Damien D Pearse

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Designing cell- and gene-based regeneration strategies to repair the injured spinal cord
    D D Pearse
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Leonard M Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 23:438-52. 2006
  2. pmc Suspension matrices for improved Schwann-cell survival after implantation into the injured rat spinal cord
    Vivek Patel
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 27:789-801. 2010
  3. ncbi request reprint Cellular repair strategies for spinal cord injury
    Damien D Pearse
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, Department of Neurological Surgery, Lois Pope LIFE Center, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Expert Opin Biol Ther 6:639-52. 2006
  4. ncbi request reprint cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
    Nat Med 10:610-6. 2004
  5. ncbi request reprint Inhibition of tumour necrosis factor-alpha by antisense targeting produces immunophenotypical and morphological changes in injury-activated microglia and macrophages
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, PO Box 016960 R 48, Miami, FL 33101, USA
    Eur J Neurosci 20:3387-96. 2004
  6. ncbi request reprint Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery
    Damien D Pearse
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Glia 55:976-1000. 2007
  7. ncbi request reprint Histopathological and behavioral characterization of a novel cervical spinal cord displacement contusion injury in the rat
    D D Pearse
    The Miami Project to Cure Paralysis, Neurological Surgery, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 22:680-702. 2005
  8. pmc Transduced Schwann cells promote axon growth and myelination after spinal cord injury
    Kevin L Golden
    The Miami Project to Cure Paralysis and the Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
    Exp Neurol 207:203-17. 2007
  9. pmc Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury
    Haruo Kanno
    Miami Project to Cure Paralysis, Department of Neurological Surgery, Neuroscience Program, Interdisciplinary Stem Cell Institute, and Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, United Kingdom, and Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan, 9808574
    J Neurosci 34:1838-55. 2014
  10. doi request reprint The assessment of adeno-associated vectors as potential intrinsic treatments for brainstem axon regeneration
    Ryan R Williams
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, Miami, FL 33136, USA
    J Gene Med 14:20-34. 2012

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Designing cell- and gene-based regeneration strategies to repair the injured spinal cord
    D D Pearse
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Leonard M Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 23:438-52. 2006
    ....
  2. pmc Suspension matrices for improved Schwann-cell survival after implantation into the injured rat spinal cord
    Vivek Patel
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 27:789-801. 2010
    ..The use of a matrix to suspend cells prior to implantation should be an important consideration for achieving improved survival and effectiveness of cellular therapies for future clinical application...
  3. ncbi request reprint Cellular repair strategies for spinal cord injury
    Damien D Pearse
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, Department of Neurological Surgery, Lois Pope LIFE Center, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Expert Opin Biol Ther 6:639-52. 2006
    ..Although the progression of cell therapies from laboratory to clinical implementation has been slow, human SCI safety and efficacy trials involving several cell types within the US appear to be close at hand...
  4. ncbi request reprint cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
    Nat Med 10:610-6. 2004
    ..These findings show that cAMP levels are key for protection, growth and myelination of injured CNS axons in vivo and recovery of function...
  5. ncbi request reprint Inhibition of tumour necrosis factor-alpha by antisense targeting produces immunophenotypical and morphological changes in injury-activated microglia and macrophages
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, PO Box 016960 R 48, Miami, FL 33101, USA
    Eur J Neurosci 20:3387-96. 2004
    ..However, at the peak of microglial activation after injury, the activation state of microglia/macrophages is not stable and this process may still be reversible by blocking TNF-alpha...
  6. ncbi request reprint Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery
    Damien D Pearse
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Glia 55:976-1000. 2007
    ....
  7. ncbi request reprint Histopathological and behavioral characterization of a novel cervical spinal cord displacement contusion injury in the rat
    D D Pearse
    The Miami Project to Cure Paralysis, Neurological Surgery, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 22:680-702. 2005
    ..Characterization of this novel model is presented to enable and encourage its future use in the design and experimental testing of therapeutic strategies that may be used for human SCI...
  8. pmc Transduced Schwann cells promote axon growth and myelination after spinal cord injury
    Kevin L Golden
    The Miami Project to Cure Paralysis and the Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
    Exp Neurol 207:203-17. 2007
    ..These results demonstrate the therapeutic potential for utilizing neurotrophin-transduced SCs to repair the injured spinal cord...
  9. pmc Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury
    Haruo Kanno
    Miami Project to Cure Paralysis, Department of Neurological Surgery, Neuroscience Program, Interdisciplinary Stem Cell Institute, and Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, United Kingdom, and Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan, 9808574
    J Neurosci 34:1838-55. 2014
    ..This is the first evidence that the combination of SC transplants engineered to secrete neurotrophin and chondroitinase further improves axonal regeneration and locomotor and sensory function. ..
  10. doi request reprint The assessment of adeno-associated vectors as potential intrinsic treatments for brainstem axon regeneration
    Ryan R Williams
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, Miami, FL 33136, USA
    J Gene Med 14:20-34. 2012
    ..Given that numerous transgenes have been identified as potential candidates, the present study demonstrates how to determine whether their expression by AAV has a direct intrinsic effect on axon regeneration...
  11. doi request reprint The combination of human neuronal serotonergic cell implants and environmental enrichment after contusive SCI improves motor recovery over each individual strategy
    Mary J Eaton
    VA Medical Center, Miami, FL 33136, United States
    Behav Brain Res 194:236-41. 2008
    ..This recovery of motor function after SCI suggests that the combinatory use of serotonergic hNT2.19 cell grafts plus EE is a meaningful strategy to modestly improve motor dysfunction that accompanies contusive SCI...
  12. ncbi request reprint Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord
    Matthijs F L Meijs
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurotrauma 21:1415-30. 2004
    ..Recovery of hind limb function was similar in both groups. Despite the neuroprotective effects of FGF-2, improved effects on axonal regeneration and functional recovery were not observed...
  13. pmc Inhibition of NADPH oxidase activation in oligodendrocytes reduces cytotoxicity following trauma
    Joshua T Johnstone
    The Miami Project to Cure Paralysis, University of Miami, Miami, Florida, United States of America
    PLoS ONE 8:e80975. 2013
    ..These studies lead to a better understanding of oligodendrocyte death after trauma and identify potential therapeutic targets in disorders involving demyelination and oligodendrocyte death. ..
  14. doi request reprint Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury
    Mousumi Ghosh
    The Miami Project to Cure Paralysis, The University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Glia 60:1839-59. 2012
    ..Targeting PDE4B2 may be a putative therapeutic direction for reducing microglia activation in CNS injury and neurodegenerative diseases...
  15. doi request reprint Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI
    Jenny Fortun
    The Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 26:941-53. 2009
    ....
  16. ncbi request reprint Social and environmental enrichment improves sensory and motor recovery after severe contusive spinal cord injury in the rat
    Yerko Berrocal
    The Miami Project to Cure Paralysis, Miller School of Medicine at the University of Miami, Miami, Florida, USA
    J Neurotrauma 24:1761-72. 2007
    ..These data suggest that immediate use of SEE after contusive SCI is able to improve overall spinal cell survival and prevent much of the sensory and motor dysfunction that accompanies contusive SCI...
  17. ncbi request reprint Transplantation strategies to promote repair of the injured spinal cord
    Mary Bartlett Bunge
    The Miami Project to Cure Paralysis, Department of Cell Biology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Rehabil Res Dev 40:55-62. 2003
    ....
  18. pmc Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury
    Dominic M Maggio
    The Miami Project to Cure Paralysis, The Neuroscience Program, The Interdisciplinary Stem Cell Institute, University of Miami, Miller School of Medicine, Miami, Florida, USA
    J Neurotrauma 29:2244-9. 2012
    ..These results support the effectiveness of targeting iNOS acutely as a therapeutic approach after SCI...
  19. pmc Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury
    Roberta Brambilla
    Department of Neurological Surgery, University of Miami, Florida 33136, USA
    J Neurochem 110:765-78. 2009
    ....
  20. doi request reprint Combining neurotrophin-transduced schwann cells and rolipram to promote functional recovery from subacute spinal cord injury
    Govinder Flora
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA
    Cell Transplant 22:2203-17. 2013
    ..These findings demonstrate the therapeutic potential for a combination therapy involving the maintenance of cyclic AMP levels and neurotrophin-transduced SCs to repair the subacutely injured spinal cord. ..
  21. ncbi request reprint Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species
    Edgar A Jaimes
    Department of Veterans Affairs Medical Center, Renal Division, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Am J Physiol Renal Physiol 294:F385-92. 2008
    ..These studies unveil novel mechanistic pathways that may play a role in the pathogenesis of hypertensive renal injury...
  22. pmc Modulation of the cAMP signaling pathway after traumatic brain injury
    Coleen M Atkins
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Exp Neurol 208:145-58. 2007
    ..These results demonstrate that the cAMP-PKA signaling cascade is downregulated after TBI, and that treatment with a PDE IV inhibitor improves histopathological outcome and decreases inflammation after TBI...
  23. ncbi request reprint Survival, integration, and axon growth support of glia transplanted into the chronically contused spinal cord
    D J Barakat
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell Transplant 14:225-40. 2005
    ....
  24. doi request reprint Angiotensin II increases the expression of the transcription factor ETS-1 in mesangial cells
    Damien D Pearse
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Am J Physiol Renal Physiol 294:F1094-100. 2008
    ..Furthermore, rats infused with ANG II manifested increased glomerular expression of ETS-1. These studies unveil novel pathways that may play an important role in the pathogenesis of renal injury when RAS is activated...
  25. doi request reprint Stem and progenitor cell therapies: recent progress for spinal cord injury repair
    J Louro
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33136, USA
    Neurol Res 30:5-16. 2008
    ....
  26. ncbi request reprint Increased spinal c-Fos expression with noxious and non-noxious peripheral stimulation after severe spinal contusion
    Y A Berrocal
    The Miami Project to Cure Paralysis, Miami, FL 33136, United States
    Neurosci Lett 413:58-62. 2007
    ..These altered responses may represent a functional anatomical reorganization of spinal cord circuitry leading to increased dorsal horn c-Fos expression as a response to severe chronic contusive damage to the spinal cord sensory pathways...
  27. ncbi request reprint Schwann cell transplantation improves reticulospinal axon growth and forelimb strength after severe cervical spinal cord contusion
    S M Schaal
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33101, USA
    Cell Transplant 16:207-28. 2007
    ....
  28. ncbi request reprint Comparison of iNOS inhibition by antisense and pharmacological inhibitors after spinal cord injury
    D D Pearse
    The Miami Project to Cure Paralysis and the Department of Neurological Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neuropathol Exp Neurol 62:1096-107. 2003
    ..Furthermore, we demonstrate that the antisense inhibition of iNOS is more efficacious than currently available pharmacological agents...
  29. ncbi request reprint Neuronal populations capable of regeneration following a combined treatment in rats with spinal cord transection
    Romana Vavrek
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
    J Neurotrauma 24:1667-73. 2007
    ..Determining the mechanisms for the superior capability of these cell populations to regenerate may provide valuable clues in the design of future treatment approaches...
  30. ncbi request reprint Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord
    Karim Fouad
    University of Alberta, Faculty of Rehabilitation Medicine, Edmonton, Canada T6G 2G4
    J Neurosci 25:1169-78. 2005
    ..Our study tests how proven experimental treatments interact in a well-established animal model, thus providing needed direction for the development of future combinatory treatment regimens...
  31. ncbi request reprint Methylprednisolone and other confounders to spinal cord injury clinical trials
    Marca L Sipski
    Department of Physical Medicine and Rehabilitation at the University of Alabama, Birmingham 35249 7330, USA
    Nat Clin Pract Neurol 2:402-3. 2006