Aimin Peng

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer
    Ling Wang
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Mol Cancer Ther 11:2401-9. 2012
  2. ncbi Serine/threonine phosphatases in the DNA damage response and cancer
    A Peng
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Oncogene 29:5977-88. 2010
  3. ncbi A novel role for greatwall kinase in recovery from DNA damage
    Aimin Peng
    Howard Hughes Medical Institute, Department of Pharmacology, University of Colorado School of Medicine, Aurora, USA
    Cell Cycle 9:4364-9. 2010
  4. ncbi Greatwall and Polo-like kinase 1 coordinate to promote checkpoint recovery
    Aimin Peng
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Biol Chem 286:28996-9004. 2011
  5. ncbi Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation
    Aimin Peng
    Howard Hughes Medical Institute, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Curr Biol 20:387-96. 2010
  6. ncbi Monoclonal antibodies against Xenopus greatwall kinase
    Ling Wang
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska, USA
    Hybridoma (Larchmt) 30:469-74. 2011
  7. ncbi DNA damage signaling in early Xenopus embryos
    Aimin Peng
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Cell Cycle 7:3-6. 2008
  8. ncbi Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos
    Aimin Peng
    Howard Hughes Medical Institute, Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mol Cell Biol 27:6852-62. 2007

Detail Information

Publications8

  1. ncbi Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer
    Ling Wang
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Mol Cancer Ther 11:2401-9. 2012
    ..Thus, this study reveals that chemoresistance in oral SCCs is partially attributed to deficiencies in DNA damage signaling, and Wip1 is an effective drug target for enhanced cancer therapy...
  2. ncbi Serine/threonine phosphatases in the DNA damage response and cancer
    A Peng
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Oncogene 29:5977-88. 2010
    ..Similar to the kinases in this pathway, phosphatases may also be intimately involved in cancer progression and present valuable targets for cancer therapy...
  3. ncbi A novel role for greatwall kinase in recovery from DNA damage
    Aimin Peng
    Howard Hughes Medical Institute, Department of Pharmacology, University of Colorado School of Medicine, Aurora, USA
    Cell Cycle 9:4364-9. 2010
    ..Moreover, activation of Cdk1 after the removal of damaged DNA is regulated by Gwl. Collectively, these results defines Gwl as a new regulator of the DDR, which plays an important role in recovery from DNA damage...
  4. ncbi Greatwall and Polo-like kinase 1 coordinate to promote checkpoint recovery
    Aimin Peng
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Biol Chem 286:28996-9004. 2011
    ..Coordinated interplays between Plx1 and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery...
  5. ncbi Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation
    Aimin Peng
    Howard Hughes Medical Institute, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Curr Biol 20:387-96. 2010
    ..Checkpoint activation induced by DNA double-strand breaks (DSB) is dependent on the ATM kinase, a master regulator of the DNA damage response (DDR) that is activated through autophosphorylation and monomerization...
  6. ncbi Monoclonal antibodies against Xenopus greatwall kinase
    Ling Wang
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska, USA
    Hybridoma (Larchmt) 30:469-74. 2011
    ..These results illustrate a new tool to study loss-of-function of Gwl, and support its essential role in mitosis. Finally, we demonstrated the usefulness of the MAb against human Gwl/MASTL...
  7. ncbi DNA damage signaling in early Xenopus embryos
    Aimin Peng
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Cell Cycle 7:3-6. 2008
    ..We propose that this novel mode of "in trans" regulation is employed in the DNA damage response to modulate a broad range of chromatin-associated activities in a genome-wide manner...
  8. ncbi Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos
    Aimin Peng
    Howard Hughes Medical Institute, Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mol Cell Biol 27:6852-62. 2007
    ....