D B Peden

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Development of atopy and asthma: candidate environmental influences and important periods of exposure
    D B Peden
    Department of Pediatrics and The Center for Environmental Medicine and Lung Biology, The School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 108:475-82. 2000
  2. ncbi request reprint The epidemiology and genetics of asthma risk associated with air pollution
    David B Peden
    Department of Pediatrics, School of Medicine, The University of North Carolina at Chapel Hill, NC 27599, USA
    J Allergy Clin Immunol 115:213-9; quiz 220. 2005
  3. ncbi request reprint Air pollution in asthma: effect of pollutants on airway inflammation
    D B Peden
    The Center for Environmental Medicine and Lung Biology, The University of North Carolina School of Medicine, Chapel Hill 27599 7310, USA
    Ann Allergy Asthma Immunol 87:12-7. 2001
  4. doi request reprint The role of oxidative stress and innate immunity in O(3) and endotoxin-induced human allergic airway disease
    David B Peden
    Division of Pediatric Allergy, Immunology, Rheumatology and Infectious Diseases, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Immunol Rev 242:91-105. 2011
  5. pmc Pollutants and asthma: role of air toxics
    David B Peden
    Department of Pediatrics, and Center for Environmental Medicine and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Environ Health Perspect 110:565-8. 2002
  6. ncbi request reprint Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, 27599, USA
    J Allergy Clin Immunol 112:353-61. 2003
  7. pmc The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 124:1222-1228.e5. 2009
  8. pmc Effect of inhaled dust mite allergen on regional particle deposition and mucociliary clearance in allergic asthmatics
    W D Bennett
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Exp Allergy 41:1719-28. 2011
  9. pmc Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cyst Fibros 5:17-25. 2006
  10. pmc Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone
    Michelle L Hernandez
    Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 126:537-44.e1. 2010

Detail Information

Publications46

  1. pmc Development of atopy and asthma: candidate environmental influences and important periods of exposure
    D B Peden
    Department of Pediatrics and The Center for Environmental Medicine and Lung Biology, The School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 108:475-82. 2000
    ....
  2. ncbi request reprint The epidemiology and genetics of asthma risk associated with air pollution
    David B Peden
    Department of Pediatrics, School of Medicine, The University of North Carolina at Chapel Hill, NC 27599, USA
    J Allergy Clin Immunol 115:213-9; quiz 220. 2005
    ..A number of public health, pharmaceutical, and nutriceutical interventions might mitigate the effects of pollutant exposure and deserve further study...
  3. ncbi request reprint Air pollution in asthma: effect of pollutants on airway inflammation
    D B Peden
    The Center for Environmental Medicine and Lung Biology, The University of North Carolina School of Medicine, Chapel Hill 27599 7310, USA
    Ann Allergy Asthma Immunol 87:12-7. 2001
    ....
  4. doi request reprint The role of oxidative stress and innate immunity in O(3) and endotoxin-induced human allergic airway disease
    David B Peden
    Division of Pediatric Allergy, Immunology, Rheumatology and Infectious Diseases, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Immunol Rev 242:91-105. 2011
    ..Such interventions include specific inhibitors of innate immunity and antioxidant therapies designed to counter the effects of pollutants on cell signaling...
  5. pmc Pollutants and asthma: role of air toxics
    David B Peden
    Department of Pediatrics, and Center for Environmental Medicine and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Environ Health Perspect 110:565-8. 2002
    ..These agents have been observed to activate NF-Kappa B. Reviewed in this article are the actions of specific air pollutants on airway inflammation in humans and potential common response pathways for ozone, PM, and several air toxics...
  6. ncbi request reprint Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, 27599, USA
    J Allergy Clin Immunol 112:353-61. 2003
    ..Macrophage and neutrophil functions have been reported to be modified by endotoxin in vitro and in vivo, and response to endotoxin is mediated largely by airway phagocytes and related to allergic inflammation...
  7. pmc The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 124:1222-1228.e5. 2009
    ..Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known whether GSTM1 modulates these ozone responses in vivo in human subjects...
  8. pmc Effect of inhaled dust mite allergen on regional particle deposition and mucociliary clearance in allergic asthmatics
    W D Bennett
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Exp Allergy 41:1719-28. 2011
    ..Acute exacerbations in allergic asthmatics may lead to impaired ability to clear mucus from the airways, a key factor in asthma morbidity...
  9. pmc Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cyst Fibros 5:17-25. 2006
    ....
  10. pmc Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone
    Michelle L Hernandez
    Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 126:537-44.e1. 2010
    ..Ozone causes an immediate decrease in lung function and increased airway inflammation. The role of atopy and asthma in modulation of ozone-induced inflammation has not been determined...
  11. ncbi request reprint Airway response to concomitant exposure with endotoxin and allergen in atopic asthmatics
    M W Eldridge
    Department of Pediatrics, and General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, USA
    J Toxicol Environ Health A 61:27-37. 2000
    ..Moreover, these studies may provide further evidence that concomitant exposure to allergen and endotoxin is an important factor in asthma pathogenesis...
  12. pmc Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases
    Eva Lorenz
    Department of Rheumatology, TARC University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
    Respir Med 102:567-73. 2008
    ..The results indicate that the regulation of human calgranulin expression and the ratio of S100A8/A9 to S100A12 may provide important insights in the mechanism of respiratory inflammation...
  13. pmc Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 228:135-43. 2008
    ..Moreover, blockage of MAPK and NFkappaB activation inhibited LPS-induced TLR4 expression. In summary, LPS-induced CD40 expression in monocytic cells involves MAPKs and NFkappaB...
  14. doi request reprint Regulation of cyclooxygenase-2 expression by cAMP response element and mRNA stability in a human airway epithelial cell line exposed to zinc
    Weidong Wu
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC 2759, USA
    Toxicol Appl Pharmacol 231:260-6. 2008
    ..Taken together, these data demonstrate that the CRE and mRNA stability regulates COX-2 expression induced in BEAS-2B cells exposed to extracellular Zn2+...
  15. pmc Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteers
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7310, USA
    Environ Health Perspect 116:799-805. 2008
    ..High-dose inhaled corticosteroids can reduce O(3)-induced airway inflammation, but their effect on innate immune activation is unknown...
  16. doi request reprint Climate change and allergic disease
    Katherine M Shea
    Department of Maternal and Child Health, School of Public Health, Chapel Hill, NC 27599 1105, USA
    J Allergy Clin Immunol 122:443-53; quiz 454-5. 2008
    ..A number of practical primary and secondary prevention strategies are suggested at the end of the review to assist in meeting this unprecedented public health challenge...
  17. pmc Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
    Biochem Biophys Res Commun 379:573-7. 2009
    ..In summary, LPS-induced CD40 expression on human PBMCs through activation of NFkappaB and JNK, and partially through the induction of IFNgamma production...
  18. pmc Low-level ozone exposure induces airways inflammation and modifies cell surface phenotypes in healthy humans
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
    Inhal Toxicol 22:593-600. 2010
    ..These findings need to be replicated in a similar experiment that includes a control air exposure...
  19. pmc Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers
    Haibo Zhou
    The Center for Environmental Medicine, Asthma and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Respir Med 103:1358-65. 2009
    ..The effect of CC genotype on severity of COPD is analogous with the effect of this genotype in risk for asthma. CD14 may be a factor in the pathophysiology of COPD, as it is in asthma and smoking-related cardiovascular diseases...
  20. pmc Neutrophilic inflammation is associated with altered airway hydration in stable asthmatics
    Ceila E Loughlin
    Department of Pediatrics, Division of Pediatric Pulmonology, The School of Medicine, University of North Carolina, 130 Mason Farm Road, 5th floor Bioinformatics Bldg, CB 7217, Chapel Hill, NC 27599 7217, USA
    Respir Med 104:29-33. 2010
    ..Using sputum percent solids, as an indicator of airway hydration, we sought relationships between airway hydration and other known markers of neutrophilic (TH1) and allergic (TH2) inflammation in stable asthma...
  21. doi request reprint Advances in environmental and occupational respiratory diseases in 2009
    David B Peden
    Division of Pediatric Allergy, Immunology Rheumatology and Infectious Diseases and the Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Allergy Clin Immunol 125:559-62. 2010
    ..New approaches to immunotherapy, novel vaccine techniques, and methods to reduce risks for severe allergic disease were addressed...
  22. pmc Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, 27599, USA
    Environ Health Perspect 118:982-7. 2010
    ..Exposure to zinc oxide (ZnO) in environmental and occupational settings causes acute pulmonary responses through the induction of proinflammatory mediators such as interleukin-8 (IL-8)...
  23. pmc Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge
    Michelle L Hernandez
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Inhal Toxicol 22:648-56. 2010
    ....
  24. ncbi request reprint Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivo
    Neil E Alexis
    Center for Environmental Biology, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, NC 27599, USA
    J Allergy Clin Immunol 115:345-50. 2005
    ..We have been studying the innate immune response of airways cells of healthy human volunteers to inhaled LPS, a Toll-like receptor 4 (TLR4) ligand, and have shown that macrophage phagocytic capacity is blunted...
  25. ncbi request reprint Inhalation of low-dose endotoxin favors local T(H)2 response and primes airway phagocytes in vivo
    Neil E Alexis
    UNC School of Medicine, UNC Chapel Hill, Chapel Hill, NC 27599, USA
    J Allergy Clin Immunol 114:1325-31. 2004
    ..Conversely, we recently reported that very low doses of endotoxin, which are not associated with neutrophil influx, enhance response to allergen in the nasal and bronchial airway...
  26. doi request reprint Development of an inhaled endotoxin challenge protocol for characterizing evoked cell surface phenotype and genomic responses of airway cells in allergic individuals
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ann Allergy Asthma Immunol 100:206-15. 2008
    ..Inhaled endotoxin protocols have been used to evaluate airway cell surface phenotypes associated with antigen presentation and innate immunity in healthy volunteers, but not in allergic volunteers...
  27. ncbi request reprint Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers
    Neil E Alexis
    Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina at Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 117:1396-403. 2006
    ..In vitro, endotoxin on coarse fraction particulate matter (PM2.5-10) accounts for the majority of the ability of PM2.5-10 to induce cytokine responses from alveolar macrophages...
  28. ncbi request reprint Influences on the development of allergy and asthma
    David B Peden
    Center for Environmental Medicine and Lung Biology, 104 Mason Farm Road, CB 7310 School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7310, USA
    Toxicology 181:323-8. 2002
    ..Reviewed in this article are genetic, inflammatory and lifestyle factors which contribute to development of allergy in childhood...
  29. ncbi request reprint IL-4 induces IL-6 and signs of allergic-type inflammation in the nasal airways of nonallergic individuals
    Neil Alexis
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
    Clin Immunol 104:217-20. 2002
    ..These data demonstrate that IL-4 can modulate both allergic- and nonallergic-type inflammatory responses in the nasal airways of nonallergic individuals...
  30. ncbi request reprint Advances in environmental and occupational disorders 2006
    David B Peden
    Division of Pediatric Immunology and Infectious Diseases and the Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 119:1127-32. 2007
    ..Thus, this particular area of our specialty thrives as a result of clinical, mechanistic, epidemiologic, and translational observations. This article reviews a number of these papers presented in the Journal in 2006...
  31. pmc Coarse particulate matter (PM2.5-10) affects heart rate variability, blood lipids, and circulating eosinophils in adults with asthma
    Karin Yeatts
    Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7310, USA
    Environ Health Perspect 115:709-14. 2007
    ..5-10 microm (PM(2.5-10))] and fine (PM(2.5)) size range...
  32. ncbi request reprint Repeated measurement of nasal lavage fluid chemokines in school-age children with asthma
    Terry L Noah
    Department of Pediatrics, School of Medicine, The University of North Carolina at Chapel Hill, 27599 7220, USA
    Ann Allergy Asthma Immunol 96:304-10. 2006
    ..Cross-sectional studies in asthmatic patients suggest that chemokines such as interleukin 8 (IL-8) are overproduced by respiratory epithelium...
  33. ncbi request reprint Effect of pollutants in rhinitis
    D B Peden
    Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, 104 Mason Farm Road, CB 7310, School of Medicine, Chapel Hill, NC 27599 7310, USA
    Curr Allergy Asthma Rep 1:242-6. 2001
    ..This article examines the effect of ozone and particulate air pollution of TH2-type inflammation in the airway and how nasal defenses protect the upper and lower airway from adverse effects of pollutants...
  34. ncbi request reprint CD14-dependent airway neutrophil response to inhaled LPS: role of atopy
    N Alexis
    Center for Environmental Medicine and Lung Biology, Department of Pediatrics, University of North Carolina-Chapel Hill, 27599-7310, USA
    J Allergy Clin Immunol 107:31-5. 2001
    ..CONCLUSION: Constitutive airway CD14 expression can predict the magnitude of the PMN response after inhaled LPS. Atopy appears to play a role in the level of CD14 expression and may contribute to LPS sensitivity in asthmatic subjects...
  35. doi request reprint In vivo uptake of inhaled particles by airway phagocytes is enhanced in patients with mild asthma compared with normal volunteers
    J C Lay
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC 27599 7310, USA
    Thorax 64:313-20. 2009
    ....
  36. doi request reprint Modulation of asthma by endotoxin
    V Doreswamy
    Department of Pediatrics, Division of Allergy, Immunology, Rheumatology and Infectious Diseases Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Clin Exp Allergy 41:9-19. 2011
    ..We focus on studies since 2001 that have explored the role of endotoxin in asthma and the gene-environment interactions of the endotoxin effect...
  37. pmc In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects
    Jessica Wiser
    The Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7310, USA
    Free Radic Biol Med 45:40-9. 2008
    ..Further, in vitro treatment of human monocytes with gamma-CEHC and alpha-CEHC inhibits ROS generation and LPS-induced degradation of IkappaB and JNK activation...
  38. doi request reprint Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype
    Madeline A Dillon
    Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7310, USA
    Occup Environ Med 68:783-5. 2011
    ..To determine if the GSTM1 null genotype is a risk factor for increased inflammatory response to inhaled endotoxin...
  39. pmc Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma
    Frank Schaumann
    Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Str 1, 30625 Hannover, Germany
    Am J Respir Crit Care Med 177:1307-13. 2008
    ..High levels of endotoxin are associated with asthma symptoms and the current use of asthma medication. However, the underlying mechanisms by which endotoxin modulates asthma are not completely understood...
  40. ncbi request reprint Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol
    James G Wagner
    Department of Pathobiology and Diagnostic Investigation, Michigan State University, 211 Food Safety and Toxicology Building, East Lansing, MI 48824, USA
    Free Radic Biol Med 43:1176-88. 2007
    ..These data demonstrate broad anti-inflammatory effects of a gammaT and suggest that it may be an effective therapy of allergic airway inflammation...
  41. ncbi request reprint Low-dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmatics
    Brian Boehlecke
    J Allergy Clin Immunol 112:1241-3. 2003
  42. ncbi request reprint Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humans
    Neil E Alexis
    National Health and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Clin Immunol 111:126-31. 2004
    ..Consequently, CD11b may be a useful biomarker for predicting susceptibility to airway neutrophilic inflammation caused by pollutants...
  43. ncbi request reprint Effect of ozone exposure on airway responses to inhaled allergen in asthmatic subjects
    Lisa L Chen
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, and Medical Service, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Chest 125:2328-35. 2004
    ..Spirometric parameters do not necessarily reflect the airway inflammatory effects of inhaled ozone or allergen...
  44. ncbi request reprint Inflammatory response of the airway to inhaled endotoxin correlates with body mass index in atopic patients with asthma but not in normal volunteers
    Neil E Alexis
    J Allergy Clin Immunol 117:1185-6. 2006
  45. ncbi request reprint Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals
    John C Lay
    J Allergy Clin Immunol 120:719-22. 2007
  46. ncbi request reprint Advances in environmental and occupational disorders
    Robert K Bush
    Section of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin, Madison, WI53705, USA
    J Allergy Clin Immunol 117:1367-73. 2006
    ..That these interactions have proved to be remarkably complex comes as no surprise to the allergy and immunology community because allergists and immunologists have long appreciated the role of environmental influences on disease...