John Peluso

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Multiplicity of progesterone's actions and receptors in the mammalian ovary
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 75:2-8. 2006
  2. doi request reprint Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biol Reprod 88:20. 2013
  3. pmc Evidence for a genomic mechanism of action for progesterone receptor membrane component-1
    John J Peluso
    Department of Cell Biology, University of CT Health Center, Farmington, CT 06030, United States
    Steroids 77:1007-12. 2012
  4. pmc Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 153:3929-39. 2012
  5. ncbi request reprint Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action
    J J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 147:3133-40. 2006
  6. ncbi request reprint N-cadherin mediated cell contact inhibits germinal vesicle breakdown in mouse oocytes maintained in vitro
    J J Peluso
    Cell Biology and Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Reproduction 131:429-37. 2006
  7. ncbi request reprint Progesterone maintains basal intracellular adenosine triphosphate levels and viability of spontaneously immortalized granulosa cells by promoting an interaction between 14-3-3sigma and ATP synthase beta/precursor through a protein kinase G-dependent mecha
    John J Peluso
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030 1230, USA
    Endocrinology 148:2037-44. 2007
  8. ncbi request reprint Non-genomic actions of progesterone in the normal and neoplastic mammalian ovary
    John J Peluso
    Department of Cell Biology, University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA
    Semin Reprod Med 25:198-207. 2007
  9. pmc Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 m
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Endocrinology 149:534-43. 2008
  10. doi request reprint Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Clin Endocrinol Metab 93:1592-9. 2008

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Multiplicity of progesterone's actions and receptors in the mammalian ovary
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 75:2-8. 2006
    ....
  2. doi request reprint Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biol Reprod 88:20. 2013
    ..Surprisingly, PGRMC1-PAIRBP1 interaction is not required for P4 binding or the cellular localization of PGRMC1 but rather appears to couple PGRMC1 to downstream components of the P4-PGRMC1 signal transduction pathway...
  3. pmc Evidence for a genomic mechanism of action for progesterone receptor membrane component-1
    John J Peluso
    Department of Cell Biology, University of CT Health Center, Farmington, CT 06030, United States
    Steroids 77:1007-12. 2012
    ....
  4. pmc Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 153:3929-39. 2012
    ....
  5. ncbi request reprint Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action
    J J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 147:3133-40. 2006
    ..At the plasma membrane, these two proteins interact to form a complex that is required for P4 to transduce its antiapoptotic action...
  6. ncbi request reprint N-cadherin mediated cell contact inhibits germinal vesicle breakdown in mouse oocytes maintained in vitro
    J J Peluso
    Cell Biology and Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Reproduction 131:429-37. 2006
    ..The involvement of FGF receptors is supported by the observations that FGF and a N-cadherin peptide known to activate FGF receptors inhibit GVBD...
  7. ncbi request reprint Progesterone maintains basal intracellular adenosine triphosphate levels and viability of spontaneously immortalized granulosa cells by promoting an interaction between 14-3-3sigma and ATP synthase beta/precursor through a protein kinase G-dependent mecha
    John J Peluso
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030 1230, USA
    Endocrinology 148:2037-44. 2007
    ....
  8. ncbi request reprint Non-genomic actions of progesterone in the normal and neoplastic mammalian ovary
    John J Peluso
    Department of Cell Biology, University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA
    Semin Reprod Med 25:198-207. 2007
    ....
  9. pmc Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 m
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Endocrinology 149:534-43. 2008
    ..Additional studies are required to more precisely delineate the role of each PGRMC1 domain in transducing P4's antiapoptotic action...
  10. doi request reprint Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Clin Endocrinol Metab 93:1592-9. 2008
    ..Progesterone (P4) influences ovarian cancer cells by an unknown mechanism...
  11. pmc Progesterone activates a progesterone receptor membrane component 1-dependent mechanism that promotes human granulosa/luteal cell survival but not progesterone secretion
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Clin Endocrinol Metab 94:2644-9. 2009
    ..Progesterone (P4) promotes its own secretion and the survival of human granulosa/luteal (GL) cells...
  12. doi request reprint Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 150:4846-54. 2009
    ..Taken together, these findings indicate that PGRMC1 plays an essential role in the development and CDDP sensitivity of human ovarian tumors...
  13. pmc Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression
    J J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell Endocrinol 320:153-61. 2010
    ..Taken together, the present studies suggest a genomic component to PGRMC1's anti-apoptotic mechanism of action, which requires the presence of the PGRMC1 dimer...
  14. pmc Progesterone signaling mediated through progesterone receptor membrane component-1 in ovarian cells with special emphasis on ovarian cancer
    John J Peluso
    Department of Cell Biology, University of CT Health Center, Farmington, CT 06030, USA
    Steroids 76:903-9. 2011
    ..How PGRMC1 regulates cell viability and in turn tumor growth is not known but part of the mechanism likely involves the regulation of genes that promote cell survival and inhibit apoptosis...
  15. ncbi request reprint Expression and function of PAIRBP1 within gonadotropin-primed immature rat ovaries: PAIRBP1 regulation of granulosa and luteal cell viability
    John J Peluso
    Department of Cell Biology, University of Conneticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 73:261-70. 2005
    ..The exact mechanism of PAIRBP1's action remains to be elucidated, but it may involve an interaction with PGRMC1...
  16. ncbi request reprint Rapid actions of progesterone on granulosa cells
    John J Peluso
    Department of Physiology and Obstetrics and Gynecology, University of CT Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Steroids 69:579-83. 2004
    ..A nearly identical unnamed protein was found in a cDNA library of mouse lung (Accession number: AK004678). Whether RDA288 functions as a membrane receptor for P4 remains to be determined...
  17. ncbi request reprint Progesterone maintains large rat granulosa cell viability indirectly by stimulating small granulosa cells to synthesize basic fibroblast growth factor
    J J Peluso
    Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 60:290-6. 1999
    ..Basic FGF then activates its receptors within large GCs, and this initiates a signal transduction pathway that maintains large GC viability...
  18. ncbi request reprint N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival
    J J Peluso
    Departments of Physiology and Obstetrics and Gynecology, University of Connecticut Health Center, Farmington 06030, USA
    Biol Signals Recept 9:115-21. 2000
    ..This hypothesis requires further testing and validation...
  19. ncbi request reprint Effect of disrupting cell contact on the nuclear accumulation of beta-catenin and subsequent apoptosis of rat ovarian surface epithelial cells in vitro
    J J Peluso
    Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Endocrine 12:295-302. 2000
    ..If calcium-dependent cell contacts are broken, beta-catenin accumulates within the nucleus, where it promotes transcription and ultimately the apoptotic death of ROSE-179 cells...
  20. ncbi request reprint E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity
    J J Peluso
    Departments of Physiology and Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 64:1183-90. 2001
    ....
  21. ncbi request reprint Characterization of a putative membrane receptor for progesterone in rat granulosa cells
    J J Peluso
    Departments of Physiology and Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 65:94-101. 2001
    ..These studies taken together support the concept that the 60-kDa P(4) binding protein functions as a low-affinity, high-capacity membrane receptor for P(4)...
  22. ncbi request reprint Basic fibroblast growth factor maintains calcium homeostasis and granulosa cell viability by stimulating calcium efflux via a PKC delta-dependent pathway
    J J Peluso
    Departments of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 142:4203-11. 2001
    ....
  23. ncbi request reprint Progesterone mediates its anti-mitogenic and anti-apoptotic actions in rat granulosa cells through a progesterone-binding protein with gamma aminobutyric acidA receptor-like features
    J J Peluso
    Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington 06030, USA
    Biol Reprod 58:1131-7. 1998
    ..Collectively, these studies suggest that P4 mediates its anti-mitotic and anti-apoptotic effects through this 60-kDa P4BP, which has GABA(A) receptor-like properties and is localized within the surface membrane of GCs...
  24. ncbi request reprint Involvement of an unnamed protein, RDA288, in the mechanism through which progesterone mediates its antiapoptotic action in spontaneously immortalized granulosa cells
    J J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 145:3014-22. 2004
    ..Finally, pretreatment with the RDA288 antibody blocked P4's antiapoptotic actions. Taken together, these data suggest that RDA288 plays a significant role in mediating P4's antiapoptotic action in granulosa cells...
  25. ncbi request reprint Membrane-initiated events account for progesterone's ability to regulate intracellular free calcium levels and inhibit rat granulosa cell mitosis
    John J Peluso
    Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biol Reprod 67:379-85. 2002
    ..This antibody was also used in immunocytochemical studies to detect a protein that was associated with the plasma membrane of SIGCs. It is proposed that this 60-kDa protein mediates P(4)'s membrane-initiated actions...
  26. ncbi request reprint Expression pattern and role of a 60-kilodalton progesterone binding protein in regulating granulosa cell apoptosis: involvement of the mitogen-activated protein kinase cascade
    J J Peluso
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 68:122-8. 2003
    ....
  27. ncbi request reprint Progesterone as a regulator of granulosa cell viability
    J J Peluso
    Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Steroid Biochem Mol Biol 85:167-73. 2003
    ..These studies support the concept that the 60kDa P4 binding protein functions as membrane receptor for P4 which activates a PKG-dependent mechanism to regulate granulosa cell survival...
  28. ncbi request reprint Progesterone regulation of human granulosa/luteal cell viability by an RU486-independent mechanism
    Lawrence Engmann
    Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Clin Endocrinol Metab 91:4962-8. 2006
    ..Progesterone (P4) inhibits human granulosa/luteal cell apoptosis by an unknown mechanism...
  29. doi request reprint In vitro viability and secretory capacity of human luteinized granulosa cells after gonadotropin-releasing hormone agonist trigger of oocyte maturation
    Lawrence Engmann
    Center for Advanced Reproductive Services, University of Connecticut Health Center, Dowling South Building, 263 Farmington Avenue, Farmington, CT 06030 6224, USA
    Fertil Steril 96:198-202. 2011
    ....
  30. pmc Murine cytomegalovirus influences Foxj1 expression, ciliogenesis, and mucus plugging in mice with allergic airway disease
    Carol A Wu
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1319, USA
    Am J Pathol 172:714-24. 2008
    ..Together, these findings suggest that MCMV infection of the airway epithelium enhances goblet cell metaplasia and diminishes efficient mucociliary clearance in mice with AAD, resulting in increased mucus plugging...
  31. ncbi request reprint Basic fibroblast growth factor (bFGF) regulation of the plasma membrane calcium ATPase (PMCA) as part of an anti-apoptotic mechanism of action
    John J Peluso
    Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biochem Pharmacol 66:1363-9. 2003
    ..The ability of bFGF to stimulate calcium efflux involved the plasma membrane calcium ATPase (PMCA). Interestingly, bFGF-activated PKCdelta appeared to regulate PMCA activity in part by promoting its membrane localization...
  32. pmc Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways
    Carol A Wu
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030 1319, USA
    Cell Immunol 264:32-41. 2010
    ..Thus, IL-5 production by BEC can impact the microenvironment of the lung, modifying pathologic and protective immune responses in the airways...
  33. ncbi request reprint Reciprocal regulation by estradiol 17-beta of ezrin and cadherin-catenin complexes in pituitary GH3 cells
    Perry M Smith
    Department of Physiology, University of Connecticut Health Center, Farmington 06030, USA
    Endocrine 17:219-28. 2002
    ..These findings indicate that E2 enriches the cell membrane with ezrin-membrane protein complexes by both increasing ezrin expression and by enlarging the relative area of nonadhesive membrane to which ezrin is targeted...
  34. doi request reprint Progesterone receptor membrane component 1--many tasks for a versatile protein
    Ralf M Losel
    Clinical Pharmacology Mannheim, University of Heidelberg, Mannheim, Germany
    Steroids 73:929-34. 2008
    ..Here, we summarize a few sometimes neglected pieces of evidence from the literature along with unpublished findings on the properties and functions of PGRMC1...
  35. doi request reprint Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human
    Ling Zhang
    Vincent Center for Reproductive Biology, Harvard Medical School, Boston, MA 02114, USA
    Mol Cell Endocrinol 287:81-9. 2008
    ..These studies provide a platform from which to build a clearer understanding of P(4) actions in the female reproductive tract and placental tissues that are mediated by non-classical mechanisms...

Research Grants8

  1. Regulation of Oocyte Viability by Granulosa Cell Contact
    John Peluso; Fiscal Year: 2004
    ..abstract_text> ..
  2. Protein Kinase G Regulation of Granulosa Cell Viability
    John Peluso; Fiscal Year: 2006
    ..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. ..
  3. Progesterone regulation of human luteal cell viability
    John Peluso; Fiscal Year: 2006
    ..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. ..
  4. PAIRBP & PGRMC1 act as a membrane receptor complex to mediate P4's ovarian action
    John Peluso; Fiscal Year: 2007
    ..These new pharmacological agents could have utility in the development contraceptives and in treating infertility and some forms of cancer. ..
  5. PAIRBP & PGRMC1 act as a membrane receptor complex to mediate P4's ovarian action
    John Peluso; Fiscal Year: 2009
    ..These new pharmacological agents could have utility in the development contraceptives and in treating infertility and some forms of cancer. ..
  6. PAIRBP & PGRMC1 act as a membrane receptor complex to mediate P4's ovarian action
    John J Peluso; Fiscal Year: 2010
    ..These new pharmacological agents could have utility in the development contraceptives and in treating infertility and some forms of cancer. ..
  7. PAIRBP & PGRMC1 act as a membrane receptor complex to mediate P4's ovarian action
    John J Peluso; Fiscal Year: 2010
    ..These new pharmacological agents could have utility in the development contraceptives and in treating infertility and some forms of cancer. ..