Chrystal M Paulos
Affiliation: University of Pennsylvania
- The inducible costimulator (ICOS) is critical for the development of human T(H)17 cellsChrystal M Paulos
Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Sci Transl Med 2:55ra78. 2010..These findings have provided the rationale for designing new clinical trials for tumor immunotherapy...
- Adoptive immunotherapy: good habits instilled at youth have long-term benefitsChrystal M Paulos
Abramson Family Cancer Research Institute, University of Pennsylvania, BRB II III, Room 554, 421 Curie Boulevard, Philadelphia, PA, 19104 6160, USA
Immunol Res 42:182-96. 2008..We also describe how aAPCs can be used to broaden ACT to treat patients with a wide variety of cancers, chronic infectious diseases, and autoimmune manifestations...
- Putting the brakes on BTLA in T cell-mediated cancer immunotherapyChrystal M Paulos
Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104 6160, USA
J Clin Invest 120:76-80. 2010..We discuss these findings in the context of the expanding field of cosignaling molecules and their implications for T cell-based therapies for cancer...
- Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumorYangbing Zhao
Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine and Thoracic Oncology Research Laboratory and Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
Cancer Res 70:9053-61. 2010..This approach may increase the therapeutic index of T cells engineered to express powerful activation domains without the associated safety concerns of integrating viral vectors...
- Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cellsMatthew J Frigault
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
Cancer Immunol Res 3:356-67. 2015..The identification of CARs that confer constitutive or nonconstitutive growth patterns may explain observations that CAR T cells have differential survival patterns in clinical trials. Cancer Immunol Res; 3(4); 356-67. ©2015 AACR. ..