CELESTE LEIGH contact PEARCE

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Determination of sequence variation and haplotype structure for the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes: investigation of role in pubertal timing
    Ines L Sedlmeyer
    Division of Endocrinology and Genetics, Department of Medicine, Children s Hospital, Hravard Medical School, Boston, MA 02115, USA
    J Clin Endocrinol Metab 90:1091-9. 2005
  2. pmc Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer
    Celeste Leigh Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:880-90. 2013
  3. pmc Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Lancet Oncol 13:385-94. 2012
  4. pmc The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery
    Bradley E Aouizerat
    Department of Physiological Nursing, Institute for Human Genetics, University of California San Francisco, 94143 0610, USA
    Curr HIV/AIDS Rep 8:38-44. 2011
  5. pmc Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity
    Debra Hawes
    Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
    Breast Cancer Res 8:R24. 2006
  6. pmc Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 20:2263-72. 2011
  7. doi request reprint Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestin
    Celeste Leigh Pearce
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Cancer 115:531-9. 2009
  8. pmc Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium
    C L Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Br J Cancer 100:412-20. 2009
  9. pmc No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned
    C Leigh Pearce
    1Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 17:2456-61. 2008
  10. doi request reprint Comprehensive evaluation of ESR2 variation and ovarian cancer risk
    Celeste Leigh Pearce
    USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:393-6. 2008

Research Grants

Detail Information

Publications17

  1. ncbi request reprint Determination of sequence variation and haplotype structure for the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes: investigation of role in pubertal timing
    Ines L Sedlmeyer
    Division of Endocrinology and Genetics, Department of Medicine, Children s Hospital, Hravard Medical School, Boston, MA 02115, USA
    J Clin Endocrinol Metab 90:1091-9. 2005
    ..We conclude that genetic variation in GNRH1 and GNRHR is not likely to be a substantial modulator of pubertal timing in the general population...
  2. pmc Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer
    Celeste Leigh Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:880-90. 2013
    ..However, the interplay between such risk factors and susceptibility loci has not been studied...
  3. pmc Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Lancet Oncol 13:385-94. 2012
    ..We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer...
  4. pmc The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery
    Bradley E Aouizerat
    Department of Physiological Nursing, Institute for Human Genetics, University of California San Francisco, 94143 0610, USA
    Curr HIV/AIDS Rep 8:38-44. 2011
    ..Recent findings from these GWAS are reviewed, new directions for research are identified, and the promise of systems biology to yield novel insights is discussed...
  5. pmc Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity
    Debra Hawes
    Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
    Breast Cancer Res 8:R24. 2006
    ....
  6. pmc Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 20:2263-72. 2011
    ..25). IGF2 is emerging as an important gene for ovarian cancer; additional genotyping is warranted to further confirm these associations with IGF2 and to narrow down the region harboring the causal SNP...
  7. doi request reprint Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestin
    Celeste Leigh Pearce
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Cancer 115:531-9. 2009
    ....
  8. pmc Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium
    C L Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Br J Cancer 100:412-20. 2009
    ..CYP3A4 encodes a key enzyme in oestrogen metabolism and our finding between rs2740574 and risk of ovarian cancer suggests that this pathway may be involved in ovarian carcinogenesis. Additional follow-up is warranted...
  9. pmc No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned
    C Leigh Pearce
    1Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 17:2456-61. 2008
    ..Overall, this report highlights the importance of rigorous genotyping quality control measures and replication efforts in genetic association studies...
  10. doi request reprint Comprehensive evaluation of ESR2 variation and ovarian cancer risk
    Celeste Leigh Pearce
    USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:393-6. 2008
    ..28-11.73; P = 0.016). Haplotype D was also reported by the BPC3 to be associated with increased risk of breast cancer. This haplotype warrants further investigation to rule out any effect with invasive ovarian cancer risk...
  11. pmc Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis
    C L Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    Br J Cancer 98:282-8. 2008
    ..80, 95% CI 0.62-1.04, P=0.100). These data suggest that while these three variants in the PGR are not associated with ovarian cancer overall, the PROGINS variant may play a modest role in risk of endometrioid ovarian cancer...
  12. ncbi request reprint Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis
    Celeste Leigh Pearce
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    J Natl Cancer Inst 97:51-9. 2005
    ..We set out to refine the association between common variation at the PGR gene locus and these two diseases...
  13. ncbi request reprint BRCA1 variants in a family study of African-American and Latina women
    Roberta McKean-Cowdin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MS 44, Los Angeles, CA 90089 9175, USA
    Hum Genet 116:497-506. 2005
    ..We believe this to be the largest study of high-risk African-American and Latina women sequenced for variants in the BRCA1 gene to date...
  14. ncbi request reprint Prevention of cancers of the breast, endometrium and ovary
    Malcolm C Pike
    USC Norris Cancer Center, Los Angeles, CA, USA
    Oncogene 23:6379-91. 2004
    ..Some recent epidemiological findings in endometrial and ovarian cancer suggest new avenues for possible chemoprevention of these cancers...
  15. ncbi request reprint Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breast
    DeShawn Taylor
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA
    Breast Cancer Res Treat 118:161-8. 2009
    ..Short-term changes in PRA expression while the chemoprevention is being administered may be a more useful marker...
  16. pmc Consortium analysis of 7 candidate SNPs for ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
    Int J Cancer 123:380-8. 2008
    ..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
  17. doi request reprint The effects of common genetic variants in oncogenes on ovarian cancer survival
    Lydia Quaye
    Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 14:5833-9. 2008
    ..The aim of this study was to evaluate associations between common germline genetic variants in the oncogenes BRAF, ERBB2, KRAS, NMI, and PIK3CA, and survival after a diagnosis of epithelial ovarian cancer...

Research Grants5

  1. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    ..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
  2. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ....
  3. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    CELESTE PEARCE; Fiscal Year: 2009
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  4. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  5. Identifying Ovarian Cancer Susceptibility Alleles using Genome-Wide Scan Data
    CELESTE LEIGH contact PEARCE; Fiscal Year: 2010
    ..We will also fine map the five regions definitively shown to harbor an ovarian cancer susceptibility alleles and address a key methodological challenge faced in studies of these kinds. ..