Gurudutt Pendyala

Summary

Affiliation: University of Nebraska Medical Center
Location: Omaha, USA
Grants:
Current Support:
Nebraska Research Initiative Role:PI
08/01/12-07/31/14
Total Directs = $100,000
“Strategies to prevent relapse in chronic methamphetamine abusers”
The goal of this research is to examine the impact of anti-neuroinflammation drugs on the relapse of methamphetamine self-administration while using a systems biology approach to identify molecular targets mediating the effectiveness of this potential treatment.

Completed:
The Milton Safenowitz Post Doctoral Fellowship
Grant Number: Pendyala 1387
Aug 2007- July 2009
Grantor: The ALS Association
“The metabolome of the Cerebrospinal fluid: Signature for ALS”.

Publications

  1. pmc Methamphetamine and inflammatory cytokines increase neuronal Na+/K+-ATPase isoform 3: relevance for HIV associated neurocognitive disorders
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e37604. 2012
  2. pmc Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, 68198 5800, USA
    AIDS Res Hum Retroviruses 27:179-82. 2011
  3. pmc Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198, USA
    Genome Med 2:22. 2010
  4. pmc Quantitative plasma proteomic profiling identifies the vitamin E binding protein afamin as a potential pathogenic factor in SIV induced CNS disease
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Proteome Res 9:352-8. 2010
  5. pmc Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 8:2253-60. 2009
  6. doi request reprint Time of day-dependent sorting of the vesicular glutamate transporter to the plasma membrane
    Mahesh Darna
    AG Functional Cell Biology, Institute for Integrative Neuroanatomy, Charité Centre 2 for Basic Medicine, 10115 Berlin, Germany
    J Biol Chem 284:4300-7. 2009
  7. pmc Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques
    William R Wikoff
    Department of Molecular Biology and Center for Mass Spectrometry, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 118:2661-9. 2008
  8. ncbi request reprint Biomarkers for neuroAIDS: the widening scope of metabolomics
    Gurudutt Pendyala
    Molecular and Integrative Neurosciences Department, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmune Pharmacol 2:72-80. 2007
  9. ncbi request reprint Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2
    Sowmya V Yelamanchili
    AG Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, 10115 Berlin, Germany
    J Biol Chem 281:15671-9. 2006
  10. ncbi request reprint The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Nat Med 11:35-42. 2005

Detail Information

Publications12

  1. pmc Methamphetamine and inflammatory cytokines increase neuronal Na+/K+-ATPase isoform 3: relevance for HIV associated neurocognitive disorders
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e37604. 2012
    ..Given its function in maintaining ionic gradients and emerging role as a signaling molecule, changes in ATP1A3 yields insights into the mechanisms associated with HAND and interactions with drugs of abuse...
  2. pmc Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, 68198 5800, USA
    AIDS Res Hum Retroviruses 27:179-82. 2011
    ....
  3. pmc Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198, USA
    Genome Med 2:22. 2010
    ..Metabolomics has not yet been widely used for biomarker discovery, but early work shows that it has great potential...
  4. pmc Quantitative plasma proteomic profiling identifies the vitamin E binding protein afamin as a potential pathogenic factor in SIV induced CNS disease
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Proteome Res 9:352-8. 2010
    ..Using such an approach, we show its successful application in identifying differential fingerprints in SIV/HIV induced CNS disease...
  5. pmc Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 8:2253-60. 2009
    ..This study reveals new central nervous system alterations in lentivirus-induced neurological disease, and this technique can be applied to other systems in which limited amounts of biofluids can be obtained...
  6. doi request reprint Time of day-dependent sorting of the vesicular glutamate transporter to the plasma membrane
    Mahesh Darna
    AG Functional Cell Biology, Institute for Integrative Neuroanatomy, Charité Centre 2 for Basic Medicine, 10115 Berlin, Germany
    J Biol Chem 284:4300-7. 2009
    ..We conclude that VGLUTs are sorted diurnally to the plasma membrane to modulate glutamate transmission during a day/night cycle, whereas VGAT expression is not oscillating but is increased in the presence of a light/dark cycle...
  7. pmc Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques
    William R Wikoff
    Department of Molecular Biology and Center for Mass Spectrometry, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 118:2661-9. 2008
    ..The identification of specific metabolites as well as mechanisms of their increase illustrates the potential of mass-based metabolomics to address problems in CNS biochemistry and neurovirology, as well as neurodegenerative diseases...
  8. ncbi request reprint Biomarkers for neuroAIDS: the widening scope of metabolomics
    Gurudutt Pendyala
    Molecular and Integrative Neurosciences Department, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmune Pharmacol 2:72-80. 2007
    ....
  9. ncbi request reprint Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2
    Sowmya V Yelamanchili
    AG Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, 10115 Berlin, Germany
    J Biol Chem 281:15671-9. 2006
    ..A reduced amount of VGLUT1 per vesicle is probably achieved by means of selective sorting controlled by clock genes...
  10. ncbi request reprint The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Nat Med 11:35-42. 2005
    ..Collectively, these data establish glutamate as a link between dysfunction of the circadian clock gene Per2 and enhanced alcohol intake...
  11. pmc Protective role for the disulfide isomerase PDIA3 in methamphetamine neurotoxicity
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e38909. 2012
    ..The current study implicates PDIA3 to be an important cellular neuroprotective mechanism against a toxic drug, and as a potential target for therapeutic investigations...