR-based antihypertensive treatment strategy is an alternative to a beta-blocker-based strategy in adults with CAD and diabetes...
  70. ncbi request reprint Efficacy and safety of sildenafil citrate in men with erectile dysfunction and stable coronary artery disease
    Robert F Debusk
    Stanford Cardiac Rehabilitation Program, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Am J Cardiol 93:147-53. 2004
    ..There were no serious drug-related cardiovascular effects. Thus, sildenafil is an effective and well-tolerated treatment for ED in men with CAD. Sildenafil was not associated with additional safety risks in this patient population...
  71. ncbi request reprint Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in women
    Timothy R Wessel
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
    JAMA 292:1179-87. 2004
    ..Individual contributions of obesity and physical fitness (physical activity and functional capacity) to risk of coronary heart disease in women remain unclear...
  72. ncbi request reprint Managing hypertension in European patients with coronary artery disease: design, results, and clinical implications of INVEST
    Carl J Pepine
    Ital Heart J 5:411-6. 2004
  73. ncbi request reprint Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)
    B Delia Johnson
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 109:2993-9. 2004
    ..The prognostic implications of these findings are unknown...
  74. ncbi request reprint Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women's Ischemia Syndrome Evaluation
    Oscar C Marroquin
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 109:714-21. 2004
    ..The interrelationship between metabolic status and CAD on cardiovascular risk in women is not known...
  75. ncbi request reprint Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: executive summary
    Noel Bairey Merz
    Circulation 109:805-7. 2004
  76. ncbi request reprint Hostility scores are associated with increased risk of cardiovascular events in women undergoing coronary angiography: a report from the NHLBI-Sponsored WISE Study
    Marian B Olson
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Psychosom Med 67:546-52. 2005
    ..To evaluate hostility-related personality traits assessed by the Cook Medley Hostility Inventory and to relate these to the occurrence of adverse cardiac events in women with suspected myocardial ischemia...
  77. ncbi request reprint A drug dose model for predicting clinical outcomes in hypertensive coronary disease patients
    William J Elliott
    Department of Preventive Medicine, Rush Medical College of Rush University, Chicago, IL 60612, USA
    J Clin Hypertens (Greenwich) 7:654-63. 2005
    ....
  78. ncbi request reprint Social networks are associated with lower mortality rates among women with suspected coronary disease: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation study
    Thomas Rutledge
    University of California, San Diego, San Diego, California, USA
    Psychosom Med 66:882-8. 2004
    ..To examine the association between social relationships measured by the Social Network Scale and coronary artery disease (CAD) risk and mortality among a sample of women with suspected CAD...
  79. ncbi request reprint Blood pressure control and improved cardiovascular outcomes in the International Verapamil SR-Trandolapril Study
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione, Universita Milano Bicocca, Milan, Italy
    Hypertension 50:299-305. 2007
    ..Consistency of BP control during treatment provides additional information on the protective effect of antihypertensive treatment. Physicians need to be concerned at each visit if BP is not controlled...
  80. ncbi request reprint Anger, hostility, and cardiac symptoms in women with suspected coronary artery disease: the Women's Ischemia Syndrome Evaluation (WISE) Study
    David S Krantz
    Department of Medical and Clinical Psychology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, USA
    J Womens Health (Larchmt) 15:1214-23. 2006
    ..To determine the relationship of anger and hostility to angiographic coronary artery disease (CAD), symptoms, and functional status among women with suspected CAD...
  81. ncbi request reprint Inflammation in atherosclerosis: some thoughts about acute coronary syndromes
    Alexandra R Lucas
    Robarts Research Institute, Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Circulation 113:e728-32. 2006
  82. ncbi request reprint Obesity paradox in patients with hypertension and coronary artery disease
    Seth Uretsky
    Division of Cardiology, St Luke s Roosevelt Hospital, New York, NY, USA
    Am J Med 120:863-70. 2007
    ..However, whether this phenomenon exists in patients with hypertension and coronary artery disease is not known...
  83. pmc Predicting stroke risk in hypertensive patients with coronary artery disease: a report from the INVEST
    Antonio Coca
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Stroke 39:343-8. 2008
    ..Accordingly, factors predicting stroke risk in hypertensive, clinically stable coronary artery disease patients were determined with data from the INternational VErapamil SR-trandolapril STudy (INVEST)...
  84. ncbi request reprint Assessment of women with suspected myocardial ischemia: review of findings of the Women's Ischemia Syndrome Evaluation (WISE) Study
    Jannet F Lewis
    Division of Cardiology, George Washington University Medical Center, Suite 4 414, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA
    Curr Womens Health Rep 2:110-4. 2002
    ..The following discussion provides an overview of the WISE study and reviews the reported and published data from the study...
  85. ncbi request reprint The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health--National Heart, Lung, and Blood Institute--sponsored Women's Ischemia Syndrome Evaluation
    Leslee J Shaw
    Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, Calif, USA
    Circulation 114:894-904. 2006
    ..Few data exist regarding the type and intensity of resource consumption in women with chest pain after coronary angiography...
  86. ncbi request reprint Depression symptom severity and reported treatment history in the prediction of cardiac risk in women with suspected myocardial ischemia: The NHLBI-sponsored WISE study
    Thomas Rutledge
    Department of Psychiatry, VA San Diego Healthcare System and University of California, San Diego, CA 92161, USA
    Arch Gen Psychiatry 63:874-80. 2006
    ..Typically, however, studies in this area focus only on baseline symptom severity and lack any data concerning symptom duration or symptom history...
  87. ncbi request reprint Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?
    Franz H Messerli
    Division of Cardiology, St Luke s Roosevelt Hospital, New York, New York 10019, USA
    Ann Intern Med 144:884-93. 2006
    ..Because coronary perfusion occurs mainly during diastole, patients with coronary artery disease (CAD) could be at increased risk for coronary events if diastolic pressure falls below critical levels...
  88. ncbi request reprint Effect of ACAT inhibition on the progression of coronary atherosclerosis
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:1253-63. 2006
    ..The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects...
  89. ncbi request reprint The role of carnitine in myocardial dysfunction
    Daniel F Pauly
    Division of Cardiovascular Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Kidney Dis 41:S35-43. 2003
    ..Because a dialysis-related carnitine disorder is common among these patients, L-carnitine supplementation would be among these specific therapies...
  90. ncbi request reprint Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)
    B Delia Johnson
    Graduate School of Public Health, University of Pittsburgh, Parran 127, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Circulation 109:726-32. 2004
    ..However, prior studies have yielded inconsistent results, and the independent predictive value of SAA for coronary artery disease (CAD) severity and cardiovascular events remains unclear...

Research Grants7

  1. Renin Angiotensin for Coronary Microvascular Dysfunction
    Carl Pepine; Fiscal Year: 2005
    ....
  2. UFCC for Cardiovascular Cell Therapy Research Network
    Carl Pepine; Fiscal Year: 2007
    ..This work will improve our understanding of the role of cell therapy in patients with CAD and heart failure. (End of Abstract) ..
  3. Ancillary Functional Studies for the CCTRN
    Carl Pepine; Fiscal Year: 2009
    ..Results from ancillary studies in this proposal are crucially important for the interpretation of current CCTRN trials and will be used to construct future CCTRN cell therapy trials. (End of Abstract) ..
  4. Ancillary Functional Studies for the CCTRN
    Mark S Segal; Fiscal Year: 2010
    ..Results from ancillary studies in this proposal are crucially important for the interpretation of current CCTRN trials and will be used to construct future CCTRN cell therapy trials. (End of Abstract) ..