Research Topics
Species | D B PedenSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Advances in environmental and occupational disorders in 2012David B Peden
Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, and Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7310, USA
J Allergy Clin Immunol 131:668-74. 2013..Identification of novel allergens can improve diagnostics, risk factor analysis can aid preventative approaches, and studies of genetic-environmental interactions and immune mechanisms will lead to better therapeutics...
Effect of pollutants in rhinitisD B Peden
Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, 104 Mason Farm Road, CB 7310, School of Medicine, Chapel Hill, NC 27599 7310, USA
Curr Allergy Asthma Rep 1:242-6. 2001..This article examines the effect of ozone and particulate air pollution of TH2-type inflammation in the airway and how nasal defenses protect the upper and lower airway from adverse effects of pollutants...- Advances in environmental and occupational disorders 2006David B Peden
Division of Pediatric Immunology and Infectious Diseases and the Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
J Allergy Clin Immunol 119:1127-32. 2007..Thus, this particular area of our specialty thrives as a result of clinical, mechanistic, epidemiologic, and translational observations. This article reviews a number of these papers presented in the Journal in 2006... - Advances in environmental and occupational respiratory disease in 2010David B Peden
Division of Pediatric Allergy, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7310, USA
J Allergy Clin Immunol 127:696-700. 2011..New effective approaches to asthma therapy have been identified. Exposure reduction through air filtration and novel immunotherapy approaches, such as sublingual therapy, have made significant advances... - Advances in environmental and occupational respiratory diseases in 2009David B Peden
Division of Pediatric Allergy, Immunology Rheumatology and Infectious Diseases and the Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Allergy Clin Immunol 125:559-62. 2010..New approaches to immunotherapy, novel vaccine techniques, and methods to reduce risks for severe allergic disease were addressed... - Influences on the development of allergy and asthmaDavid B Peden
Center for Environmental Medicine and Lung Biology, 104 Mason Farm Road, CB 7310 School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7310, USA
Toxicology 181:323-8. 2002..Reviewed in this article are genetic, inflammatory and lifestyle factors which contribute to development of allergy in childhood... - Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjectsNeil E Alexis
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, 27599, USA
J Allergy Clin Immunol 112:353-61. 2003.... 
The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjectsNeil E Alexis
Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, Chapel Hill, NC 27599 7310, USA
J Allergy Clin Immunol 124:1222-1228.e5. 2009..Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known whether GSTM1 modulates these ozone responses in vivo in human subjects...- Attenuation of host defense function of lung phagocytes in young cystic fibrosis patientsNeil E Alexis
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cyst Fibros 5:17-25. 2006..These impairments can be reproduced by incubation of non-CF cells with NE, while SP-A can partially reverse them. Decreasing protease activity and increasing collectin activity may be beneficial in early CF... - Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozoneMichelle L Hernandez
Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
J Allergy Clin Immunol 126:537-44.e1. 2010..Ozone causes an immediate decrease in lung function and increased airway inflammation. The role of atopy and asthma in modulation of ozone-induced inflammation has not been determined... - Air pollution in asthma: effect of pollutants on airway inflammationD B Peden
The Center for Environmental Medicine and Lung Biology, The University of North Carolina School of Medicine, Chapel Hill 27599 7310, USA
Ann Allergy Asthma Immunol 87:12-7. 2001.... - In vivo uptake of inhaled particles by airway phagocytes is enhanced in patients with mild asthma compared with normal volunteersJ C Lay
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC 27599 7310, USA
Thorax 64:313-20. 2009.... - IL-4 induces IL-6 and signs of allergic-type inflammation in the nasal airways of nonallergic individualsNeil Alexis
Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
Clin Immunol 104:217-20. 2002..These data demonstrate that IL-4 can modulate both allergic- and nonallergic-type inflammatory responses in the nasal airways of nonallergic individuals... - Influence of C-159T SNP of the CD14 gene promoter on lung function in smokersHaibo Zhou
The Center for Environmental Medicine, Asthma and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Respir Med 103:1358-65. 2009..The effect of CC genotype on severity of COPD is analogous with the effect of this genotype in risk for asthma. CD14 may be a factor in the pathophysiology of COPD, as it is in asthma and smoking-related cardiovascular diseases... - Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cellsWeidong Wu
Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
Biochem Biophys Res Commun 379:573-7. 2009..In summary, LPS-induced CD40 expression on human PBMCs through activation of NFkappaB and JNK, and partially through the induction of IFNgamma production... - Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseasesEva Lorenz
Department of Rheumatology, TARC University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
Respir Med 102:567-73. 2008..The results indicate that the regulation of human calgranulin expression and the ratio of S100A8/A9 to S100A12 may provide important insights in the mechanism of respiratory inflammation... - Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cellsWeidong Wu
Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 228:135-43. 2008..Moreover, blockage of MAPK and NFkappaB activation inhibited LPS-induced TLR4 expression. In summary, LPS-induced CD40 expression in monocytic cells involves MAPKs and NFkappaB... - Climate change and allergic diseaseKatherine M Shea
Department of Maternal and Child Health, School of Public Health, Chapel Hill, NC 27599 1105, USA
J Allergy Clin Immunol 122:443-53; quiz 454-5. 2008..A number of practical primary and secondary prevention strategies are suggested at the end of the review to assist in meeting this unprecedented public health challenge... - Development of an inhaled endotoxin challenge protocol for characterizing evoked cell surface phenotype and genomic responses of airway cells in allergic individualsNeil E Alexis
Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Ann Allergy Asthma Immunol 100:206-15. 2008..Inhaled endotoxin protocols have been used to evaluate airway cell surface phenotypes associated with antigen presentation and innate immunity in healthy volunteers, but not in allergic volunteers... - Regulation of cyclooxygenase-2 expression by cAMP response element and mRNA stability in a human airway epithelial cell line exposed to zincWeidong Wu
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC 2759, USA
Toxicol Appl Pharmacol 231:260-6. 2008..Taken together, these data demonstrate that the CRE and mRNA stability regulates COX-2 expression induced in BEAS-2B cells exposed to extracellular Zn2+... - Coarse particulate matter (PM2.5-10) affects heart rate variability, blood lipids, and circulating eosinophils in adults with asthmaKarin Yeatts
Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7310, USA
Environ Health Perspect 115:709-14. 2007..5-10 microm (PM(2.5-10))] and fine (PM(2.5)) size range... - Neutrophilic inflammation is associated with altered airway hydration in stable asthmaticsCeila E Loughlin
Department of Pediatrics, Division of Pediatric Pulmonology, The School of Medicine, University of North Carolina, 130 Mason Farm Road, 5th floor Bioinformatics Bldg, CB 7217, Chapel Hill, NC 27599 7217, USA
Respir Med 104:29-33. 2010..Using sputum percent solids, as an indicator of airway hydration, we sought relationships between airway hydration and other known markers of neutrophilic (TH1) and allergic (TH2) inflammation in stable asthma... - Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteersNeil E Alexis
Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina at Chapel Hill, NC 27599 7310, USA
J Allergy Clin Immunol 117:1396-403. 2006..In vitro, endotoxin on coarse fraction particulate matter (PM2.5-10) accounts for the majority of the ability of PM2.5-10 to induce cytokine responses from alveolar macrophages... - Low-level ozone exposure induces airways inflammation and modifies cell surface phenotypes in healthy humansNeil E Alexis
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
Inhal Toxicol 22:593-600. 2010..These findings need to be replicated in a similar experiment that includes a control air exposure... - Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cellsWeidong Wu
Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, 27599, USA
Environ Health Perspect 118:982-7. 2010..Exposure to zinc oxide (ZnO) in environmental and occupational settings causes acute pulmonary responses through the induction of proinflammatory mediators such as interleukin-8 (IL-8)... - Pollutants and asthma: role of air toxicsDavid B Peden
Department of Pediatrics, and Center for Environmental Medicine and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
Environ Health Perspect 110:565-8. 2002..These agents have been observed to activate NF-Kappa B. Reviewed in this article are the actions of specific air pollutants on airway inflammation in humans and potential common response pathways for ozone, PM, and several air toxics... - Inhalation of low-dose endotoxin favors local T(H)2 response and primes airway phagocytes in vivoNeil E Alexis
UNC School of Medicine, UNC Chapel Hill, Chapel Hill, NC 27599, USA
J Allergy Clin Immunol 114:1325-31. 2004..Conversely, we recently reported that very low doses of endotoxin, which are not associated with neutrophil influx, enhance response to allergen in the nasal and bronchial airway... - The epidemiology and genetics of asthma risk associated with air pollutionDavid B Peden
Department of Pediatrics, School of Medicine, The University of North Carolina at Chapel Hill, NC 27599, USA
J Allergy Clin Immunol 115:213-9; quiz 220. 2005..A number of public health, pharmaceutical, and nutriceutical interventions might mitigate the effects of pollutant exposure and deserve further study... - Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivoNeil E Alexis
Center for Environmental Biology, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, NC 27599, USA
J Allergy Clin Immunol 115:345-50. 2005..We have been studying the innate immune response of airways cells of healthy human volunteers to inhaled LPS, a Toll-like receptor 4 (TLR4) ligand, and have shown that macrophage phagocytic capacity is blunted... - Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challengeMichelle L Hernandez
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
Inhal Toxicol 22:648-56. 2010.... - Repeated measurement of nasal lavage fluid chemokines in school-age children with asthmaTerry L Noah
Department of Pediatrics, School of Medicine, The University of North Carolina at Chapel Hill, 27599 7220, USA
Ann Allergy Asthma Immunol 96:304-10. 2006..Cross-sectional studies in asthmatic patients suggest that chemokines such as interleukin 8 (IL-8) are overproduced by respiratory epithelium... - Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteersNeil E Alexis
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7310, USA
Environ Health Perspect 116:799-805. 2008..High-dose inhaled corticosteroids can reduce O(3)-induced airway inflammation, but their effect on innate immune activation is unknown... - Development of atopy and asthma: candidate environmental influences and important periods of exposureD B Peden
Department of Pediatrics and The Center for Environmental Medicine and Lung Biology, The School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Environ Health Perspect 108:475-82. 2000.... - Blunting airway eosinophilic inflammation results in a decreased airway neutrophil response to inhaled LPS in patients with atopic asthma: a role for CD14N E Alexis
Center for Environmental Medicine and Lung Biology, Department of Pediatrics and Medicine, University of North Carolina-Chapel Hill 27599-7310, USA
J Allergy Clin Immunol 108:577-80. 2001..04). Our data suggest that decreasing airway allergic inflammation with corticosteroids results in both decreased expression of CD14 on airway monocytic cells and a decreased PMN response to inhaled LPS... - Airway response to concomitant exposure with endotoxin and allergen in atopic asthmaticsM W Eldridge
Department of Pediatrics, and General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, USA
J Toxicol Environ Health A 61:27-37. 2000..Moreover, these studies may provide further evidence that concomitant exposure to allergen and endotoxin is an important factor in asthma pathogenesis... - Modulation of asthma by endotoxinV Doreswamy
Department of Pediatrics, Division of Allergy, Immunology, Rheumatology and Infectious Diseases Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
Clin Exp Allergy 41:9-19. 2011..We focus on studies since 2001 that have explored the role of endotoxin in asthma and the gene-environment interactions of the endotoxin effect... - CD14-dependent airway neutrophil response to inhaled LPS: role of atopyN Alexis
Center for Environmental Medicine and Lung Biology, Department of Pediatrics, University of North Carolina-Chapel Hill, 27599-7310, USA
J Allergy Clin Immunol 107:31-5. 2001..CONCLUSION: Constitutive airway CD14 expression can predict the magnitude of the PMN response after inhaled LPS. Atopy appears to play a role in the level of CD14 expression and may contribute to LPS sensitivity in asthmatic subjects... - In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjectsJessica Wiser
The Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7310, USA
Free Radic Biol Med 45:40-9. 2008..Further, in vitro treatment of human monocytes with gamma-CEHC and alpha-CEHC inhibits ROS generation and LPS-induced degradation of IkappaB and JNK activation... - Effect of inhaled dust mite allergen on regional particle deposition and mucociliary clearance in allergic asthmaticsW D Bennett
Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Clin Exp Allergy 41:1719-28. 2011..Acute exacerbations in allergic asthmatics may lead to impaired ability to clear mucus from the airways, a key factor in asthma morbidity... - Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individualsJohn C Lay
J Allergy Clin Immunol 120:719-22. 2007 - Low-dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmaticsBrian Boehlecke
J Allergy Clin Immunol 112:1241-3. 2003 - Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humansNeil E Alexis
National Health and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Clin Immunol 111:126-31. 2004..Consequently, CD11b may be a useful biomarker for predicting susceptibility to airway neutrophilic inflammation caused by pollutants... - Effect of ozone exposure on airway responses to inhaled allergen in asthmatic subjectsLisa L Chen
Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, and Medical Service, San Francisco General Hospital, University of California, San Francisco, CA, USA
Chest 125:2328-35. 2004..Our results do suggest, however, that a subgroup of asthmatics may acquire increased sensitivity to aeroallergens after exposure to ozone... - Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherolJames G Wagner
Department of Pathobiology and Diagnostic Investigation, Michigan State University, 211 Food Safety and Toxicology Building, East Lansing, MI 48824, USA
Free Radic Biol Med 43:1176-88. 2007..These data demonstrate broad anti-inflammatory effects of a gammaT and suggest that it may be an effective therapy of allergic airway inflammation... - Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthmaFrank Schaumann
Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Str 1, 30625 Hannover, Germany
Am J Respir Crit Care Med 177:1307-13. 2008..High levels of endotoxin are associated with asthma symptoms and the current use of asthma medication. However, the underlying mechanisms by which endotoxin modulates asthma are not completely understood... - Inflammatory response of the airway to inhaled endotoxin correlates with body mass index in atopic patients with asthma but not in normal volunteersNeil E Alexis
J Allergy Clin Immunol 117:1185-6. 2006 - Advances in environmental and occupational disordersRobert K Bush
Section of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin, Madison, WI53705, USA
J Allergy Clin Immunol 117:1367-73. 2006..That these interactions have proved to be remarkably complex comes as no surprise to the allergy and immunology community because allergists and immunologists have long appreciated the role of environmental influences on disease...
Research Grants
- Airway Biology of Acute Asthma: Translational StudiesDavid Peden; Fiscal Year: 2007..abstract_text> ..
- Ozone and LPS-Induced Airway Inflammation In Humans In VivoDavid Peden; Fiscal Year: 2007..That low level ozone will enhance response to LPS. Testing these hypotheses will be used to better define the ways that O3 and LPS interact to exacerbate airway disease. ..
- ENDOTOXIN AND BRONCHIAL INFLAMMATION IN ASTHMADavid Peden; Fiscal Year: 2005..We will also employ nasal challenge and in vitro studies of monocytic cells to examine the effect of GM-CSF and other candidate cytokines produced by IgE-mediated inflammation on in vivo and in vitro response to LPS ..
- ENDOTOXIN AND BRONCHIAL INFLAMMATION IN ASTHMADavid Peden; Fiscal Year: 2001..Finally, practical data on the effect of LPS in asthmatics (at levels found in typical work settings) and the ability of standard anti-inflammatory therapy to protect asthmatic workers unavoidable exposed to LPS will be obtained. ..
- CD14 AND LPS-INDUCED INFLAMMATION IN CHRONIC BRONCHITISDavid Peden; Fiscal Year: 2003..Finally, the investigators will genotype cohorts of COPD patients and healthy smokers to determine if the T allele is a risk factor in development of COPD in those who smoke. ..