Martin Paulus

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Neural systems underlying approach and avoidance in anxiety disorders
    Robin L Aupperle
    Department of Psychiatry, University of California, San Diego UCSD, California 92037 0985, USA
    Dialogues Clin Neurosci 12:517-31. 2010
  2. pmc Sex differences in the neural processing of aversive interoceptive events: the benefit of relief
    Giulia Galli
    Dipartimento di Scienze Neurologiche e Neurosensoriali, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    PLoS ONE 8:e84044. 2013
  3. pmc Interoception and drug addiction
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA Psychiatry Service, VA San Diego Healthcare System, La Jolla, CA, USA Electronic address
    Neuropharmacology 76:342-50. 2014
  4. pmc The breathing conundrum-interoceptive sensitivity and anxiety
    Martin P Paulus
    University of California, San Diego, California Veterans Affairs San Diego Health Care System, San Diego, CA 92093, USA
    Depress Anxiety 30:315-20. 2013
  5. pmc Emotion and decision-making: affect-driven belief systems in anxiety and depression
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Trends Cogn Sci 16:476-83. 2012
  6. pmc Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans
    Alan N Simmons
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Biol Mood Anxiety Disord 1:6. 2011
  7. pmc Subjecting elite athletes to inspiratory breathing load reveals behavioral and neural signatures of optimal performers in extreme environments
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e29394. 2012
  8. pmc A neuroscience approach to optimizing brain resources for human performance in extreme environments
    Martin P Paulus
    University of California, San Diego, 92037, USA
    Neurosci Biobehav Rev 33:1080-8. 2009
  9. pmc Differential brain activation to angry faces by elite warfighters: neural processing evidence for enhanced threat detection
    Martin P Paulus
    University of California San Diego, San Diego, California, United States of America
    PLoS ONE 5:e10096. 2010
  10. pmc Neural basis of reward and craving--a homeostatic point of view
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037 0985, USA
    Dialogues Clin Neurosci 9:379-87. 2007

Detail Information

Publications107 found, 100 shown here

  1. pmc Neural systems underlying approach and avoidance in anxiety disorders
    Robin L Aupperle
    Department of Psychiatry, University of California, San Diego UCSD, California 92037 0985, USA
    Dialogues Clin Neurosci 12:517-31. 2010
    ....
  2. pmc Sex differences in the neural processing of aversive interoceptive events: the benefit of relief
    Giulia Galli
    Dipartimento di Scienze Neurologiche e Neurosensoriali, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    PLoS ONE 8:e84044. 2013
    ..These results indicate that men are particularly sensitive to reward associated with the termination of an aversive event, which may signal relief. ..
  3. pmc Interoception and drug addiction
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA Psychiatry Service, VA San Diego Healthcare System, La Jolla, CA, USA Electronic address
    Neuropharmacology 76:342-50. 2014
    ..Second, one may be able to reduce the urge to act by increasing the frontal control network, i.e. inhibiting the urge to use by employing cognitive training. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  4. pmc The breathing conundrum-interoceptive sensitivity and anxiety
    Martin P Paulus
    University of California, San Diego, California Veterans Affairs San Diego Health Care System, San Diego, CA 92093, USA
    Depress Anxiety 30:315-20. 2013
    ..Altered breathing may be useful as a physiological marker of anxiety as well as a treatment target using interoceptive interventions...
  5. pmc Emotion and decision-making: affect-driven belief systems in anxiety and depression
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Trends Cogn Sci 16:476-83. 2012
    ....
  6. pmc Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans
    Alan N Simmons
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Biol Mood Anxiety Disord 1:6. 2011
    ..abstract:..
  7. pmc Subjecting elite athletes to inspiratory breathing load reveals behavioral and neural signatures of optimal performers in extreme environments
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e29394. 2012
    ..We examined the hypothesis that elite athletes, compared to control subjects, show attenuated insular cortex activation during an aversive interoceptive challenge...
  8. pmc A neuroscience approach to optimizing brain resources for human performance in extreme environments
    Martin P Paulus
    University of California, San Diego, 92037, USA
    Neurosci Biobehav Rev 33:1080-8. 2009
    ..This hypothesis can be translated into an experimental approach that may be useful for quantifying the degree to which individuals are particularly suited to performing optimally in demanding environments...
  9. pmc Differential brain activation to angry faces by elite warfighters: neural processing evidence for enhanced threat detection
    Martin P Paulus
    University of California San Diego, San Diego, California, United States of America
    PLoS ONE 5:e10096. 2010
    ..The purpose of this study was to examine brain processing differences between elite warfighters and comparison subjects in brain structures that are important for emotion processing and interoception...
  10. pmc Neural basis of reward and craving--a homeostatic point of view
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037 0985, USA
    Dialogues Clin Neurosci 9:379-87. 2007
    ..Craving and urges are among the most notable responses, and may have important functions to preserve homeostasis...
  11. ncbi request reprint Superior temporal gyrus and insula provide response and outcome-dependent information during assessment and action selection in a decision-making situation
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, USA
    Neuroimage 25:607-15. 2005
    ..Furthermore, the superior temporal gyrus may play an important role in integrating previous actions and successful outcomes into one's decision-making strategy...
  12. ncbi request reprint Neurobiology of decision-making: quo vadis?
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, USA
    Brain Res Cogn Brain Res 23:2-10. 2005
    ..Several important research groups have contributed a diverse set of approaches to study decision-making and its underlying neurobiology. Insights from these studies may provide important directions for future research in this area...
  13. ncbi request reprint Neural activation patterns of methamphetamine-dependent subjects during decision making predict relapse
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 62:761-8. 2005
    ..Relapse is a common clinical problem in individuals with substance dependence. Previous studies have implicated a multifactorial process underlying relapse; however, the contribution of specific neural substrates has not yet been examined...
  14. ncbi request reprint Decision-making dysfunctions in psychiatry--altered homeostatic processing?
    Martin P Paulus
    Department of Psychiatry, University of California at San Diego, 8950 Villa La Jolla Drive, La Jolla, CA 92037 0985, USA
    Science 318:602-6. 2007
    ....
  15. pmc Role of functional magnetic resonance imaging in drug discovery
    Martin P Paulus
    Department of Psychiatry, University of California, San Diego UCSD, 8950 Villa La Jolla Drive, Suite C 213, La Jolla, CA 92037, USA
    Neuropsychol Rev 17:179-88. 2007
    ....
  16. ncbi request reprint Anterior cingulate activity modulates nonlinear decision weight function of uncertain prospects
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 9116, USA
    Neuroimage 30:668-77. 2006
    ....
  17. ncbi request reprint Reduced behavioral and neural activation in stimulant users to different error rates during decision making
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California, San Diego, California, USA
    Biol Psychiatry 63:1054-60. 2008
    ..Here, the hypothesis is examined that stimulant-using subjects adjust their decision making less as a function of errors as evidenced by attenuated behavioral and neural substrate activation patterns...
  18. doi request reprint The role of neuroimaging for the diagnosis and treatment of anxiety disorders
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, California 92037 0985, USA
    Depress Anxiety 25:348-56. 2008
    ....
  19. pmc Interoception in anxiety and depression
    Martin P Paulus
    Department of Psychiatry, University of California, San Diego, 8939 Villa La Jolla Drive, La Jolla, CA 92037, USA
    Brain Struct Funct 214:451-63. 2010
    ..We conclude that depression and anxiety are not simply interoceptive disorders but are altered interoceptive states as a consequence of noisily amplified self-referential interoceptive predictive belief states...
  20. pmc The role of interoception and alliesthesia in addiction
    Martin P Paulus
    Department of Psychiatry, University of California, San Diego, CA 92037, USA
    Pharmacol Biochem Behav 94:1-7. 2009
    ..The model thereby provides new potential targets for interventions that are aimed at changing the internal state that puts the individual at risk for continued substance use...
  21. ncbi request reprint Individuals with schizophrenia present hypo- and hyperactivation during implicit cueing in an inhibitory task
    Estibaliz Arce
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, CA 92093 0985, USA
    Neuroimage 32:704-13. 2006
    ..The primary purpose of this investigation was to assess the neural correlates of implicit cueing during an inhibitory task in schizophrenia when performance accuracy was matched with healthy comparison subjects...
  22. ncbi request reprint Error rate and outcome predictability affect neural activation in prefrontal cortex and anterior cingulate during decision-making
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Neuroimage 15:836-46. 2002
    ..quot;..
  23. ncbi request reprint Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine and Department of Psychiatry, University of California, San Diego, USA
    Arch Gen Psychiatry 62:282-8. 2005
    ..A large body of evidence suggests that the amygdala and associated limbic structures play a critical role in the expression of anxiety and may be treatment targets for anxiolytic drugs...
  24. pmc Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, California 92093 0603, USA
    Alcohol Clin Exp Res 30:1363-71. 2006
    ..A low level of response to alcohol is a major risk factor for the development of alcohol dependence, but neural correlates of this marker are unclear...
  25. doi request reprint Inhibition-related activity in subgenual cingulate is associated with symptom severity in major depression
    Scott Matthews
    Department of Psychiatry, University of California San Diego, La Jolla, CA, United States
    Psychiatry Res 172:1-6. 2009
    ..Among MDD individuals, inhibition-related subgenual activation correlated with depressive symptom severity, implicating subgenual ACC in inhibitory control processes related to clinical depression...
  26. ncbi request reprint Anterior cingulate activation in high trait anxious subjects is related to altered error processing during decision making
    Martin P Paulus
    Department of Psychiatry, University of California Sand Diego, La Jolla 92093 9116, USA
    Biol Psychiatry 55:1179-87. 2004
    ....
  27. pmc Accumulation of neural activity in the posterior insula encodes the passage of time
    Marc Wittmann
    Department of Psychiatry, University of California San Diego, 8939 Villa La Jolla Dr, Suite 200, La Jolla, CA 92037 0985, USA
    Neuropsychologia 48:3110-20. 2010
    ..This is the first time that an accumulation function in the posterior insula is detected that might be correlated with the encoding of time intervals...
  28. ncbi request reprint Habituation of attentional networks during emotion processing
    Justin S Feinstein
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, CA 92093, USA
    Neuroreport 13:1255-8. 2002
    ....
  29. ncbi request reprint Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine and Department of Psychiatry, University of California at San Diego, La Jolla, 92093 0603, USA
    Biol Psychiatry 53:65-74. 2003
    ..This study examined whether the degree of success and the degree of predictability differentially affected MD's decision making...
  30. pmc Predicting treatment outcome in stimulant dependence
    Martina Reske
    Department of Psychiatry, University of California San Diego, La Jolla, CA92037 0985, USA
    Ann N Y Acad Sci 1141:270-83. 2008
    ..Fourth, we discuss future directions, critical experiments, and the utility of functional neuroimaging as a clinical tool...
  31. ncbi request reprint Parietal dysfunction is associated with increased outcome-related decision-making in schizophrenia patients
    Martin P Paulus
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
    Biol Psychiatry 51:995-1004. 2002
    ..This study tested the hypothesis that schizophrenia patients show less decision-making-related activation in the prefrontal and parietal cortex...
  32. pmc A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men
    William Perry
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, MC 0804, La Jolla, CA 92093 0804, USA
    Arch Gen Psychiatry 66:1072-80. 2009
    ..Exploration is fundamental to survival and is dysregulated in these 2 disorders. Although exploratory behavior in rodents has been widely studied, surprisingly little work has examined this critical function in humans...
  33. doi request reprint Neurocircuity of eating disorders
    Walter H Kaye
    Department of Psychiatry, University of California, San Diego, CA, USA
    Curr Top Behav Neurosci 6:37-57. 2011
    ..This chapter reviews brain imaging findings in anorexia and bulimia nervosa which characterize brain circuitry that may contribute to the pathophysiology of eating disorders (EDs)...
  34. pmc Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Psychopharmacology (Berl) 215:697-707. 2011
    ..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions...
  35. doi request reprint Decreased psychological well-being in late 'chronotypes' is mediated by smoking and alcohol consumption
    Marc Wittmann
    Generation Research Program, Human Science Center, Ludwig Maximilian University, Munich, Germany
    Subst Use Misuse 45:15-30. 2010
    ..We suggest that 'chronotype' is introduced as an additional factor in substance use, that is, when considering motives for smoking and drinking...
  36. pmc Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects
    Tony T Yang
    Department of Psychiatry, University of California, San Diego, United States
    Neurosci Lett 428:109-14. 2007
    ..Finally, the results of the present study lay the foundation for future research to investigate whether adolescents with mood or anxiety disorders show an altered coupling between processing emotionally salient events and ANS activity...
  37. pmc Intolerance of uncertainty correlates with insula activation during affective ambiguity
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, USA
    Neurosci Lett 430:92-7. 2008
    ..Previously observed insula hyperactivity in anxiety disorder individuals may therefore be directly linked to altered processes of uncertainty...
  38. pmc Exaggerated and disconnected insular-amygdalar blood oxygenation level-dependent response to threat-related emotional faces in women with intimate-partner violence posttraumatic stress disorder
    Gregory A Fonzo
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California San Diego, San Diego, California, USA
    Biol Psychiatry 68:433-41. 2010
    ..This study examined the hypothesis that women with IPV-PTSD show a dysregulation of this limbic sensory system while processing threat-related emotional faces...
  39. ncbi request reprint Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder
    Scott C Matthews
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, United States
    J Affect Disord 111:13-20. 2008
    ..The aim of this study was to examine the degree to which alterations in amygdala-cingulate FC relate to severity of current depressive symptoms in a group of depressed individuals without significant co-morbidities...
  40. pmc Functioning of neural systems supporting emotion regulation in anxiety-prone individuals
    Laura Campbell-Sills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
    Neuroimage 54:689-96. 2011
    ..Anxious participants required greater engagement of lateral and medial PFC in order to successfully reduce negative emotions...
  41. pmc Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence
    Alan N Simmons
    Department of Psychiatry, University of California San Diego, and VA San Diego Healthcare System, San Diego, California 92037, USA
    Biol Psychiatry 64:681-90. 2008
    ..Victims of IPV are often preoccupied by the anticipation of impending harm. This investigation tested the hypothesis that IPV-related PTSD individuals show exaggerated insula reactivity to the anticipation of aversive stimuli...
  42. pmc Escitalopram effects on insula and amygdala BOLD activation during emotional processing
    Estibaliz Arce
    Department of Psychiatry, Laboratory of Biology Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 196:661-72. 2008
    ..The amygdala and insular cortex are integral to the processing of emotionally salient stimuli. We have shown in healthy volunteers that an anxiolytic agent, lorazepam, dose-dependently attenuates activation of limbic structures...
  43. pmc Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Bldg 13, MC 9151 B, La Jolla, CA 92161, USA
    Arch Gen Psychiatry 65:1275-84. 2008
    ..Chronic pain and depression are highly comorbid conditions, yet little is known about the neurobiological basis of pain processing in major depressive disorder (MDD)...
  44. pmc Depressed adolescents demonstrate greater subgenual anterior cingulate activity
    Tony T Yang
    Department of Psychiatry, University of California, San Diego, CA, USA
    Neuroreport 20:440-4. 2009
    ..These results establish for the first time abnormal functioning of the sgACC in depressed adolescents and have important implications for understanding the underlying neural correlates and potential treatments of adolescent depression...
  45. pmc Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers
    Scott C Matthews
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Psychiatry Res 182:81-7. 2010
    ..These results show that SSRIs change medial cortical activity and may alter self-evaluation...
  46. pmc Adolescents with major depression demonstrate increased amygdala activation
    Tony T Yang
    University of California, San Diego, CA 92123, USA
    J Am Acad Child Adolesc Psychiatry 49:42-51. 2010
    ....
  47. pmc The quantitative assessment of motor activity in mania and schizophrenia
    Arpi Minassian
    University of California, Department of Psychiatry, San Diego, CA, USA
    J Affect Disord 120:200-6. 2010
    ..We used an ambulatory monitoring device to quantify motor activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM)...
  48. ncbi request reprint Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroimage 19:1439-48. 2003
    ..These results are consistent with the hypothesis that insula activation serves as a critical neural substrate to instantiate aversive somatic markers that guide risk-taking decision-making behavior...
  49. pmc Subchronic SSRI administration reduces insula response during affective anticipation in healthy volunteers
    Alan N Simmons
    University of California, San Diego, CA 92161 0151B, USA
    Int J Neuropsychopharmacol 12:1009-20. 2009
    ....
  50. pmc Alcohol cue reactivity task development
    Carmen Pulido
    University of California San Diego, Department of Psychiatry, 3350 La Jolla Village Drive 151B, San Diego, CA 92161, United States
    Addict Behav 35:84-90. 2010
    ..This project systematically created an alcohol cue reactivity task for studies with non-drinkers, using well-characterized stimuli...
  51. pmc Heart rate variability in bipolar mania and schizophrenia
    Brook L Henry
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92103 0851, United States
    J Psychiatr Res 44:168-76. 2010
    ..We recorded cardiac activity and assessed HRV in acutely hospitalized manic bipolar (BD) and schizophrenia (SCZ) patients compared to age- and gender-matched healthy comparison (HC) subjects...
  52. doi request reprint Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence
    Irina A Strigo
    University of California at San Diego, La Jolla, California 92161, USA
    Biol Psychiatry 68:442-50. 2010
    ..The aim of this study was to examine the neurobehavioral correlates of experimental pain in women with IPV-related PTSD...
  53. ncbi request reprint Heritability of anterior cingulate response to conflict: an fMRI study in female twins
    Scott C Matthews
    Laboratory of Biological Dynamics and Theoretical Medicine, CA, USA
    Neuroimage 38:223-7. 2007
    ..These results suggest an endophenotype that may be applied to various psychiatric disorders that are both highly heritable and associated with altered dACC function...
  54. ncbi request reprint Time and decision making: differential contribution of the posterior insular cortex and the striatum during a delay discounting task
    Marc Wittmann
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 9116A, USA
    Exp Brain Res 179:643-53. 2007
    ....
  55. ncbi request reprint Anticipation of emotionally aversive visual stimuli activates right insula
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
    Neuroreport 15:2261-5. 2004
    ..These findings indicate that common neural circuitry is involved in the anticipation of (and, perhaps, the subjective experience of anticipating) aversive affective and noxious physical stimuli...
  56. ncbi request reprint Selective activation of the nucleus accumbens during risk-taking decision making
    Scott C Matthews
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroreport 15:2123-7. 2004
    ..These findings may provide target neural systems to study in subjects who exhibit problematic risk-taking behaviors and may partially explain why certain risky behaviors occur...
  57. ncbi request reprint Increased sensitivity to error during decision-making in bipolar disorder patients with acute mania
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    J Affect Disord 82:203-8. 2004
    ..In this study we examined whether BD patients with psychotic mania show altered patterns of decision-making as a function of the frequency of incorrect predictions or error rate...
  58. ncbi request reprint Cortical and subcortical brain regions involved in rule-based category learning
    J Vincent Filoteo
    Department of Psychiatry, University of California, San Diego, CA, USA
    Neuroreport 16:111-5. 2005
    ..Results are consistent with theories suggesting that a frontal-striatal circuit is involved in rule-based category learning...
  59. pmc Young adult stimulant users' increased striatal activation during uncertainty is related to impulsivity
    David S Leland
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California, San Diego, USA
    Neuroimage 33:725-31. 2006
    ..Drug. Alcohol Depend. 78, 83-90). Since outcome uncertainty is a critical element of risk, we investigated whether such individuals have different neural responses to uncertainty than their stimulant-naive peers...
  60. ncbi request reprint Level of response to alcohol and brain response during visual working memory
    Susan F Tapert
    Veterans Affairs San Diego Healthcare System, University of California San Diego, San Diego, California 92161, USA
    J Stud Alcohol 65:692-700. 2004
    ..This study examined neural correlates of the low level of response to alcohol using functional magnetic resonance imaging (FMRI) during a challenging visual working memory task...
  61. ncbi request reprint An insular view of anxiety
    Martin P Paulus
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92037, USA
    Biol Psychiatry 60:383-7. 2006
    ....
  62. ncbi request reprint Increased risk-taking decision-making but not altered response to punishment in stimulant-using young adults
    David S Leland
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California, San Diego, CA 92093 9116, USA
    Drug Alcohol Depend 78:83-90. 2005
    ....
  63. ncbi request reprint Contribution of functional neuroimaging to understanding neuropsychiatric side effects of interferon in hepatitis C
    Scott C Matthews
    Department of Psychiatry, University of California, San Diego, CA, USA
    Psychosomatics 45:281-6. 2004
    ....
  64. ncbi request reprint Functional subdivisions within anterior cingulate cortex and their relationship to autonomic nervous system function
    Scott C Matthews
    Department of Psychiatry, University of California San Diego, San Diego, CA 92093, USA
    Neuroimage 22:1151-6. 2004
    ....
  65. ncbi request reprint The balance between approach and avoidance behaviors in a novel object exploration paradigm in mice
    Susan B Powell
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, 0804, La Jolla, CA 92093, USA
    Behav Brain Res 152:341-9. 2004
    ..In combination, these results show that the approach and avoidance dimensions of novelty seeking can be manipulated experimentally and may be used in subsequent studies to examine the effects of drugs of abuse...
  66. pmc Impaired time perception and motor timing in stimulant-dependent subjects
    Marc Wittmann
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 9116A, USA
    Drug Alcohol Depend 90:183-92. 2007
    ..Altered time processing in SDI could explain why SDI have difficulty delaying gratification...
  67. ncbi request reprint Schizophrenia subjects show intact success-related neural activation but impaired uncertainty processing during decision-making
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California at San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 28:795-806. 2003
    ..In contrast, task-related activation in SZS was not modulated by the degree of uncertainty. Thus, SZS failed to utilize the parietal cortex to process decision-making situations with highly uncertain outcomes...
  68. ncbi request reprint Neural response to alcohol stimuli in adolescents with alcohol use disorder
    Susan F Tapert
    Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California San Diego, 92161, USA
    Arch Gen Psychiatry 60:727-35. 2003
    ..We hypothesized that teens with alcohol use disorder would show greater brain response than nonabusing teens to alcohol images relative to neutral beverage images in limbic and frontal brain regions...
  69. ncbi request reprint Ventromedial prefrontal cortex activation is critical for preference judgments
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroreport 14:1311-5. 2003
    ..These findings are consistent with the role of the ventromedial prefrontal cortex in the representation of complex appetitive states...
  70. ncbi request reprint Left inferior prefrontal cortex activation during a semantic decision-making task predicts the degree of semantic organization
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, 92093 0603, USA
    Neuroimage 28:30-8. 2005
    ..This finding is consistent with the role of the IPFC in establishing self-generated semantic relationships between stimuli...
  71. ncbi request reprint Trend detection via temporal difference model predicts inferior prefrontal cortex activation during acquisition of advantageous action selection
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, and Department of Psychiatry, University of California San Diego, and Veterans Affairs San Diego Healthcare System, 92093 0603, USA
    Neuroimage 21:733-43. 2004
    ..These findings are consistent with the hypothesis that the inferior prefrontal cortex computes a trend from previously experienced action-outcome sequences based on a value function derived from the temporal difference model...
  72. ncbi request reprint From sensory processes to conscious perception
    Justin S Feinstein
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, USA
    Conscious Cogn 13:323-35. 2004
    ..These results are discussed in light of a neural framework for conscious processing...
  73. pmc Functional MRI of inhibitory processing in abstinent adolescent marijuana users
    Susan F Tapert
    VA San Diego Healthcare System, 3350 La Jolla Village Drive 116B, San Diego, CA 92161, USA
    Psychopharmacology (Berl) 194:173-83. 2007
    ..We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent marijuana users after 28 days of abstinence...
  74. ncbi request reprint Dissociation of inhibition from error processing using a parametric inhibitory task during functional magnetic resonance imaging
    Scott C Matthews
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, California, USA
    Neuroreport 16:755-60. 2005
    ....
  75. ncbi request reprint Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, San Diego, CA 92093 0603, USA
    Neuropsychopharmacology 26:53-63. 2002
    ..These results support the basic hypothesis that stimulant-dependent subjects exhibit fundamental cognitive deficits during decision-making that are consistent with both orbitofrontal and dorsolateral prefrontal dysfunction...
  76. pmc Cross-species assessments of motor and exploratory behavior related to bipolar disorder
    Brook L Henry
    University of California San Diego, Department of Psychiatry, La Jolla, CA, USA
    Neurosci Biobehav Rev 34:1296-306. 2010
    ....
  77. ncbi request reprint Effects of two nights sleep deprivation and two nights recovery sleep on response inhibition
    Sean P A Drummond
    Department of Psychiatry, University of California San Diego, 92161, USA
    J Sleep Res 15:261-5. 2006
    ..These data suggest that individuals experience difficulty in withholding an inappropriate response during TSD, even when they are able to attend to the incoming stimuli and respond accurately to appropriate stimuli...
  78. ncbi request reprint Anterior cingulate cortex and benefit of predictive cueing on response inhibition in stimulant dependent individuals
    David S Leland
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:184-90. 2008
    ..The need to inhibit behavior is often forewarned by cues that do not call for immediate inhibition. We sought to determine whether such cues would engage the ACC and improve inhibition in MD individuals...
  79. pmc Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of "emotional allodynia"
    Irina A Strigo
    Department of Psychiatry, Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, 8950 Villa La Jolla Dr, Suite C213, La Jolla, CA 92037 0985, USA
    Psychosom Med 70:338-44. 2008
    ..Existing evidence indicates that MDD may be associated with altered pain processing. However, the extent to which alterations in experimentally controlled heat pain sensations are related to increased affective bias in MDD is unknown...
  80. ncbi request reprint Increased amygdala and insula activation during emotion processing in anxiety-prone subjects
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Dr, Suite B 218, La Jolla, CA 92037, USA
    Am J Psychiatry 164:318-27. 2007
    ..It is uncertain whether this heightened amygdala reactivity is specific to treatment-seeking patients with anxiety disorders or is a general feature of individuals with increased anxiety-related temperamental traits...
  81. doi request reprint Anxiety vulnerability is associated with altered anterior cingulate response to an affective appraisal task
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, The Anxiety and Traumatic Stress Disorders Program, Department of Psychiatry, University of California San Diego, La Jolla, California 92037 0985, USA
    Neuroreport 19:1033-7. 2008
    ..Collectively, these data indicate that anxious individuals activate the dorsal and ventral components of the ACC differently during affective appraisal...
  82. pmc Association between individual differences in self-reported emotional resilience and the affective perception of neutral faces
    Estibaliz Arce
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037 0985, United States
    J Affect Disord 114:286-93. 2009
    ..We used a novel experimental paradigm to test the hypothesis that highly resilient individuals show a judgment bias towards positive emotions...
  83. pmc Lorazepam dose-dependently decreases risk-taking related activation in limbic areas
    Estibaliz Arce
    Department of Psychiatry, Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, 8950 Villa La Jolla Dr, Suite C213, La Jolla, CA 92037 0985, USA
    Psychopharmacology (Berl) 189:105-16. 2006
    ..Several studies have examined the role of different neurotransmitter systems in modulating risk-taking behavior...
  84. pmc Adolescent subgenual anterior cingulate activity is related to harm avoidance
    Tony T Yang
    Department of Psychiatry, University of California, San Diego, California 92123, USA
    Neuroreport 20:19-23. 2009
    ..Greater harm avoidance levels were significantly associated with increased inhibition-related sgACC activity. These results establish, for the first time, a link between personality and differential sgACC activation in adolescents...
  85. ncbi request reprint Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, USA
    Biol Psychiatry 60:402-9. 2006
    ....
  86. ncbi request reprint Decision making, impulsivity and time perception
    Marc Wittmann
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Trends Cogn Sci 12:7-12. 2008
    ..Here, we develop the theoretical background on concepts of time perception, which could lead to an empirically based notion of the association between an altered sense of time and impulsivity...
  87. ncbi request reprint Affective ambiguity for a group recruits ventromedial prefrontal cortex
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, 92037, USA
    Neuroimage 29:655-61. 2006
    ..This supports the dissociation of the ACC into dorsal cognitive and ventral affective divisions, and suggests that the ventromedial PFC may play a critical role in appraising affective tone in a complex display of multiple human faces...
  88. doi request reprint New insights into symptoms and neurocircuit function of anorexia nervosa
    Walter H Kaye
    Eating Disorder Treatment and Research Program, Department of Psychiatry, University of California, San Diego, La Jolla Village Professional Center, 8950 Villa La Jolla Drive, Suite C 207, La Jolla, California 92037, USA
    Nat Rev Neurosci 10:573-84. 2009
    ..For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa...
  89. ncbi request reprint Adults with autism show increased sensitivity to outcomes at low error rates during decision-making
    Arpi Minassian
    Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    J Autism Dev Disord 37:1279-88. 2007
    ..Thus, behavioral paradigms that provide frequent reinforcement may be helpful in modifying decision-making abilities in AD...
  90. ncbi request reprint Functional abnormalities of medial temporal cortex during novel picture learning among patients with chronic schizophrenia
    Lisa T Eyler Zorrilla
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Schizophr Res 59:187-98. 2003
    ..Learning deficits are prominent among patients with chronic schizophrenia and are associated with poor everyday functioning. Little is known, however, about the brain physiology underlying these difficulties with encoding new information...
  91. ncbi request reprint The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice
    Alasdair M Barr
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Neuropsychopharmacology 29:221-8. 2004
    ....
  92. pmc Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants?
    Scott Mackey
    Dept Psychiatry, University of California, San Diego, La Jolla, CA 92037, United States
    Neurosci Biobehav Rev 37:300-16. 2013
    ..Future research should include longitudinal designs on larger sample sizes and examine other stages of exposure to psychostimulants...
  93. ncbi request reprint Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects
    Jennifer E McDowell
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    Biol Psychiatry 51:216-23. 2002
    ..The current study tests hypotheses about the neural substrates of normal and abnormal saccadic performance among subjects with schizophrenia...
  94. ncbi request reprint Time-varying amygdala response to emotional faces in generalized social phobia
    Darren W Campbell
    Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada
    Biol Psychiatry 62:455-63. 2007
    ..We tested for such amygdala deficits to emotional faces in a sample of individuals with SP...
  95. ncbi request reprint MDMA affects both error-rate dependent and independent aspects of decision-making in a two-choice prediction task
    Franz X Vollenweider
    University Hospital of Psychiatry and Heffter Research Center, University of Zurich, Zurich, Switzerland
    J Psychopharmacol 19:366-74. 2005
    ..These results support the hypothesis that acute administration of MDMA affects success-related response selection during decision-making...
  96. ncbi request reprint Chaos and schizophrenia: does the method fit the madness?
    Martin P Paulus
    Department of Psychiatry, University of California, and Veterans Affairs San Diego Health Care System, San Diego, California, USA
    Biol Psychiatry 53:3-11. 2003
    ....
  97. ncbi request reprint Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control
    Susanna L Fryer
    Joint Doctoral Program in Clinical Psychology, San Diego State University, University of California, San Diego, California, USA
    Alcohol Clin Exp Res 31:1415-24. 2007
    ..This study characterized the neural substrates underlying the disinhibited behavioral profile of individuals with fetal alcohol spectrum disorders (FASD)...
  98. ncbi request reprint Error-rate-related caudate and parietal cortex activation during decision making
    Steven P Verney
    Department of Psychiatry and San Diego Veterans Affairs Health Care System, CA, USA
    Neuroreport 14:923-8. 2003
    ..Therefore, less response switching and increased response predictability during decision making can be directly related to the degree of activation in the caudate and posterior parietal cortex...

Research Grants19

  1. NEUROIMAGING OF DECISION MAKING IN STIMULANT ADDICTION
    Martin Paulus; Fiscal Year: 2003
    ..Moreover, this study will provide the basis for future investigations to determine whether the dysregulation in decision-making is a consequence of chronic use or a risk factor for the development of stimulant dependence. ..
  2. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin P Paulus; Fiscal Year: 2010
    ..g. using real-time fMRI?? ..
  3. Negative reinforcement and interoceptive dysfunction in stimulant dependence.
    Martin Paulus; Fiscal Year: 2009
    ..g. to dampen the influence of negative "gut feelings" on decision-making or risk-taking and thereby increase the chance of abstinence. ..
  4. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin Paulus; Fiscal Year: 2009
    ..g. using real-time fMRI?? ..
  5. STIMULANT DEPENDENCE: NEURAL MECHANISMS OF RELAPSE
    Martin Paulus; Fiscal Year: 2007
    ..This project will link systems neuroscience with clinical research in substance use disorders thereby providing cognitive neuroscience and neuroimaging insights into dysfunctions associated with substance use disorders. ..
  6. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin Paulus; Fiscal Year: 2006
    ....
  7. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin Paulus; Fiscal Year: 2007
    ....
  8. Time processing in stimulant users: Impulsivity and temporal discounting
    Martin Paulus; Fiscal Year: 2007
    ..The current study will inform treatment programs to create intervention strategies that manipulate the temporal delay of rewards to shape more adaptive behavior. ..
  9. STIMULANT DEPENDENCE: NEURAL MECHANISMS OF RELAPSE
    Martin Paulus; Fiscal Year: 2006
    ..This project will link systems neuroscience with clinical research in substance use disorders thereby providing cognitive neuroscience and neuroimaging insights into dysfunctions associated with substance use disorders. ..
  10. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin Paulus; Fiscal Year: 2006
    ....
  11. STIMULANT DEPENDENCE: NEURAL MECHANISMS OF RELAPSE
    Martin Paulus; Fiscal Year: 2005
    ..This project will link systems neuroscience with clinical research in substance use disorders thereby providing cognitive neuroscience and neuroimaging insights into dysfunctions associated with substance use disorders. ..
  12. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin Paulus; Fiscal Year: 2005
    ....
  13. STIMULANT DEPENDENCE: NEURAL MECHANISMS OF RELAPSE
    Martin Paulus; Fiscal Year: 2004
    ..This project will link systems neuroscience with clinical research in substance use disorders thereby providing cognitive neuroscience and neuroimaging insights into dysfunctions associated with substance use disorders. ..
  14. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin Paulus; Fiscal Year: 2004
    ....
  15. MDMA & Amphetamine--Behavioral Organization in Mice
    Martin Paulus; Fiscal Year: 2003
    ..The results from these studies will provide a set of measures derived from a widely used behavioral paradigm to examine the molecular basis of the effects of drugs of abuse using genetically modified mice. ..
  16. Negative reinforcement and interoceptive dysfunction in stimulant dependence.
    Martin P Paulus; Fiscal Year: 2010
    ..g. to dampen the influence of negative "gut feelings" on decision-making or risk-taking and thereby increase the chance of abstinence. ..