Research Topics
Species | E J PearceSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Priming of the immune response by schistosome eggsE J Pearce
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104 6076, USA
Parasite Immunol 27:265-70. 2005..In this review I will focus on the underlying basis for the Th2 bias in the immune response to egg antigens...- The immunobiology of schistosomiasisEdward J Pearce
Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
Nat Rev Immunol 2:499-511. 2002..Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice... 
Reverse genetics and the study of the immune response to schistosomesE J Pearce
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Parasite Immunol 30:215-21. 2008....- Th2 response polarization during infection with the helminth parasite Schistosoma mansoniEdward J Pearce
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Immunol Rev 201:117-26. 2004..In this article, we discuss the factors influencing Th2 response polarization during infection with S. mansoni... - Th2 differentiation is unaffected by Jagged2 expression on dendritic cellsConnie M Krawczyk
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 180:7931-7. 2008..Moreover, retrovirally induced expression of Jagged2 did not enhance the ability of DCs to induce Th2 cell responses. Our data indicate that Jagged2 expression by DCs is not sufficient or required for Th2 cell differentiation... 
Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expressionJustin J Taylor
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4539, USA
J Clin Invest 119:1019-28. 2009..Together, these data indicate that the decline in Th2 cell responsiveness during chronic schistosomiasis is the net result of the upregulation of GRAIL expression in response to repeated Ag stimulation...- T follicular helper cells differentiate from Th2 cells in response to helminth antigensArielle Glatman Zaretsky
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 206:991-9. 2009..The relationship of TFH cells to the Th2 lineage was confirmed when TFH cells were found to develop from CXCR5(-) PD-1(-) IL-4/GFP(+) CD4(+) T cells after their transfer into naive mice and antigen challenge in vivo... - Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responsesLaura Cervi
Departments of. Pathobiology and Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 172:2016-20. 2004.... - Helminth antigens modulate TLR-initiated dendritic cell activationColleen M Kane
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Immunol 173:7454-61. 2004..These findings indicate that SEA exerts potent anti-inflammatory effects by directly regulating the ability of DC to respond to TLR ligands... - TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell developmentJie Sun
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
J Immunol 174:742-51. 2005..Our findings indicate that DCs can provide potent negative as well as positive instruction for Th response polarization, and that these instructional signals are distinct and independent... - Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector populationJustin J Taylor
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
J Immunol 176:5839-47. 2006..Thus, the magnitude and phenotype of the egg-induced effector Th response are controlled by a parallel response within the Treg population... - Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88Colleen M Kane
Department of Pathobiology, School of Veterinary Medicine, 318 Hill Pavilion, 380 S University Ave, Philadelphia, PA 19104, USA
Infect Immun 76:5754-9. 2008..Moreover, TLR2 and TLR4 are not required for SEA-pulsed DCs to induce Th2 responses in naïve mice... - Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasiteFraser A Marshall
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 181:7562-70. 2008.... - MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunityJacqueline G Perrigoue
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Immunol 10:697-705. 2009..Collectively, our studies suggest that major histocompatibility complex class II-dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection... - Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cellsJie Sun
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 178:1635-44. 2007..Our findings suggest that DCs provide instructional signals for T cell differentiation before cytokine-mediated Th cell selection and outgrowth... 
IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lungJacqueline G Perrigoue
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 204:481-7. 2007..Together, these data implicate IL-31R signaling as a novel negative regulatory pathway that specifically limits type 2 inflammation...- Progress towards a vaccine for schistosomiasisEdward J Pearce
Department of Pathobiology, Room 203D, Johnson Pavilion, 3610 Hamilton Walk, University of Pennsylvania, Philadelphia, PA 19104 6076, USA
Acta Trop 86:309-13. 2003..However, there is a danger that momentum towards the goal of developing a vaccine against schistosomiasis is dissipating. This article reviews the current situation in this important area of schistosomiasis research... - Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell functionLucas Carvalho
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunology 126:28-34. 2009..This review attempts to summarize our understanding of the effects of helminth products on dendritic cell biology... - CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responsesAmy D Straw
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104, USA
J Immunol 170:727-34. 2003..However, the ability of this activation pathway to induce IL-12 production by DC is restrained in S. mansoni-infected, but not T. gondii-infected, mice by Ag-responsive CD11c(-) cells... - Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiationDavid Artis
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, 19104, USA
J Immunol 174:7154-9. 2005..Taken together, these studies identify a novel requirement for DC-intrinsic expression of NF-kappaB1 in regulating the MAPK pathway and governing the competence of DC to instruct Th2 cell differentiation... - Th1 and Th2 cells help CD8 T-cell responsesMelinda J Ekkens
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 380 South University Ave, Philadelphia, PA 19104 4593, USA
Infect Immun 75:2291-6. 2007.... - Functional plasticity in memory T helper cell responsesConnie M Krawczyk
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA
J Immunol 178:4080-8. 2007..These findings reveal that both effector and central memory Th1 and Th2 cells possess the capacity to respond to environmental cues to produce pathogen-appropriate cytokines of the opposing lineage... - A bone morphogenetic protein homologue in the parasitic flatworm, Schistosoma mansoniTori C Freitas
Department of Pathiobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Parasitol 39:281-7. 2009..With the previous description of a TGF-beta subfamily homologue in S. mansoni, ligands representing both arms of the TGF-beta superfamily have now been described in this trematode... - Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responsesLucas P Carvalho
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19103, USA
J Immunol 181:6473-80. 2008.... - Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiationRajan M Thomas
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 285:2545-53. 2010..These studies demonstrate that Ikaros, a factor with an established role in lymphocyte development, also regulates the development of peripheral T helper responses... - CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response developmentAmy S McKee
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Immunol 173:1224-31. 2004..The data suggest that natural Treg cells and, to a lesser extent, Th2 cells play roles in suppressing Th1 responses and ensuring Th2 polarization during schistosomiasis... - Memory CD4 T cells enhance primary CD8 T-cell responsesConnie M Krawczyk
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room 318 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104 4539, USA
Infect Immun 75:3556-60. 2007..These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting... - TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoniTori C Freitas
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS Pathog 3:e52. 2007.... - An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growthErinn B Rankin
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6051, USA
Cancer Biol Ther 2:687-93. 2003..Interestingly, the enhancement was also apparent in uninfected animals suggesting that IFN-gamma and its anti-angiogenic effects underlie both infection-dependent and -independent tumor surveillance... - Regulation of dendritic cell function by pathogen-derived molecules plays a key role in dictating the outcome of the adaptive immune responseEdward J Pearce
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6008, USA
Chem Immunol Allergy 90:82-90. 2006..Thus as part of their pathogen-specific response programs, DC can exert negative as well as positive signals for Th response polarization. These effects may have powerful and systemic effects on disease outcome... - Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondiiAmy S McKee
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:2632-40. 2004..The ability of T. gondii to temporarily evade recognition could provide a selective advantage that permits dissemination and establishment before adaptive immune response initiation... - Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activationConnie M Krawczyk
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA
Blood 115:4742-9. 2010..Our data pinpoint TLR-mediated metabolic conversion as essential for DC maturation and function and reveal it as a potential target for intervention in the control of excessive inflammation and inappropriately regulated immune responses... - Suppression of Th2 cell development by Notch ligands Delta1 and Delta4Jie Sun
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA
J Immunol 180:1655-61. 2008..The promotion of Th1 cell development by Delta is not a reflection of the delivery of pro-Th1 instructional signal, but rather it is the result of a block in the downstream effects initiated by IL-4 signaling... - Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lungMeera G Nair
Department of Pathobiology, University of Pennsylvania, Philadelphia, 19104, USA
J Exp Med 206:937-52. 2009..Collectively, these data identify a previously unrecognized role for AAMac-derived RELM-alpha in limiting the pathogenesis of Th2 cytokine-mediated pulmonary inflammation, in part through the regulation of CD4(+) T cell responses... - IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophagesA E O'Connell
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Parasite Immunol 31:741-9. 2009..Thus, lethality during M. corti infection of IL-4(-/-) mice is associated with decreased Th2 cytokines, increased Th1 cytokines and impairment of alternatively activated macrophages... - Long-term suppression of cathepsin B levels by RNA interference retards schistosome growthJason M Correnti
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104-6008, USA
Mol Biochem Parasitol 143:209-15. 2005..The report sheds new light on the role of SmCB1 and provides a template for using RNAi to examine gene function in the mammal-parasitic stages of schistosomes during early development in vitro and in vivo... - Transfection of Schistosoma mansoni by electroporation and the description of a new promoter sequence for transgene expressionJason M Correnti
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 318 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104 4539, USA
Int J Parasitol 37:1107-15. 2007..The methodology described herein will facilitate ectopic expression of genes of interest in schistosomes... - Transgene expression in Schistosoma mansoni: introduction of RNA into schistosomula by electroporationJason M Correnti
Department of Pathobiology, University of Pennsylvania, 203D Johnson Pavilion, 3610 Hamilton Walk, Philadelphia 19104-6076, USA
Mol Biochem Parasitol 137:75-9. 2004.... - Tegumental expression of a novel type II receptor serine/threonine kinase (SmRK2) in Schistosoma mansoniSean G Forrester
Department of Pathobiology, University of Pennsylvania, 202D Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA
Mol Biochem Parasitol 136:149-56. 2004..We hypothesize that SmRK2 is the receptor partner for the previously reported type I RSTK SmRK1 (or SmTbetaR1) and that together these proteins constitute a receptor system for receiving signals from the mammalian host... - Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interactionAndrew S MacDonald
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunol 168:4643-9. 2002..These data indicate that CD40/CD154 interaction is required to allow development of a Th2-dominated immune response to S. mansoni and support the view that failure to develop such a response can have fatal consequences... - Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasisElisabeth A Patton
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Infect Immun 70:177-84. 2002..NO is largely responsible for the impaired T-cell functions in infected IL-4(-/-) mice, as inhibition of iNOS significantly enhanced proliferation and IFN-gamma production... - Cutting edge: Th2 response induction by dendritic cells: a role for CD40Andrew S MacDonald
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunol 168:537-40. 2002..acnes. CD40-CD154 interaction can therefore play a major role in Th2 response induction... - Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivoGabriele Schramm
Research Center Borstel, Borstel, Germany
J Immunol 178:6023-7. 2007..Thus, IPSE/alpha-1 induces basophils to produce IL-4 even in the absence of Ag-specific IgE... - Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasisAnne Camille La Flamme
Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
J Immunol 170:470-6. 2003..Together these results indicate that C3 enhances Th2 responses during schistosome infection, potentiates PZQ-mediated parasite clearance, and reduces chemotherapy-induced proinflammatory mediator production... - Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivoGeorgia Perona-Wright
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
Eur J Immunol 36:2367-75. 2006..Surprisingly, the critical source of IL-10 in this process is neither T nor B cells. These data illustrate the distinct actions of IL-10 during differently polarised, pathogen-focussed, DC-driven immune responses in vivo... - Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cellsAndrew S MacDonald
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunol 168:3127-30. 2002..These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC... - Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophagesAnne Camille La Flamme
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Parasite Immunol 24:339-45. 2002..major after in vitro infection. These results suggest that pre-existence of a strong Th2 response-dominated infection can alter the responses to Th1-inducing pathogens at peripheral sites and impair Th1-mediated effector functions... - 14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoformSharon McGonigle
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, NY 14853, USA
Int J Parasitol 32:685-93. 2002..These results suggest that the individual 14-3-3 proteins may have evolved to play isoform-specific roles in the development and survival of S. mansoni within its host... - Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoniAmelia Ribeiro de Jesus
, , Universidade Federal da Bahia, Bahia, Brazil
J Infect Dis 185:98-105. 2002..Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis... - Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta responseSharon McGonigle
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Biochemistry 41:579-87. 2002..The interaction of these two regulatory proteins with each other and with the TGF beta receptors and their relative expression levels are likely to be important in fine-tuning the regulation of TGF beta signal transduction... - piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoniMaria E Morales
Department of Tropical Medicine, Tulane University, Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
FASEB J 21:3479-89. 2007..This is the first report of chromosomal integration of a transgene and somatic transgenesis of this important human pathogen, in this instance accomplished by mobilization of the piggyBac transposon... - Immunology of parasitic helminth infectionsAndrew S MacDonald
Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853-6401, USA
Infect Immun 70:427-33. 2002 - Genetic manipulation of schistosomesPaul J Brindley
Department of Tropical Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Int J Parasitol 37:465-73. 2007..Recent reports dealing with approaches and tools to manipulate the genome and gene expression in schistosomes are reviewed here...
Research Grants
- SCHISTOSOME EGG INDUCED TH2 RESPONSESEdward Pearce; Fiscal Year: 2007..abstract_text> ..