Bruce F Pennington

Summary

Affiliation: University of Denver
Country: USA

Publications

  1. ncbi request reprint Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Genet 30:86-91. 2002
  2. ncbi request reprint From single to multiple deficit models of developmental disorders
    Bruce F Pennington
    Department of Psychology, University of Denver, 2155 S Race St, Denver, CO 80208, USA
    Cognition 101:385-413. 2006
  3. pmc Individual prediction of dyslexia by single versus multiple deficit models
    Bruce F Pennington
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    J Abnorm Psychol 121:212-24. 2012
  4. ncbi request reprint Gene x Environment interactions in speech sound disorder predict language and preliteracy outcomes
    Lauren M McGrath
    University of Denver, Department of Psychology, Frontier Hall, 2155 S Race Street, Denver, CO 80209, USA
    Dev Psychopathol 19:1047-72. 2007
  5. ncbi request reprint Test of alternative hypotheses explaining the comorbidity between attention-deficit/hyperactivity disorder and conduct disorder
    Soo Hyun Rhee
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    J Abnorm Child Psychol 36:29-40. 2008
  6. pmc Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder
    Jenni Rosenberg
    Department of Psychology, University of Denver, Denver, CO 80208 0001, USA
    J Child Psychol Psychiatry 53:243-51. 2012
  7. pmc Etiology and neuropsychology of comorbidity between RD and ADHD: the case for multiple-deficit models
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Cortex 46:1345-61. 2010
  8. pmc The SWAN captures variance at the negative and positive ends of the ADHD symptom dimension
    Anne B Arnett
    University of Denver, Frontier Hall, 2155 S Race St, Denver, CO 80208, USA
    J Atten Disord 17:152-62. 2013
  9. pmc What influences literacy outcome in children with speech sound disorder?
    Robin L Peterson
    Department of Psychology, University of Denver, Denver, CO, USA
    J Speech Lang Hear Res 52:1175-88. 2009
  10. pmc Genetic covariation between brain volumes and IQ, reading performance, and processing speed
    Rebecca S Betjemann
    Department of Psychology, D 12, Regis University, 3333 Regis Blvd, Denver, CO 80221, USA
    Behav Genet 40:135-45. 2010

Detail Information

Publications54

  1. ncbi request reprint Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Genet 30:86-91. 2002
    ..This is the first report of QTL-based genome-wide scanning for a human cognitive trait...
  2. ncbi request reprint From single to multiple deficit models of developmental disorders
    Bruce F Pennington
    Department of Psychology, University of Denver, 2155 S Race St, Denver, CO 80208, USA
    Cognition 101:385-413. 2006
    ..It describes how this model evolved out of our attempts to understand two comorbidities, those between dyslexia and attention deficit hyperactivity disorder (ADHD) and between dyslexia and speech sound disorder (SSD)...
  3. pmc Individual prediction of dyslexia by single versus multiple deficit models
    Bruce F Pennington
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    J Abnorm Psychol 121:212-24. 2012
    ..We discuss the clinical implications of these results for both diagnosis of school-age children and preschool prediction of children at risk for dyslexia...
  4. ncbi request reprint Gene x Environment interactions in speech sound disorder predict language and preliteracy outcomes
    Lauren M McGrath
    University of Denver, Department of Psychology, Frontier Hall, 2155 S Race Street, Denver, CO 80209, USA
    Dev Psychopathol 19:1047-72. 2007
    ..The direction of these interactions and possible interpretations are explored in the discussion...
  5. ncbi request reprint Test of alternative hypotheses explaining the comorbidity between attention-deficit/hyperactivity disorder and conduct disorder
    Soo Hyun Rhee
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    J Abnorm Child Psychol 36:29-40. 2008
    ..The results suggest that correlated risk factors are a better explanation for the comorbidity between ADHD and CD than a third, independent ADHD+CD subtype...
  6. pmc Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder
    Jenni Rosenberg
    Department of Psychology, University of Denver, Denver, CO 80208 0001, USA
    J Child Psychol Psychiatry 53:243-51. 2012
    ..However, previous research indicates that RD and ADHD enter into opposite gene by environment (G × E) interactions...
  7. pmc Etiology and neuropsychology of comorbidity between RD and ADHD: the case for multiple-deficit models
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Cortex 46:1345-61. 2010
    ..Attention-deficit/hyperactivity disorder (ADHD) and reading disability (RD) are complex childhood disorders that frequently co-occur, but the etiology of this comorbidity remains unknown...
  8. pmc The SWAN captures variance at the negative and positive ends of the ADHD symptom dimension
    Anne B Arnett
    University of Denver, Frontier Hall, 2155 S Race St, Denver, CO 80208, USA
    J Atten Disord 17:152-62. 2013
    ..The Strengths and Weaknesses of ADHD Symptoms and Normal Behavior (SWAN) Rating Scale differs from previous parent reports of ADHD in that it was designed to also measure variability at the positive end of the symptom spectrum...
  9. pmc What influences literacy outcome in children with speech sound disorder?
    Robin L Peterson
    Department of Psychology, University of Denver, Denver, CO, USA
    J Speech Lang Hear Res 52:1175-88. 2009
    ..The authors report the literacy of children with SSD at ages 7-9, compared with controls and national norms, and relative to language skill and SSD persistence (both measured at age 5-6)...
  10. pmc Genetic covariation between brain volumes and IQ, reading performance, and processing speed
    Rebecca S Betjemann
    Department of Psychology, D 12, Regis University, 3333 Regis Blvd, Denver, CO 80221, USA
    Behav Genet 40:135-45. 2010
    ..64), and white matter (r (g) = .89), but not prefrontal cortex. The only brain measure to share genetic influence with reading was total brain volume (r (g) = .32), which also shared genetic influences with processing speed...
  11. pmc Gene X environment interactions in reading disability and attention-deficit/hyperactivity disorder
    Bruce F Pennington
    Department of Psychology, University of Denver, USA
    Dev Psychol 45:77-89. 2009
    ..However, they did not find a G x E interaction at the favorable end of the ADHD symptom dimension. The authors conclude with implications for future research...
  12. ncbi request reprint Processing speed deficits in attention deficit/hyperactivity disorder and reading disability
    Michelle A Shanahan
    Department of Psychology, University of Denver, Denver, Colorado, USA
    J Abnorm Child Psychol 34:585-602. 2006
    ....
  13. pmc Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder
    L Cinnamon Bidwell
    Department of Psychology, University of Colorado, Boulder, Colorado, USA
    Biol Psychiatry 62:991-8. 2007
    ..Neurocognitive deficits associated with attention-deficit/hyperactivity disorder (ADHD) might be useful intermediate endophenotypes for determining specific genetic pathways that contribute to ADHD...
  14. doi request reprint Do motivational incentives reduce the inhibition deficit in ADHD?
    Michelle A Shanahan
    Department of Psychology, University of Denver, CO 80208 0001, USA
    Dev Neuropsychol 33:137-59. 2008
    ..Hence, as predicted by the inhibition theory, children with ADHD performed worse than controls irrespective of incentives...
  15. ncbi request reprint Children with comorbid speech sound disorder and specific language impairment are at increased risk for attention-deficit/hyperactivity disorder
    Lauren M McGrath
    Department of Psychology, University of Denver, Frontier Hall 2155 S Race St, Denver, CO 80209, USA
    J Abnorm Child Psychol 36:151-63. 2008
    ..In addition, an unexpected interaction emerged such that children with SLI and normalized-SSD had significantly higher ADHD inattentive ratings than the other subgroups. A proposed explanation for this interaction is discussed...
  16. pmc A cross-lagged model of the development of ADHD inattention symptoms and rapid naming speed
    Anne B Arnett
    Department of Psychology, University of Denver, Frontier Hall 2155 S Race St, Denver, CO 80208, USA
    J Abnorm Child Psychol 40:1313-26. 2012
    ..Likewise, inattention symptoms have a small but significant predictive effect on subsequent rapid naming. The findings support a reciprocal relationship between naming speed and ADHD inattentive symptoms...
  17. pmc Neuropsychological components of intellectual disability: the contributions of immediate, working, and associative memory
    Jamie O Edgin
    Department of Psychology, University of Denver, Denver, Colorado, USA
    J Intellect Disabil Res 54:406-17. 2010
    ..g. Down syndrome (DS) and Williams syndrome (WS)] allows us to test whether or not these dissociations may extend across cognitive domains, including PFC and hippocampal memory processes...
  18. doi request reprint Relations among speech, language, and reading disorders
    Bruce F Pennington
    Department of Psychology, University of Denver, Colorado 80208, USA
    Annu Rev Psychol 60:283-306. 2009
    ..We evaluate which comorbidity models can be rejected or supported as explanations for why and how these three disorders overlap and what new data are needed to better define their relations...
  19. ncbi request reprint Neuropsychology and genetics of speech, language, and literacy disorders
    Robin L Peterson
    Department of Psychology, University of Denver, 2155 South Race Street, Denver, CO 80208, USA
    Pediatr Clin North Am 54:543-61, vii. 2007
    ..Research across levels of analysis is progressing rapidly to promote understanding not only of each disorder by itself but also of the relationships of the three disorders to each other...
  20. ncbi request reprint Executive function in preschoolers with autism: evidence consistent with a secondary deficit
    Benjamin E Yerys
    Department of Psychology, University of Denver, 2155 S Race Street, Denver, CO 80208, USA
    J Autism Dev Disord 37:1068-79. 2007
    ..Alternative hypotheses are also considered...
  21. doi request reprint Directional effects between rapid auditory processing and phonological awareness in children
    Erin Phinney Johnson
    University of Denver, CO, USA
    J Child Psychol Psychiatry 50:902-10. 2009
    ..Alternative theories suggest that impaired PA may have more of a top-down effect on auditory processing...
  22. ncbi request reprint Testing hypotheses regarding the causes of comorbidity: examining the underlying deficits of comorbid disorders
    Soo Hyun Rhee
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    J Abnorm Psychol 114:346-62. 2005
    ..The ability to distinguish the correct model decreased as the sample size and the correlation between the underlying deficits and the symptom scores decreased, suggesting that the issue of power should be considered carefully...
  23. ncbi request reprint Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Psychiatry 57:1336-46. 2005
    ..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
  24. pmc Developmental dyslexia
    Robin L Peterson
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    Lancet 379:1997-2007. 2012
    ..Six predisposing candidate genes have been identified, and evidence shows gene by environment interaction...
  25. ncbi request reprint Pre-literacy skills of subgroups of children with speech sound disorders
    Nancy A Raitano
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    J Child Psychol Psychiatry 45:821-35. 2004
    ..Previous studies have documented that two important dimensions of heterogeneity are the presence of a comorbid language impairment (LI) and the persistence of SSD, but these factors have not been examined separately...
  26. doi request reprint How neuropsychology informs our understanding of developmental disorders
    Bruce F Pennington
    Department of Psychology, University of Denver, 2155 S Race Street, Denver, Colorado 80208 4403, USA
    J Child Psychol Psychiatry 50:72-8. 2009
    ....
  27. ncbi request reprint Neuropsychological analyses of comorbidity between reading disability and attention deficit hyperactivity disorder: in search of the common deficit
    Erik G Willcutt
    Department of Psychology, University of Colorado at Boulder, CO 80309, USA
    Dev Neuropsychol 27:35-78. 2005
    ..Slow and variable processing speed was characteristic of all 3 clinical groups, suggesting that measures of this domain may be useful for future studies that search for the common genes that increase susceptibility to RD and ADHD...
  28. ncbi request reprint Deficient implicit phonological representations in children with dyslexia
    Richard Boada
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    J Exp Child Psychol 95:153-93. 2006
    ..Results provide strong support for less mature implicit phonological representations in children with dyslexia...
  29. ncbi request reprint The neuropsychology of Down syndrome: evidence for hippocampal dysfunction
    Bruce F Pennington
    Department of Psychology, University of Denver CO 80208, USA
    Child Dev 74:75-93. 2003
    ..It is interesting that these results are similar to what has been found in a mouse model of DS. Such a model will make it easier to understand the neurobiological mechanisms that lead to the development of hippocampal dysfunction in DS...
  30. ncbi request reprint Etiology of the comorbidity between RD and ADHD: exploration of the non-random mating hypothesis
    Melanie C Friedman
    Department of Psychology, University of Denver, Denver, Colorado 80208, USA
    Am J Med Genet B Neuropsychiatr Genet 120:109-15. 2003
    ..There was little evidence to support that non-random mating also contributes to this comorbidity in the present sample...
  31. ncbi request reprint Modeling rater disagreement for ADHD: are parents or teachers biased?
    Christie A Hartman
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, 4200 East 9th Ave, Box C 268 35, Denver, CO 80262, USA
    J Abnorm Child Psychol 35:536-42. 2007
    ....
  32. ncbi request reprint Analyzing comorbidity
    Bruce F Pennington
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    Adv Child Dev Behav 33:263-304. 2005
  33. ncbi request reprint Brain structure correlates of component reading processes: implications for reading disability
    Erin Phinney
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    Cortex 43:777-91. 2007
    ....
  34. pmc Which children benefit from letter names in learning letter sounds?
    Rebecca Treiman
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Cognition 106:1322-38. 2008
    ..Our results suggest that a wide range of children use the names of letters to help learn the sounds and that phonological awareness, as conventionally measured, is not required in order to do so...
  35. pmc Subtypes of developmental dyslexia: testing the predictions of the dual-route and connectionist frameworks
    Robin L Peterson
    University of Denver, Department of Psychology, Denver, CO, USA
    Cognition 126:20-38. 2013
    ..Further, a subset of controls could read normally despite impaired orthographic coding. The findings are discussed in terms of improvements to both models that might help better account for all cases of developmental dyslexia...
  36. ncbi request reprint Spatial cognition in autism spectrum disorders: superior, impaired, or just intact?
    Jamie O Edgin
    University of Denver, CO, USA
    J Autism Dev Disord 35:729-45. 2005
    ..There was no evidence for impairments in EF or in processing global/local information, therefore contradicting these two theories. The implications of these results for these two theories are discussed...
  37. ncbi request reprint Toward a new neuropsychological model of attention-deficit/hyperactivity disorder: subtypes and multiple deficits
    Bruce F Pennington
    Department of Psychology, University of Denver, Denver, CO 80210 4638, USA
    Biol Psychiatry 57:1221-3. 2005
  38. ncbi request reprint Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands
    Dianne L Koczat
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Autism Dev Disord 32:513-8. 2002
    ..These deficits deserve further evaluation as a potential endophenotypic marker for genetic risk for autism...
  39. ncbi request reprint Breakthroughs in the search for dyslexia candidate genes
    Lauren M McGrath
    University of Denver, Department of Psychology, Frontier Hall, 2155 S Race St, Denver, CO 80208, USA
    Trends Mol Med 12:333-41. 2006
    ..When causal variants are identified, they will need to be considered within a multifactorial framework, which is likely to involve gene-gene and gene-environment interactions, to make accurate predictions of diagnostic status...
  40. ncbi request reprint Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network
    Sally Ozonoff
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Autism Dev Disord 34:139-50. 2004
    ....
  41. ncbi request reprint The perception of animacy in young children with autism
    M D Rutherford
    McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Autism Dev Disord 36:983-92. 2006
    ..These results are discussed in terms of the social orienting theory of autism, and the possibility that animacy perception might be preserved in autism, even if it is not used automatically...
  42. pmc DCDC2 is associated with reading disability and modulates neuronal development in the brain
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:17053-8. 2005
    ..The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that DCDC2 is a candidate gene for RD...
  43. ncbi request reprint Interrelations among social-cognitive skills in young children with autism
    Malinda Carpenter
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Autism Dev Disord 32:91-106. 2002
    ..Implications for theories of social-cognitive and language development are discussed...
  44. ncbi request reprint Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder
    Erik G Willcutt
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet 114:260-8. 2002
    ....
  45. ncbi request reprint Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Psychiatr Genet 12:35-41. 2002
    ..Our study outlines the approach necessary for the identification of genetic variants causing dyslexia susceptibility in an epidemiological population of dyslexics...
  46. ncbi request reprint The relation between sluggish cognitive tempo and DSM-IV ADHD
    Christie A Hartman
    Institute for Behavioral Genetics and Department of Psychology, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
    J Abnorm Child Psychol 32:491-503. 2004
    ..These results suggest that SCT is an internally consistent construct that is significantly associated with DSM-IV inattention...
  47. pmc A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 75:1046-58. 2004
    ..In addition, the QTL effect may be largely limited to the severe range of reading disability...
  48. ncbi request reprint Understanding comorbidity: a twin study of reading disability and attention-deficit/hyperactivity disorder
    Erik G Willcutt
    University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Am J Med Genet B Neuropsychiatr Genet 144:709-14. 2007
    ....
  49. doi request reprint Impairments in phonological processing and nonverbal intellectual function in parents of children with autism
    Gwen L Schmidt
    Colorado State University, Fort Collins, CO, USA
    J Clin Exp Neuropsychol 30:557-67. 2008
    ..Our finding of nonword repetition difficulties, along with others' previous findings for nonword reading in autism families, suggests that problems in phonological processing might be characteristic of the broad autism phenotype...
  50. ncbi request reprint TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, 464 Congress Avenue, New Haven, CT 06520 8081, USA
    Hum Genet 118:87-90. 2005
    ..Alternatively, the published findings of association with markers in EKN1 may reflect linkage disequilibrium with variation in another gene(s) in the region...
  51. ncbi request reprint Linkage of speech sound disorder to reading disability loci
    Shelley D Smith
    University of Nebraska Medical Center, USA
    J Child Psychol Psychiatry 46:1057-66. 2005
    ..The present study tested whether SSD is linked to replicated risk loci for RD...
  52. ncbi request reprint Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypes
    Richard D Todd
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Psychol Psychiatry 46:1067-73. 2005
    ..The goal of the current study is to test whether population-based ADHD subtypes defined by latent class analysis help resolve issues of variable findings across individual gene association studies...
  53. ncbi request reprint Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?
    Alysa E Doyle
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Child Psychol Psychiatry 46:774-803. 2005
    ..Thus far, potential endophenotypes for ADHD have not been systematically studied...
  54. ncbi request reprint Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses
    Karen E Deffenbacher
    Center for Human Molecular Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, NE Medical Center MMI Rm 3085, Omaha, NE 68198 5455, USA
    Hum Genet 115:128-38. 2004
    ..The results of the association study have thereby allowed us to significantly reduce the number of possible candidate genes and to prioritize genes for further mutation screening...