Niels Pedersen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The effects of dog breed development on genetic diversity and the relative influences of performance and conformation breeding
    N Pedersen
    Koret Foundation Center for Veterinary Genetics of the Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Anim Breed Genet 130:236-48. 2013
  2. doi request reprint Genetic characterization of healthy and sebaceous adenitis affected Standard Poodles from the United States and the United Kingdom
    N C Pedersen
    Center for Companion Animal Health, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Tissue Antigens 80:46-57. 2012
  3. doi request reprint Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats
    Niels C Pedersen
    Center for Companion Animal Health, University of California, One Shields Avenue, Davis, CA 95616, USA
    Virus Res 165:17-28. 2012
  4. doi request reprint Multiple autoimmune diseases syndrome in Italian Greyhounds: preliminary studies of genome-wide diversity and possible associations within the dog leukocyte antigen (DLA) complex
    Niels C Pedersen
    Center for Companion Animal Health, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Vet Immunol Immunopathol 145:264-76. 2012
  5. pmc Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, USA
    Retrovirology 4:25. 2007
  6. pmc Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group
    Barbara Bighignoli
    Istituto di Zootecnica, Faculty of Veterinary Medicine, University of Milan, Milan, Italy
    BMC Genet 8:27. 2007
  7. pmc Genetic variation analysis of the Bali street dog using microsatellites
    Dawn N Irion
    Veterinary Genetics Laboratory, Center for Veterinary Genetics, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    BMC Genet 6:6. 2005
  8. ncbi request reprint Dog leukocyte antigen class II-associated genetic risk testing for immune disorders of dogs: simplified approaches using Pug dog necrotizing meningoencephalitis as a model
    Niels Pedersen
    Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Vet Diagn Invest 23:68-76. 2011
  9. ncbi request reprint Listeria monocytogenes and Serratia marcescens infections as models for Th1/Th2 immunity in laboratory cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Vet Immunol Immunopathol 63:83-103. 1998
  10. doi request reprint Pathogenesis of feline enteric coronavirus infection
    Niels C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95694, USA
    J Feline Med Surg 10:529-41. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint The effects of dog breed development on genetic diversity and the relative influences of performance and conformation breeding
    N Pedersen
    Koret Foundation Center for Veterinary Genetics of the Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Anim Breed Genet 130:236-48. 2013
    ..Compared with their village dog relatives, all modern breed dogs exhibit reduced genetic diversity. Genetic diversity was even more reduced among breeds under selection for show/conformation...
  2. doi request reprint Genetic characterization of healthy and sebaceous adenitis affected Standard Poodles from the United States and the United Kingdom
    N C Pedersen
    Center for Companion Animal Health, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Tissue Antigens 80:46-57. 2012
    ....
  3. doi request reprint Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats
    Niels C Pedersen
    Center for Companion Animal Health, University of California, One Shields Avenue, Davis, CA 95616, USA
    Virus Res 165:17-28. 2012
    ..No evidence could be found to support a recent theory that FIPVs and FECVs are genetically distinct...
  4. doi request reprint Multiple autoimmune diseases syndrome in Italian Greyhounds: preliminary studies of genome-wide diversity and possible associations within the dog leukocyte antigen (DLA) complex
    Niels C Pedersen
    Center for Companion Animal Health, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Vet Immunol Immunopathol 145:264-76. 2012
    ..However, high density SNP association mapping across the DLA region and CFA12 did not corroborate the association...
  5. pmc Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, USA
    Retrovirology 4:25. 2007
    ..Accordingly, to model HIV-1 RT responses, 12 macaques were inoculated with RT-SHIV, a chimeric SIV containing HIV-1 RT, and started on prolonged tenofovir therapy 5 months later...
  6. pmc Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group
    Barbara Bighignoli
    Istituto di Zootecnica, Faculty of Veterinary Medicine, University of Milan, Milan, Italy
    BMC Genet 8:27. 2007
    ..The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types...
  7. pmc Genetic variation analysis of the Bali street dog using microsatellites
    Dawn N Irion
    Veterinary Genetics Laboratory, Center for Veterinary Genetics, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    BMC Genet 6:6. 2005
    ..Australian dingoes and 28 American Kennel Club breeds were compared to the Bali Street Dog (BSD) for allelic diversity, heterozygosities, F-statistics, GST estimates, Nei's DA distance and phylogenetic relationships...
  8. ncbi request reprint Dog leukocyte antigen class II-associated genetic risk testing for immune disorders of dogs: simplified approaches using Pug dog necrotizing meningoencephalitis as a model
    Niels Pedersen
    Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Vet Diagn Invest 23:68-76. 2011
    ....
  9. ncbi request reprint Listeria monocytogenes and Serratia marcescens infections as models for Th1/Th2 immunity in laboratory cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Vet Immunol Immunopathol 63:83-103. 1998
    ..Interleukin-12, an important Th1 cytokine, was elevated to equal levels in both infections as were the Th2 cytokines IL-4 and IL-10...
  10. doi request reprint Pathogenesis of feline enteric coronavirus infection
    Niels C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95694, USA
    J Feline Med Surg 10:529-41. 2008
    ..Pregnancy, parturition and lactation had no influence on fecal shedding by queens. Methylprednisolone acetate treatment did not induce non-shedders to shed and shedders to increase shedding...
  11. ncbi request reprint An isolated epizootic of hemorrhagic-like fever in cats caused by a novel and highly virulent strain of feline calicivirus
    N C Pedersen
    Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Microbiol 73:281-300. 2000
    ..FCV-Ari caused a disease that was reminiscent of Rabbit Hemorrhagic Disease, a highly fatal calicivirus infection of older rabbits...
  12. ncbi request reprint 16alpha-Bromo-epiandrosterone therapy modulates experimental feline immunodeficiency virus viremia: initial enhancement leading to long-term suppression
    Niels C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Immunol Immunopathol 94:133-48. 2003
    ....
  13. pmc Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1
    Michael J Hofman
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Antimicrob Agents Chemother 48:3483-90. 2004
    ..Virus isolated from these two animals contained the K103N and Y188C or Y188L mutations. The RT-SHIV-rhesus macaque model may prove useful for studies of antiretroviral drug combinations that include efavirenz...
  14. ncbi request reprint An outbreak of virulent systemic feline calicivirus disease
    Kate E Hurley
    Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 224:241-9. 2004
    ....
  15. pmc Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase
    Koen K A Van Rompay
    California Regional Primate Research Center, University of California, Davis, California 95616, USA
    J Virol 76:6083-92. 2002
    ..These data demonstrate that the M184V mutation in SIV conferred a slightly reduced fitness but did not affect disease outcome...
  16. pmc Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine
    Jeffrey P Murry
    Center for Comparative Medicine, University of California, Davis 95616, USA
    J Virol 77:1120-30. 2003
    ..All animals receiving this combination developed the K65R mutation. These results demonstrate that the combination of PMPA with 3TC or (-)-FTC selects for the K65R mutation and against the M184V mutation in SIV RT...
  17. ncbi request reprint [Feline calicivirus infection]
    Niels C Pedersen
    School of Veterinary Medicine, University of California, Davis, USA
    Tijdschr Diergeneeskd 130:275-7. 2005
  18. pmc Localization of canine brachycephaly using an across breed mapping approach
    Danika Bannasch
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 5:e9632. 2010
    ..These results demonstrate that non-segregating traits under strong selection are equally tractable to genetic analysis using small sample numbers...
  19. pmc The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populations
    Monika J Lipinski
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA
    Genomics 91:12-21. 2008
    ..Three recently derived breeds were not distinct from their parental breeds of origin. Pure breeding was associated with a loss of genetic diversity; however, this loss did not correlate with breed popularity or age...
  20. ncbi request reprint A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens
    Xiaoying Shen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 88:2793-9. 2007
    ..Overall, these findings confirmed that the severe virus attenuation for both replication and pathogenicity exhibited by a vif-deleted FIV mutant is similar for both neonatal and adult hosts...
  21. ncbi request reprint Virulent systemic feline calicivirus infection: local cytokine modulation and contribution of viral mutants
    Janet Foley
    School of Veterinary Medicine, Department of Medicine and Epidemiology, University of California, Davis, CA 95616, USA
    J Feline Med Surg 8:55-61. 2006
    ..Understanding the features contributing to the emergence of this disease is critical for management and prevention of this and similar outbreaks attributable to RNA viruses in animals and humans...
  22. pmc Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, California 95616, USA
    Antimicrob Agents Chemother 48:1469-87. 2004
    ....
  23. pmc Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage
    Mark W Neff
    Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11725-30. 2004
    ....
  24. pmc Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1
    Thomas W North
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    J Virol 79:7349-54. 2005
    ..These results mimic HAART of HIV-1-infected humans. The RT-SHIV/rhesus macaque model should be useful for studies of tissue reservoirs and sites of residual replication that are not possible or practical with humans...
  25. ncbi request reprint Y chromosome haplotype analysis in purebred dogs
    Danika L Bannasch
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Mamm Genome 16:273-80. 2005
    ..5%). A network analysis of the haplotypes revealed further relationships between the breeds as well as deep rooting of many of the breed-specific haplotypes, particularly among breeds of African origin...
  26. ncbi request reprint The effects of HHV-8 vMIP-II on SIVmac251 infection and replication competent and incompetent SIVmac239Delta3 vectors
    Kevin V Morris
    Department of Medicine 0678, Stein Clinical Research Building, Room 402, University of California, La Jolla, San Diego, CA 92093 0678, USA
    Virus Res 94:103-12. 2003
    ..These data suggest that replication defective SIV vectors expressing immunobiolgic genes such as vMIP-II may prove useful in gene therapies, particularly in augmenting immune responses in chronically infected individuals...
  27. ncbi request reprint Infection and re-infection of domestic cats with various Bartonella species or types: B. henselae type I is protective against heterologous challenge with B. henselae type II
    Kazuhiro Yamamoto
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Microbiol 92:73-86. 2003
    ..henselae type II and challenged with B. henselae type I. Such results are of major importance for future feline Bartonella vaccine development...
  28. ncbi request reprint Effect of preexisting FeLV infection or FeLV and feline immunodeficiency virus coinfection on pathogenicity of the small variant of Haemobartonella felis in cats
    Jeanne W George
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Vet Res 63:1172-8. 2002
    ..To investigate the effects of preexisting FeLV infection or FeLV and feline immunodeficiency (FIV) coinfection on the pathogenicity of the small variant of Haemobartonella felis (Hfsm, California variant) in cats...
  29. ncbi request reprint In vivo cytokine response to experimental feline infectious peritonitis virus infection
    Gregg A Dean
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Microbiol 97:1-12. 2003
    ..A possible role for TNF-alpha in the previously described FIPV-induced lymphocyte apoptosis is also suggested...
  30. ncbi request reprint Characterization of a mobilization-competent simian immunodeficiency virus (SIV) vector containing a ribozyme against SIV polymerase
    Kevin V Morris
    Department of Medicine, Stein Clinical Research Building Room 402, University of California San Diego, La Jolla, CA 92093 0665, USA
    J Gen Virol 85:1489-96. 2004
    ..These findings provide direct evidence that mobilization of an anti-retroviral SIV gene therapy vector is feasible in the SIV/macaque model...
  31. ncbi request reprint Feline lymphoma in the post-feline leukemia virus era
    Mathilde Louwerens
    Utrecht University, School of Veterinary Medicine, Utrecht, The Netherlands
    J Vet Intern Med 19:329-35. 2005
    ..A high incidence of mediastinal lymphomas in young Siamese or Oriental breeds also was observed, supporting previous studies. Associations of intestinal lymphoma and inflammatory bowel disease and diet should be further considered...
  32. ncbi request reprint Recommendations from workshops of the second international feline coronavirus/feline infectious peritonitis symposium
    Diane D Addie
    Department of Veterinary Pathology, Companion Animal Diagnostics, Institute of Comparative Medicine, Bearsden Road, Glasgow Scotland G61 1QH, UK
    J Feline Med Surg 6:125-30. 2004
    ..The workshops were chaired by the three authors and the recommendations are presented in this paper...
  33. pmc Feline coronavirus serotypes 1 and 2: seroprevalence and association with disease in Switzerland
    Maya Kummrow
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
    Clin Diagn Lab Immunol 12:1209-15. 2005
    ..When serology is used in addition to clinical signs, hematology, and clinical chemistry results as an aid to diagnose clinical FIP, TGEV shows a diagnostic efficiency equal to that of a FCoV antigen...