C H Pegelow
Affiliation: University of Miami
- Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell diseaseCharles H Pegelow
Department of Pediatrics, University of Miami, Miami, FL 33101, USA
Blood 99:3014-8. 2002..Until safe and effective preventive strategies against infarct recurrence are discovered, MRI studies are best reserved for children with neurologic symptoms, neuropsychometric deficits, or elevated cerebral artery velocities...
- Hydroxyurea and sickle cell anemia: effect on quality of lifeSamir K Ballas
Cardeza Foundation, Department of Medicine, Jefferson Medical College, Philadelphia, PA, USA
Health Qual Life Outcomes 4:59. 2006..The morbidity associated with this disease is known to have serious negative impact on the overall quality of life(QOL) of affected individuals...
- Stroke in children with sickle cell anaemia: aetiology and treatmentC H Pegelow
University of Miami School of Medicine, Florida 33101, USA
Paediatr Drugs 3:421-32. 2001..A condition that mimics the moyamoya syndrome radiographically, as well as for its risk of haemorrhage, can be found in children with partly occluded cerebral arteries either as a result of stroke or silent infarct...
- Silent infarcts in children with sickle cell anemia and abnormal cerebral artery velocityC H Pegelow
Department of Pediatrics R 131, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Arch Neurol 58:2017-21. 2001..A substantial minority of neurologically normal children with sickle cell disease have lesions consistent with cerebral infarction as seen on magnetic resonance imaging (MRI)...
- Financial analysis of chronic transfusion for stroke prevention in sickle cell diseaseA S Wayne
Department of Pediatrics, Division of Pediatric Hematology Oncology, Sickle Cell Center, and Pediatric Pharmacy Department, University of Miami School of Medicine, Jackson Memorial Medical Center, Miami, FL, USA
Blood 96:2369-72. 2000..These data should be considered in reference to cost and efficacy analyses of alternative therapies for sickle cell disease, such as allogeneic bone marrow transplantation...
- Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial strokeDouglas J Scothorn
University of Texas Southwestern Medical Center, Dallas, TX, USA
J Pediatr 140:348-54. 2002..038). CONCLUSIONS: The absence of an antecedent or concurrent medical event associated with an initial stroke is a major risk factor for subsequent stroke while receiving regular transfusions...
- Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatmentMartin H Steinberg
Boston University School of Medicine, Center of Excellence in Sickle Cell Disease, Boston Medical Center, Boston, Mass 02118, USA
JAMA 289:1645-51. 2003..Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels reduce morbidity and mortality...
- Alpha Thalassemia is associated with decreased risk of abnormal transcranial Doppler ultrasonography in children with sickle cell anemiaLewis L Hsu
Emory University School of Medicine and Georgia Comprehensive Sickle Cell Center, Atlanta, Georgia 30303, USA
J Pediatr Hematol Oncol 25:622-8. 2003..The association of alpha thalassemia-2 and normal TCD adds to the evidence on the protective effects of alpha thalassemia-2 in SCD and highlights the contribution of epistatic factors...
- Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccinationThomas V Adamkiewicz
Centers for Disease Control and Prevention, and Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive NE, Atlanta, GA 30333, USA
J Pediatr 143:438-44. 2003..The pneumococcal-polysaccharide vaccine was 80.4% effective within 3 years after vaccination (95% CI, 39.7, 93.6). Children with sickle cell disease of all ages may benefit from PVC boosted with polysaccharide vaccination...
- Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP studyRobert J Adams
Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
Blood 103:3689-94. 2004..Substantial differences in the probability of conversion to abnormal TCD were observed, with younger children and those with higher velocity more likely to have an abnormal TCD with rescreening...
- A prospective study of the relationship over time of behavior problems, intellectual functioning, and family functioning in children with sickle cell disease: a report from the Cooperative Study of Sickle Cell DiseaseRobert J Thompson
Duke University, 114 Allen Building, Box 90042, Durham, NC 27708 0042, USA
J Pediatr Psychol 28:59-65. 2003..To longitudinally assess the relationship of behavioral problems, intellectual functioning, and family functioning in children with sickle cell disease (SCD)...