MARK A PEIFER

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
  2. pmc Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
    Mark Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:437-40. 2003
  3. pmc Abelson kinase regulates epithelial morphogenesis in Drosophila
    E E Grevengoed
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 155:1185-98. 2001
  4. pmc Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component
    Steven H Myster
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 160:433-49. 2003
  5. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
  6. pmc Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 167:135-47. 2004
  7. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
  8. pmc A role for a novel centrosome cycle in asymmetric cell division
    Nasser M Rusan
    Department of Biology and 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 177:13-20. 2007
  9. pmc Original CIN: reviewing roles for APC in chromosome instability
    Nasser M Rusan
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 181:719-26. 2008
  10. pmc Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth, and axon targeting?
    Nasser M Rusan
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 183:203-12. 2008

Collaborators

Detail Information

Publications25

  1. pmc Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
    ..We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics...
  2. pmc Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
    Mark Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:437-40. 2003
    ..2003; Davis et al., 2003; Xiao et al., 2003)...
  3. pmc Abelson kinase regulates epithelial morphogenesis in Drosophila
    E E Grevengoed
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 155:1185-98. 2001
    ..We discuss possible models for Abl function during epithelial morphogenesis in light of these data...
  4. pmc Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component
    Steven H Myster
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 160:433-49. 2003
    ..Together, these data suggest that p120 is an important positive modulator of adhesion but that it is not an essential core component of adherens junctions...
  5. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
    ..We also examined other actin regulators. Loss of Abl leads to changes in the localization of the Arp2/3 complex and the formin Diaphanous, and mutations in diaphanous or capping protein beta enhance abl phenotypes...
  6. pmc Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 167:135-47. 2004
    ..Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues...
  7. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..These results reveal key steps in the assembly of the apical domain in Drosophila...
  8. pmc A role for a novel centrosome cycle in asymmetric cell division
    Nasser M Rusan
    Department of Biology and 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 177:13-20. 2007
    ..We propose a two-step mechanism to ensure faithful spindle positioning: the novel centrosome cycle produces a single interphase MTOC, coarsely aligning the spindle, and spindle-cortex interactions refine this alignment...
  9. pmc Original CIN: reviewing roles for APC in chromosome instability
    Nasser M Rusan
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 181:719-26. 2008
    ..However, a closer look reveals a complex story that raises more questions than answers...
  10. pmc Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth, and axon targeting?
    Nasser M Rusan
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 183:203-12. 2008
    ..These data suggest that proposed cytoskeletal roles for APCs in mammals should be reassessed using loss of function tools...
  11. pmc Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from crumblin' aPart
    Mara C Duncan
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 183:971-4. 2008
    ..Tepass. 2008. J. Cell. Biol. 183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins...
  12. pmc The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction
    Jessica K Sawyer
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 186:57-73. 2009
    ..Instead, Cno localizes to AJs by a Rap1- and actin-dependent mechanism. These data suggest that Cno regulates linkage between AJs and the actin cytoskeleton during morphogenesis...
  13. pmc Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm
    Jeremiah F Roeth
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS ONE 4:e7634. 2009
    ..Tissue morphogenesis and organogenesis require that cells retain stable cell-cell adhesion while changing shape and moving. One mechanism to accommodate this plasticity in cell adhesion involves regulated trafficking of junctional proteins...
  14. ncbi request reprint Cell biology. Travel bulletin--traffic jams cause tumors
    M Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Science 289:67-9. 2000
    ..As Peifer discusses in a lively Perspective, new work (Bilder et al.) identifies some of the molecular characters that direct proteins to their different cellular destinations...
  15. ncbi request reprint The ballet of morphogenesis: unveiling the hidden choreographers
    Mark Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
    Cell 109:271-4. 2002
    ..Several recent papers reveal new insights into the mechanisms by which cells turn their perceptions about fate into action, focusing on the role of Wnt signal transduction in cell polarization and migration...
  16. ncbi request reprint Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus
    M Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Science 287:1606-9. 2000
  17. ncbi request reprint The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning
    D G McEwen
    Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, Department of Biology, The University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Development 127:3607-17. 2000
    ..Together, these results demonstrate that MAP-Kinase and Wingless signaling cooperate in both the dorsal and ventral epidermis, and suggest that Wingless may activate both the Wingless and the Jun N-terminal kinase signaling cascades...
  18. pmc Roles of the C terminus of Armadillo in Wingless signaling in Drosophila
    R T Cox
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Genetics 153:319-32. 1999
    ..These data suggest that the C-terminal domain plays a complex role in Wingless signaling and that Armadillo recruits the transcriptional machinery via multiple contact sites, which act in an additive fashion...
  19. pmc Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis
    R T Cox
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    J Cell Biol 134:133-48. 1996
    ..These disruptions in the integrity of epithelia block the appropriate morphogenetic movements of gastrulation. These results provide the first demonstration of the effect of loss of adherens junctions on Drosophila embryonic development...
  20. ncbi request reprint Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Nat Cell Biol 3:933-8. 2001
    ..Together, these data suggest that APC2, Armadillo and alpha-catenin provide an important link between spindles and cortical actin, and that this link is regulated by Zeste-white 3 kinase...
  21. ncbi request reprint Activated armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila
    J J Loureiro
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Dev Biol 235:33-44. 2001
    ..These results suggest that only certain cells are affected by activation of Armadillo/beta-catenin, and that Armadillo/beta-catenin does not play a general role in inhibiting cell migration or process extension...
  22. ncbi request reprint Drosophila alpha-catenin and E-cadherin bind to distinct regions of Drosophila Armadillo
    L M Pai
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    J Biol Chem 271:32411-20. 1996
    ..Our data complement and extend results obtained in studies of vertebrate adherens junctions, providing a foundation for understanding how junctional proteins assemble and a basis for interpreting existing mutations and creating new ones...
  23. ncbi request reprint Wnt signaling: the naked truth?
    D G McEwen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 27599 3280, USA
    Curr Biol 11:R524-6. 2001
    ..Recent studies of the Naked cuticle protein suggest a mechanism for the inactivation of the canonical pathway and concomitant activation of the planar cell polarity pathway...
  24. ncbi request reprint Wingless can't fly so it hitches a ride with dynein
    S H Myster
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Bioessays 23:869-72. 2001
    ..Correct localization is shown to be required for biological activity, and a mechanism of RNA transport involving the microtubule motor dynein has been revealed...
  25. pmc Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization
    J C Adam
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 11:3123-35. 2000
    ..Together, the results suggest that some cell-division events in Drosophila do not require septin function, that there is functional differentiation among the Drosophila septins, or both...

Research Grants29

  1. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2003
    ..Determine APC2's role in cytoskeletal regulation, and 4. Use genetic and biochemical approaches to define new partners for APC2. ..
  2. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2004
    ..Determine APC2's role in cytoskeletal regulation, and 4. Use genetic and biochemical approaches to define new partners for APC2. ..
  3. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2002
    ..Aim IV. Complete the genetic screen for genes which interact with arm in cell adhesion, signaling or other functions, and characterize the interactors. ..
  4. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2001
    ..Aim IV. Complete the genetic screen for genes which interact with arm in cell adhesion, signaling or other functions, and characterize the interactors. ..
  5. ADHESIVE JUNCTIONS AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 1992
    ..Finally, we will morphologically characterize intercellular adhesive junctions, and examine whether armadillo mutations disrupt their formation or structure...
  6. Cell adhesion, signal transduction and cytoskeletal regulation in Drosophila
    Mark Peifer; Fiscal Year: 2009
    ..We hypothesize that Ena helps generate distinct actin structures using different domains and partners, and that Ena is integrated with other actin regulators in filopodia. We will test these hypotheses. ..
  7. Cell adhesion, signal transduction and cytoskeletal regulation in Drosophila
    Mark Peifer; Fiscal Year: 2010
    ..We hypothesize that Ena helps generate distinct actin structures using different domains and partners, and that Ena is integrated with other actin regulators in filopodia. We will test these hypotheses. ..
  8. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2009
    ..We have developed a model system to explore how the tumor suppressor APC normally regulates cell communication and cell behavior, to allow better understanding of what goes wrong in human disease. ..
  9. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2005
    ..Determine APC2's role in cytoskeletal regulation, and 4. Use genetic and biochemical approaches to define new partners for APC2. ..
  10. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2005
    ..Aim 2: Define the mechanisms by which AJs are coupled to the actin cytoskeleton. Aim 3: Characterize novel roles of AJ proteins in cell polarity, spindle orientation and MT organization ..
  11. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2010
    ..We have developed a model system to explore how the tumor suppressor APC normally regulates cell communication and cell behavior, to allow better understanding of what goes wrong in human disease. ..
  12. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2004
    ..Aim 2: Define the mechanisms by which AJs are coupled to the actin cytoskeleton. Aim 3: Characterize novel roles of AJ proteins in cell polarity, spindle orientation and MT organization ..
  13. Cell adhesion, signal transduction and cytoskeletal regulation in Drosophila
    Mark Peifer; Fiscal Year: 2009
    ..We hypothesize that Ena helps generate distinct actin structures using different domains and partners, and that Ena is integrated with other actin regulators in filopodia. We will test these hypotheses. ..
  14. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2001
    ..Aim IV. Complete the genetic screen for genes which interact with arm in cell adhesion, signaling or other functions, and characterize the interactors. ..
  15. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2009
    ..We have developed a model system to explore how the tumor suppressor APC normally regulates cell communication and cell behavior, to allow better understanding of what goes wrong in human disease. ..
  16. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 1999
    ..Aim IV. Complete the genetic screen for genes which interact with arm in cell adhesion, signaling or other functions, and characterize the interactors. ..
  17. ADHESIVE JUNCTIONS AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 1993
    ..Finally, we will morphologically characterize intercellular adhesive junctions, and examine whether armadillo mutations disrupt their formation or structure...
  18. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2000
    ..Aim IV. Complete the genetic screen for genes which interact with arm in cell adhesion, signaling or other functions, and characterize the interactors. ..
  19. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2007
    ..Aim 2: Define the mechanisms by which AJs are coupled to the actin cytoskeleton. Aim 3: Characterize novel roles of AJ proteins in cell polarity, spindle orientation and MT organization ..
  20. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2006
    ..Aim 2: Define the mechanisms by which AJs are coupled to the actin cytoskeleton. Aim 3: Characterize novel roles of AJ proteins in cell polarity, spindle orientation and MT organization ..
  21. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  22. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2002
    ..Determine APC2's role in cytoskeletal regulation, and 4. Use genetic and biochemical approaches to define new partners for APC2. ..