Genomes and Genes
Affiliation: University of California
- Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imaging dataH Ratiney
Department of Neurology, University of California, 185 Berry Street, Box 0946, San Francisco, CA 94107, USA
MAGMA 20:143-55. 2007....
- A genome-wide association study of brain lesion distribution in multiple sclerosisPierre Antoine Gourraud
Department of Neurology, School of Medicine, University of California, San Francisco, 675 Nelson Rising Lane, Suite 215, San Francisco, CA 94158, USA
Brain 136:1012-24. 2013....
- Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosisSergio E Baranzini
Department of Neurology, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
Brain 133:2603-11. 2010..Spectroscopy-based imaging provides a novel quantitative endophenotype for genetic association studies directed towards identifying new factors that contribute to the heterogeneity of clinical expression of multiple sclerosis...
- High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patientsMeredith Metcalf
UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94017, USA
J Neuroimaging 20:141-7. 2010..Clear involvement of the GM was observed with improved morphological detail in comparison to imaging at lower-field strength...
- Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adultsEmmanuelle Waubant
UCSF Regional Pediatric Multiple Sclerosis Center, 350 Parnassus Ave, Ste 908, San Francisco, CA 94117, USA
Arch Neurol 66:967-71. 2009..To compare initial brain magnetic resonance imaging (MRI) characteristics of children and adults at multiple sclerosis (MS) onset...
- Connecting white matter injury and thalamic atrophy in clinically isolated syndromesRoland G Henry
Department of Radiology and Biomedical Imaging, University of California at San Francisco, USA
J Neurol Sci 282:61-6. 2009..66, p<0.001), a finding not observed in regions outside the thalamocortical white matter. These results provide compelling evidence for a direct relationship between white matter lesions and thalamic atrophy in CIS patients...
- Pathway and network-based analysis of genome-wide association studies in multiple sclerosisSergio E Baranzini
Department of Neurology, School of Medicine, University of California San Francisco, 513 Parnassus Ave Room S 256, San Francisco, CA 94143 0435, USA
Hum Mol Genet 18:2078-90. 2009..In addition to the immunological pathways previously identified, we report here for the first time the potential involvement of neural pathways in MS susceptibility...
- TE-averaged two-dimensional proton spectroscopic imaging of glutamate at 3 TRadhika Srinivasan
Center for Molecular and Functional Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 1739, USA
Neuroimage 30:1171-8. 2006....
- Measurement of in vivo multi-component T2 relaxation times for brain tissue using multi-slice T2 prep at 1.5 and 3 TJoonmi Oh
Department of Radiology, Center for Molecular and Functional Imaging, University of California, San Francisco, CA 94107, USA
Magn Reson Imaging 24:33-43. 2006..The use of the eight-channel head coil involved more accurate quantification of T2 relaxation times particularly when the number of echoes was limited...
- Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysisDavid C Mohr
Department of Psychiatry, University of California, San Francisco, CA 94142, USA
BMJ 328:731. 2004..To quantify the association between stressful life events and exacerbations of multiple sclerosis...
- Measurement of whole-brain atrophy in multiple sclerosisDaniel Pelletier
Multiple Sclerosis Center, University of California San Francisco, 350 Parnassus Avenue, Suite 908, San Francisco, CA 94117, USA
J Neuroimaging 14:11S-19S. 2004..Determination of the relative reproducibility, precision, sensitivity, and validity of these methods will promote the use of whole-brain atrophy measures as components of comprehensive MRI-based outcome assessment in MS clinical trials...
- Corpus callosum axonal injury in multiple sclerosis measured by proton magnetic resonance spectroscopic imagingJoonmi Oh
Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107, USA
Arch Neurol 61:1081-6. 2004..Axonal damage has been observed in normal-appearing white matter (NAWM) for patients with multiple sclerosis (MS)...
- Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 TRadhika Srinivasan
Center for Molecular and Functional Imaging, Department of Radiology, University of California San Francisco, 185 Berry Street, 350, San Francisco, CA 94107 1739, USA
Brain 128:1016-25. 2005..001) myo-inositol levels in acute lesions compared with control white matter. These in vivo results support the hypothesis that altered glutamate metabolism is present in brains of multiple sclerosis patients...
- A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosisDavid C Mohr
Department of Psychiatry and Neurology, University of California, San Francisco, CA 94131, USA
Brain Behav Immun 20:27-36. 2006..These three hypotheses are not necessarily mutually exclusive. Data on psychosocial mediators and moderators are also briefly reviewed and future research directions are discussed...
- Directional diffusion in relapsing-remitting multiple sclerosis: a possible in vivo signature of Wallerian degenerationRoland G Henry
Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
J Magn Reson Imaging 18:420-6. 2003..To examine the role of directional dependence of the apparent diffusion coefficients in the evaluation of normal-appearing brain regions of patients with relapsing-remitting multiple sclerosis...
- Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosisEllen M Mowry
Multiple Sclerosis Center, Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
Ann Neurol 72:234-40. 2012..We sought to determine whether vitamin D status is associated with developing new T2 lesions or contrast-enhancing lesions on brain magnetic resonance imaging (MRI) in relapsing multiple sclerosis (MS)...
- The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspectsAlireza Minagar
Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Neurology 80:210-9. 2013....
- Switching multiple sclerosis patients with breakthrough disease to second-line therapyTamara Castillo-Trivino
Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
PLoS ONE 6:e16664. 2011..The effect of natalizumab monotherapy in patients with breakthrough disease is unknown...
- MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosisRadhika Srinivasan
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94107 1739, USA
Magn Reson Imaging 28:163-70. 2010..Reduced GSH was also observed in a MS WM lesion. This preliminary investigation demonstrates the potential of this marker to probe oxidative state in MS...
- Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association dataJoanne H Wang
Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0435, USA
Genome Med 3:3. 2011..Nevertheless, the knowledge of MS genetics remains incomplete, with many risk alleles still to be revealed...
- Molecular and Genetic Predictors of Disability Progression in MSDaniel Pelletier; Fiscal Year: 2010....