Affiliation: University of California
Watanabe R, Eckstrand C, Liu H, Pedersen N. Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq. Vet Res. 2018;49:81 pubmed publisher
..Analysis of KEGG associated gene transcripts indicated that Th1 polarization overshadowed Th2 polarization, but the addition of relevant B cell associated genes previously linked to FIP macrophages tended to alter this perception. ..
Pedersen N, Liu H, Gandolfi B, Lyons L. The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis. Vet Immunol Immunopathol. 2014;162:33-40 pubmed publisher
..The only common and strong association identified between the various GWAS case configurations was for the 34.7-45.8Mb region of chromosome A3. No obvious candidate genes were present in this region. ..
Murphy B, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, et al
. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018;219:226-233 pubmed publisher
..In an experimental FIPV infection of cats, GS-441524 treatment caused a rapid reversal of disease signs and return to normality with as little as two weeks of treatment in 10/10 cats and with no apparent toxicity. ..
Pedersen N, Dean G, Bernales J, Sukura A, Higgins J. Listeria monocytogenes and Serratia marcescens infections as models for Th1/Th2 immunity in laboratory cats. Vet Immunol Immunopathol. 1998;63:83-103 pubmed
..Interleukin-12, an important Th1 cytokine, was elevated to equal levels in both infections as were the Th2 cytokines IL-4 and IL-10. ..
Pedersen N, Liu H, Millon L, Greer K. Dog leukocyte antigen class II-associated genetic risk testing for immune disorders of dogs: simplified approaches using Pug dog necrotizing meningoencephalitis as a model. J Vet Diagn Invest. 2011;23:68-76 pubmed
Pedersen N, Liu H, McLaughlin B, Sacks B. Genetic characterization of healthy and sebaceous adenitis affected Standard Poodles from the United States and the United Kingdom. Tissue Antigens. 2012;80:46-57 pubmed publisher
Pedersen N, Eckstrand C, Liu H, Leutenegger C, Murphy B. Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection. Vet Microbiol. 2015;175:157-66 pubmed publisher
..FIPV genomic RNA was also found to be highly macrophage associated within diseased tissues and effusions as determined by RT-qPCR and immunohistochemistry but was not present in blood. ..
Pedersen N, Liu H, Durden M, Lyons L. Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection. Vet Immunol Immunopathol. 2016;171:17-20 pubmed publisher
..Therefore, survival after both primary and secondary infection was decreased rather than increased by positive selection for resistance. The common genetic factor associated with this diminished resistance was a loss of heterozygosity. ..
Bighignoli B, Niini T, Grahn R, Pedersen N, Millon L, Polli M, et al
. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group. BMC Genet. 2007;8:27 pubmed
..The A and b CMAH alleles described herein can distinguish type A and type B cats without blood sample collections. CMAH represents the first blood group gene identified outside of non-human primates and humans. ..