Jane Paulsen

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Refining the diagnosis of Huntington disease: the PREDICT-HD study
    Kevin M Biglan
    Department of Neurology, University of Rochester Rochester, NY, USA
    Front Aging Neurosci 5:12. 2013
  2. pmc Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:71. 2006
  3. ncbi request reprint Preparing for preventive clinical trials: the Predict-HD study
    Jane S Paulsen
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Arch Neurol 63:883-90. 2006
  4. ncbi request reprint Critical periods of suicide risk in Huntington's disease
    Jane S Paulsen
    Department of Psychology, University of Iowa, Roy J and Lucille A Carver College of Medicine, 1 305 Medical Education Bldg, Iowa City, IA 52241 1000, USA
    Am J Psychiatry 162:725-31. 2005
  5. ncbi request reprint Brain structure in preclinical Huntington's disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 59:57-63. 2006
  6. ncbi request reprint Depression and stages of Huntington's disease
    Jane S Paulsen
    University of Iowa, 1 305 Medical Education Building, Iowa City, IA 52242, USA
    J Neuropsychiatry Clin Neurosci 17:496-502. 2005
  7. pmc Striatal and white matter predictors of estimated diagnosis for Huntington disease
    Jane S Paulsen
    University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States
    Brain Res Bull 82:201-7. 2010
  8. pmc Functional imaging in Huntington's disease
    Jane S Paulsen
    Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Exp Neurol 216:272-7. 2009
  9. pmc Detection of Huntington's disease decades before diagnosis: the Predict-HD study
    J S Paulsen
    University of Iowa, Roy J and Lucille A Carver College of Medicine Research, 1 305 Medical Education Building, Iowa City, IA 52242 1000, USA
    J Neurol Neurosurg Psychiatry 79:874-80. 2008
  10. pmc Challenges assessing clinical endpoints in early Huntington disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
    Mov Disord 25:2595-603. 2010

Detail Information

Publications73

  1. pmc Refining the diagnosis of Huntington disease: the PREDICT-HD study
    Kevin M Biglan
    Department of Neurology, University of Rochester Rochester, NY, USA
    Front Aging Neurosci 5:12. 2013
    ..A multidimensional method results in an earlier diagnosis with less motor and cognitive impairment than a motor diagnosis. Findings have implications for designing preventive trials and providing clinical care in prodromal HD...
  2. pmc Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:71. 2006
    ....
  3. ncbi request reprint Preparing for preventive clinical trials: the Predict-HD study
    Jane S Paulsen
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Arch Neurol 63:883-90. 2006
    ..The optimal design and outcome measures for preventive clinical trials in neurodegenerative diseases are unknown...
  4. ncbi request reprint Critical periods of suicide risk in Huntington's disease
    Jane S Paulsen
    Department of Psychology, University of Iowa, Roy J and Lucille A Carver College of Medicine, 1 305 Medical Education Bldg, Iowa City, IA 52241 1000, USA
    Am J Psychiatry 162:725-31. 2005
    ..Although the underlying mechanisms of suicidal ideation in Huntington's disease are poorly understood, it is critical for health care providers to be aware of periods during which patients may be at an increased risk...
  5. ncbi request reprint Brain structure in preclinical Huntington's disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 59:57-63. 2006
    ..This study was designed to assess the morphology of the brain in participants who had previously undergone elective DNA analyses for the HD mutation who did not currently have a clinical diagnosis of HD (preclinical HD subjects)...
  6. ncbi request reprint Depression and stages of Huntington's disease
    Jane S Paulsen
    University of Iowa, 1 305 Medical Education Building, Iowa City, IA 52242, USA
    J Neuropsychiatry Clin Neurosci 17:496-502. 2005
    ..Despite the public health impact of depression, available treatments are underutilized in HD, and research is needed to document the efficacy and effectiveness of standard depression treatments in this population...
  7. pmc Striatal and white matter predictors of estimated diagnosis for Huntington disease
    Jane S Paulsen
    University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States
    Brain Res Bull 82:201-7. 2010
    ....
  8. pmc Functional imaging in Huntington's disease
    Jane S Paulsen
    Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Exp Neurol 216:272-7. 2009
    ..Strengths and limitations of the utilization of functional imaging in HD are discussed and recommendations are offered to facilitate future research endeavors...
  9. pmc Detection of Huntington's disease decades before diagnosis: the Predict-HD study
    J S Paulsen
    University of Iowa, Roy J and Lucille A Carver College of Medicine Research, 1 305 Medical Education Building, Iowa City, IA 52242 1000, USA
    J Neurol Neurosurg Psychiatry 79:874-80. 2008
    ..Here we estimate the approximate onset and initial course of various measurable aspects of HD relative to the time of eventual diagnosis...
  10. pmc Challenges assessing clinical endpoints in early Huntington disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
    Mov Disord 25:2595-603. 2010
    ..We conclude that future clinical trials designed for very early disease will require the development of new and more sensitive measures of real-life function...
  11. ncbi request reprint Incidence of and risk factors for hallucinations and delusions in patients with probable AD
    J S Paulsen
    Departments of Psychiatry and Neurology, University of Iowa, Iowa City 52242 1057, USA
    Neurology 54:1965-71. 2000
    ..To examine the incidence of and risk factors for hallucinations and delusions associated with patients clinically diagnosed with probable AD...
  12. pmc Cognitive impairment in Huntington disease: diagnosis and treatment
    Jane S Paulsen
    Departments of Psychiatry, Neurology, Neurosciences, and Psychology, The University of Iowa Roy J and Lucille A Carver College of Medicine, Research, Iowa City, IA, 52242 1000, USA
    Curr Neurol Neurosci Rep 11:474-83. 2011
    ..Efforts are now underway to develop valid and reliable measures of cognition in the prodrome as well as in all stages of HD so that clinical trials can be conducted using cognitive outcomes...
  13. ncbi request reprint Neurobehaviors and psychotic symptoms in Alzheimer's disease
    J S Paulsen
    Department of Psychiatry, University of Iowa, Iowa City, USA
    J Int Neuropsychol Soc 6:815-20. 2000
    ..Furthermore, findings provide preliminary evidence indicating which specific type of neurobehavioral abnormalities are related to the presence of distressing psychotic symptoms...
  14. pmc Neuropsychiatric aspects of Huntington's disease
    J S Paulsen
    Department of Psychiatry, The University of Iowa, 2880 JPP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Neurol Neurosurg Psychiatry 71:310-4. 2001
    ..Gaining a better understanding of neuropsychiatric symptoms is essential, as these symptoms have implications for disease management, prognosis, and quality of life for patients and caregivers...
  15. ncbi request reprint Clinical markers of early disease in persons near onset of Huntington's disease
    J S Paulsen
    University of Iowa, Iowa City, 52242 1000, USA
    Neurology 57:658-62. 2001
    ..As genes for late-onset neurodegenerative diseases are identified, the need for accurate assessment of phenoconversion (i.e., the transition from health to the disease phenotype) will be important...
  16. pmc Earliest functional declines in Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, The University of Iowa, Iowa City, IA, USA
    Psychiatry Res 178:414-8. 2010
    ..These are also important areas for clinical monitoring and treatment planning as up to 65% experienced loss in at least one area prior to diagnosis...
  17. pmc Cerebral cortex structure in prodromal Huntington disease
    Peggy C Nopoulos
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA 52242, USA
    Neurobiol Dis 40:544-54. 2010
    ..Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum...
  18. pmc Comorbidities of obsessive and compulsive symptoms in Huntington's disease
    Karen E Anderson
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Nerv Ment Dis 198:334-8. 2010
    ..Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan...
  19. pmc "Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness
    Kevin Duff
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    J Neuropsychiatry Clin Neurosci 22:196-207. 2010
    ..Participant/companion discrepancies, especially closest to Huntington's disease diagnosis, might suggest early lack of awareness in these individuals...
  20. ncbi request reprint Patients with Huntington's disease have impaired awareness of cognitive, emotional, and functional abilities
    Karin F Hoth
    Department of Psychology, University of Iowa, Iowa City, IA, USA
    J Clin Exp Neuropsychol 29:365-76. 2007
    ..Future studies will benefit also from examining the association between awareness and cognition in larger samples...
  21. ncbi request reprint Cognitive changes in Huntington's disease
    Jane S Paulsen
    University of Iowa, Department of Psychiatry and Neurology, Iowa City, Iowa, USA
    Adv Neurol 96:209-25. 2005
  22. pmc In their own words: reports of stigma and genetic discrimination by people at risk for Huntington disease in the International RESPOND-HD study
    Janet K Williams
    College of Nursing, University of Iowa, Iowa City, IA 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1150-9. 2010
    ..Findings document that reports of genetic discrimination are highly individual, and both policy as well as interpersonal factors contribute to the outcome of potentially discriminating events...
  23. ncbi request reprint Cognitive and psychiatric aspects of Huntington disease contribute to functional capacity
    Carissa Nehl
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242, USA
    J Nerv Ment Dis 192:72-4. 2004
  24. ncbi request reprint Neuropsychological characteristics of patients in a hospital-based eating disorder program
    John D Bayless
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 42242, USA edu
    Ann Clin Psychiatry 14:203-7. 2002
    ..Depression level and body mass were not associated with cognitive impairment. Whether effective restoration of weight and resolution of core psychopathology contribute to reversal of cognitive deficits requires further research...
  25. ncbi request reprint The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients
    Jovier D Evans
    Department of Psychiatry, University of California, San Diego, California, USA
    Biol Psychiatry 53:422-30. 2003
    ..This study sought to determine the relative importance of cognitive measures in predicting various domains of everyday functional capacity in older outpatients with schizophrenia...
  26. ncbi request reprint Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease
    Joseph R Sadek
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Neuropsychology 18:692-9. 2004
    ..The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage...
  27. pmc Self-paced timing detects and tracks change in prodromal Huntington disease
    Kelly C Rowe
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Neuropsychology 24:435-42. 2010
    ..This study compares self-paced timing performance (cross-sectionally and longitudinally) between participants with prodromal Huntington's disease (pr-HD) and a comparison group of gene non-expanded participants from affected families (NC)...
  28. pmc CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches
    Douglas R Langbehn
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 153:397-408. 2010
    ..The Langbehn et al. model appears accurate enough to have substantial utility in various research contexts. We also emphasize remaining caveats, many of which are relevant for any direct application to genetic counseling...
  29. ncbi request reprint "No one else sees the difference: "family members' perceptions of changes in persons with preclinical Huntington disease
    Janet K Williams
    College of Nursing, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 144:636-41. 2007
    ..Findings further support the need for a more comprehensive assessment and management of early HD symptoms as well as support for family members...
  30. ncbi request reprint Regression-based formulas for predicting change in RBANS subtests with older adults
    Kevin Duff
    Department of Psychiatry, University of Iowa, MEB 1 308, Iowa City, IA 52242 1000, USA
    Arch Clin Neuropsychol 20:281-90. 2005
    ..A case example is presented that utilizes the formulas...
  31. pmc Development of the Huntington disease family concerns and strategies survey from focus group data
    Janet K Williams
    College of Nursing, University of Iowa, Iowa City, IA 52242, USA
    J Nurs Meas 18:83-99. 2010
    ..83 or above. The measure can be used to generate reliable and valid data to identify adult family members' health-related concerns and management strategies for themselves and persons with HD...
  32. pmc Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington's disease
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Ann Clin Psychiatry 20:1-3. 2008
    ..Huntington's disease (HD) is a progressive, neuropsychiatric disorder, and limited reports indicate that risperidone might improve motor and psychiatric functioning for these patients...
  33. pmc Experiences of teens living in the shadow of Huntington Disease
    Kathleen J H Sparbel
    College of Nursing, The University of Iowa, Iowa City, IA, USA
    J Genet Couns 17:327-35. 2008
    ..Recognizing patterns of teen experiences may help health care providers develop strategies to support coping by teens in HD families...
  34. pmc Short-term practice effects in amnestic mild cognitive impairment: implications for diagnosis and treatment
    Kevin Duff
    Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Int Psychogeriatr 20:986-99. 2008
    ..Practice effects have been widely reported in healthy older adults, but these improvements due to repeat exposure to test materials have been more equivocal in individuals with mild cognitive impairment (MCI)...
  35. pmc Obsessive and compulsive symptoms in prediagnosed Huntington's disease
    Leigh J Beglinger
    University of Iowa, Department of Psychiatry, MEB 1 321, Iowa City, IA 52242 1000, USA
    J Clin Psychiatry 69:1758-65. 2008
    ..Although psychiatric symptoms have been reported in individuals with the HD gene expansion prior to clinical diagnosis (pre-HD), little is known about OCS in this phase of disease...
  36. pmc The emotional experiences of family carers in Huntington disease
    Janet K Williams
    College of Nursing, The University of Iowa, USA
    J Adv Nurs 65:789-98. 2009
    ..This paper is a report of a study conducted to examine the emotional experience of caregiving by family carers of people with Huntington disease and to describe strategies they used to deal with that experience...
  37. pmc Fully automated analysis using BRAINS: AutoWorkup
    Ronald Pierson
    The University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA
    Neuroimage 54:328-36. 2011
    ..Application of AutoWorkup for the analysis of data from the 32-site, multivendor PREDICT-HD study yield estimates of reliability to be greater than or equal to 0.90 for all tissues and regions...
  38. pmc Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1000, USA
    J Clin Psychopharmacol 29:484-7. 2009
    ..Atomoxetine is a norepinephrine reuptake inhibitor approved for treatment of attention-deficit/hyperactivity disorder...
  39. pmc Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Clin Exp Neuropsychol 32:573-8. 2010
    ..The RBANS provided additional information about other cognitive domains affected (e.g., memory) and may be a useful measure for tracking longitudinal change...
  40. pmc Cognitive deficits in Huntington's disease on the Repeatable Battery for the Assessment of Neuropsychological Status
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Clin Exp Neuropsychol 32:231-8. 2010
    ..Although additional research is needed, the current study supports the clinical applicability of the RBANS in patients with HD...
  41. pmc Neural bases of dysphoria in early Huntington's disease
    Sergio Paradiso
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
    Psychiatry Res 162:73-87. 2008
    ..This study elucidates possible mechanisms contributing to psychiatric disturbances of emotion often found in patients with Huntington's disease...
  42. ncbi request reprint Capacity to provide informed consent for participation in schizophrenia and HIV research
    David J Moser
    Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52240, USA
    Am J Psychiatry 159:1201-7. 2002
    ....
  43. pmc Practice effects in the prediction of long-term cognitive outcome in three patient samples: a novel prognostic index
    Kevin Duff
    University of Iowa, Department of Psychiatry, MEB 1 308, Iowa City, IA 52242 1000, United States
    Arch Clin Neuropsychol 22:15-24. 2007
    ..Additionally, this prognostic index could be used to offer interventions to patients who are in the earliest stages of progressive neurodegenerative disorders...
  44. ncbi request reprint Neuropsychological performance is associated with vascular function in patients with atherosclerotic vascular disease
    David J Moser
    Department of Psychiatry, W278 GH, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1000, USA
    Arterioscler Thromb Vasc Biol 27:141-6. 2007
    ..The current study was conducted to confirm and extend those findings in a much larger, nonoverlapping sample...
  45. ncbi request reprint White matter volume and cognitive dysfunction in early Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cogn Behav Neurol 18:102-7. 2005
    ..Fewer studies have examined other cerebral structures in early HD and potential associations with cognition...
  46. ncbi request reprint Blood vessel function and cognition in elderly patients with atherosclerosis
    David J Moser
    Department of Psychiatry, MEB 1 328, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1000, USA
    Stroke 35:e369-72. 2004
    ..This study was conducted to determine the relationship between blood vessel function and cognition in elderly patients with atherosclerosis...
  47. ncbi request reprint Concordance between the CVLT and the WMS-III word lists test
    Bradley D McDowell
    Department of Psychiatry, Psychiatry Research, 1 287 Medical Education Bldg, University of Iowa, Iowa City, IA 52242 1000, USA
    Arch Clin Neuropsychol 19:319-24. 2004
    ..When diagnostic outcomes were discordant for free recall measures, the CVLT indicated impairment more often than did the WLT...
  48. ncbi request reprint Coercion and informed consent in research involving prisoners
    David J Moser
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City 52240, USA
    Compr Psychiatry 45:1-9. 2004
    ..Despite serious past incidents, ethicists will need to consider the possibility that prisoners have become an overprotected population...
  49. ncbi request reprint Cognitive impairment in anorexia nervosa is not due to depressed mood
    Bradley D McDowell
    Department of Psychiatry, 1 287 Medical Education Building, University of Iowa, Iowa City, IA 52242 1000, USA
    Int J Eat Disord 33:351-5. 2003
    ..It is unclear whether these deficits are linked to co-morbid depression in this population. We examined the relationship between depressive symptoms and cognitive functioning...
  50. ncbi request reprint Neuropsychological functioning pretreatment and posttreatment in an inpatient eating disorders program
    David J Moser
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52240, USA
    Int J Eat Disord 33:64-70. 2003
    ..This study was conducted to determine whether neuropsychological dysfunction associated with anorexia nervosa resolves with inpatient treatment...
  51. ncbi request reprint Neuropsychological and psychiatric functioning pre- and posthematopoietic stem cell transplantation in adult cancer patients: a preliminary study
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
    J Int Neuropsychol Soc 13:172-7. 2007
    ..Education about these possible pretransplant sequelae and the potential for rebound may be helpful to patients and families as they prepare for this treatment and the recovery period...
  52. ncbi request reprint Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD study
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 62:1341-6. 2007
    ..Psychiatric disturbances are relatively common in manifest Huntington's disease (HD), but less is known about these symptoms in the earliest phase of the illness...
  53. ncbi request reprint Probability of obsessive and compulsive symptoms in Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 61:415-8. 2007
    ..The purpose of this study was to examine the probability of obsessive and compulsive (OC) symptoms across stages of Huntington's disease (HD) with both cross sectional and longitudinal data...
  54. ncbi request reprint Morphology of the cerebral cortex in preclinical Huntington's disease
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA
    Am J Psychiatry 164:1428-34. 2007
    ..Cortical morphology was evaluated in subjects with known gene expansion for Huntington's disease and no manifest disease...
  55. ncbi request reprint Predictors of diagnosis in Huntington disease
    Douglas R Langbehn
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Neurology 68:1710-7. 2007
    ..The objective is to examine the prognostic significance of these early clinical signs and symptoms regarding time until unequivocal clinical HD diagnosis...
  56. pmc The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242 1000, USA
    Arch Clin Neuropsychol 26:98-109. 2011
    ....
  57. pmc Patient and caregiver quality of life in Huntington's disease
    Rebecca E Ready
    Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Mov Disord 23:721-6. 2008
    ..Clinical implications of results are discussed. Future work is needed because subjective QOL is an important outcome measure in therapeutic trials...
  58. ncbi request reprint Prism adaptation in schizophrenia
    Nirav O Bigelow
    Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, USA
    Brain Cogn 61:235-42. 2006
    ..Deficits in prism adaptation among schizophrenia patients may be due to abnormalities in motor programming arising from the disruptions within the neural networks that subserve PL...
  59. ncbi request reprint Factor analysis of the frontal systems behavior scale (FrSBe)
    Julie C Stout
    Department of Psychology, Indiana University, Bloomington 47405 7007, USA
    Assessment 10:79-85. 2003
    ..The FrSBe factor structure supports its utility for assessing both the severity of the three frontal syndromes in aggregate and separately...
  60. ncbi request reprint fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    AJNR Am J Neuroradiol 25:1715-21. 2004
    ..The current study was designed to examine the relative sensitivity of fMRI compared with that of behavioral testing and morphometric measurements in detecting early neurodegenerative changes related to Huntington's disease (HD)...
  61. pmc Couples' attributions for work function changes in prodromal Huntington disease
    Nancy R Downing
    University of Iowa College of Nursing, Iowa City, IA, USA
    J Genet Couns 19:343-52. 2010
    ..In persons with prodromal HD the relationship between attributions and use of coping strategies for symptoms that interfere with job functioning is unknown...
  62. pmc Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease
    Elizabeth Penziner
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:320-5. 2008
    ..Discrimination concerns remain high in this sample and point to the need for more information to determine the extent and scope of the problem...
  63. ncbi request reprint fMRI detection of early neural dysfunction in preclinical Huntington's disease
    Janice L Zimbelman
    Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, and Schey Center for Cognitive Neuroimaging, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Int Neuropsychol Soc 13:758-69. 2007
    ..These results suggest that fMRI is sensitive to neural dysfunction occurring more than 12 years prior to the estimated onset of manifest HD...
  64. pmc Stability of neuropsychological performance in anorexia nervosa
    Ania E Mikos
    University of Florida, Gainesville, FL 32610, USA
    Ann Clin Psychiatry 20:9-13. 2008
    ..We investigated the stability of neuropsychological performance and eating disorder (EDO) symptoms before, immediately after, and 2 years after inpatient treatment. We also examined relationships between neuropsychological and EDO measures...
  65. ncbi request reprint Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches
    Sean C Hinton
    Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Int Neuropsychol Soc 13:539-43. 2007
    ..Motor timing variability, but not accuracy, may serve as a marker to define the earliest behavioral changes in HD. The present study is among the first to examine the relationship between behavioral measures and YEO in pre-HD...
  66. ncbi request reprint Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease
    Shannon A Johnson
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
    Brain 130:1732-44. 2007
    ..In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition...
  67. pmc Preclinical Huntington's disease: compensatory brain responses during learning
    Andrew Feigin
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Neurol 59:53-9. 2006
    ..Nonetheless, this mechanism may not be sufficient to sustain a normal level of task performance, even during the presymptomatic stage of the disease...
  68. ncbi request reprint Neurocognitive deficits related to poor decision making in people behind bars
    Eldad Yechiam
    Technion Israel Institute of Technology, Haifa, Israel
    Psychon Bull Rev 15:44-51. 2008
    ..The present cognitive model provides a novel way for building a bridge between cognitive neuroscience and complex human behaviors...
  69. pmc Verbal episodic memory declines prior to diagnosis in Huntington's disease
    Andrea C Solomon
    Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th Street, Bloomington, IN 47405, USA
    Neuropsychologia 45:1767-76. 2007
    ..These findings indicate that verbal episodic memory is affected in early pre-diagnostic HD and may decline as striatal volumes decrease and individuals approach the motor diagnostic threshold...
  70. pmc Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease
    Yvonne Bombard
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Eur J Hum Genet 16:279-89. 2008
    ..These results help identify areas where more education and support is needed and provide direction to genetic professionals supporting their clients as they confront issues of GD and genetic testing...
  71. pmc Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16
    Luc Djousse
    Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA
    Neurogenetics 5:109-14. 2004
    ..Furthermore, the modifier may be present on both HD and normal chromosomes bearing the 3 allele of the MSX1 marker...
  72. pmc A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, and Bioinformatics Program, School of Public Health, Boston University, Boston, MA, USA
    Am J Hum Genet 73:682-7. 2003
    ..Suggestive evidence for linkage was found at 4p16 (LOD=1.93), 6p21-23 (LOD=2.29), and 6q24-26 (LOD=2.28), which may be useful for investigation of genes that modify age at onset of HD...

Research Grants24

  1. NEUROBIOLOGICAL PREDICTORS OF HUNTINGTON'S DISEASE
    Jane Paulsen; Fiscal Year: 2007
    ..In addition to the contribution this will make towards early intervention in HD, our findings are likely to improve our understanding of the functional pathophysiology of other neurodegenerative and genetic illnesses. ..
  2. Cognitive and functional brain changes in preclinical Huntington's disease (HD)
    Jane S Paulsen; Fiscal Year: 2010
    ..The proposed project will advance our understanding of the neurobiology of HD as well as the role of corticostriatal circuitry in mediating cognitive functions. ..
  3. Neurobiological Predictors of Huntington's Disease
    Jane S Paulsen; Fiscal Year: 2010
    ..Continuation of PREDICT-HD will refine the markers as tools for clinical trials so that new drugs can be tested to slow and eventually to prevent HD. ..
  4. Response of a Sample Population with the Deleterious HD allele RESPOND-HD
    Jane Paulsen; Fiscal Year: 2007
    ..This study will be among the first to compare ethical, legal and social experiences of having known genetic risk. ..
  5. Cognitive and functional brain changes in preclinical Huntington's disease (HD)
    Jane Paulsen; Fiscal Year: 2007
    ..The proposed project will advance our understanding of the neurobiology of HD as well as the role of corticostriatal circuitry in mediating cognitive functions. ..
  6. NEUROPSYCHOLOGY AND DEMENTIA
    Jane Paulsen; Fiscal Year: 2002
    ..This award will facilitate the candidate's research efforts towards understanding brain-behavior relations in dementia and using this knowledge to assist families and individuals in treatment planning for the future. ..
  7. NEUROBIOLOGICAL PREDICTORS OF HUNTINGTON'S DISEASE
    Jane Paulsen; Fiscal Year: 2004
    ..These more comprehensive evaluations will include a videotaped examination, volumetric magnetic resonance imaging, detailed neuropsychometric testing and behavioral ratings. ..
  8. Neurobiological Predictors of Huntington's Disease
    Jane S Paulsen; Fiscal Year: 2010
    ..Early markers of HD have been identified 10-20 years before the HD diagnosis is given. Continuation of PREDICT-HD will refine the markers as tools for clinical trials so that new drugs can be tested to slow and eventually to prevent HD. ..