Paul Pentel

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc New directions in nicotine vaccine design and use
    Paul R Pentel
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA Electronic address
    Adv Pharmacol 69:553-80. 2014
  2. ncbi request reprint Vaccination against nicotine does not prevent nicotine-induced changes in fetal nicotinic receptor binding and c-fos mRNA expression in rats
    P R Pentel
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Neurotoxicol Teratol 28:589-96. 2006
  3. ncbi request reprint Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats
    P R Pentel
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55422, USA
    J Pharmacol Exp Ther 317:660-6. 2006
  4. ncbi request reprint Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:413-21. 2007
  5. ncbi request reprint Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:395-402. 2007
  6. ncbi request reprint Safety and immunogenicity of a nicotine conjugate vaccine in current smokers
    Dorothy K Hatsukami
    Cancer Center, Tobacco Use Research Center, University of Minnesota Medical School, 2701 University Avenue SE, Minneapolis, MN 55414, USA
    Clin Pharmacol Ther 78:456-67. 2005
  7. pmc Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies
    Mark G LeSage
    Minneapolis Medical Research Foundation, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    AAPS J 8:E65-75. 2006
  8. doi request reprint Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Exp Clin Psychopharmacol 16:86-97. 2008
  9. ncbi request reprint Developing the science base for reducing tobacco harm
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Nicotine Tob Res 9:S537-53. 2007
  10. pmc Nicotine pharmacokinetics and subjective effects of three potential reduced exposure products, moist snuff and nicotine lozenge
    Michael Kotlyar
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Tob Control 16:138-42. 2007

Research Grants

  1. TSE Inhalation System
    Paul Pentel; Fiscal Year: 2005
  2. Vaccine Effects on Fetal Nicotine Exposure in Rats
    Paul Pentel; Fiscal Year: 2005
  3. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2006
  4. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2005
  5. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2007
  6. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2009
  7. Multivalent Vaccine for Opiate Addiction
    Paul Pentel; Fiscal Year: 2009
  8. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2009
  9. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul R Pentel; Fiscal Year: 2010
  10. Multivalent Vaccine for Opiate Addiction
    Paul R Pentel; Fiscal Year: 2010

Detail Information

Publications30

  1. pmc New directions in nicotine vaccine design and use
    Paul R Pentel
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA Electronic address
    Adv Pharmacol 69:553-80. 2014
    ..Next-generation immunotherapies are likely to be substantially more effective than first-generation vaccines. ..
  2. ncbi request reprint Vaccination against nicotine does not prevent nicotine-induced changes in fetal nicotinic receptor binding and c-fos mRNA expression in rats
    P R Pentel
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Neurotoxicol Teratol 28:589-96. 2006
    ..The lack of effect of vaccination suggests that the cumulative exposure of fetal tissues to nicotine may influence the measured parameters to a greater extent than peak exposure levels...
  3. ncbi request reprint Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats
    P R Pentel
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55422, USA
    J Pharmacol Exp Ther 317:660-6. 2006
    ..In the setting of chronic nicotine dosing, antibodies with a moderate affinity for nicotine produced substantial effects on the early distribution of nicotine to brain and were as effective as higher affinity antibodies...
  4. ncbi request reprint Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:413-21. 2007
    ..Animal models could be useful for this purpose...
  5. ncbi request reprint Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:395-402. 2007
    ..e., an "extinction burst"). However, the presence of an extinction burst in animal models of nicotine self-administration (NSA) has not been studied extensively...
  6. ncbi request reprint Safety and immunogenicity of a nicotine conjugate vaccine in current smokers
    Dorothy K Hatsukami
    Cancer Center, Tobacco Use Research Center, University of Minnesota Medical School, 2701 University Avenue SE, Minneapolis, MN 55414, USA
    Clin Pharmacol Ther 78:456-67. 2005
    ..The 30-day abstinence rate was significantly different across the 4 doses (P = .02), with the highest rate of abstinence occurring with 200 microg. The nicotine vaccine appears to be a promising medication for tobacco dependence...
  7. pmc Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies
    Mark G LeSage
    Minneapolis Medical Research Foundation, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    AAPS J 8:E65-75. 2006
    ..Taken together, the work completed to date provides substantial evidence that immunologic interventions could play an important role in future treatment strategies for tobacco dependence...
  8. doi request reprint Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Exp Clin Psychopharmacol 16:86-97. 2008
    ..This model may be useful for characterizing underlying factors and potential consequences of compensatory smoking...
  9. ncbi request reprint Developing the science base for reducing tobacco harm
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Nicotine Tob Res 9:S537-53. 2007
    ..A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future...
  10. pmc Nicotine pharmacokinetics and subjective effects of three potential reduced exposure products, moist snuff and nicotine lozenge
    Michael Kotlyar
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Tob Control 16:138-42. 2007
    ..To compare nicotine pharmacokinetics and subjective effects of three new smokeless tobacco potential reduced exposure products (PREPs; Ariva, Revel and Stonewall) with moist snuff (Copenhagen) and medicinal nicotine (Commit lozenge)...
  11. pmc Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 205:599-611. 2009
    ..Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing the feasibility of harm reduction interventions...
  12. pmc Stability of the nicotine metabolite ratio in ad libitum and reducing smokers
    Marc E Mooney
    University of Minnesota, Transdisciplinary Tobacco Use Research Center, 2701 University Avenue South East, Suite 201, Minneapolis, MN 55414, USA
    Cancer Epidemiol Biomarkers Prev 17:1396-400. 2008
    ..Our objective was to evaluate the correlates and stability of the 3-HC to cotinine ratio in ad libitum and reducing smokers, using nicotine replacement therapy (NRT), over a period of months...
  13. pmc Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 93:105-11. 2009
    ..The Nic311 doses used have been shown to attenuate the behavioral effects of nicotine, suggesting that the use of passive immunization to treat nicotine addiction is not likely to precipitate withdrawal...
  14. ncbi request reprint The TEAM project: the effectiveness of smoking cessation intervention with hospital patients
    Deborah J Hennrikus
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Prev Med 40:249-58. 2005
    ....
  15. ncbi request reprint Hospital-based program for increasing the availability of emergency contraception: simulating nonprescription access
    Paul R Pentel
    University of Minnesota Medical School, and Division of Clinical Pharmacology, Hennepin County Medical Center, Minneapolis 55415, USA
    Am J Health Syst Pharm 61:777-80. 2004
    ..A hospital-based program simulating nonprescription access to emergency contraception (EC) is described...
  16. ncbi request reprint Lack of effect of 5HT3 antagonist in mediating subjective and behavioral responses to cotinine
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota, 2701 University Avenue, 201, Minneapolis, MN 55414, USA
    Pharmacol Biochem Behav 75:1-7. 2003
    ..The data do not strongly support the hypothesis that 5HT(3) agonism is the mechanism by which cotinine offsets the effects of nicotine...
  17. pmc Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, United States
    Pharmacol Biochem Behav 96:217-27. 2010
    ....
  18. ncbi request reprint Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats
    Mark G LeSage
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 184:409-16. 2006
    ..It is not known whether such a vaccine can attenuate nicotine's reinforcing effects...
  19. doi request reprint Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA
    J Pharmacol Exp Ther 325:985-93. 2008
    ..These data indicate that providing higher serum NicAb concentrations improves the efficacy of immunotherapy against nicotine and that supplementing vaccination with passive immunization is a potential strategy to accomplish this...
  20. ncbi request reprint A vaccine for nicotine dependence: targeting the drug rather than the brain
    Paul Pentel
    Department of Medicine, Hennepin County Medical Center, University of Minneapolis, MN 55415, USA
    Respiration 69:193-7. 2002
    ....
  21. ncbi request reprint Continuous nicotine infusion reduces nicotine self-administration in rats with 23-h/day access to nicotine
    Mark G LeSage
    Minneapolis Medical Research Foundation, D 3 Lab, Mail Code 860, 825 South 8th Street, Minneapolis, MN 55415, USA
    Pharmacol Biochem Behav 72:279-89. 2002
    ..The highest nicotine infusion rate had no sustained effect on food-maintained responding, demonstrating its specificity for suppression of NSA. These data provide a model for studying NRT in the rat...
  22. ncbi request reprint Reinstatement of nicotine self-administration in rats by presentation of nicotine-paired stimuli, but not nicotine priming
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 79:507-13. 2004
    ....
  23. ncbi request reprint Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: time course and influence of nicotine dosing regimen
    Daniel E Keyler
    Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Biochem Pharmacol 69:1385-95. 2005
    ..These data comment on the safety of vaccination against nicotine during pregnancy, and suggest that vaccination may reduce the distribution of nicotine to fetal brain under some nicotine dosing conditions...
  24. pmc Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 85:575-83. 2006
    ....
  25. ncbi request reprint Effects of continuous nicotine infusion on nicotine self-administration in rats: relationship between continuously infused and self-administered nicotine doses and serum concentrations
    Mark G LeSage
    Minneapolis Medical Research Foundation, D3 860, 914 South 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 170:278-86. 2003
    ..One reason for this limited efficacy may be that typical serum nicotine concentrations provided by NRT do not match the peak arterial nicotine concentrations achieved from smoking...
  26. ncbi request reprint Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats
    Daniel Keyler
    College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA
    Cancer Lett 202:1-9. 2003
    ....
  27. ncbi request reprint Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats
    Junran Cao
    Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, USA
    Neuropsychopharmacology 32:2025-35. 2007
    ..Although pharmacokinetic studies showed that acetaldehyde did not change nicotine levels in either brain or serum, nicotine penetration into the brain was slower in juveniles as compared to adults...
  28. ncbi request reprint Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta
    Ilona A Nekhayeva
    Department of Obstetrics and Gynecology, OB GYN Maternal Fetal Medicine, University of Texas Medical Branch, Galveston, 301 University Blvd, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 70:1664-72. 2005
    ..Therefore, the data cited in this report suggest that the use of nicotine-specific antibodies might reduce fetal exposure to the drug, and that antibody affinity for nicotine is a key determinant of the extent of nicotine transfer...
  29. ncbi request reprint Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose pellet delivery in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, MN 55404, USA
    Pharmacol Biochem Behav 83:585-91. 2006
    ..Therefore, PR schedules of natural reinforcement may provide information on the motivational effects of nicotine withdrawal complimentary to that obtained from ICSS threshold studies...
  30. ncbi request reprint Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats
    Martin Skott
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    J Orthop Res 24:1472-9. 2006
    ..Serum levels of nicotine were between 40-50 ng/mL in the group given nicotine alone and the group given tobacco extract plus nicotine (equivalent to serum levels observed in persons smoking one to two packs of cigarettes per day)...

Research Grants28

  1. TSE Inhalation System
    Paul Pentel; Fiscal Year: 2005
    ..This instrumentation will considerably expand the capabilities and scope of the specific projects involved. ..
  2. Vaccine Effects on Fetal Nicotine Exposure in Rats
    Paul Pentel; Fiscal Year: 2005
    ..abstract_text> ..
  3. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2006
    ..These data will expand our understanding of the mechanisms, limitations and clinical potential of both vaccination and passive immunization for the treatment or prevention of nicotine dependence. ..
  4. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2005
    ..These data will expand our understanding of the mechanisms, limitations and clinical potential of both vaccination and passive immunization for the treatment or prevention of nicotine dependence. ..
  5. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2007
    ..These data will expand our understanding of the mechanisms, limitations and clinical potential of both vaccination and passive immunization for the treatment or prevention of nicotine dependence. ..
  6. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2009
    ..They address the principal limitations of a new therapeutic strategy which already appears to have clinical efficacy. ..
  7. Multivalent Vaccine for Opiate Addiction
    Paul Pentel; Fiscal Year: 2009
    ..This could provide an additional type of medication for those opiate addicts or abusers who find the currently available options unacceptable, or possibly for use in addition to existing medications to enhance their efficacy. ..
  8. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2009
    ..This proposal will develop and study the utility of delivering nicotine to rats via exposure to cigarette smoke, and assess whether it allows better evaluation of nicotine vaccine efficacy and can expedite its further development. ..
  9. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul R Pentel; Fiscal Year: 2010
    ..They address the principal limitations of a new therapeutic strategy which already appears to have clinical efficacy. ..
  10. Multivalent Vaccine for Opiate Addiction
    Paul R Pentel; Fiscal Year: 2010
    ..This could provide an additional type of medication for those opiate addicts or abusers who find the currently available options unacceptable, or possibly for use in addition to existing medications to enhance their efficacy. ..
  11. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2009
    ..They address the principal limitations of a new therapeutic strategy which already appears to have clinical efficacy. ..
  12. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2005
    ..These data will expand our understanding of the mechanisms, limitations and clinical potential of both vaccination and passive immunization for the treatment or prevention of nicotine dependence. ..
  13. IMMUNIZATION TO BLOCK THE CENTRAL EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 1999
    ....
  14. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2000
    ..abstract_text> ..
  15. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2001
    ..abstract_text> ..
  16. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2002
    ..abstract_text> ..
  17. Vaccine Effects on Fetal Nicotine Exposure in Rats
    Paul Pentel; Fiscal Year: 2002
    ..abstract_text> ..
  18. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2002
    ..abstract_text> ..
  19. Vaccine Effects on Fetal Nicotine Exposure in Rats
    Paul Pentel; Fiscal Year: 2003
    ..abstract_text> ..
  20. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2003
    ..These data will expand our understanding of the mechanisms, limitations and clinical potential of both vaccination and passive immunization for the treatment or prevention of nicotine dependence. ..
  21. Vaccine Effects on Fetal Nicotine Exposure in Rats
    Paul Pentel; Fiscal Year: 2004
    ..abstract_text> ..
  22. Vaccine Effects on Fetal Nicotine Exposure in Rats
    Paul Pentel; Fiscal Year: 2003
    ..abstract_text> ..
  23. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul Pentel; Fiscal Year: 2004
    ..These data will expand our understanding of the mechanisms, limitations and clinical potential of both vaccination and passive immunization for the treatment or prevention of nicotine dependence. ..
  24. Preclinical studies of a heroin/morphine vaccine for opiate addiction
    Paul R Pentel; Fiscal Year: 2010
    ....