Genomes and Genes
CELESTE LEIGH contact PEARCE
Affiliation: University of Southern California
- Determination of sequence variation and haplotype structure for the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes: investigation of role in pubertal timingInes L Sedlmeyer
Division of Endocrinology and Genetics, Department of Medicine, Children s Hospital, Hravard Medical School, Boston, MA 02115, USA
J Clin Endocrinol Metab 90:1091-9. 2005..We conclude that genetic variation in GNRH1 and GNRHR is not likely to be a substantial modulator of pubertal timing in the general population...
- Combined and Interactive Effects of Environmental and GWAS-Identified Risk Factors in Ovarian CancerCeleste Leigh Pearce
Corresponding Author Celeste Leigh Pearce, 1441 Eastlake Avenue, Norris Topping Tower, Room 4417, Los Angeles, CA 90089
Cancer Epidemiol Biomarkers Prev 22:880-90. 2013..However, the interplay between such risk factors and susceptibility loci has not been studied...
- Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studiesCeleste Leigh Pearce
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
Lancet Oncol 13:385-94. 2012..We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer...
- The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discoveryBradley E Aouizerat
Department of Physiological Nursing, Institute for Human Genetics, University of California San Francisco, 94143 0610, USA
Curr HIV/AIDS Rep 8:38-44. 2011..Recent findings from these GWAS are reviewed, new directions for research are identified, and the promise of systems biology to yield novel insights is discussed...
- Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activityDebra Hawes
Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
Breast Cancer Res 8:R24. 2006..The increased breast cancer risk associated with increased mammographic densities may simply be a reflection of increased epithelial cell numbers. Why epithelium is concentrated in high CT density areas remains to be explained...
- Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer riskCeleste Leigh Pearce
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hum Mol Genet 20:2263-72. 2011..25). IGF2 is emerging as an important gene for ovarian cancer; additional genotyping is warranted to further confirm these associations with IGF2 and to narrow down the region harboring the causal SNP...
- Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestinCeleste Leigh Pearce
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Cancer 115:531-9. 2009....
- Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association ConsortiumC L Pearce
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Br J Cancer 100:412-20. 2009..CYP3A4 encodes a key enzyme in oestrogen metabolism and our finding between rs2740574 and risk of ovarian cancer suggests that this pathway may be involved in ovarian carcinogenesis. Additional follow-up is warranted...
- No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learnedC Leigh Pearce
1Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hum Mol Genet 17:2456-61. 2008..Overall, this report highlights the importance of rigorous genotyping quality control measures and replication efforts in genetic association studies...
- Comprehensive evaluation of ESR2 variation and ovarian cancer riskCeleste Leigh Pearce
USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 17:393-6. 2008..28-11.73; P = 0.016). Haplotype D was also reported by the BPC3 to be associated with increased risk of breast cancer. This haplotype warrants further investigation to rule out any effect with invasive ovarian cancer risk...
- Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysisC L Pearce
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
Br J Cancer 98:282-8. 2008..80, 95% CI 0.62-1.04, P=0.100). These data suggest that while these three variants in the PGR are not associated with ovarian cancer overall, the PROGINS variant may play a modest role in risk of endometrioid ovarian cancer...
- Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysisCeleste Leigh Pearce
Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
J Natl Cancer Inst 97:51-9. 2005..We set out to refine the association between common variation at the PGR gene locus and these two diseases...
- BRCA1 variants in a family study of African-American and Latina womenRoberta McKean-Cowdin
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MS 44, Los Angeles, CA 90089 9175, USA
Hum Genet 116:497-506. 2005..We believe this to be the largest study of high-risk African-American and Latina women sequenced for variants in the BRCA1 gene to date...
- Prevention of cancers of the breast, endometrium and ovaryMalcolm C Pike
USC Norris Cancer Center, Los Angeles, CA, USA
Oncogene 23:6379-91. 2004..Some recent epidemiological findings in endometrial and ovarian cancer suggest new avenues for possible chemoprevention of these cancers...
- Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breastDeShawn Taylor
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA
Breast Cancer Res Treat 118:161-8. 2009..Short-term changes in PRA expression while the chemoprevention is being administered may be a more useful marker...
- Consortium analysis of 7 candidate SNPs for ovarian cancerSusan J Ramus
Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
Int J Cancer 123:380-8. 2008..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
- The effects of common genetic variants in oncogenes on ovarian cancer survivalLydia Quaye
Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
Clin Cancer Res 14:5833-9. 2008..The aim of this study was to evaluate associations between common germline genetic variants in the oncogenes BRAF, ERBB2, KRAS, NMI, and PIK3CA, and survival after a diagnosis of epithelial ovarian cancer...
- The Progesterone Receptor Gene and Ovarian Cancer RiskCELESTE PEARCE; Fiscal Year: 2005..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
- Ovarian Cancer and Gonadotropin SignalingCELESTE PEARCE; Fiscal Year: 2007....
- A Pooled Analysis to Identify New Ovarian Cancer Risk FactorsCELESTE PEARCE; Fiscal Year: 2009..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
- A Pooled Analysis to Identify New Ovarian Cancer Risk FactorsCeleste Leigh Pearce; Fiscal Year: 2010..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
- Identifying Ovarian Cancer Susceptibility Alleles using Genome-Wide Scan DataCELESTE LEIGH contact PEARCE; Fiscal Year: 2010..We will also fine map the five regions definitively shown to harbor an ovarian cancer susceptibility alleles and address a key methodological challenge faced in studies of these kinds. ..