Reinhold Penner

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
    Christine Peinelt
    Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    Nat Cell Biol 8:771-3. 2006
  2. pmc A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating
    Annette Lis
    Center for Biomedical Research, The Queen s Medical Center, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Gen Physiol 136:673-86. 2010
  3. pmc Regulation of TRPM2 by extra- and intracellular calcium
    John Starkus
    Pacific Biosciences Research Center, University of Hawaii, Honolulu, HI 96822, USA
    J Gen Physiol 130:427-40. 2007
  4. pmc TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice
    Adriana Sumoza-Toledo
    Laboratory for Cellular and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A, Burns School of Medicine, University of Hawai i, 1301 Punchbowl St, Honolulu, HI, 96813, USA
    J Inflamm (Lond) 10:19. 2013
  5. pmc STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion
    Markus Thiel
    Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl St, Honolulu, HI 96813, USA
    J Physiol 591:1433-45. 2013
  6. ncbi request reprint Store-operated calcium entry: a tough nut to CRAC
    Reinhold Penner
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    Sci STKE 2004:pe38. 2004
  7. pmc STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation
    Suhel Parvez
    Center for Biomedical Research and John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    FASEB J 22:752-61. 2008
  8. ncbi request reprint CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties
    Annette Lis
    Center for Biomedical Research, The Queen s Medical Center, Honolulu, Hawaii 96813, USA
    Curr Biol 17:794-800. 2007
  9. pmc Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release
    Adriana Sumoza-Toledo
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, Queen s Medical Center, Honolulu, Hawaii, USA
    FASEB J 25:3529-42. 2011
  10. pmc 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
    Christine Peinelt
    Queen s Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    J Physiol 586:3061-73. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
    Christine Peinelt
    Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    Nat Cell Biol 8:771-3. 2006
    ..Overexpression of both proteins greatly potentiates I(CRAC), suggesting that STIM1 and CRACM1 mutually limit store-operated currents and that CRACM1 may be the long-sought CRAC channel...
  2. pmc A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating
    Annette Lis
    Center for Biomedical Research, The Queen s Medical Center, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Gen Physiol 136:673-86. 2010
    ..Collectively, these findings identify a single amino acid in the N terminus of CRAC channels as a critical element for store-operated gating of CRAC channels...
  3. pmc Regulation of TRPM2 by extra- and intracellular calcium
    John Starkus
    Pacific Biosciences Research Center, University of Hawaii, Honolulu, HI 96822, USA
    J Gen Physiol 130:427-40. 2007
    ..We conclude that ADPR is responsible for TRPM2 gating and Ca(2+) facilitates activation via calmodulin...
  4. pmc TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice
    Adriana Sumoza-Toledo
    Laboratory for Cellular and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A, Burns School of Medicine, University of Hawai i, 1301 Punchbowl St, Honolulu, HI, 96813, USA
    J Inflamm (Lond) 10:19. 2013
    ....
  5. pmc STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion
    Markus Thiel
    Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl St, Honolulu, HI 96813, USA
    J Physiol 591:1433-45. 2013
    ....
  6. ncbi request reprint Store-operated calcium entry: a tough nut to CRAC
    Reinhold Penner
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    Sci STKE 2004:pe38. 2004
    ..Here we review the progress made on the characterization of store-operated currents and the challenges encountered in identifying the molecular components of store-operated Ca2+ entry...
  7. pmc STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation
    Suhel Parvez
    Center for Biomedical Research and John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    FASEB J 22:752-61. 2008
    ..The results reveal a novel bimodal control of CRAC channels by STIM2, the store dependence and CaM regulation, which indicates that the STIM2/CRACM1 complex may be under the control of both luminal and cytoplasmic Ca2+ levels...
  8. ncbi request reprint CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties
    Annette Lis
    Center for Biomedical Research, The Queen s Medical Center, Honolulu, Hawaii 96813, USA
    Curr Biol 17:794-800. 2007
    ....
  9. pmc Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release
    Adriana Sumoza-Toledo
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, Queen s Medical Center, Honolulu, Hawaii, USA
    FASEB J 25:3529-42. 2011
    ..These results highlight TRPM2 as a key player regulating DC chemotaxis through its function as Ca(2+) release channel and confirm ADP-ribose as a novel second messenger for intracellular Ca(2+) mobilization...
  10. pmc 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
    Christine Peinelt
    Queen s Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    J Physiol 586:3061-73. 2008
    ....
  11. pmc TRPM7 channel is regulated by magnesium nucleotides via its kinase domain
    Philippe Demeuse
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, 96813, USA
    J Gen Physiol 127:421-34. 2006
    ..We conclude that the nucleotide-dependent regulation of TRPM7 is mediated by the nucleotide binding site on the channel's endogenous kinase domain and interacts synergistically with a Mg(2+) binding site extrinsic to that domain...
  12. ncbi request reprint Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels
    Martin Kolisek
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    Mol Cell 18:61-9. 2005
    ..Our results establish TRPM2 as a coincidence detector for ADPR and cADPR signaling and provide a functional context for cADPR as a second messenger for Ca2+ influx...
  13. pmc Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils
    Ingo Lange
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, United States
    Cell Calcium 44:604-15. 2008
    ....
  14. pmc The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels
    Zheng Zhang
    From the Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813 and
    J Biol Chem 289:5217-27. 2014
    ..Thus, TRPM6 modulates the functionality of TRPM7, and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7·M6 channel complex. ..
  15. ncbi request reprint TRPM4 controls insulin secretion in pancreatic beta-cells
    Henrique Cheng
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, 1301 Punchbowl Street, UHT 8, Honolulu, HI 96813, USA
    Cell Calcium 41:51-61. 2007
    ....
  16. pmc Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels
    Susanna Zierler
    The Queen s Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Biol Chem 286:39328-35. 2011
    ....
  17. pmc TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions
    Mahealani K Monteilh-Zoller
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    J Gen Physiol 121:49-60. 2003
    ....
  18. pmc TRPM7 is regulated by halides through its kinase domain
    Haijie Yu
    Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl St, Honolulu, HI 96813, USA
    Cell Mol Life Sci 70:2757-71. 2013
    ....
  19. ncbi request reprint Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes
    Andreas Beck
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl St UHT 8, Honolulu, Hawaii 96813, USA
    FASEB J 20:962-4. 2006
    ..We conclude that cADPR and NAADP, in combination with ADPR, represent physiological co-activators of TRPM2 that contribute to Ca2+ influx in T lymphocytes and presumably other cell types that express this channel...
  20. pmc Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain
    Ryuichi Takezawa
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 101:6009-14. 2004
    ..Taken together, our results demonstrate that TRPM7 activity is up- and down-regulated through its endogenous kinase in a cAMP- and PKA-dependent manner...
  21. pmc The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification
    John G Starkus
    University of Hawaii, Pacific Biosciences Research Center, Queens Medical Center, University Tower, 814, 1356 Lusitania Street, Honolulu, HI 96813, USA
    J Physiol 588:1227-40. 2010
    ..We conclude that protons compete with Na(+) and Ca(2+) for channel permeation and channel closure results from a competitive antagonism of protons at an intracellular Ca(2+) binding site...
  22. ncbi request reprint A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity
    Ryuichi Takezawa
    Laboratory of Cell and Molecular Signalling, Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl St, UHT 8, Honolulu, HI 96813, USA
    Mol Pharmacol 69:1413-20. 2006
    ....
  23. ncbi request reprint Cell cycle-dependent regulation of store-operated I(CRAC) and Mg2+-nucleotide-regulated MagNuM (TRPM7) currents
    Dawn Tani
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, 1301 Punchbowl Street, UHT 8, Honolulu, HI 96813, USA
    Cell Calcium 41:249-60. 2007
    ..Taken together, our results demonstrate that both store-operated calcium influx via I(CRAC) and MagNuM are regulated at crucial checkpoints during cell cycle progression...
  24. pmc TRPM2 functions as a lysosomal Ca2+-release channel in beta cells
    Ingo Lange
    Center for Biomedical Research, The Queen s Medical Center, Honolulu, HI 96813, USA
    Sci Signal 2:ra23. 2009
    ..Thus, ADPR and TRPM2 represent multimodal signaling elements regulating Ca2+ mobilization in beta cells through membrane depolarization, Ca2+ influx, and release of Ca2+ from intracellular stores...
  25. pmc IP(3) receptor subtype-dependent activation of store-operated calcium entry through I(CRAC)
    Christine Peinelt
    Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    Cell Calcium 45:326-30. 2009
    ..This suggests that the expression pattern of IP(3)R contributes to the formation of specialized CRAC stores in B cells...
  26. pmc Activation of store-operated I(CRAC) by hydrogen peroxide
    Morten Grupe
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, 1301 Punchbowl St, Honolulu, HI 96813, USA
    Cell Calcium 48:1-9. 2010
    ..Our data suggest that H2O2 can activate Ca(2+) entry through TRPM2 as well as store-operated CRAC channels, thereby adding a new facet to ROS-induced Ca(2+) signaling...
  27. pmc Lipopolysaccharide-induced down-regulation of Ca2+ release-activated Ca2+ currents (I CRAC) but not Ca2+-activated TRPM4-like currents (I CAN) in cultured mouse microglial cells
    Andreas Beck
    Queen s Center for Biomedical Research, Laboratory of Cell and Molecular Signalling, The Queen s Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    J Physiol 586:427-39. 2008
    ..In this scenario, I CAN expression would remain constant, although its activity would automatically be reduced due to the diminished calcium influx capacity of the cell...
  28. ncbi request reprint The TRPM ion channel subfamily: molecular, biophysical and functional features
    Andrea Fleig
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center and Department of Cell and Molecular Biology, John A Burns School of Medicine, The University of Hawaii, Honolulu, HI 96813, USA
    Trends Pharmacol Sci 25:633-9. 2004
    ..TRPM channels are involved in several physiological and pathological conditions in electrically excitable and non-excitable cells, which make them exciting targets for drug discovery...
  29. ncbi request reprint Emerging roles of TRPM channels
    Andrea Fleig
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center, Honolulu, HI 96813, USA
    Novartis Found Symp 258:248-58; discussion 258-66. 2004
    ..They activate and function in the context of a variety of physiological and pathological conditions, which make them exciting targets for drug discovery...
  30. pmc Discrimination of intracellular calcium store subcompartments using TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) release channel activity
    Helen Turner
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, USA
    Biochem J 371:341-50. 2003
    ..These results provide unequivocal evidence that a specific 'CRAC store' exists within the InsP(3)-releasable calcium stores and describe a novel methodology for manipulation of intracellular free calcium...
  31. ncbi request reprint Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors
    Brandi Castillo
    College of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii 96813, USA
    J Biomol Screen 15:498-507. 2010
    ..The quality of the bioassay window is excellent based on an established statistical parameter used to evaluate high-throughput screening window quality (Z and Z' factors > or =0.5)...
  32. pmc Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM
    Meredith C Hermosura
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    J Physiol 539:445-58. 2002
    ....
  33. pmc TRPM2: a multifunctional ion channel for calcium signalling
    Adriana Sumoza-Toledo
    Center for Biomedical Research, The Queen s Medical Center, University of Hawaii, 1301 Punchbowl Street UHT 8, HI 96813, USA
    J Physiol 589:1515-25. 2011
    ..The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases...
  34. ncbi request reprint TRPM2
    Malika Faouzi
    Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl Street, Honolulu, HI, 96813, USA
    Handb Exp Pharmacol 222:403-26. 2014
    ..g., cytokines, neurotransmitters, insulin) and in extreme cases can induce apoptotic and necrotic cell death under oxidative stress. ..
  35. ncbi request reprint TRPM4 regulates calcium oscillations after T cell activation
    Pierre Launay
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 306:1374-7. 2004
    ..This increase in Ca2+ influx enhanced interleukin-2 production. Thus, TRPM4-mediated depolarization modulates Ca2+ oscillations, with downstream effects on cytokine production in T lymphocytes...
  36. pmc Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes
    Yasuo Mori
    Center for Integrative Bioscience, Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    J Exp Med 195:673-81. 2002
    ....
  37. ncbi request reprint TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization
    Pierre Launay
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 109:397-407. 2002
    ....
  38. ncbi request reprint Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7
    Carsten Schmitz
    Department of Pediatrics, University of Washington and Children s Hospital and Regional Medical Center, Seattle, WA 98195, USA
    Cell 114:191-200. 2003
    ..Overall, our results indicate that TRPM7 has a central role in Mg(2+) homeostasis as a Mg(2+) uptake pathway regulated through a functional coupling between its channel and kinase domains...
  39. ncbi request reprint A unified nomenclature for the superfamily of TRP cation channels
    Craig Montell
    Mol Cell 9:229-31. 2002
  40. pmc TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i
    Dirk Prawitt
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Proc Natl Acad Sci U S A 100:15166-71. 2003
    ..TRPM5 can be activated physiologically by inositol 1,4,5-trisphosphate-producing receptor agonists, and it may therefore couple intracellular Ca2+ release to electrical activity and subsequent cellular responses...
  41. ncbi request reprint D-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of d-myo-inositol 1,3,4,5-tetrakisphosphate: biological activity and pH-dependent conformational properties
    Graeme Horne
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
    Biochem Biophys Res Commun 320:1262-70. 2004
    ..We conclude that the 6-OH group in Ins(1,3,4,5)P(4) is crucial for its physicochemical behaviour and biological properties of this key inositol phosphate...
  42. ncbi request reprint CRACM1 multimers form the ion-selective pore of the CRAC channel
    Monika Vig
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Biol 16:2073-9. 2006
    ..Our data provide unequivocal evidence that CRACM1 multimers form the Ca(2+)-selective CRAC-channel pore...
  43. pmc TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
    Shinichiro Yamamoto
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo ku, Kyoto 615 8510, Japan
    Nat Med 14:738-47. 2008
    ..We propose functional inhibition of TRPM2 channels as a new therapeutic strategy for treating inflammatory diseases...

Research Grants21

  1. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2001
    ..abstract_text> ..
  2. Inositol (1,4,5) trisphoshate response thresholds
    Reinhold Penner; Fiscal Year: 2007
    ..This compartment is notable for its low sensitivity (i.e., high threshold) to InsP3. ..
  3. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2007
    ....
  4. Molecular components of the store-operated CRAC channel
    Reinhold Penner; Fiscal Year: 2009
    ....
  5. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2009
    ....
  6. Molecular components of the store-operated CRAC channel
    Reinhold Penner; Fiscal Year: 2010
    ....
  7. Inositol (1,4,5) trisphoshate response thresholds
    Reinhold Penner; Fiscal Year: 2006
    ..This compartment is notable for its low sensitivity (i.e., high threshold) to InsP3. ..
  8. An ADP-ribose dependent cation channel encoded by LTRPC2
    Reinhold Penner; Fiscal Year: 2005
    ..Finally, we will seek to identify the mechanisms responsible for ADPR production by investigating the major enzymes and pathways involved in its metabolism. ..
  9. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2005
    ..abstract_text> ..
  10. An ADP-ribose dependent cation channel encoded by LTRPC2
    Reinhold Penner; Fiscal Year: 2002
    ..Finally, we will seek to identify the mechanisms responsible for ADPR production by investigating the major enzymes and pathways involved in its metabolism. ..
  11. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2002
    ..abstract_text> ..
  12. An ADP-ribose dependent cation channel encoded by LTRPC2
    Reinhold Penner; Fiscal Year: 2003
    ..Finally, we will seek to identify the mechanisms responsible for ADPR production by investigating the major enzymes and pathways involved in its metabolism. ..
  13. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2003
    ..abstract_text> ..
  14. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2004
    ..abstract_text> ..
  15. Inositol (1,4,5) trisphoshate response thresholds
    Reinhold Penner; Fiscal Year: 2004
    ..This compartment is notable for its low sensitivity (i.e., high threshold) to InsP3. ..
  16. An ADP-ribose dependent cation channel encoded by LTRPC2
    Reinhold Penner; Fiscal Year: 2004
    ..Finally, we will seek to identify the mechanisms responsible for ADPR production by investigating the major enzymes and pathways involved in its metabolism. ..
  17. Inositol (1,4,5) trisphoshate response thresholds
    Reinhold Penner; Fiscal Year: 2005
    ..This compartment is notable for its low sensitivity (i.e., high threshold) to InsP3. ..
  18. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2010
    ....