Research Topics
| Aimee S PayneSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage displayAimee S Payne
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 115:888-99. 2005..Detailed characterization of these pemphigus mAbs should lead to a better understanding of the immunopathogenesis of disease and to more specifically targeted therapeutic approaches...
Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotypeAimee S Payne
Department of Dermatology, University of Pennsylvania, 220 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Arch Dermatol 141:1567-73. 2005..Recent structure-function studies have identified complexities in the genotype-phenotype correlation of the p63 syndromes...- Dermatologic toxicity of chemotherapeutic agentsAimee S Payne
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Semin Oncol 33:86-97. 2006..This review will focus on the cutaneous side effects of the newer classes of chemotherapy drugs, including targeted monoclonal antibody therapy and small molecule inhibitors... - Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigusJun Yamagami
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 183:5615-21. 2009..However, presentation of peptides from Dsg1 by preDsg1-specific B cells may be one step in developing autoimmunity in PF... - Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapyJohn R Stanley
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Vet Dermatol 20:327-30. 2009..In summary, the antibody response is restricted and, therefore, it may be feasible to target the specific pathogenic antibodies for therapy... - Targeting pemphigus autoantibodies through their heavy-chain variable region genesAimee S Payne
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Invest Dermatol 127:1681-91. 2007..Together, these data suggest novel V(H) gene-targeted approaches toward PV treatment... - Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicityJun Yamagami
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 120:4111-7. 2010..These studies indicate that H-CDR3 is critical for pathogenicity of a human autoantibody, that a small region (even 1 amino acid) can mediate pathogenicity, and that pathogenicity can be uncoupled from binding in these antibodies... - p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgarisXuming Mao
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 286:1283-91. 2011..Treatments aimed at increasing keratinocyte adhesion could be used in conjunction with immunosuppressive agents, potentially leading to safer and more effective combination therapy regimens... - Autoimmunity to desmocollin 3 in pemphigus vulgarisXuming Mao
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA
Am J Pathol 177:2724-30. 2010.... - Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodiesXuming Mao
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Invest Dermatol 129:908-18. 2009..Monovalent human PV anti-Dsg mAbs reproduce the effects of polyclonal PV IgG on Dsg3 and will facilitate future studies to further dissect the cellular mechanisms for the loss of cell adhesion in pemphigus... - The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin Vipul Kumar
Division of Immunology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Am J Pathol 178:983-8. 2011..The cytoplasmic association of AIRE with the intermediate filament network in human epidermal and follicular keratinocytes may provide a new path to understanding the ectodermal abnormalities associated with the APECED syndrome... - Desmosomes and disease: pemphigus and bullous impetigoAimee S Payne
Department of Dermatology, University of Pennsylvania, Philadelphia, 415 Curie Boulevard, 211 Clinical Research Building, Pennsylvania, 19104 USA
Curr Opin Cell Biol 16:536-43. 2004..These studies offer new insight into the potential mechanisms of acantholysis in pemphigus and staphylococcal-associated blistering disease, with implications for the role of desmogleins in desmosomal structure and function... - Seeking approval: present and future therapies for pemphigus vulgarisXuming Mao
University of Pennsylvania, Department of Dermatology, 217A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Curr Opin Investig Drugs 9:497-504. 2008..This review focuses on pemphigus therapies that are currently in preclinical or clinical trials, as well as potential novel therapies based on recent advances in the understanding of the pathophysiology of this disease... - Beyond steric hindrance: the role of adhesion signaling pathways in the pathogenesis of pemphigusPreety Sharma
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
J Dermatol Sci 48:1-14. 2007..In this review, we will summarize the evidence supporting a role for steric hindrance and signaling mechanisms in the pathogenesis of pemphigus acantholysis and discuss potential analogues in the classical cadherin literature... - Cloning and genetic characterization of human pemphigus autoantibodiesAimee S Payne
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Am Acad Dermatol 55:e2. 2006 - Adjuvant rituximab therapy of pemphigus: a single-center experience with 31 patientsLuisa Lunardon
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
Arch Dermatol 148:1031-6. 2012..The end point for efficacy was complete remission of disease taking no or minimal therapy... - Reliability and convergent validity of two outcome instruments for pemphigusMisha Rosenbach
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19119, USA
J Invest Dermatol 129:2404-10. 2009..Subset analysis suggests that for this population of mild-to-moderate disease activity, the PDAI captures more variability in cutaneous disease than the ABSIS... - Cleavage isn't everything: potential novel mechanisms of exfoliative toxin-mediated blisteringTakeru Funakoshi
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA
Am J Pathol 177:2682-4. 2010..This Commentary describes breakthroughs in understanding the interactions between desmoglein 1 and plakogloben in staphylococcal-mediated blistering skin diseases... - Consensus statement on definitions of disease, end points, and therapeutic response for pemphigusDedee F Murrell
Department of Dermatology at St George Hospital, University of NSW, Sydney, Australia
J Am Acad Dermatol 58:1043-6. 2008..These should assist in development of consistent reporting of outcomes in future studies...
Research Grants
- Role of autoantibody isotype in pemphigus pathogenesisAimee S Payne; Fiscal Year: 2010....