Usha Pendurthi

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc Proteolysis of CCN1 by plasmin: functional implications
    Usha R Pendurthi
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Cancer Res 65:9705-11. 2005
  2. pmc Tissue factor activation: is disulfide bond switching a regulatory mechanism?
    Usha R Pendurthi
    Biomedical Research Division, University of Texas Health Science Center at Tyler, TX 75708, USA
    Blood 110:3900-8. 2007
  3. pmc Role of tissue factor disulfides and lipid rafts in signaling
    Usha R Pendurthi
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Thromb Res 122:S14-8. 2008
  4. ncbi request reprint Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, Tex 75708, USA
    Arterioscler Thromb Vasc Biol 22:1421-6. 2002
  5. pmc Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor
    Usha R Pendurthi
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, TX 75708, USA
    Thromb Res 125:S19-22. 2010
  6. pmc Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 285:20410-20. 2010
  7. pmc Tissue factor pathway inhibitor attenuates the progression of malignant pleural mesothelioma in nude mice
    Laterrica Williams
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 US Highway 271, Biomedical Research Building, Laboratory C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 46:173-9. 2012
  8. pmc Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae
    Vineet Awasthi
    Biomedical Research Division, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 27:1447-55. 2007
  9. pmc Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications
    Ramesh C Nayak
    Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 114:1974-86. 2009
  10. pmc Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption
    Hema Kothari
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 115:4273-83. 2010

Research Grants

  1. Cyr61 and CTGF: Mediators of Factor VIIa signaling
    Usha Pendurthi; Fiscal Year: 2004
  2. Tissue Factor-factor Vlla signaling
    Usha Pendurthi; Fiscal Year: 2007
  3. Tissue Factor-factor Vlla signaling
    Usha Pendurthi; Fiscal Year: 2010

Collaborators

Detail Information

Publications32

  1. pmc Proteolysis of CCN1 by plasmin: functional implications
    Usha R Pendurthi
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Cancer Res 65:9705-11. 2005
    ....
  2. pmc Tissue factor activation: is disulfide bond switching a regulatory mechanism?
    Usha R Pendurthi
    Biomedical Research Division, University of Texas Health Science Center at Tyler, TX 75708, USA
    Blood 110:3900-8. 2007
    ..Overall, the present data undermine the recently proposed hypothesis that PDI-mediated disulfide exchange plays a role in regulating TF procoagulant and cell signaling functions...
  3. pmc Role of tissue factor disulfides and lipid rafts in signaling
    Usha R Pendurthi
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Thromb Res 122:S14-8. 2008
    ..The review also discusses the importance of TF localization in lipid rafts and caveolae in maintaining its coagulant and signaling functions...
  4. ncbi request reprint Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, Tex 75708, USA
    Arterioscler Thromb Vasc Biol 22:1421-6. 2002
    ..The aim of the present study was to elucidate potential mechanisms by which plasmin affects various cellular processes...
  5. pmc Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor
    Usha R Pendurthi
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, TX 75708, USA
    Thromb Res 125:S19-22. 2010
    ....
  6. pmc Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 285:20410-20. 2010
    ..Overall, our data show that Zn(2+) binds to protein C/APC, which results in conformational changes in protein C/APC that favor their binding to EPCR...
  7. pmc Tissue factor pathway inhibitor attenuates the progression of malignant pleural mesothelioma in nude mice
    Laterrica Williams
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 US Highway 271, Biomedical Research Building, Laboratory C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 46:173-9. 2012
    ..These observations suggest that the interactions of TF and TFPI represent a novel therapeutic target in the treatment of MPM...
  8. pmc Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae
    Vineet Awasthi
    Biomedical Research Division, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 27:1447-55. 2007
    ..The objective of the present study is to investigate the role of lipid rafts and caveolae in modulating TF-VIIa signaling and coagulant functions...
  9. pmc Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications
    Ramesh C Nayak
    Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 114:1974-86. 2009
    ..Overall, our results show that FVIIa or activated protein C binding to EPCR promotes EPCR endocytosis, and EPCR-mediated endocytosis may facilitate the transcytosis of FVIIa and its clearance from the circulation...
  10. pmc Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption
    Hema Kothari
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 115:4273-83. 2010
    ..Our data provide clear evidence that TF lacking the Cys186-Cys209 bond is coagulantly active once it is complexed with FVIIa, and TF de-encryption does not require Cys186-Cys209 disulfide bond formation...
  11. pmc Tissue factor trafficking in fibroblasts: involvement of protease-activated receptor-mediated cell signaling
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Science Center at Tyler, TX 75708, USA
    Blood 110:161-70. 2007
    ..However, PAR2 activation is found to be critical for the FVIIa-induced TF endocytosis. Overall the data herein provide novel insights into the role of PARs in regulating cell surface TF expression...
  12. pmc Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
    Samit Ghosh
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 282:11849-57. 2007
    ..Overall, the present data provide convincing evidence that EPCR serves as a cellular binding site for FVII/FVIIa. Further studies are needed to evaluate the pathophysiological consequences and relevance of FVIIa binding to EPCR...
  13. pmc Cellular localization and trafficking of tissue factor
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Center at Tyler, TX 75708, USA
    Blood 107:4746-53. 2006
    ..This mechanism could play an important role in hemostasis in response to vascular injury by increasing TF activity where and when it is needed...
  14. ncbi request reprint Mechanism of resveratrol-mediated suppression of tissue factor gene expression
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, 75708, USA
    Thromb Haemost 87:155-62. 2002
    ..In summary, our results indicate that resveratrol does not inhibit the activation or translocation of NF-kappaB/Rel proteins but inhibits NF-kappaB/Rel-dependent transcription by impairing the transactivation potential of p65...
  15. pmc Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration
    Gertrud M Hjortoe
    Biomedical Research Division, University of Texas Health Center at Tyler, TX 75708, USA
    Blood 103:3029-37. 2004
    ..In summary, the studies described herein provide insight into how TF may contribute to tumor invasion...
  16. pmc Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Blood 105:153-60. 2005
    ..Overall, the data presented herein suggest that membrane cholesterol functions as a positive regulator of TF function by maintaining TF receptors, probably in noncaveolar lipid rafts, in a high-affinity state for VIIa binding...
  17. ncbi request reprint Asbestos induces tissue factor in Beas-2B human lung bronchial epithelial cells in vitro
    Alexei Iakhiaev
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Lung 182:251-64. 2004
    ..The mechanism involves alterations in steady-state TF mRNA that do not involve posttranscriptional regulation, implicating control of TF gene expression at the transcriptional level through Sp1 or other transcription factors...
  18. pmc Tissue factor-factor VIIa signaling
    L Vijaya Mohan Rao
    Biomedical Research Division, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 25:47-56. 2005
    ..In the present article, we review the emerging data on the mechanism of TF-mediated cell signaling and how it regulates various cellular responses, with particular focus on TF-VIIa protease-dependent signaling...
  19. ncbi request reprint Regulation of tissue factor-factor VIIa expression on cell surfaces: a role for tissue factor-factor VIIa endocytosis
    L Vijaya Mohan Rao
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biochem 253:131-40. 2003
    ..In this article, we provide a comprehensive review on the regulation of TF-VIIa functional expression by these other mechanisms, with a particular emphasis on TF-VIIa endocytosis, and our perspective of these studies...
  20. ncbi request reprint Urokinase induces its own expression in Beas2B lung epithelial cells
    Sreerama Shetty
    Department of Medical Specialties, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 283:L319-28. 2002
    ....
  21. pmc Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Semin Hematol 45:S21-4. 2008
    ..This article reviews current knowledge of FVIIa interaction with TF and EPCR on cell surfaces with a specific focus on how these interactions may contribute to FVIIa and TF clearance, thereby regulating TF-FVIIa activity...
  22. pmc Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol
    Gurjeet Kaur
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA
    Thromb Res 119:247-56. 2007
    ..Among major red wine phenolics, quercetin appears to be the predominant suppressor of TF induction...
  23. pmc Factor VIIa binding to endothelial cell protein C receptor
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX, USA
    Thromb Res 122:S3-6. 2008
    ..FVIIa binding to EPCR may also contribute to FVIIa clearance. This review summarizes recent data on FVIIa interaction with EPCR and discusses potential physiological significance and consequences of the interaction...
  24. ncbi request reprint Effect of wine phenolics and stilbene analogues on tissue factor expression in endothelial cells
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Thromb Res 106:205-11. 2002
  25. pmc The urokinase receptor supports tumorigenesis of human malignant pleural mesothelioma cells
    Torry A Tucker
    The Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Biomedical Research Building, Lab C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 42:685-96. 2010
    ....
  26. pmc Analysis of factor VIIa binding to relipidated tissue factor by surface plasmon resonance
    Prosenjit Sen
    The University of Texas Health Science Center at Tyler, Texas 75708, USA
    Blood Coagul Fibrinolysis 21:376-9. 2010
    ..The present data suggest that SPR binding studies using TF embedded in phospholipids is more appropriate for investigating how FVIIa (or FVIIa mutants/derivatives) may interact with TF in physiological settings...
  27. ncbi request reprint Resveratrol suppresses agonist-induced monocyte adhesion to cultured human endothelial cells
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA
    Thromb Res 106:243-8. 2002
  28. ncbi request reprint Factor VIIa/tissue factor-induced signaling: a link between clotting and disease
    Usha R Pendurthi
    Biomedical Research, University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Vitam Horm 64:323-55. 2002
    ....
  29. ncbi request reprint Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogen
    Buka Samten
    Department of Microbiology and Immunology, and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 168:3520-6. 2002
    ..These data suggest that reduced expression of CREB nuclear proteins in tuberculosis patients results in decreased IFN-gamma promoter activity and reduced IFN-gamma production...
  30. pmc Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing
    Athanasios N Athanasopoulos
    Department of Internal Medicine I, University Heidelberg, D 69120 Heidelberg, Germany
    J Biol Chem 282:26746-53. 2007
    ..Such a loop could be operative during fracture healing...
  31. pmc Bovine protein disulfide isomerase-enhanced tissue factor coagulant function: is phospholipid contaminant in it the real culprit?
    Hema Kothari
    Blood 111:3295-6. 2008
  32. pmc Sharing tissue factor: a winning strategy in tumorigenesis
    L Vijaya Mohan Rao
    Arterioscler Thromb Vasc Biol 28:1885-6. 2008

Research Grants8

  1. Cyr61 and CTGF: Mediators of Factor VIIa signaling
    Usha Pendurthi; Fiscal Year: 2004
    ....
  2. Tissue Factor-factor Vlla signaling
    Usha Pendurthi; Fiscal Year: 2007
    ..The proposed studies will provide valuable information in understanding how TF contributes to tumorigenesis. These studies will also provide clues on potential therapeutic targets for prevention of cancer progression. ..
  3. Tissue Factor-factor Vlla signaling
    Usha Pendurthi; Fiscal Year: 2010
    ..The proposed studies will provide valuable information in understanding how TF contributes to tumorigenesis. These studies will also provide clues on potential therapeutic targets for prevention of cancer progression. ..